CN107375347A - The thickening-purification technology preparation method of ganoderma spove powder - Google Patents
The thickening-purification technology preparation method of ganoderma spove powder Download PDFInfo
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- CN107375347A CN107375347A CN201710537509.3A CN201710537509A CN107375347A CN 107375347 A CN107375347 A CN 107375347A CN 201710537509 A CN201710537509 A CN 201710537509A CN 107375347 A CN107375347 A CN 107375347A
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- Prior art keywords
- thickening
- ganoderma
- liquid
- purification technology
- lucidum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides a kind of thickening-purification technology preparation method of ganoderma spove powder, it comprises the following steps：Step 1, ganoderma lucidum is cleaned, ganoderma lucidum is crushed after cleaning, it is standby to crush placement；Step 2, the Reishi sporule in the glossy ganoderma powder crushed in extraction step one；Step 3, broken wall treatment is carried out to the Reishi sporule in step 2；Step 4, the Reishi sporule handled well in step 3 is fermented, ganoderma lucidum fermented liquid is obtained after fermentation；Step 5, is filtered and separation of solid and liquid etc. to the ganoderma lucidum fermented liquid in step 4.The present invention in the case where not destroying the material of lucidum spore powder, can improve the concentration of lucidum spore powder, improve product quality, improve the utilization rate of product, its capacity is absorbed by human body.
Description
Technical field
The present invention relates to a kind of thickening-purification technology preparation method, in particular it relates to which a kind of concentration of ganoderma spove powder is net
Change preparation method.
Background technology
Ganoderma lucidum is the general name of Basidiomycetes On Polyporaceae red sesame and purple sesame, has and strengthens the body resistance to consolidate the constitution and other effects, ganoderma lucidum spore
Sub- powder is the elite of ganoderma lucidum, and lucidum spore powder has antitumor, hypoglycemic, raising body immunity, strengthens the disease-resistant energy of body
Power, liver protection, anti-inflammation, antipyretic-antalgic, reduce transaminase, reduce after cholesterol, the effect such as calmness, but Reishi sporule are taken not
Easily by human consumption, and ganoderma lucidium spore powder wall breaking method mainly utilizes chemical method broken wall or heating means broken wall now, profit
Chemically broken wall is that lucidum spore powder is added into chemical solvent immersion, other PROCESS FOR TREATMENTs is then carried out again, using chemistry
Method broken wall, the composition difficulty or ease separation of chemical solvent is clean, and when people take with other medicines, the chemical substance of residual may
Reacted with other medicines, or chemical analysis directly causes damage to human body；Using the method for heating, due to heating repeatedly,
Temperature is too high, and spore includes active material and is killed or its ingredient change.Product be present in the lucidum spore powder of these methods extraction
Concentration is not high enough, the problems such as product quality is low.
The content of the invention
For in the prior art the defects of, the technical problem to be solved in the present invention is to provide a kind of ganoderma spove powder
Thickening-purification technology preparation method, it in the case where not destroying the material of lucidum spore powder, can improve the concentration of lucidum spore powder,
Product quality is improved, the utilization rate of product is improved, its capacity is absorbed by human body.
According to an aspect of the present invention, there is provided a kind of thickening-purification technology preparation method of ganoderma spove powder, it includes
Following steps：
Step 1, ganoderma lucidum is cleaned, ganoderma lucidum is crushed after cleaning, it is standby to crush placement；
Step 2, the Reishi sporule in the glossy ganoderma powder crushed in extraction step one；
Step 3, broken wall treatment is carried out to the Reishi sporule in step 2；
Step 4, the Reishi sporule handled well in step 3 is fermented, ganoderma lucidum fermented liquid is obtained after fermentation；
Step 5, is filtered and separation of solid and liquid to the ganoderma lucidum fermented liquid in step 4；
Step 6, filtering and the good lucidum liquid of separation of solid and liquid in step 5 are carried out extraction thickening-purification technology；
Step 7, the lucidum liquid good to thickening-purification technology carry out finished product processing.
Preferably, the filter type in the step 5 is suspension is situated between by a kind of filtering with many pores
Matter, suspension thalline and residual media thing is trapped in above this medium, and reach a kind of operation of Solid-Liquid Separation.
Preferably, the step 6 is to be allowed to be changed into the solution of high concentration from the solution removing water or solvent of low concentration.
Preferably, the step 5 uses a kind of following filter type：Natural filtration, pressure filtration, vacuum filter, centrifugation
Filtering.
Preferably, the step 6 is by the way of a kind of following extraction thickening-purification technology：Atmospheric evaporation purification, thin film evaporation
Purification, dry decontamination.
Compared with prior art, the present invention has following beneficial effect：The present invention can not destroy lucidum spore powder
Material in the case of, improve the concentration of lucidum spore powder, improve product quality, improve the utilization rate of product, make its capacity quilt
Human body is absorbed.
Embodiment
With reference to specific embodiment, the present invention is described in detail.Following examples will be helpful to the technology of this area
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this area
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection domain.
The thickening-purification technology preparation method of ganoderma spove powder of the present invention comprises the following steps：
Step 1, ganoderma lucidum is cleaned, ganoderma lucidum is crushed after cleaning, it is standby to crush placement；
Step 2, the Reishi sporule in the glossy ganoderma powder crushed in extraction step one；
Step 3, broken wall treatment is carried out to the Reishi sporule in step 2；
Step 4, the Reishi sporule handled well in step 3 is fermented, ganoderma lucidum fermented liquid is obtained after fermentation；
Step 5, is filtered and separation of solid and liquid to the ganoderma lucidum fermented liquid in step 4；
Step 6, filtering and the good lucidum liquid of separation of solid and liquid in step 5 are carried out extraction thickening-purification technology；
Step 7, the lucidum liquid good to thickening-purification technology carry out finished product processing.
Filter type in the step 5 is to make suspension make to hang by a kind of filter medium with many pores
Floating thalline and residual media thing are trapped in above this medium, and reach a kind of operation of Solid-Liquid Separation.
Filter type in the step 5 includes following several：
First, natural filtration, it mainly produces motive force by a filtrate potential difference and causes filtering；
2nd, pressure filtration, it is mainly with the pressure suffered by a compressed gas larger fluid or defeated sample liquid with a pump
Motive force of the hydraulic pressure as filtering is produced when delivering to filter；
3rd, vacuum filter, itself and pressure filtration are on the contrary, be just to be vacuumized under filter medium, to increase on filter medium
Under pressure difference, promote solvent have rotary drum vacuum filter by filter medium, conventional vacuum filter；
4th, centrifugal filtration, by the use of rotary drum, centrifugal force as the motive force of filtering, makes suspension caused by rotation at a high speed for it
Middle thalline separates with liquid；Because caused centrifugal force is larger, the rate of filtration is very fast, most uses in medicinal fungi is produced
Centrifugation apparatus has heavy configuration centrifuge, horizontal centrifuge, tubular-bowl centrifuge, link-suspended basket centrifuge etc.；Wherein 3-foot from
Scheming is a kind of conventional centrifuge of current medicinal fungi production, and it has simple in construction, smooth operation, floor space small, solid
The advantages that scapus does not wear, especially suitable for small lot, the medium bulk crystalline material of multi items and very thin shape material
Dehydration.
The step 6 is to be allowed to be changed into the solution of high concentration, heating and decompression from the solution removing water or solvent of low concentration
One of the most frequently used method of vaporation-type, such convenient use.
The mode of extraction thickening-purification technology in the step 6 includes following several：
First, atmospheric evaporation purifies, and thickening-purification technology liquid to be extracted evaporates at ambient pressure, is steamed using a kind of stainless steel of jacket type
Pot is sent out, this equipment is an open Dumpage type folder evaporation boiler, and chuck pot is fixed in hollow shaft, has pot wheel that pot can be made any on axle
Rotate, steam is passed through from connecting tube, and condensed water flows out from connecting tube, and active ingredient of this equipment suitable for liquid is heat-resisting
's；Product chemical stability is strong, molten coal again without flammability, and it is nontoxic with it is harmless；
2nd, thin film evaporation purifies, and is liquid is formed film, increase gasification surface, accelerates evaporation；Steamed using a film
There is upright heating tube in hair device, heat transfer area is larger, and liquid under reduced pressure, into heating tube, pulls into liquid of evaporation thin
Film runs through the inwall of pipe, continuous evaporation, is the advantages of thin film evaporation：Liquid film surface is very big, and heat transfer is fast and uniform, and liquid exists
Evaporation tube residence time is very short, accordingly even when temperature is slightly higher, material is not easy to destroy；
3rd, dry decontamination, the process that the aqueous solvent in the solid of humidity, paste, concentrate and liquid is evolved；Its mesh
Be improve product stability, it is met defined standard, the thickening-purification technology of Ganoderma lucidum mycelium body fluid zymotic fluid is typically often adopted
With spray dry scrubbing method；Spray drying is that feed liquid (aqueous more than 50% solution, suspension, pulpous state liquid etc.) is sprayed into mist
Drop is scattered in thermal current, moisture is evaporated rapidly and is turned into granular dried product；The effect of spray dry scrubbing is decided by
Droplet size, when fogdrop diameter is 10um or so, the number of drops that every liter of liquid is formed can reach 1.92 × 10The gross area
600m can be reached2, for usual fogdrop diameter between 10~50um, surface area is big, and evaporation is exceedingly fast, and drying time is very short, the several seconds
To number 10 seconds, moisture evaporation, which takes away heat, can also be such that the temperature of drop and surrounding reduces rapidly；Therefore can dry at ambient pressure
Heat sensitive material, change operating condition can also adjust the granularity and water content of product, and can be made it is hollow pay spherical products,
It is easy to dissolve；Spray dry scrubbing device includes：Spray chamber, liquid sprayer, heat air and it is connected into spray chamber
Equipment, from damp-heat air separate fine powder device；Air is filtered through a filter frame, and air heating is sent into by an air blower
Room, the air pressure of oven heats pipe maintain 8.5kgcm-2, add 130 DEG C of air themperature；Material is by an air compressor or one
Individual high-pressure pump is with 70Kgcm-2Pressure be sprayed into mist, evaporation drying immediately of being met in spray chamber with hot-air, obtain superfine
The finished product of purification；The fine powder of dry decontamination largely falls the drying fine powder taken away in the bottom of spray chamber, fraction by hot-air
Then it is collected in bag hose, waste gas is discharged into outdoor through centrifugal exhaust blower air blower；The principle of cooling spray drying is profit
Make air dehydration before heating with hygroscopic agent, reduce air humidity, the temperature of spray drying can be further reduced, so as to improve
The quality of spray dried products.
The specific embodiment of the present invention is described above.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring the substantive content of the present invention.
Claims (5)
1. the thickening-purification technology preparation method of a kind of ganoderma spove powder, it is characterised in that comprise the following steps：
Step 1, ganoderma lucidum is cleaned, ganoderma lucidum is crushed after cleaning, it is standby to crush placement；
Step 2, the Reishi sporule in the glossy ganoderma powder crushed in extraction step one；
Step 3, broken wall treatment is carried out to the Reishi sporule in step 2；
Step 4, the Reishi sporule handled well in step 3 is fermented, ganoderma lucidum fermented liquid is obtained after fermentation；
Step 5, is filtered and separation of solid and liquid to the ganoderma lucidum fermented liquid in step 4；
Step 6, filtering and the good lucidum liquid of separation of solid and liquid in step 5 are carried out extraction thickening-purification technology；
Step 7, the lucidum liquid good to thickening-purification technology carry out finished product processing.
2. the thickening-purification technology preparation method of ganoderma spove powder according to claim 1, it is characterised in that the step
Filter type in five is suspension is made suspension thalline and remaining culture by a kind of filter medium with many pores
Substratess are trapped in above this medium, and reach a kind of operation of Solid-Liquid Separation.
3. the thickening-purification technology preparation method of ganoderma spove powder according to claim 1, it is characterised in that the step
Sixth, it is allowed to be changed into the solution of high concentration from the solution removing water or solvent of low concentration.
4. the thickening-purification technology preparation method of ganoderma spove powder according to claim 1, it is characterised in that the step
Five use a kind of following filter type：Natural filtration, pressure filtration, vacuum filter, centrifugal filtration.
5. the thickening-purification technology preparation method of ganoderma spove powder according to claim 1, it is characterised in that the step
Six by the way of a kind of following extraction thickening-purification technology：Atmospheric evaporation purification, thin film evaporation purification, dry decontamination.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710537509.3A CN107375347A (en) | 2017-07-04 | 2017-07-04 | The thickening-purification technology preparation method of ganoderma spove powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710537509.3A CN107375347A (en) | 2017-07-04 | 2017-07-04 | The thickening-purification technology preparation method of ganoderma spove powder |
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| Publication Number | Publication Date |
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| CN107375347A true CN107375347A (en) | 2017-11-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710537509.3A Pending CN107375347A (en) | 2017-07-04 | 2017-07-04 | The thickening-purification technology preparation method of ganoderma spove powder |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857030A (en) * | 2015-04-30 | 2015-08-26 | 黄宇明 | Wall breaking method for ganoderma lucidum spore powder and product obtained with same |
-
2017
- 2017-07-04 CN CN201710537509.3A patent/CN107375347A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857030A (en) * | 2015-04-30 | 2015-08-26 | 黄宇明 | Wall breaking method for ganoderma lucidum spore powder and product obtained with same |
Non-Patent Citations (1)
| Title |
|---|
| 屈直等: "灵芝液体深层发酵技术研究进展", 《热带农业科学》 * |
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Application publication date: 20171124 |