CN107375079A - A kind of extracting method of cacao seed extract and its application in hand frost - Google Patents
A kind of extracting method of cacao seed extract and its application in hand frost Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/81—Preparation or application process involves irradiation
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Abstract
The invention discloses a kind of extracting method of cacao seed extract, comprise the following steps：(1) by cocoa seed cleaning, drying, ultramicro grinding can cross 40 mesh sieves, standby；(2) cocoa seed powder 30g is added in deionized water, temperature is then raised to 30 60 DEG C, then add compound biological enzyme 0.5 3%, be 4.0 6.0 with acid for adjusting pH, after stirring, keep 0.5 3H of enzymolysis；(3) and then it is brought rapidly up to 100 DEG C of progress quick inactivatings, is cooled to 60 DEG C of microwave radiation exaractions after inactivating 1MIN, microwave power is 500 700W, the 50MIN of Microwave Extraction time 20；(4) extraction solution is filtered, is removed slag, concentrated and is dried in vacuo and to be obtained cocoa seed elite.Present invention also offers a kind of crease-resistant anti-inflammatory to repair hand lotion.The present invention uses biological enzyme combination microwave extract method, more leniently cocoa seed material is decomposed by enzyme reaction, promote the release of active ingredient, be not damaged so as to remain cocoa seed elite to greatest extent, and the intervention of microwave is even more to greatly increase efficiency in advance.
Description
Technical field
The present invention relates to daily technical field of skin care, more particularly to a kind of extracting method of cacao seed extract and its
Application in hand frost.
Background technology
Cacao seed extract be it is a kind of from natural cocoa chocolate tree extraction active component, cocoa chocolate tree (Theobroma
Cacao tropical central and south america equator forest) is originated in.Cacao seed extract contains abundant active component, such as brass
Class：Anthocyanidin, catechuic acid, raw anthocyanidin, OPC, amino acids：Alanine, arginine, glutamic acid, glycine, bad ammonia
Acid, proline, alkaloid：Caffeine, theobromine, theophylline, vitamins：B1, B2, B3, B5, vitamin C, mineral matter class：Calcium,
Phosphorus, copper, magnesium, phytate etc..These nutriments so that the extract has good anti-oxidant and anti-inflammatory activity.
In the prior art, the extracting method of cacao seed extract has a lot, such as hot reflux extraction method, supercritical fluid extraction
Follow the example of, ultrasonic extraction, microwave loss mechanisms, leaching method etc..And these methods have that extraction efficiency is low, and technique is complex, consumption
The problems such as duration, extraction cost are high, and environmental pollution is larger.
The content of the invention
It is an object of the invention to overcome, the cocoa seed extraction efficiency in the presence of prior art is low, the time is long, extraction is pure
Degree is inadequate, it is not green enough the problems such as, there is provided a kind of energy-conserving and environment-protective, extraction efficiency is high, the simple biology enzyme of operating procedure-micro-
Ripple extraction method.The inventive method shortens extraction time, and mild condition by the catalysis of biology enzyme, by microwave radiation technology,
Accelerate the utilization speed of molecule, also increase intermolecular collision frequency, molecule is reached the state of activation, cell membrane and cell membrane
Rupture, the active ingredient outflow of intracellular, so as to improve extraction efficiency.
The present invention, using in frost in one's hands, plays also by the cacao seed extract that biology enzyme-Microwave Extraction technique is extracted
Anti-oxidant and anti-inflammatory of cacao seed extract and other effects, there is provided one kind is gently non-stimulated with crease-resistant, anti-inflammatory, property, energy
Effectively calm sensitive skin, the taste hand cream for skin of releiving.
To solve above technical problem, the present invention adopts the following technical scheme that, a kind of extracting method of cacao seed extract,
Comprise the following steps：
(1) by cocoa seed cleaning, drying, ultramicro grinding can cross 40 mesh sieves, standby；
(2) the cocoa seed powder 30g by step (1) pretreatment is added in deionized water, and temperature then is raised into 30-60 DEG C,
Then compound biological enzyme 0.5-3% is added, is 4.0-6.0 with acid for adjusting pH, after stirring, keeps enzymolysis 0.5-3H；
(3) after step (2) enzymolysis, then it is brought rapidly up to 100 DEG C of progress quick inactivatings, 60 is cooled to after inactivating 1MIN
DEG C microwave radiation exaraction, microwave power 500-700W, Microwave Extraction time 20-50MIN；
(4) extraction solution is filtered, is removed slag, concentrated and is dried in vacuo and to be obtained cocoa seed elite.
Further, present inventor find using compound biological enzyme i.e. by pectase, cellulase, zytase,
Papain presses 1：0.5：1：1 ratio is prepared, and is added by 0.5%-3% addition, and complex enzyme has than single enzyme
Higher extraction efficiency, be inside cocoa seed containing a variety of effective functional components, by compound biology enzyme can more fully by
The constituent hydrolysis or degraded of plant cell wall.And by orthogonal experiment single_factor method, obtain 1：0.5：1：1 this proportioning energy
Obtain more effective enzymolysis efficiency.
Preferably, 50 DEG C of the hydrolysis temperature, adds 1% compound biological enzyme, and regulation PH is 4.5, enzymolysis time 1.5h,
Microwave power 600W, Microwave Extraction time 30min, on this condition, the extraction efficiency highest of cacao seed extract.
The present invention uses biological enzyme combination microwave extract method, by enzyme reaction more leniently by cocoa seed material point
Solution, promotes the release of active ingredient, is not damaged so as to remain cocoa seed elite to greatest extent, and the intervention of microwave is even more
Efficiency in advance is greatly increased, and reduces the discharge of pollutant, extraction process is simple, easy to operation, realizes " green
Extract engineering ".
Present invention also offers a kind of crease-resistant anti-inflammatory to repair hand lotion, by weight percentage including following component：
Emulsifying agent 0.1-~8%
NMF 0.1~30%
Emollient 0.1~30%
Cacao seed extract 0.1~5%
Stable thickener 0.1~3%
Preservative, the essence of suitable reason
Surplus is deionized water.
Preferably, the emulsifying agent be selected from tristerin (and) PEG-100 stearates, cetyl glucoside,
At least one of ceteareth -20, soybean lecithin.
It is furthermore preferred that tristerin (and) mixture of PEG-100 stearates and cetyl glucoside, dosage
For 2%-5%.
Cetyl glucoside is a kind of New-type emulsifier of plant origin, and it is a kind of natural polysaccharide to substitute as biography
The ethoxylate groups of one of nonionic surfactant feature of uniting, are thus obtained a kind of by hydrophilic glucosides and the cocounut oil of oleophylic
The naturally occurring emulsifying agent that chain is formed, the unique glycosidic structure middle part of cetyl glucoside is containing any chemical substance, solvent, epoxy second
Ring and dioxanes, so opening the approach of the ecological product of a new generation.Its with tristerin (and) PEG-100 stearates
Arrange in pairs or groups by a certain percentage, highly stable cream system can be obtained, and assign the appearance of product fine.
Preferably, the emulsifying agent is that described NMF is 1,3 butanediols, propane diols, glycerine, glycine betaine, honey day
At least one of right moisturizing factor, trehalose.
It is furthermore preferred that the emulsifying agent is the mixture of glycerine and glycine betaine, dosage 3%-8%.
Glycine betaine is extracted from beet root completely, pure gentle containing 99% active matter, suitable for various skins.Except assigning
Moisturizing performance is given, it is same to tackle oxidation stimulation and UV damages, reduce chemical stimulation, physical damnification, and surface-active
Stimulated caused by agent.In addition can also stimulation collagen synthesis, make skin moisturizing flexible.
Preferably, the emollient is dimethicone, isopropyl palmitate, jojoba oil, cera alba, lanolin, ore deposit
At least one of fat, shea butter, caprylic/capric triglyceride.
It is furthermore preferred that the mixture of the caprylic/capric triglyceride, dimethicone and shea butter, dosage 7-
15%.
Shea butter, the entitled shea butter of English, are a kind of natural oils extracted from the Butyrospermum pulp of West Africa,
Butyrospermum produces the dry ground band with equator annex, and about 10 meters of the height of tree, tree crown is wide, and fruit is pears type or ellipse, and pulp is soft
It is soft.Shea butter has the effect of good deep layer is moistened, and suitable dryness typically is made by each large enterprises, Combination skin uses
Product.Long-term use of shea butter or the skin care item containing shea butter, can not only prevent season cracking, moreover it is possible to further
Recover and keep the natural elasticity of skin, there is good deep layer to moisten effect.
Caprylic/capric triglyceride is high salubrious degree grease, the derivative of platymiscium source grease it be using heat point
Method extraction is evaporated because there is compatible feature it and human body skin, so also being adapted for Oily use, and will not be blocked
It has non-greasy texture to pore, can lubricate and make the soft effect of skin, and have the function of filtering ultraviolet.
Had the advantages that with technical scheme：
1st, the present invention is prepared cocoa seed and skimmed the cream off milk using biology enzyme-microwave coordination extraction method, the maximum of biology enzyme extraction
Advantage is exactly that gentle, energy-conservation, Extracting temperature be not high, rich in all types of amino acid, minerals and vitamins class inside cocoa seed
Working substance, if using existing heat reflow method, sour formulation, supercritical fluid extraction etc., it is possible in extraction process
The effective active thing of cocoa seed is destroyed, and uses multiplex-enzyme extraction method, can effectively preserve the effective active of extract,
Environmental protection and energy saving, product is easy to purify, simple to operate.
2nd, the present invention uses microwave cooperating while using biology enzyme extraction, by microwave radiation technology, accelerates the fortune of molecule
Dynamic speed, also increases intermolecular collision frequency, molecule is reached the state of activation, cell membrane and membranolysis, intracellular
Active ingredient flows out, and substantially increases extraction efficiency, and has higher extraction efficiency than single enzyme with complex enzyme, in cocoa seed
Head is containing a variety of effective functional components, more fully can be hydrolyzed the constituent of plant cell wall by compound biology enzyme
Or degraded.And by orthogonal experiment single_factor method, obtain 1：0.5：1：1 this proportioning can obtain more effective enzymolysis efficiency..
3rd, cacao seed extract is rich in the polyhydric phenols of flavonoids, has good anti-oxidation characteristics, by protecting skin thin
The structure of born of the same parents and slow down the aging of skin.Meanwhile cacao seed extract is rich in flavonoids：Anthocyanidin, catechuic acid, OPC,
Raw anthocyanidin and vitamin C, research have shown that cacao seed extract has anti-inflammatory efficacy.It contain nuclear factor (NF- κ B) and
Transcription activating protein (AP-1), both transcription factors regulate and control COX-2 expression jointly, and one of key enzyme can adjust inflammation
Disease, in addition, magnesium and N-coumaroyldopami can strengthen the anti-inflammatory efficacy of cocoa seed.Therefore cacao seed extract is in hand frost
Upper application, can assign hand frost has wrinkle reduction, prevents skin aging, moistens nutrition skin, keeps and recovers elasticity, prevents skin
Skin allergy, anti-inflammatory are releived and other effects, are especially suitable for sensitive skin and are used.
Embodiment
The technical scheme in the embodiment of the present invention is clearly and completely described below in conjunction with specific embodiment.
Extracting method design embodiments 1-3 of the present invention, comparative example 4-5, to preferably making comparisons explanation for extracting factor,
Refer to table 1.
Table 1
It can be obtained by data above analysis, if solely using enzymatic isolation method or microwave method, the extraction that can not be got well
Efficiency, and both can greatly improve efficiency after combining, also, present inventor find using compound biological enzyme i.e. by
Pectase, cellulase, zytase, papain press 1：0.5：1：1 ratio is prepared, and by 0.5%-3% addition
Amount addition, complex enzyme have higher extraction efficiency than single enzyme, are containing a variety of effective functional components inside cocoa seed, pass through
Compound biology enzyme more fully can hydrolyze the constituent of plant cell wall or degraded.And pass through orthogonal experiment single factor test
Method, obtain 1：0.5： 1：1 this proportioning can obtain more effective enzymolysis efficiency.
50 DEG C of the optimal hydrolysis temperature of extracting method of the present invention, 1% compound biological enzyme is added, regulation PH is 4.5, enzymolysis
Time 1.5h, microwave power 600W, Microwave Extraction time 30min, at optimum conditions the yield of microwave cooperating enzyme process be
35.76%.Compared with single microwave method (19.16%), 16.6% is improved；Compared with enzymatic isolation method (16.85%), improve
18.91%.
Cacao seed extract achieved above is applied in skin care hand frost, and preferred embodiment and comparative example, table 2 below
For 3 preferred embodiments and 4 comparative examples, wherein comparative example 5 is the preferable hand frost product of sales volume on the market.
Table 2
The effect of to above-mentioned 8 compositions, carries out instrument efficacy assessment, two methods of human body evaluation carry out effect and commented
Estimate, arbitrarily select 240 volunteers, after entering group, every group is 30 volunteers, early, middle and late use, is used continuously 28 days,
Finally draw average result as shown in table 3.
Table 3：The effect of embodiment and comparative example, assesses test result
Chicken embryo chorioallantoic membrane blood vessel experiment (CAMVA), is 10 irritation tests of carry out to sample described in following table,
Average value is removed, 0 point is non-stimulated, and 5 points are capillary severe haemorrhage, and fraction is higher, and excitant is bigger.
Itch or dermatitis described in following table alleviate situation test, are to choose 64 to have dermatitis or itch or have other skins quick
The volunteer of sense, points 8 groups, every group of 8 people, using hand frost after morning and evening clean skin, it is used continuously 28 days, fills in use feedback table, 0
It is divided into no improvement situation, 10 points are complete maintenance hand inflammation, itch situation.
From above experimental data：
The hand that embodiment 1-3 employs present composition raw material composition, configuration proportion and preparing process are prepared
Cream composition, for comparative example, no matter having in cuticula moisture, or skin elasticity, skin lines reparation
It is obvious to improve, and it has excellent releive skin, anti-inflammatory and other effects.And what comparative example was opened using using currently on the market
The hand cream composition for the raw material application that anti-aging and anti-inflammatory are releived, as a result its effect is relatively more general, and commercially available sales volume is higher
Product effect be also compare it is general.
As can be seen here, by the cocoa seed elite of the biology enzyme-Microwave Extraction technique extraction, releived in anti-aging and anti-inflammatory
Aspect has the effect of excellent, it using in one's hands white or other composite skin care products, can play moisturizing skin, repair
The barrier function of multiple skin, skin aging is prevented, keep and recover skin elasticity, prevent allergic, anti-inflammatory is releived, and promoting should
With having a extensive future.
Described above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (10)
1. a kind of extracting method of cacao seed extract, it is characterised in that comprise the following steps：
(1) by cocoa seed cleaning, drying, ultramicro grinding can cross 40 mesh sieves, standby；
(2) the cocoa seed powder 30g by step (1) pretreatment is added in deionized water, temperature then is raised into 30-60 DEG C, then
Compound biological enzyme 0.5-3% is added, is 4.0-6.0 with acid for adjusting pH, after stirring, keeps enzymolysis 0.5-3H；
(3) after step (2) enzymolysis, then it is brought rapidly up to 100 DEG C of progress quick inactivatings, 60 DEG C of microwaves is cooled to after inactivating 1MIN
Assisted extraction, microwave power 500-700W, Microwave Extraction time 20-50MIN；
(4) extraction solution is filtered, is removed slag, concentrated and is dried in vacuo and to be obtained cocoa seed elite.
2. the extracting method of cacao seed extract according to claim 1, it is characterised in that：Described compound biological enzyme by
Pectase, cellulase, zytase, papain press 1：0.5：1：1 ratio is prepared, and by 0.5%-3% addition
Amount.
3. the extracting method of cacao seed extract according to claim 1, it is characterised in that：50 DEG C of the hydrolysis temperature,
1% compound biological enzyme is added, regulation PH is 4.5, enzymolysis time 1.5h, microwave power 600W, Microwave Extraction time 30min.
4. a kind of crease-resistant anti-inflammatory repaiies hand lotion, it is characterised in that by weight percentage including following component：
Emulsifying agent 0.1-~8%
NMF 0.1~30%
Emollient 0.1~30%
Cacao seed extract 0.1~5%
Stable thickener 0.1~3%
Preservative, the essence of suitable reason
Surplus is deionized water.
5. a kind of crease-resistant anti-inflammatory according to claim 4 repaiies hand lotion, it is characterised in that：The emulsifying agent is selected from stearic acid
Glyceride (and) PEG-100 stearates, cetyl glucoside, ceteareth -20, in soybean lecithin at least
It is a kind of.
6. a kind of crease-resistant anti-inflammatory according to claim 5 repaiies hand lotion, it is characterised in that：Tristerin (and) PEG-
The mixture of 100 stearates and cetyl glucoside, dosage 2%-5%.
7. a kind of crease-resistant anti-inflammatory according to claim 4 repaiies hand lotion, it is characterised in that：The emulsifying agent is described guarantor
Humectant is at least one of 1,3 butanediols, propane diols, glycerine, glycine betaine, honey NMF, trehalose.
8. a kind of crease-resistant anti-inflammatory according to claim 7 repaiies hand lotion, it is characterised in that：The emulsifying agent is glycerine and sweet tea
The mixture of dish alkali, dosage 3%-8%.
9. a kind of crease-resistant anti-inflammatory according to claim 4 repaiies hand lotion, it is characterised in that：The emollient is dimethyl-silicon
Oil, isopropyl palmitate, jojoba oil, cera alba, lanolin, vaseline, in shea butter, caprylic/capric triglyceride extremely
Few one kind.
10. a kind of crease-resistant anti-inflammatory according to claim 9 repaiies hand lotion, it is characterised in that：The caprylic/capric triglycerin
The mixture of fat, dimethicone and shea butter, dosage 7-15%.
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| CN108085129A (en) * | 2018-02-09 | 2018-05-29 | 王忠良 | A kind of wood wax oil preparation method |
| CN113101255A (en) * | 2021-04-19 | 2021-07-13 | 广东梵蜜琳生物科技有限公司 | Anti-premature composition and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108085129A (en) * | 2018-02-09 | 2018-05-29 | 王忠良 | A kind of wood wax oil preparation method |
| CN113101255A (en) * | 2021-04-19 | 2021-07-13 | 广东梵蜜琳生物科技有限公司 | Anti-premature composition and preparation method and application thereof |
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Application publication date: 20171124 |