CN107364822B - Automatic sub-packaging equipment of high accuracy radioactive liquid medicine - Google Patents
Automatic sub-packaging equipment of high accuracy radioactive liquid medicine Download PDFInfo
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- CN107364822B CN107364822B CN201710739281.6A CN201710739281A CN107364822B CN 107364822 B CN107364822 B CN 107364822B CN 201710739281 A CN201710739281 A CN 201710739281A CN 107364822 B CN107364822 B CN 107364822B
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- penicillin bottle
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/007—Applications of control, warning or safety devices in filling machinery
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B1/00—Closing bottles, jars or similar containers by applying stoppers
- B67B1/005—Feeding stoppers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B1/00—Closing bottles, jars or similar containers by applying stoppers
- B67B1/04—Closing bottles, jars or similar containers by applying stoppers by inserting threadless stoppers, e.g. corks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/001—Cleaning of filling devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/16—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus using suction
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/24—Devices for supporting or handling bottles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C3/00—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus; Filling casks or barrels with liquids or semiliquids
- B67C3/02—Bottling liquids or semiliquids; Filling jars or cans with liquids or semiliquids using bottling or like apparatus
- B67C3/22—Details
- B67C3/26—Filling-heads; Means for engaging filling-heads with bottle necks
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
Abstract
The invention discloses and describes a high-precision radioactive liquid medicine automatic subpackaging device, which comprises: a filling and plugging system, a subpackaging system and a control system; the subpackaging equipment is arranged between the penicillin bottle sample inlet rail and the penicillin bottle sample outlet rail and is positioned above the station conveying device; conveying the penicillin bottle row seat and the penicillin bottles placed in the penicillin bottle row seat to a penicillin bottle outlet column along a straight line from an inlet station positioned on the penicillin bottle inlet column by using a station conveying device; the equipment has the characteristics of radiation resistance, high micro-packaging precision, high packaging speed, high automation degree and the like, and provides a technical basis for packaging various radioactive liquid medicines.
Description
Technical Field
The invention relates to high-precision automatic subpackaging equipment for radioactive liquid medicine, which is used in the production field of isotope radioactive medicines.
Background
The iodine-131 oral solution is used as one of conventional radiopharmaceuticals in nuclear medicine, and is mainly used for diagnosing and treating thyroid cancer and hyperthyroidism. Iodine-131 oral solution is one of the main growth points of iodine-131 products, and the production value is on the rising trend in recent years.
Because the iodine-131 oral solution product has small volume and high activity, the subpackaging mode adopts manual operation at present, and equipment cannot meet the increasing production quantity. The split charging system is the most central part in the existing production process and plays a vital role in production quality. In contrast to this: firstly, the existing subpackaging equipment can not complete the subpackaging of the iodine-131 sodium iodide oral liquid quickly and efficiently, and the subpackaging mainly depends on the operation skills of production personnel and the proficiency degree of application of a manipulator. The production efficiency is low, the irradiation time by radioactivity is long, the personal dosage is higher, the personnel cost is higher due to the fact that operators change duty, and the existing production capacity cannot meet the increasing market demand. With the expansion of the radiopharmaceutical market and the increasing prominence of the contradiction between supply and demand, a novel split charging system is urgently needed to improve the productivity. And the production equipment of the radioactive medicines requires miniaturization, radiation resistance, low failure rate and the like. Compared with the common medicines, the market of the radiopharmaceuticals is small, and large medical equipment and equipment manufacturers lack sufficient power to develop complete equipment to meet the market demand. Production equipment of radiopharmaceuticals still stays in a relatively original state, and production equipment of iodine-131 sodium iodide oral liquid which completely meets the actual production requirements is lacked in the market.
Disclosure of Invention
Aiming at the problem of large-scale batch production of radioactive liquid medicine products at present, the invention combines the characteristics of production process and operation environment, and completes the development of high-precision automatic radioactive liquid medicine subpackaging equipment through careful development. The equipment has the characteristics of radiation resistance, high micro-packaging precision, high packaging speed, high automation degree and the like. The successful development of the invention also provides a technical basis for the split charging of various radioactive liquid medicines.
The invention relates to high-precision automatic radioactive liquid medicine subpackaging equipment, which comprises: a filling and plugging system, a subpackaging system and a control system; the subpackaging equipment is arranged between the penicillin bottle sample inlet rail and the penicillin bottle sample outlet rail and is positioned above the station conveying device; the penicillin bottle arranging seat and the penicillin bottles placed in the penicillin bottle arranging seat are linearly conveyed to the penicillin bottle outlet column from an inlet station positioned on the penicillin bottle inlet column by using the station conveying device, and the station conveying device is also provided with a station detector for detecting stations where the penicillin bottle arranging seat is positioned; the filling and plugging system comprises a tungsten steel shielding sleeve, a radioactive raw material liquid bottle, a rotary lifting filling device, a waste liquid bottle, a dilution filling support, a rubber plug pressing and plugging device, a rubber plug vibration queuing device and a row seat pushing device; the penicillin bottle row seat is arranged on a station conveying device in the penicillin bottle sampling fence and is arranged on the inner side of an inlet station of the filling and plugging system; the rotary lifting filling device is positioned at the next station of the inlet station, and the rotary lifting filling device adopts a servo motor to control the rotation and lifting of a mechanical arm of the rotary lifting filling device; the raw material liquid filling needle is arranged on a mechanical arm of the rotary lifting filling device; the raw material liquid filling needle can rotate to one side of the tungsten steel shielding sleeve and descends into a radioactive raw material liquid bottle in the tungsten steel shielding sleeve to absorb radioactive raw material liquid medicine; a waste liquid bottle is placed on one side of the rotary lifting filling device and is used for containing waste liquid of the raw material liquid filling needle; a dilution filling support positioned at a dilution filling station is arranged at the other side of the rotary lifting filling device, and a diluent filling needle is arranged on the dilution filling support; a penicillin bottle plugging module consisting of a rubber plug plugging device and a rubber plug vibrating queuing device is arranged on one side of the diluting and filling station and is used for penicillin bottle plugging and plugging operation; the rubber plug pressing device comprises a pneumatic push rod and a reversible rubber plug limiter; the rubber plug vibrating queuing device comprises a vibrating hopper, a vibrating disc and a rubber plug guiding groove, and the rubber plug guiding groove is connected to the upper part of a rubber plug limiter of the rubber plug pressing device; the base arranging and pushing device is arranged at the next station of the rubber plug vibrating queuing device and is right opposite to the penicillin bottle outlet column, and the base arranging and pushing device pushes the penicillin bottle base into the penicillin bottle outlet column.
The split charging system comprises a filling pump, a cleaning liquid bottle, a diluting liquid bottle and an upper computer; the filling pump consists of two filling pump modules, the liquid inlet end of one filling pump module of the filling pump is inserted into the diluent bottle, and the liquid outlet end of the filling pump module is connected to the diluent filling needle through a pipeline; the liquid inlet end of the other path of filling pump module of the filling pump is inserted into the cleaning liquid bottle, and the liquid outlet end of the path of filling pump module is connected to the raw material liquid filling needle through a pipeline; the pipeline adopts a polytetrafluoroethylene pipe; the control end of the filling pump is connected to the upper computer, and the upper computer generates and sends filling parameters for controlling the filling pump.
The control system comprises a subpackage system controller and a touch screen; the sub-packaging system controller is connected to the filling and plugging system through a cable and is used for controlling and monitoring the operation of the rotary lifting filling device, the station detector, the rubber plug pressing and plugging device, the rubber plug vibrating and queuing device, the row seat pushing device and the station conveying device; the touch screen is connected with the subpackage system controller through a serial interface, an operator sets parameters of each controlled device through the touch screen, and the operation condition of the high-precision radioactive liquid medicine automatic subpackage device is monitored.
More preferably: the rubber plug vibrating queuing device adopts an electromagnetic vibrating disk as a rubber plug feeding part;
more preferably: the motors of the station conveying device and the rotary lifting filling device adopt servo motors as driving parts for rotation and displacement;
more preferably: the filling pump can adopt a peristaltic pump, a plunger pump or an injection pump, and in order to ensure high-precision subpackage, the injection pump is mainly adopted as a core subpackage component.
Drawings
The invention is further described below with reference to the accompanying drawings.
Fig. 1 is a schematic structural diagram of an automatic high-precision radioactive liquid medicine subpackaging device.
In the figure: 1. the device comprises a touch screen, 2 parts of a subpackaging system controller, 3 parts of an upper computer, 4 parts of a cleaning liquid bottle, 5 parts of a diluent bottle, 6 parts of a filling pump, 7 parts of a penicillin bottle sample introduction column, 8 parts of a penicillin bottle row seat, 9 parts of a tungsten steel shielding sleeve, 10 parts of a raw material liquid filling needle, 11 parts of a rotary lifting filling machine, 11-1 parts of a rotary servo motor, 11-2 parts of a lifting servo motor, 11-3 parts of a mechanical arm, 12 parts of a waste liquid bottle, 13 parts of a dilution filling support, 14 parts of a diluent filling needle, 15 parts of a rubber plug pressing device, 15-1 parts of a rubber plug limiter, 15-2 parts of a pneumatic push rod, 16 parts of a rubber plug vibrating queuing device, 16-1 vibrating hopper, 16-2 vibrating plates, 16-3 rubber plug guide grooves, 17 parts of a row seat pushing device, 18 parts of a penicillin bottle sample discharge column, 19 parts of a station conveying device, 21 cables, 22 position detectors and 23 radioactive raw material liquid bottles.
Detailed Description
The present solution will be further described with reference to specific embodiments.
Referring to fig. 1, the high-precision automatic radioactive liquid medicine subpackaging equipment comprises a filling and plugging system, a subpackaging system and a control system; the split charging equipment is arranged between the penicillin bottle sample inlet rail 7 and the penicillin bottle sample outlet rail 18 and is positioned above the station conveying device 19; the penicillin bottle arranging seat 8 and the penicillin bottles placed in the penicillin bottle arranging seat 8 are linearly conveyed to a penicillin bottle outlet column 18 from an inlet station positioned on a penicillin bottle inlet column 7 by a station conveying device 19, and the station conveying device 19 is further provided with a station detector 22 for detecting the station where the penicillin bottle arranging seat 8 is positioned; the filling and plugging system comprises a tungsten steel shielding sleeve 9, a radioactive raw material liquid bottle 23, a rotary lifting filling device 11, a waste liquid bottle 12, a dilution filling support 13, a rubber plug pressing and plugging device 15, a rubber plug vibration queuing device 16 and a row seat pushing device 17; the penicillin bottle row seat 8 is arranged on a station conveying device 19 in the penicillin bottle sampling fence 7 and is arranged on the inner side of an inlet station of the filling and plugging system; the rotary lifting filling device 11 is positioned at the next station of the inlet station, and the rotary lifting filling device 11 adopts a servo motor to control the rotation and lifting of a mechanical arm 11-3 of the rotary lifting filling device; the raw material liquid filling needle 10 is arranged on a mechanical arm 11-3 of the rotary lifting filling device 11; the raw material liquid filling needle 10 can rotate to one side of the tungsten steel shielding sleeve 9 and descends into a radioactive raw material liquid bottle 23 in the tungsten steel shielding sleeve 9 to absorb radioactive raw material liquid medicine; a waste liquid bottle 12 is arranged on one side of the rotary lifting filling device 11, and the waste liquid bottle 12 is used for containing waste liquid of the raw material liquid filling needle 10; a dilution filling support 13 positioned at a dilution filling station is arranged at the other side of the rotary lifting filling device 11, and a diluent filling needle 14 is arranged on the dilution filling support 13; a penicillin bottle plugging module consisting of a rubber plug pressing device 15 and a rubber plug vibrating queuing device 16 is arranged on one side of the diluting and filling station and is used for penicillin bottle plugging and corking operations; the rubber plug pressing device 15 comprises a pneumatic push rod 15-2 and a reversible rubber plug limiter 15-1; the rubber plug vibration queuing device 16 comprises a vibration hopper 16-1, a vibration disc 16-2 and a rubber plug guide groove 16-3, wherein the rubber plug guide groove 16-3 is connected to the upper part of a rubber plug limiter 15-1 of the rubber plug pressing device 15; the base arranging and pushing device 17 is arranged at the next station of the rubber plug vibrating queuing device 16 and is right opposite to the penicillin bottle outlet column 18, and the base arranging and pushing device 17 pushes the penicillin bottle base arranging 8 into the penicillin bottle outlet column 18.
The split charging system comprises a filling pump 6, a cleaning solution bottle 4, a diluent bottle 5 and an upper computer 3; the filling pump 6 consists of two filling pump modules, the liquid inlet end of one filling pump module of the filling pump 6 is inserted into the diluent bottle 5, and the liquid outlet end of the filling pump module is connected to the diluent filling needle 14 through a pipeline; the liquid inlet end of the other path of filling pump module of the filling pump is inserted into the cleaning liquid bottle 4, and the liquid outlet end of the path of filling pump module is connected to the raw material liquid filling needle 10 through a pipeline; the pipeline adopts a polytetrafluoroethylene pipe; the control end of the filling pump 6 is connected to the upper computer 3, and the upper computer 3 generates and sends filling parameters for controlling the filling pump 6.
The control system comprises a subpackage system controller 2 and a touch screen 1; the subpackaging system controller 2 is connected to a filling and plugging system through a cable 21 and is used for controlling and monitoring the operation of the rotary lifting filling device 11, the station detector 22, the rubber plug pressing and plugging device 15, the rubber plug vibrating queuing device 16, the row seat pushing device 17 and the station conveying device 19; the touch screen 1 is connected with the subpackaging system controller 2 through a serial interface, an operator sets parameters of all controlled equipment through the touch screen 1, and the operation condition of the high-precision radioactive liquid medicine automatic subpackaging equipment is monitored.
During preparation, the upper computer 3, the subpackaging system controller 2, the filling pump 6 and the touch screen 1 are powered on, and the filling and plugging system is powered by the subpackaging system controller 2 through a cable 21. Through the human-computer interface arrangement of the upper computer 3 and the touch screen 1, the filling pump 6 and the subpackaging system controller 2 control the filling and plugging system to be initialized, the pneumatic push rod 15-2 of the seat arranging and pushing device 17 and the rubber plug plugging device 15 is driven to be filled with air, and each station is in a standby mode. And (5) placing the penicillin bottle into the penicillin bottle discharge seat and filling the penicillin bottle discharge seat 8 with the penicillin bottle discharge seat. The rubber plugs are poured into a vibration hopper 16-1 of the rubber plug queuing device. The vial run-out bar 18 is empty and the various stations are ready.
When the filling machine works, the manipulator clamps the row seat 8 filled with the penicillin bottles to the starting point of the station conveying device 19, the upper computer 3 imports the filling data file, and the filling pump 6 waits for the operation signal of the subpackaging system controller. The touch screen 1 controls the operation parameters of the subpackaging system controller 2, sets the parameters of displacement speed, original point and the like of the servo motor at each station, and can operate by clicking the operation function key of the touch screen 1 after the setting is finished. The subpackaging system controller 2 controls a station conveying device 19 to drive a conveying belt to move a penicillin bottle row seat 8 to a station of a rotary lifting filling device 11, a station detector 22 detects the position of a penicillin bottle in the penicillin bottle row seat 8 and generates a detection feedback signal to be conveyed to the subpackaging system controller 2 through a signal cable 21, the subpackaging system controller 2 judges the position of the penicillin bottle, controls the rotary lifting filling device 11 to move a raw material liquid filling needle 10 to a radioactive raw material liquid bottle 23 in a tungsten steel shielding sleeve 9, the subpackaging system controller 2 sends a control signal to a filling pump 6, the raw material liquid filling needle 10 absorbs a trace amount of radioactive raw material liquid according to filling data set in an upper computer 3, the radioactive raw material liquid filling needle is lifted and rotated to the corresponding position of the penicillin bottle in the penicillin bottle row seat 8 after the operation is finished, the filling pump 6 drives the raw material liquid filling needle 10 to drop the absorbed radioactive material liquid into the penicillin bottle, the raw material liquid is subpackaged, and the station conveying device 19 drives the penicillin bottle row seat 8 to move to a diluent filling station. The diluent filling adopts fixed station filling, and the diluent filling needle 14 is driven by the filling pump 6 and subpackaged according to the filling data of the upper computer 3. When the diluent is filled and operated, the rotary lifting station synchronously fills the radioactive raw material liquid into other penicillin bottles in the penicillin bottle row seat 8 according to the detection of the station sensor 22. After all the penicillin bottles in the penicillin bottle row seat 8 are filled according to the set data, the penicillin bottle row seat 8 is moved to the station where the rubber plug corking device 15 is located through the station conveying device 19. Meanwhile, the rotary lifting filling device 11 moves the raw material liquid filling needle 10 to the position of the waste liquid bottle 12, the filling pump 6 sucks cleaning liquid, the filling pipeline is cleaned, and cleaning waste liquid in the pipeline is pumped into the waste liquid bottle 12.
The rubber plugs are placed in a vibration hopper 16-1 of the rubber plug vibration queuing device 16, a vibration disc 16-2 vibrates to enable the rubber plugs to spirally line up and ascend, the rubber plugs which are not regularly arranged are removed in the queuing process, and the regularly arranged rubber plugs are linearly guided into a groove 16-3 until the rubber plugs fall on a rubber plug limiter 15-1 below a pneumatic push rod 15-2 of the rubber plug pressing device 15. When the penicillin bottles in the penicillin bottle arranging seat 8 are right below the rubber plug plugging device 15, the pneumatic push rod 15-2 is pressed downwards, the rubber plug limiter 15-1 is turned downwards, the rubber plug cover is pressed into the penicillin bottles, and the penicillin bottle plugging action is finished. The station conveyor 19 moves, and the rubber plug vibrating queuing device 16 repeats the plugging action to completely cover all the penicillin bottles in the penicillin bottle row seat 8. The station conveying device 19 moves the penicillin bottle discharge seats 8 to the position beside the penicillin bottle outlet columns 18, the seat discharge pushing device 17 is right opposite to the penicillin bottle outlet columns 18, the sub-packaging system controller 2 controls the seat discharge pushing device 17 to push the penicillin bottle discharge seats 8 into the penicillin bottle outlet columns 18 until all the penicillin bottle discharge seats 8 are pushed into the penicillin bottle outlet columns, and the whole process is finished.
The above description is a detailed description of the present invention with reference to examples, and the embodiments of the present invention are not to be considered as being limited to these descriptions. It will be apparent to those skilled in the art that a number of simple derivations and modifications can be made without departing from the spirit of the invention, and these are to be considered as falling within the scope of the invention.
Claims (4)
1. A high accuracy automatic partial shipment equipment of radioactive liquid medicine, it includes: a filling and plugging system, a subpackaging system and a control system; the high-precision radioactive liquid medicine automatic subpackaging equipment is arranged between a penicillin bottle sample introduction column (7) and a penicillin bottle sample discharge column (18) and is positioned above a station conveying device (19); a station conveying device (19) is utilized to convey the penicillin bottle row seat (8) and the penicillin bottles placed in the penicillin bottle row seat (8) from an inlet station positioned on a penicillin bottle sampling column (7) to a penicillin bottle outlet column (18) along a straight line, and the station conveying device (19) is further provided with a station detector (22) for detecting the station where the penicillin bottle row seat (8) is located; the method is characterized in that: the filling and plugging system comprises a tungsten steel shielding sleeve (9), a radioactive raw material liquid bottle (23), a rotary lifting filling device (11), a waste liquid bottle (12), a dilution filling support (13), a rubber plug pressing device (15), a rubber plug vibration queuing device (16) and a row seat pushing device (17); the penicillin bottle row seat (8) is arranged on a station conveying device (19) in the penicillin bottle sampling fence (7) and is arranged on the inner side of an inlet station of the filling and plugging system; the rotary lifting filling device (11) is positioned at the next station of the inlet station, and the rotary lifting filling device (11) controls the rotation and lifting of a mechanical arm (11-3) by adopting a servo motor; the raw material liquid filling needle (10) is arranged on a mechanical arm (11-3) of the rotary lifting filling device (11); the raw material liquid filling needle (10) can rotate to one side of the tungsten steel shielding sleeve (9) and descends into a radioactive raw material liquid bottle (23) in the tungsten steel shielding sleeve (9) to absorb radioactive raw material liquid medicine; a waste liquid bottle (12) is arranged on one side of the rotary lifting filling device (11), and the waste liquid bottle (12) is used for containing waste liquid of the raw material liquid filling needle (10); a dilution filling support (13) positioned at a dilution filling station is arranged at the other side of the rotary lifting filling device (11), and a diluent filling needle (14) is arranged on the dilution filling support (13); a penicillin bottle plugging module consisting of a rubber plug pressing device (15) and a rubber plug vibrating queuing device (16) is arranged on one side of the diluting and filling station and used for penicillin bottle plugging and plugging operation; the rubber plug pressing device (15) comprises a pneumatic push rod (15-2) and a reversible rubber plug limiter (15-1); the rubber plug vibration queuing device (16) comprises a vibration hopper (16-1), a vibration disc (16-2) and a rubber plug guide groove (16-3), and the rubber plug guide groove (16-3) is connected to the upper part of a rubber plug limiter (15-1) of the rubber plug pressing device (15); the arranging seat pushing device (17) is arranged at the next station of the rubber plug vibrating queuing device (16) and is right opposite to the penicillin bottle outlet column (18), and the arranging seat pushing device (17) pushes the penicillin bottle arranging seat (8) into the penicillin bottle outlet column (18); the vibration disk (16-2) is an electromagnetic vibration disk; the driving motor of the station conveying device (19) is a servo motor.
2. The automatic dispensing apparatus for high precision radioactive liquid medicine according to claim 1, wherein: the split charging system comprises a filling pump (6), a cleaning liquid bottle (4), a diluent liquid bottle (5) and an upper computer (3); the filling pump (6) consists of two filling pump modules, the liquid inlet end of one filling pump module of the filling pump (6) is inserted into the diluent bottle (5), and the liquid outlet end of the filling pump module is connected to the diluent filling needle (14) through a pipeline; the liquid inlet end of the other path of filling pump module of the filling pump is inserted into the cleaning liquid bottle (4), and the liquid outlet end of the path of filling pump module is connected to the raw material liquid filling needle (10) through a pipeline; the pipeline adopts a polytetrafluoroethylene pipe; the control end of the filling pump (6) is connected to the upper computer (3), and the upper computer (3) generates and sends filling parameters for controlling the filling pump (6).
3. A high precision automatic dispensing apparatus for radioactive liquid medicine according to claim 1 or 2, wherein: the control system comprises a subpackaging system controller (2) and a touch screen (1); the subpackaging system controller (2) is connected to the filling and plugging system through a cable (21) and is used for controlling and monitoring the operation of the rotary lifting filling device (11), the station detector (22), the rubber plug plugging device (15), the rubber plug vibration queuing device (16), the row seat pushing device (17) and the station conveying device (19); the touch screen (1) is connected with the subpackaging system controller (2) through a serial interface, an operator sets parameters of each controlled device through the touch screen (1), and the operation condition of the high-precision radioactive liquid medicine automatic subpackaging device is monitored.
4. A high precision automatic split charging equipment for radioactive liquid medicine according to claim 2, characterized in that: the filling pump (6) is a peristaltic pump, a plunger pump or a syringe pump.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710739281.6A CN107364822B (en) | 2017-08-25 | 2017-08-25 | Automatic sub-packaging equipment of high accuracy radioactive liquid medicine |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710739281.6A CN107364822B (en) | 2017-08-25 | 2017-08-25 | Automatic sub-packaging equipment of high accuracy radioactive liquid medicine |
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| CN107364822A CN107364822A (en) | 2017-11-21 |
| CN107364822B true CN107364822B (en) | 2022-09-23 |
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| CN109761181A (en) * | 2019-01-07 | 2019-05-17 | 森科（南京）医药技术有限公司 | Full-automatic sodium iodide oral liquor medicine nucleic dispenses instrument |
| CN113277458B (en) * | 2021-05-24 | 2023-01-13 | 安徽泽升科技有限公司 | Intelligent subpackaging system and method for multiple chemical reagents |
| CN114803996A (en) * | 2022-04-13 | 2022-07-29 | 深圳赛动智造科技有限公司 | Nuclear medicine subpackaging equipment and subpackaging method thereof |
| CN114771897A (en) * | 2022-04-21 | 2022-07-22 | 深圳赛动智造科技有限公司 | Intelligent radiopharmaceutical dilution subpackaging system and subpackaging method |
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