CN107362115A - A kind of preparation method of the anti-acne essence containing aloe extract - Google Patents
A kind of preparation method of the anti-acne essence containing aloe extract Download PDFInfo
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- CN107362115A CN107362115A CN201710722173.8A CN201710722173A CN107362115A CN 107362115 A CN107362115 A CN 107362115A CN 201710722173 A CN201710722173 A CN 201710722173A CN 107362115 A CN107362115 A CN 107362115A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
A kind of preparation method of the anti-acne essence containing aloe extract, belongs to Essence preparing technical field, including prepares aloe extract, prepare gloiopeltis algae extract, prepare aqueous phase liquid, prepare oil phase liquid and prepare Essence.The percutaneous permeability of aloe is very strong, and can go directly deep skin.Include abundant vitamin, amino acid, aliphatic acid, polysaccharose substance, there is natural anti-inflammatory, antibiotic effect, can clearing heat and cooling blood, available for cool blood anti-acne, toxin-expelling and face nourishing, for alleviating, removing acne has the effect of good.Gloiopeltis algae can be effectively improved the intracutaneous or subcutaneous tissue injury of acne scars, and the defect of deep wrinkles or other soft tissues.Repair acne, the wound that acne is left；There is the effect of regulation fat secretion and anti-inflammation and sterilization, especially there is good therapeutic effect to dark sore.Fibroin has the effect of repairing skin tissue's cell.The present invention's prepares that Essence natural component is high, easily absorb, anti-acne effect is good, and preparation method is simple.
Description
Technical field
The present invention relates to a kind of preparation method of Essence, more particularly to a kind of anti-acne essence containing aloe extract
Preparation method.
Background technology
Acne is a kind of chronic inflammatory skin of pilosebaceous unit, teenager is mainly apt to occur in, to teenager
Psychology and social influence it is very big.Clinical manifestation using be apt to occur in the acne of face, papule, warts, the polymorphy skin lesion such as tubercle as
Feature, nickname acne, whelk.The generation of acne mainly blocks with hypersteatosis, pilosebaceous duct, bacterium infection
It is closely related with the factor such as inflammatory reaction.Adolesce the rapid rise of level of androgen particularly testosterone in descendant's body, promotees
Enter sebaceous glands to develop and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, sebum discharge simultaneously
Obstacle, it is micro mist thorn to form horn plug.Multiple-microorganism especially propionibacterium acnes amount reproduction in hair follicle, acne propionic acid bar
Lipase caused by bacterium decomposes sebum generation free fatty, while chemotactic inflammatory cell and medium, finally induces and aggravates inflammation
Reaction.
The method for the treatment of acne has at present：Oral antibiotic/vitamin/glucocorticoid/sex hormone zinc preparation and external application
Drug therapy, the therapy such as injection treatment/laser ultraviolet in skin lesion.Although these methods also have certain effect, have
The drawbacks of certain, such as the side effect such as endo-medicine overlong time, antibiotic/hormone, injection treatment/laser ultraviolet in skin lesion
Compare pain etc. therapy, laser therapy easily forms the charring layer of black, disturbs surgical field of view, patient is not easy observation and grasps treatment
The depth reached.The result of control treatment is difficult to if if over the course for the treatment of, assurance is not in place.
For this phenomenon we in addition to hospital can be gone to use the treatment method such as medicine/laser, contained using some
The Essence of anti-acne composition also has good therapeutic effect, so as to develop the Essence of the present invention.
The content of the invention
In order to solve problems of the prior art, the present invention provides a kind of anti-acne essence containing aloe extract
Preparation method.
The present invention uses following technical scheme：
A kind of preparation method of the anti-acne essence containing aloe extract, comprises the following steps：
Step 1：Fresh aloe is cleaned, moisture is dried, is placed in drying machine at 90-100 DEG C after drying 10min,
It is put into pulverizer and crushes, the aloe after crushing is crossed into 200 mesh sieves, obtains Alose；
Step 2：Alose 10g is taken, is put in volumetric flask, adds the ethanol that 40ml volumetric concentrations are 50%, 200W ultrasounds
1h, 6000r/min centrifugal treating 20min are extracted, supernatant is collected, takes precipitation to repeat above-mentioned steps 1 time, merges supernatant twice
Liquid, and the absolute ethyl alcohol of 4 times of volumes is added, -20 DEG C of freezing alcohol precipitation 2h, 4 DEG C, 10000r/min centrifugal treating 20min, take supernatant
Liquid, rotary evaporation is concentrated into the 1/5 of original volume under the conditions of 40 DEG C, obtains aloe extract；
Step 3：Gloiopeltis algae cleans silt impurity, the dryness in the sun under normal temperature, and in -55 DEG C of vacuum freeze driers
24h is dried, is crushed, 60 mesh sieves is crossed, obtains gloiopeltis algae powder；
Step 4：10g gloiopeltis algae powder is taken to be added in the methanol solution that 40mL mass concentrations are 20%, 100W ultrasonic extractions
2h, 8000r/min centrifugal treating 20min, supernatant is collected, takes precipitation to repeat above-mentioned steps 1 time, merge supernatant twice,
And the absolute ethyl alcohol of 4 times of volumes is added, -20 DEG C of freezing alcohol precipitation 2h, 4 DEG C, 10000r/min centrifugal treating 20min, supernatant is taken,
Rotary evaporation is concentrated into the 1/5 of original volume under the conditions of 40 DEG C, obtains gloiopeltis algae extract；
Step 5：According to the mass fraction, by 8 parts of glycerine, 2 parts of propane diols, 1 part of fibroin, 1 part of essence, 0.4 part of three second
Hydramine is added in 78 parts of deionized waters, and aqueous phase liquid is made until dissolving in 70 DEG C of heating stirrings；
Step 6：According to the mass fraction, by 3 parts of aloe extracts, 1.5 parts of gloiopeltis algae extracts, 1.5 parts of methyl-silicone oils, 2
Part monoglyceride, 1.2 parts of polyoxyethylene sorbitan monolaurates, 0.8 part of compound emulsifying agent AC-402,0.4 part of xanthan gum,
Stirred under the conditions of 60 DEG C, oil phase liquid is made；
Step 7：Under conditions of being stirred continuously, oil phase liquid is added slowly in aqueous phase liquid, described oil phase liquid and
The mass ratio of aqueous phase liquid is 1:8,15min is stirred using high speed disperser, cooling discharging, both obtains Essence.
Preferably, the mixing speed of the high speed disperser described in step 7 is 5000r/min.
Preferably, the essence described in step 5 is flavoring rose essence.
The beneficial effects of the present invention are：
1) percutaneous permeability of aloe is very strong, and can go directly deep skin.Include abundant vitamin, amino acid, fat
Acid, polysaccharose substance, there is natural anti-inflammatory, antibiotic effect, can clearing heat and cooling blood, available for cool blood anti-acne, toxin-expelling and face nourishing, for
Alleviate, removing acne has the effect of good.
2) gloiopeltis algae can be effectively improved the intracutaneous or subcutaneous tissue injury of acne scars, and deep wrinkles or other are soft
The defect of tissue.Repair acne, the wound that acne is left.There is the effect of regulation fat secretion and anti-inflammation and sterilization, especially to dark
Sore has good therapeutic effect.
3) fibroin has the effect of repairing skin tissue's cell.
4) Essence natural component prepared by the present invention is high, easily absorption, anti-acne effect is good, and preparation method is simple.
Embodiment
Below with reference to specific embodiment, the present invention is described further.
Embodiment 1
A kind of preparation method of the anti-acne essence containing aloe extract, comprises the following steps：
Step 1：Fresh aloe is cleaned, moisture is dried, is placed in drying machine at 90-100 DEG C after drying 10min,
It is put into pulverizer and crushes, the aloe after crushing is crossed into 200 mesh sieves, obtains Alose；
Step 2：Alose 10g is taken, is put in volumetric flask, adds the ethanol that 40ml volumetric concentrations are 50%, 200W ultrasounds
1h, 6000r/min centrifugal treating 20min are extracted, supernatant is collected, takes precipitation to repeat above-mentioned steps 1 time, merges supernatant twice
Liquid, and the absolute ethyl alcohol of 4 times of volumes is added, -20 DEG C of freezing alcohol precipitation 2h, 4 DEG C, 10000r/min centrifugal treating 20min, take supernatant
Liquid, rotary evaporation is concentrated into the 1/5 of original volume under the conditions of 40 DEG C, obtains aloe extract；
Step 3：Gloiopeltis algae cleans silt impurity, the dryness in the sun under normal temperature, and in -55 DEG C of vacuum freeze driers
24h is dried, is crushed, 60 mesh sieves is crossed, obtains gloiopeltis algae powder；
Step 4：10g gloiopeltis algae powder is taken to be added in the methanol solution that 40mL mass concentrations are 20%, 100W ultrasonic extractions
2h, 8000r/min centrifugal treating 20min, supernatant is collected, takes precipitation to repeat above-mentioned steps 1 time, merge supernatant twice,
And the absolute ethyl alcohol of 4 times of volumes is added, -20 DEG C of freezing alcohol precipitation 2h, 4 DEG C, 10000r/min centrifugal treating 20min, supernatant is taken,
Rotary evaporation is concentrated into the 1/5 of original volume under the conditions of 40 DEG C, obtains gloiopeltis algae extract；
Step 5：According to the mass fraction, by 8 parts of glycerine, 2 parts of propane diols, 1 part of fibroin, 1 part of essence, 0.4 part of three second
Hydramine is added in 78 parts of deionized waters, and aqueous phase liquid is made until dissolving in 70 DEG C of heating stirrings；
Step 6：According to the mass fraction, by 3 parts of aloe extracts, 1.5 parts of gloiopeltis algae extracts, 1.5 parts of methyl-silicone oils, 2
Part monoglyceride, 1.2 parts of polyoxyethylene sorbitan monolaurates, 0.8 part of compound emulsifying agent AC-402,0.4 part of xanthan gum,
Stirred under the conditions of 60 DEG C, oil phase liquid is made；
Step 7：Under conditions of being stirred continuously, oil phase liquid is added slowly in aqueous phase liquid, described oil phase liquid and
The mass ratio of aqueous phase liquid is 1:8,15min is stirred using high speed disperser, cooling discharging, both obtains Essence.
The mixing speed of high speed disperser described in step 7 is 5000r/min.
Essence described in step 5 is flavoring rose essence.
The physical and chemical index of embodiment 1 is as follows：
(1) character
This product is that viscosity is suitable, fine and smooth uniform, the good Essence of stretchability.
(2) pH value inspection
A small amount of Essence, pH 6-7 are dipped with the pH test paper of wetting.
(3) caloric test
Essence is packaged in clear vial, in 4 DEG C of refrigerator cold-storage observations in one week or so without lamination.In 55 DEG C
24h in insulating box, Essence without layering, it is spoiled phenomena such as.
(4) centrifugal test
Essence is packaged in 3000r/min in tool plug test tube and centrifuges 20min, no lamination.
(5) irritation test, sensitivity test
Small white mouse back cuts off hair, smears by Essence prepared by embodiment 1 in cutting plucked position, and do not apply position and enter
Row compares, as a result without excitant and allergic reaction.
Essence prepared by Example 1 is applied in volunteer's gesture and facial expression, is observed after spending 30 minutes, does not occur rubescent, hair
Rash, foaming phenomena.
(6) room temperature places experiment
The made Essence of embodiment 1 is placed in bottle, investigation 6 months is stored at room temperature, no lamination, nothing is felt after
Change, smell are unchanged.
(7) anti-acne effect
The serious people of volunteer 15 of face acnes is chosen, the Essence of the gained of embodiment 1 is used for volunteer's face acnes
At symptom, volunteer is generally comfortable on, and acne lightens, and does not stay acne print.Continuous use through a period of time, the situation of acne are bright
Aobvious improve even is disappeared.
Claims (3)
1. a kind of preparation method of the anti-acne essence containing aloe extract, it is characterised in that comprise the following steps：
Step 1：Fresh aloe is cleaned, moisture is dried, is placed in drying machine at 90-100 DEG C after drying 10min, is put into
Crushed in pulverizer, the aloe after crushing is crossed into 200 mesh sieves, obtains Alose；
Step 2：Alose 10g is taken, is put in volumetric flask, adds the ethanol that 40ml volumetric concentrations are 50%, 200W ultrasonic extractions
1h, 6000r/min centrifugal treating 20min, supernatant is collected, takes precipitation to repeat above-mentioned steps 1 time, merge supernatant twice,
And the absolute ethyl alcohol of 4 times of volumes is added, -20 DEG C of freezing alcohol precipitation 2h, 4 DEG C, 10000r/min centrifugal treating 20min, supernatant is taken,
Rotary evaporation is concentrated into the 1/5 of original volume under the conditions of 40 DEG C, obtains aloe extract；
Step 3：Gloiopeltis algae cleans silt impurity, the dryness in the sun under normal temperature, and is dried in -55 DEG C of vacuum freeze driers
24h, crush, cross 60 mesh sieves, obtain gloiopeltis algae powder；
Step 4：10g gloiopeltis algae powder is taken to be added in the methanol solution that 40mL mass concentrations are 20%, 100W ultrasonic extraction 2h,
8000r/min centrifugal treating 20min, supernatant is collected, takes precipitation to repeat above-mentioned steps 1 time, merge supernatant twice, and add
Enter the absolute ethyl alcohol of 4 times of volumes, -20 DEG C of freezing alcohol precipitation 2h, 4 DEG C, 10000r/min centrifugal treating 20min, supernatant is taken, in 40
Rotary evaporation is concentrated into the 1/5 of original volume under the conditions of DEG C, obtains gloiopeltis algae extract；
Step 5：According to the mass fraction, by 8 parts of glycerine, 2 parts of propane diols, 1 part of fibroin, 1 part of essence, 0.4 part of triethanolamine
It is added in 78 parts of deionized waters, aqueous phase liquid is made until dissolving in 70 DEG C of heating stirrings；
Step 6：According to the mass fraction, by 3 parts of aloe extracts, 1.5 parts of gloiopeltis algae extracts, 1.5 parts of methyl-silicone oils, 2 parts of lists
Sweet fat, 1.2 parts of polyoxyethylene sorbitan monolaurates, 0.8 part of compound emulsifying agent AC-402,0.4 part of xanthan gum, 60
Stirred under the conditions of DEG C, oil phase liquid is made；
Step 7：Under conditions of being stirred continuously, oil phase liquid is added slowly in aqueous phase liquid, described oil phase liquid and aqueous phase
The mass ratio of liquid is 1:8,15min is stirred using high speed disperser, cooling discharging, both obtains Essence.
A kind of 2. preparation method of anti-acne essence containing aloe extract according to claim 1, it is characterised in that：Step
The mixing speed of high speed disperser described in rapid seven is 5000r/min.
A kind of 3. preparation method of anti-acne essence containing aloe extract according to claim 1, it is characterised in that：Step
Essence described in rapid five is flavoring rose essence.
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| CN201710722173.8A CN107362115A (en) | 2017-08-22 | 2017-08-22 | A kind of preparation method of the anti-acne essence containing aloe extract |
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| CN201710722173.8A CN107362115A (en) | 2017-08-22 | 2017-08-22 | A kind of preparation method of the anti-acne essence containing aloe extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111920734A (en) * | 2020-08-19 | 2020-11-13 | 广州黛诗莎化妆品有限公司 | Extraction process of aloe essence for removing acne |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100594882C (en) * | 2008-08-21 | 2010-03-24 | 太仓亚蕾生物制品有限公司 | Acne removing Chinese aloe renovation liquid |
| CN104856926A (en) * | 2015-05-14 | 2015-08-26 | 中国水产科学研究院南海水产研究所 | Method for extracting anti-irradiation active substances from gloiopeltis furcata |
| CN105496906A (en) * | 2016-01-29 | 2016-04-20 | 福建农林大学 | Aloe and konjac glucomannan facial mask and preparation method thereof |
-
2017
- 2017-08-22 CN CN201710722173.8A patent/CN107362115A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100594882C (en) * | 2008-08-21 | 2010-03-24 | 太仓亚蕾生物制品有限公司 | Acne removing Chinese aloe renovation liquid |
| CN104856926A (en) * | 2015-05-14 | 2015-08-26 | 中国水产科学研究院南海水产研究所 | Method for extracting anti-irradiation active substances from gloiopeltis furcata |
| CN105496906A (en) * | 2016-01-29 | 2016-04-20 | 福建农林大学 | Aloe and konjac glucomannan facial mask and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111920734A (en) * | 2020-08-19 | 2020-11-13 | 广州黛诗莎化妆品有限公司 | Extraction process of aloe essence for removing acne |
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Application publication date: 20171121 |