CN107349253A - Non-stimulated Medical antiseptic solution and preparation method thereof - Google Patents
Non-stimulated Medical antiseptic solution and preparation method thereof Download PDFInfo
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Abstract
The invention discloses non-stimulated Medical antiseptic solution and preparation method thereof, the non-stimulated Medical antiseptic solution is prepared from the following components：Sodium Diacetate, piperonal, certain herbaceous plants with big flowers acid, beta cyclodextrin, Dehydro and drographolide, arbor-vitae leaf dried powder, triethyl ethylenediamine tetraacetic acid (EDTA) calcium, ginger caul-fat, Puerarin, magnesium sulfate, ethylparaben, polyvinylpyrrolidone, medicinal hydrogen peroxide, emulsifying agent, polyethylene glycol, deionized water.Thimerosal provided by the invention being capable of quick sterilization, 30 seconds average killing logarithm values to staphylococcus aureus, pseudomonas aeruginosa, Candida albicans of effect meet national relevant regulations, simultaneously, the thimerosal of the present invention not spirituosity, non-stimulated and nontoxic, it is safe to use, meet the application requirement of medical and health industry.
Description
Technical field
The invention belongs to disinfectant technical field, and in particular to non-stimulated Medical antiseptic solution and preparation method thereof.
Background technology
Sterilization is one of important step of infection control, and it directly affects therapeutic quality.Disinfectant kind in the market
Class is various, and medical common disinfectant mainly has ethanol, iodine and PVP-I, Chlorhexidine, quaternary ammonium compound, triclosan
Deng.The features such as wherein Chlorhexidine belongs to biguanides antiseptic, and low toxicity, excitant are small, has a broad antifungal spectrum, it has anti-leather orchid well
Positive bacteria acts on, and the effect to gram-negative bacteria and fungi is weaker, small to Mycobacterium effect, invalid to brood cell.Quaternary ammonium salt
It is the complicated changeable compound of a major class, wherein alkyl BZK（Benzalkonium bromide）Widely used in clinic, though
Its right bacteriostasis is strong, but fungicidal spectrum is narrower；Such as its effect to gram-negative bacterias such as pseudomonas aeruginosas is poor, to tuberculosis
Mycobacteria and bacterial spore are then substantially invalid；Lipophilic virus can be only inactivated, and hydrophilic viruses is acted on poor.Though ethanol is doctor
With most commonly used disinfectant, but its fungicidal spectrum is narrower, and killing effect is poor, and it is bad that Disinfection Effect is used alone；In addition,
Although ethanol rate of volatilization is fast, quick-drying, it has certain excitant for wound, adds the pain of patient.Thus, open
The Medical antiseptic solution of a kind of non-stimulated and spectrum sterilization is sent for clinically infection control, improves therapeutic quality with very heavy
The meaning wanted.
The content of the invention
The purpose of the present invention is to avoid above-mentioned at least one weak point of the prior art and provide a kind of non-stimulated doctor
With thimerosal and preparation method thereof.
The purpose of the present invention is achieved through the following technical solutions：
Non-stimulated Medical antiseptic solution, it is prepared by the component of following parts by weight：Sodium Diacetate 1-7 parts, piperonal 0.8-5 parts,
Certain herbaceous plants with big flowers acid 0.4-3 parts, beta-schardinger dextrin 4-9 parts, Dehydro and drographolide 1.2-3.5 parts, arbor-vitae leaf dried powder 0.6-2.4 parts, triethyl
Ethylenediamine tetraacetic acid (EDTA) calcium 1.4-5.2 parts, ginger caul-fat 1.8-4 parts, Puerarin 1.1-3 parts, magnesium sulfate 0.6-1.5 parts, ethylparaben
0.5-1.4 parts, polyvinylpyrrolidone 5.5-9 parts, medicinal hydrogen peroxide 0.4-1.2 parts, emulsifying agent 1.5-3 parts, polyethylene glycol 8-
15 parts, deionized water 30-55 parts.
Further, the emulsifying agent is at least two in Tea Saponin, Tween 80 and this disk 40.
Further, it is prepared by the component of following parts by weight：Sodium Diacetate 1.8-6.4 parts, piperonal 1.2-4.3
Part, certain herbaceous plants with big flowers acid 0.7-2.5 parts, beta-schardinger dextrin 4.6-8.2 parts, Dehydro and drographolide 1.4-3.1 parts, arbor-vitae leaf dried powder 0.8-2.1
Part, triethyl ethylenediamine tetraacetic acid (EDTA) calcium 1.6-4.8 parts, ginger caul-fat 2.1-3.8 parts, Puerarin 1.3-2.7 parts, magnesium sulfate 0.8-1.4
Part, ethylparaben 0.7-1.3 parts, polyvinylpyrrolidone 5.8-8.6 parts, medicinal hydrogen peroxide 0.6-1.0 parts, emulsifying agent 1.7-
2.5 part, polyethylene glycol 9.3-14 parts, deionized water 35-52 parts.
Further, it is prepared by the component of following parts by weight：5.4 parts of sodium Diacetate, 3.8 parts of piperonal, certain herbaceous plants with big flowers acid 1.6
Part, 6.7 parts of beta-schardinger dextrin, 2.5 parts of Dehydro and drographolide, 1.3 parts of arbor-vitae leaf dried powder, 3.9 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium,
It is 2.7 parts of ginger caul-fat, 1.8 parts of Puerarin, 1.1 parts of magnesium sulfate, 0.9 part of ethylparaben, 7.2 parts of polyvinylpyrrolidone, medicinal
0.9 part of hydrogen peroxide, 1.9 parts of emulsifying agent, 11.2 parts of polyethylene glycol, 46 parts of deionized water.
The preparation method of non-stimulated Medical antiseptic solution described above, including following preparation process：
Step 1, weigh according to above-mentioned parts by weight；
Step 2, by sodium Diacetate, triethyl ethylenediamine tetraacetic acid (EDTA) calcium and arbor-vitae leaf dried powder add deionized water in, stir；
Step 3 and then addition beta-schardinger dextrin and polyvinylpyrrolidone, are heated to 40-60 DEG C, stir；
Step 4, by ginger caul-fat, certain herbaceous plants with big flowers acid, Puerarin, piperonal, Dehydro and drographolide add polyethylene glycol in, stir 1h, so
Add in the mixture in step 3, stir afterwards；
Step 5, by magnesium sulfate, ethylparaben, emulsifying agent and medicinal hydrogen peroxide it is well mixed after, the mixing that adds in step 4
In thing, stir, standing and defoaming, as non-stimulated Medical antiseptic solution.
Further, the mixing speed in the step 2 is 300-700rpm, mixing time 40-70min.
Further, the mixing speed in the step 3 is 500-800rpm, mixing time 20-60min.
Further, the mixing speed in the step 4 is 50-200rpm, mixing time 20-30min.
Further, the mixing speed in the step 5 is 100-300rpm, mixing time 1-3h.
As a result of above technical scheme, beneficial effects of the present invention：
Thimerosal provided by the invention can quick sterilization, effect 30 seconds is to staphylococcus aureus, pseudomonas aeruginosa, white
The average killing logarithm value of color candida albicans is respectively higher than 7.3,7.6 and 6.8, and the average killing logarithm value for meeting country is higher than 5
Regulation；In addition, the thimerosal of the present invention not spirituosity, non-stimulated and nontoxic, safe to use, meet medical and health industry should
With requiring.
Embodiment
With reference to specific embodiment, the present invention is described in further detail.Following examples are used to illustrate the present invention,
But it is not limited to the scope of the present invention.
Embodiment 1
Non-stimulated Medical antiseptic solution, it is prepared by the component of following parts by weight：1 part of sodium Diacetate, 0.8 part of piperonal, certain herbaceous plants with big flowers acid
0.4 part, 4 parts of beta-schardinger dextrin, 1.2 parts of Dehydro and drographolide, 0.6 part of arbor-vitae leaf dried powder, triethyl ethylenediamine tetraacetic acid (EDTA) calcium 1.4
Part, 1.8 parts of ginger caul-fat, 1.1 parts of Puerarin, 0.6 part of magnesium sulfate, 0.5 part of ethylparaben, 5.5 parts of polyvinylpyrrolidone, medicine
With 0.4 part of hydrogen peroxide, 1.5 parts of emulsifying agent, 8 parts of polyethylene glycol, 30 parts of deionized water.
The emulsifying agent is that mass ratio is 1:1 Tea Saponin and Tween 80.
The preparation method of non-stimulated Medical antiseptic solution described above, including following preparation process：
Step 1, weigh according to above-mentioned parts by weight；
Step 2, by sodium Diacetate, triethyl ethylenediamine tetraacetic acid (EDTA) calcium and arbor-vitae leaf dried powder add deionized water in, stir, its
Mixing speed is 300rpm, mixing time 40min；
Step 3 and then addition beta-schardinger dextrin and polyvinylpyrrolidone, are heated to 40 DEG C, stir, its mixing speed is
500rpm, mixing time 20min；
Step 4, by ginger caul-fat, certain herbaceous plants with big flowers acid, Puerarin, piperonal, Dehydro and drographolide add polyethylene glycol in, stir 1h, so
Add in the mixture in step 3, stir, its mixing speed is 50rpm, mixing time 20min afterwards；
Step 5, by magnesium sulfate, ethylparaben, emulsifying agent and medicinal hydrogen peroxide it is well mixed after, the mixing that adds in step 4
In thing, stir, its mixing speed is 100rpm, mixing time 1h, afterwards standing and defoaming, as non-stimulated medical disinfecting
Liquid.
Embodiment 2
Non-stimulated Medical antiseptic solution, it is prepared by the component of following parts by weight：7 parts of sodium Diacetate, 5 parts of piperonal, certain herbaceous plants with big flowers acid 3
Part, 9 parts of beta-schardinger dextrin, 3.5 parts of Dehydro and drographolide, 2.4 parts of arbor-vitae leaf dried powder, 5.2 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, ginger
4 parts of caul-fat, 3 parts of Puerarin, 1.5 parts of magnesium sulfate, 1.4 parts of ethylparaben, 9 parts of polyvinylpyrrolidone, medicinal hydrogen peroxide 1.2
Part, 3 parts of emulsifying agent, 15 parts of polyethylene glycol, 55 parts of deionized water.
The emulsifying agent is that mass ratio is 2:3 Tween 80 and this disk 40.
The preparation method of non-stimulated Medical antiseptic solution described above, including following preparation process：
Step 1, weigh according to above-mentioned parts by weight；
Step 2, by sodium Diacetate, triethyl ethylenediamine tetraacetic acid (EDTA) calcium and arbor-vitae leaf dried powder add deionized water in, stir, its
Mixing speed is 700rpm, mixing time 70min；
Step 3 and then addition beta-schardinger dextrin and polyvinylpyrrolidone, are heated to 60 DEG C, stir, its mixing speed is
800rpm, mixing time 60min；
Step 4, by ginger caul-fat, certain herbaceous plants with big flowers acid, Puerarin, piperonal, Dehydro and drographolide add polyethylene glycol in, stir 1h, so
Add in the mixture in step 3, stir, its mixing speed is 200rpm, mixing time 30min afterwards；
Step 5, by magnesium sulfate, ethylparaben, emulsifying agent and medicinal hydrogen peroxide it is well mixed after, the mixing that adds in step 4
In thing, stir, its mixing speed is 300rpm, mixing time 3h, afterwards standing and defoaming, as non-stimulated medical disinfecting
Liquid.
Embodiment 3
Non-stimulated Medical antiseptic solution, it is prepared by the component of following parts by weight：1.8 parts of sodium Diacetate, 1.2 parts of piperonal, certain herbaceous plants with big flowers
0.7 part of acid, 4.6 parts of beta-schardinger dextrin, 1.4 parts of Dehydro and drographolide, 0.8 part of arbor-vitae leaf dried powder, triethyl ethylenediamine tetraacetic acid (EDTA) calcium
1.6 parts, 2.1 parts of ginger caul-fat, 1.3 parts of Puerarin, 0.8 part of magnesium sulfate, 0.7 part of ethylparaben, polyvinylpyrrolidone 5.8
Part, 0.6 part of medicinal hydrogen peroxide, 1.7 parts of emulsifying agent, 9.3 parts of polyethylene glycol, 35 parts of deionized water.
The emulsifying agent is that mass ratio is 1:4:2 Tea Saponin, Tween 80 and this disk 40.
The preparation method of non-stimulated Medical antiseptic solution described above, including following preparation process：
Step 1, weigh according to above-mentioned parts by weight；
Step 2, by sodium Diacetate, triethyl ethylenediamine tetraacetic acid (EDTA) calcium and arbor-vitae leaf dried powder add deionized water in, stir, its
Mixing speed is 400rpm, mixing time 5min；
Step 3 and then addition beta-schardinger dextrin and polyvinylpyrrolidone, are heated to 50 DEG C, stir, its mixing speed is
750rpm, mixing time 50min；
Step 4, by ginger caul-fat, certain herbaceous plants with big flowers acid, Puerarin, piperonal, Dehydro and drographolide add polyethylene glycol in, stir 1h, so
Add in the mixture in step 3, stir, its mixing speed is 180rpm, mixing time 25min afterwards；
Step 5, by magnesium sulfate, ethylparaben, emulsifying agent and medicinal hydrogen peroxide it is well mixed after, the mixing that adds in step 4
In thing, stir, its mixing speed is 180rpm, mixing time 3h, afterwards standing and defoaming, as non-stimulated medical disinfecting
Liquid.
Embodiment 4
Non-stimulated Medical antiseptic solution, it is prepared by the component of following parts by weight：6.4 parts of sodium Diacetate, 4.3 parts of piperonal, certain herbaceous plants with big flowers
- 2.5 parts of acid, 8.2 parts of beta-schardinger dextrin, 3.1 parts of Dehydro and drographolide, 2.1 parts of arbor-vitae leaf dried powder, triethyl ethylenediamine tetraacetic acid (EDTA) calcium
4.8 parts, 3.8 parts of ginger caul-fat, 2.7 parts of Puerarin, 1.4 parts of magnesium sulfate, 1.3 parts of ethylparaben, polyvinylpyrrolidone 8.6
Part, 1.0 parts of medicinal hydrogen peroxide, 2.5 parts of emulsifying agent, 14 parts of polyethylene glycol, 52 parts of deionized water.
The emulsifying agent is that mass ratio is 4:1 Tea Saponin and this disk 40.
The preparation method of non-stimulated Medical antiseptic solution described above, including following preparation process：
Step 1, weigh according to above-mentioned parts by weight；
Step 2, by sodium Diacetate, triethyl ethylenediamine tetraacetic acid (EDTA) calcium and arbor-vitae leaf dried powder add deionized water in, stir, its
Mixing speed is 550rpm, mixing time 65min；
Step 3 and then addition beta-schardinger dextrin and polyvinylpyrrolidone, are heated to 48 DEG C, stir, its mixing speed is
650rpm, mixing time are 40 min；
Step 4, by ginger caul-fat, certain herbaceous plants with big flowers acid, Puerarin, piperonal, Dehydro and drographolide add polyethylene glycol in, stir 1h, so
Add in the mixture in step 3, stir, its mixing speed is 15rpm, mixing time 25min afterwards；
Step 5, by magnesium sulfate, ethylparaben, emulsifying agent and medicinal hydrogen peroxide it is well mixed after, the mixing that adds in step 4
In thing, stir, its mixing speed is 180rpm, mixing time 2h, afterwards standing and defoaming, as non-stimulated medical disinfecting
Liquid.
Embodiment 5
Non-stimulated Medical antiseptic solution, it is prepared by the component of following parts by weight：5.4 parts of sodium Diacetate, 3.8 parts of piperonal, certain herbaceous plants with big flowers
1.6 parts of acid, 6.7 parts of beta-schardinger dextrin, 2.5 parts of Dehydro and drographolide, 1.3 parts of arbor-vitae leaf dried powder, triethyl ethylenediamine tetraacetic acid (EDTA) calcium
3.9 parts, 2.7 parts of ginger caul-fat, 1.8 parts of Puerarin, 1.1 parts of magnesium sulfate, 0.9 part of ethylparaben, polyvinylpyrrolidone 7.2
Part, 0.9 part of medicinal hydrogen peroxide, 1.9 parts of emulsifying agent, 11.2 parts of polyethylene glycol, 46 parts of deionized water.
The emulsifying agent is that mass ratio is 5:2:1 Tea Saponin, Tween 80 and this disk 40.
The preparation method of non-stimulated Medical antiseptic solution described above, including following preparation process：
Step 1, weigh according to above-mentioned parts by weight；
Step 2, by sodium Diacetate, triethyl ethylenediamine tetraacetic acid (EDTA) calcium and arbor-vitae leaf dried powder add deionized water in, stir, its
Mixing speed is 550rpm, mixing time 65min；
Step 3 and then addition beta-schardinger dextrin and polyvinylpyrrolidone, are heated to 55 DEG C, stir, its mixing speed is
650rpm, mixing time are 40 min；
Step 4, by ginger caul-fat, certain herbaceous plants with big flowers acid, Puerarin, piperonal, Dehydro and drographolide add polyethylene glycol in, stir 1h, so
Add in the mixture in step 3, stir, its mixing speed is 150rpm, mixing time 28min afterwards；
Step 5, by magnesium sulfate, ethylparaben, emulsifying agent and medicinal hydrogen peroxide it is well mixed after, the mixing that adds in step 4
In thing, stir, its mixing speed is 160rpm, mixing time 2h, afterwards standing and defoaming, as non-stimulated medical disinfecting
Liquid.
Comparative example 1
This comparative example is substantially the same manner as Example 1, the difference is that only：Piperonal, magnesium sulfate and Pueraria lobota are free of in this comparative example
Root element.
Comparative example 2
This comparative example is substantially the same manner as Example 1, the difference is that only：In this comparative example without ginger caul-fat, sodium Diacetate and
Certain herbaceous plants with big flowers acid.
Correlated performance is carried out according to the traditional test methods of this area to the product prepared by above example and comparative example
Test, its test result are as shown in the table：
By upper table, thimerosal provided by the invention can quick sterilization, effect 30 seconds to staphylococcus aureus, verdigris
Pseudomonas alba, the average killing logarithm value of Candida albicans are respectively higher than 7.3,7.6 and 6.8, meet being averaged for country and kill
Logarithm value of going out is higher than 5 regulation；In addition, the thimerosal of the present invention not spirituosity, non-stimulated and nontoxic, safe to use, meet doctor
Treat the application requirement of health industry.
Claims (9)
1. non-stimulated Medical antiseptic solution, it is characterised in that be prepared by the component of following parts by weight：Sodium Diacetate 1-7 parts, Hu
Green pepper aldehyde 0.8-5 parts, certain herbaceous plants with big flowers acid 0.4-3 parts, beta-schardinger dextrin 4-9 parts, Dehydro and drographolide 1.2-3.5 parts, arbor-vitae leaf dried powder 0.6-
2.4 parts, triethyl ethylenediamine tetraacetic acid (EDTA) calcium 1.4-5.2 parts, ginger caul-fat 1.8-4 parts, Puerarin 1.1-3 parts, magnesium sulfate 0.6-1.5
Part, ethylparaben 0.5-1.4 parts, polyvinylpyrrolidone 5.5-9 parts, medicinal hydrogen peroxide 0.4-1.2 parts, emulsifying agent 1.5-3
Part, polyethylene glycol 8-15 parts, deionized water 30-55 parts.
2. non-stimulated Medical antiseptic solution according to claim 1, it is characterised in that the emulsifying agent is Tea Saponin, tween
80 and this disk 40 at least two.
3. non-stimulated Medical antiseptic solution according to claim 1, it is characterised in that by the component preparation of following parts by weight
Into：Sodium Diacetate 1.8-6.4 parts, piperonal 1.2-4.3 parts, certain herbaceous plants with big flowers acid 0.7-2.5 parts, beta-schardinger dextrin 4.6-8.2 parts, dehydration punching
Lotus lactone 1.4-3.1 parts, arbor-vitae leaf dried powder 0.8-2.1 parts, triethyl ethylenediamine tetraacetic acid (EDTA) calcium 1.6-4.8 parts, ginger caul-fat 2.1-3.8
Part, Puerarin 1.3-2.7 parts, magnesium sulfate 0.8-1.4 parts, ethylparaben 0.7-1.3 parts, polyvinylpyrrolidone 5.8-8.6
Part, medicinal hydrogen peroxide 0.6-1.0 parts, emulsifying agent 1.7-2.5 parts, polyethylene glycol 9.3-14 parts, deionized water 35-52 parts.
4. non-stimulated Medical antiseptic solution according to claim 1, it is characterised in that by the component preparation of following parts by weight
Into：5.4 parts of sodium Diacetate, 3.8 parts of piperonal, 1.6 parts of certain herbaceous plants with big flowers acid, 6.7 parts of beta-schardinger dextrin, 2.5 parts of Dehydro and drographolide, arbor-vitae
1.3 parts of leaf dried powder, 3.9 parts of triethyl ethylenediamine tetraacetic acid (EDTA) calcium, 2.7 parts of ginger caul-fat, 1.8 parts of Puerarin, 1.1 parts of magnesium sulfate, Ni Bo
Golden 0.9 part of ethyl ester, 7.2 parts of polyvinylpyrrolidone, 0.9 part of medicinal hydrogen peroxide, 1.9 parts of emulsifying agent, 11.2 parts of polyethylene glycol, go
46 parts of ionized water.
5. the preparation method of the non-stimulated Medical antiseptic solution according to claim 1-4 any one, it is characterised in that including
Following preparation process：
Step 1, weigh according to above-mentioned parts by weight；
Step 2, by sodium Diacetate, triethyl ethylenediamine tetraacetic acid (EDTA) calcium and arbor-vitae leaf dried powder add deionized water in, stir；
Step 3 and then addition beta-schardinger dextrin and polyvinylpyrrolidone, are heated to 40-60 DEG C, stir；
Step 4, by ginger caul-fat, certain herbaceous plants with big flowers acid, Puerarin, piperonal, Dehydro and drographolide add polyethylene glycol in, stir 1h, so
Add in the mixture in step 3, stir afterwards；
Step 5, by magnesium sulfate, ethylparaben, emulsifying agent and medicinal hydrogen peroxide it is well mixed after, the mixing that adds in step 4
In thing, stir, standing and defoaming, as non-stimulated Medical antiseptic solution.
6. the preparation method of non-stimulated Medical antiseptic solution according to claim 5, it is characterised in that in the step 2
Mixing speed is 300-700rpm, mixing time 40-70min.
7. the preparation method of non-stimulated Medical antiseptic solution according to claim 5, it is characterised in that in the step 3
Mixing speed is 500-800rpm, mixing time 20-60min.
8. the preparation method of non-stimulated Medical antiseptic solution according to claim 5, it is characterised in that in the step 4
Mixing speed is 50-200rpm, mixing time 20-30min.
9. the preparation method of non-stimulated Medical antiseptic solution according to claim 5, it is characterised in that in the step 5
Mixing speed is 100-300rpm, mixing time 1-3h.
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