CN107349034A - A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof - Google Patents

A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof Download PDF

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Publication number
CN107349034A
CN107349034A CN201710641054.XA CN201710641054A CN107349034A CN 107349034 A CN107349034 A CN 107349034A CN 201710641054 A CN201710641054 A CN 201710641054A CN 107349034 A CN107349034 A CN 107349034A
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China
Prior art keywords
fusion device
coatings
titanium alloy
porous
cervical vertebral
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CN201710641054.XA
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Chinese (zh)
Inventor
李海漪
伍苏华
郭征
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Air Force Medical University of PLA
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Shenzhen Dimensional Bio Medical Technology Co Ltd
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Priority to CN201710641054.XA priority Critical patent/CN107349034A/en
Publication of CN107349034A publication Critical patent/CN107349034A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/447—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages substantially parallelepipedal, e.g. having a rectangular or trapezoidal cross-section
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30772—Apertures or holes, e.g. of circular cross section
    • A61F2002/30774—Apertures or holes, e.g. of circular cross section internally-threaded
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3092—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having an open-celled or open-pored structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/3093—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth for promoting ingrowth of bone tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30952—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using CAD-CAM techniques or NC-techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30976—Designing or manufacturing processes using hydrojet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4495—Joints for the spine, e.g. vertebrae, spinal discs having a fabric structure, e.g. made from wires or fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Geometry (AREA)
  • Manufacturing & Machinery (AREA)
  • Prostheses (AREA)

Abstract

The invention discloses a kind of POROUS TITANIUM cervical vertebral fusion cage with hydroxyapatite (HA) coating and preparation method thereof, the fusion device is made up of the loose structure of solid framework structure and filling therebetween.Anterior fusion device is similar bullet-headed structure, and each edge of fusion device is that the smooth titanium alloy thin wall of entity is covered, it is possible to reduce disconnected arm risk caused by stress concentration occurs in implantation process for fusion device edge girder.Fusion device rear-center part is more than thickness 3mm circular arc entity titanium alloy structure, is prepared for screwed hole by the second stage of machining mode thereon and groove is used in art fusion device being connected to implantation handle.The screw thread can be provided than clipping more firmly with being reliably connected with groove, be easy to implant procedure in art.Hydroxyapatite (HA) coating of all girder surfaces of fusion device loose structure part all 100 150 μm or so of uniform fold a layer thickness, it may be possible to provide more excellent early stage Integrated implant effect.

Description

A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof
Technical field
The invention belongs to fixed network in spinal fusion, and in particular to a kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings And preparation method thereof.
Background technology
Disc herniation, cervical spinal instability etc. caused by cervical vertebra retrogression pathological changes are common spinal surgery diseases, to conservative Treatment nonresponder typically needs to carry out neck interbody fusion.Clinic mainly uses polyether-ether-ketone (PEEK) material or entity titanium at present The Invasive lumbar fusion device of alloy material carries out neck interbody fusion.However, these traditional Invasive lumbar fusion devices are deposited in clinical practice In many limitations：PEEK materials are bio-inert material, and material surface is wrapped up by one layer of fibr tissue after implanting, Bone-material interface bond strength deficiency, easily occur to loosen and cause Fusion failure.And although titanium alloy material has preferably Biocompatibility, but because the modulus of elasticity (110GPa) of entity titanium alloy is significantly larger than nature bone (cortex bone about 3-12GPa), Stress shielding can be produced, causes surrounding materials bone absorption and implant loosening occurs, equally easily cause Fusion failure.
In order to solve the above problems, 3D printing porous titanium alloy material and its bio-modification become the focus of research.3D Titanium can effectively be reduced and closes by controlling many kinds of parameters such as microcellular structure and porosity, pore size by printing porous titanium alloy The modulus of elasticity of gold, realize and match with the modulus of elasticity of natural bone, and loose structure can allow bone tissue to grow into wherein, increase Add bone-material area, so as to obtain more preferable bone-material interface bond strength.
Although current clinically existing a small number of cases that Cervical Fusion is carried out using 3D printing POROUS TITANIUM fusion device, are being answered The solution of some problems demands is remained during：One be due to existing metal 3D printing technique precision limitation, Shang Nan Directly to prepare the helicitic texture of precision by metal 3D printing technique, thus it is solid more using being threadedly coupled with entity fusion device Fixed difference, current porous fusion device is mainly fixed on connection handle using clamp method to implant, if gripping strength is excessive Easily cause stress raisers, increase girder risk of breakage, and the too small fixation of gripping strength is insecure, gives operation technique band It is inconvenient to come.Second, in order to ensure to be fitted close in fusion device implantation process, it is difficult to avoid to hit with upper and lower centrum sclerotin, Cause the small beam arm risk of breakage of fusion device edge (especially leading edge) part to increase.Three are that while that titanium alloy has good life Thing compatibility, but reported according to existing literature, it is slower in the Integrated implant speed that implants, early stage Integrated implant less effective.Such as The Integrated implant effect what further improves porous titanium alloy is current study hotspot.
The content of the invention
It is an object of the invention to provide one kind to be bonded cervical spinal anatomy, can reduce the disconnected arm risk of edge girder and promote Enter POROUS TITANIUM cervical vertebral fusion cage with HA coatings of early stage Integrated implant and preparation method thereof.
To reach above-mentioned purpose, the POROUS TITANIUM cervical vertebral fusion cage with HA coatings of the invention includes the circular arc of rear center Shape entity titanium alloy structure, the smooth titanium alloy thin wall structure of entity of anterior similar bullet-headed structure and filling therebetween porous The fusion device that structure is formed, offers threaded groove, in the girder of loose structure on circular arc entity titanium alloy structure On be coated with HA coatings.
The wall thickness of described titanium alloy thin wall structure is 300 microns.
Described loose structure is regular regular dodecahedron loose structure, porosity 75%, aperture 400-800 microns, girder Diameter 300-400 microns.
Described circular arc entity titanium alloy structure central thickness is 3mm.
Described fusion device upper surface is curve slope, and the overall inclination angle forward in upper surface is 3-4 °.
100-150 μm described of HA coating layer thicknesses.
The long L of described fusion device：For 13-16mm, wide W：11-13mm, high H：5-8mm, wedge angle a：17°.
The present invention has the preparation method of the POROUS TITANIUM cervical vertebral fusion cage of HA coatings, comprises the following steps：
1) metal 3D printing technique prepares fusion device base body
Neck Invasive lumbar fusion device model is designed first in CAD software, model data is then inputted into metal 3D printing equipment In, titanium alloy powder is added, porous titanium alloy cervical vertebral fusion cage basic model is prepared according to standardization program；
2) accurate machining prepares the threaded groove in fusion device rear
Added using precision optical machinery processing mode at printed porous fusion device rear circular arc entity titanium alloy structure The threaded groove of work；
3) vacuum plasma spray coating HA coatings
Porous titanium alloy fusion device is put into acetone soln to be cleaned by ultrasonic, 250-300 μm of Buddha's warrior attendant is used after drying Sand is polished, and the fusion device after polishing is put into vacuum plasma spray coating equipment, according to standard spray program in loose structure Coating thickness is 100-150 μm of HA coatings on girder.
The anterior smooth titanium alloy thin wall structure of entity for similar bullet-headed structure of fusion device of the present invention, first, can subtract Disconnected arm risk caused by stress concentration occurs in implantation process for few fusion device forward edge girder, second, enclosing fusion device The loose structure of front side, reduce the wind of spinal compression caused by charging into canalis spinalis from fusion device front portion because of bone tissue undue growth Danger.
Fusion device rear also uses smooth circular arc entity titanium alloy structure, is prepared thereon by the second stage of machining mode Threaded groove is used in art fusion device being connected to implantation handle.The threaded groove can be provided than clamping Formula more firmly with being reliably connected, is easy to implant procedure in art.
The hydroxyl of all girder surfaces of the fusion device loose structure part all 100-150 μm or so of uniform fold a layer thickness Base apatite (HA) coating.
The porous titanium alloy Invasive lumbar fusion device as made of the preparation method of the present invention, which has, is more bonded cervical spinal anatomy Profile.Its anterior similar smooth titanium alloy thin wall structure of the smooth entity of bullet-headed structure can reduce fusion device forward edge Disconnected arm risk caused by stress concentration occurs in implantation process for girder.Secondly because before entity structure encloses fusion device Trailing edge, reduce and the risk in canalis spinalis or throat is charged into from fusion device front and rear portions because of bone tissue undue growth.The fusion device uses Threaded connection pore structure can be provided in art than clipping more firm and reliable connected mode, facilitate in art and operate.In addition, Because porous part titanium alloy surface has hydroxyl apatite biological painting, using the teaching of the invention it is possible to provide more excellent early stage Integrated implant effect Fruit.
Brief description of the drawings
Fig. 1 is overall structure diagram of the present invention；
Fig. 2 is Fig. 1 top view；
Fig. 3 is Fig. 1 side view；
Fig. 4 is Fig. 1 rearview.
Embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings.
Such as Fig. 2, the wedge-shaped Invasive lumbar fusion device shown in Fig. 3, specification is：Long (L)：13-16mm, wide (W)：11-13mm is high (H)：5-8mm, wedge angle (angle shown in a)：17°.
Referring to Fig. 1-4, the present invention includes the circular arc entity titanium alloy structure 1 of rear center, anterior similar bullet-headed The fusion device that the loose structure 3 of the smooth titanium alloy thin wall structure 2 of entity and filling of structure therebetween is formed, in circular arc entity titanium The center of alloy structure 1 is offered for fusion device to be connected into the threaded groove 4 on implantation handle in art, and circular arc is real The central thickness of body titanium alloy structure 1 is 3mm, and the wall thickness of titanium alloy thin wall structure 2 is 300 microns, and loose structure 3 is rule positive 12 Face body loose structure, porosity 75%, aperture 400-800 microns, girder diameter 300-400 microns, in the girder of loose structure 3 On be coated with HA (hydroxyapatite) coating, using the teaching of the invention it is possible to provide more excellent early stage Integrated implant effect.Fusion device upper surface is arc Shape inclined-plane, fusion device upper surface are curve slope, are more bonded cervical spinal anatomy.The overall inclination angle forward in upper surface is 3-4 °, In favor of maintaining cervical vertebrae physiological bending.
Its preparation method is as follows：
1) metal 3D printing technique prepares fusion device base body
Neck Invasive lumbar fusion device model is designed first in CAD software, model data is then inputted into metal 3D printing equipment In, titanium alloy powder is added, porous titanium alloy cervical vertebral fusion cage basic model is prepared according to standardization program；
2) accurate machining prepares the threaded groove 4 in fusion device rear
Added using precision optical machinery processing mode at printed porous fusion device rear circular arc entity titanium alloy structure 1 The threaded groove 4 of work；
3) vacuum plasma spray coating HA coatings
Porous titanium alloy fusion device is put into acetone soln to be cleaned by ultrasonic, 250-300 μm of Buddha's warrior attendant is used after drying Sand is polished, and the fusion device after polishing is put into vacuum plasma spray coating equipment, according to standard spray program in loose structure 3 Coating thickness is 100-150 μm of HA coatings on girder.

Claims (8)

  1. A kind of 1. POROUS TITANIUM cervical vertebral fusion cage with HA coatings, it is characterised in that：Include the circular arc entity titanium of rear center Alloy structure (1), the porous knot of the anterior smooth titanium alloy thin wall structure (2) of entity and filling similar to bullet-headed structure therebetween The fusion device that structure (3) is formed, offers threaded groove (4), in porous knot in circular arc entity titanium alloy structure (1) center HA coatings are coated with the girder of structure (3).
  2. 2. the POROUS TITANIUM cervical vertebral fusion cage according to claim 1 with HA coatings, it is characterised in that：Described titanium alloy The wall thickness of thin-wall construction (2) is 300 microns.
  3. 3. the POROUS TITANIUM cervical vertebral fusion cage according to claim 1 with HA coatings, it is characterised in that：Described porous knot Structure (3) is regular regular dodecahedron loose structure, porosity 75%, aperture 400-800 microns, girder diameter 300-400 microns.
  4. 4. the POROUS TITANIUM cervical vertebral fusion cage according to claim 1 with HA coatings, it is characterised in that：Described circular arc Entity titanium alloy structure (1) central thickness is 3mm.
  5. 5. the POROUS TITANIUM cervical vertebral fusion cage according to claim 1 with HA coatings, it is characterised in that：Described fusion device Upper surface is curve slope, and the overall inclination angle forward in upper surface is 3-4 °.
  6. 6. the POROUS TITANIUM cervical vertebral fusion cage according to claim 1 with HA coatings, it is characterised in that：Described HA coatings 100-150 μm of thickness.
  7. 7. the POROUS TITANIUM cervical vertebral fusion cage according to claim 1 with HA coatings, it is characterised in that：Described fusion device Long L：For 13-16mm, wide W：11-13mm, high H：5-8mm, wedge angle a：17°.
  8. A kind of 8. preparation method of the POROUS TITANIUM cervical vertebral fusion cage as claimed in claim 1 with HA coatings, it is characterised in that：
    1) metal 3D printing technique prepares fusion device base body
    Neck Invasive lumbar fusion device model is designed first in CAD software, then model data is inputted in metal 3D printing equipment, added Enter titanium alloy powder, porous titanium alloy cervical vertebral fusion cage basic model is prepared according to standardization program；
    2) accurate machining prepares the threaded groove in fusion device rear
    Processed using precision optical machinery processing mode at printed porous fusion device rear circular arc entity titanium alloy structure (1) place Threaded groove (4)；
    3) vacuum plasma spray coating HA coatings
    Porous titanium alloy fusion device is put into acetone soln to be cleaned by ultrasonic, beaten after drying using 250-300 μm of diamond dust Mill, the fusion device after polishing is put into vacuum plasma spray coating equipment, according to standard spray program in the small of loose structure (3) Coating thickness is 100-150 μm of HA coatings on beam.
CN201710641054.XA 2017-07-31 2017-07-31 A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof Pending CN107349034A (en)

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108670504A (en) * 2018-04-16 2018-10-19 华中科技大学同济医学院附属同济医院 Personalized artificial vertebral body implant based on additive manufacturing and design method thereof
CN108888389A (en) * 2018-09-14 2018-11-27 北京爱康宜诚医疗器材有限公司 Articular surface fusion device
CN109730814A (en) * 2018-12-20 2019-05-10 西安铂力特增材技术股份有限公司 A kind of porous fusion device of titanium alloy and its processing method
CN109925102A (en) * 2019-04-12 2019-06-25 北京大学第三医院 Lumbar Fusion prosthese
CN109966027A (en) * 2019-04-28 2019-07-05 华南协同创新研究院 A kind of Bone Defect Repari Gradient Unit, porous support and preparation method
CN109966028A (en) * 2019-04-28 2019-07-05 华南协同创新研究院 A kind of recombiner unit, porous support and preparation method for bone implant
CN110584845A (en) * 2019-10-10 2019-12-20 广东省新材料研究所 Human body intervertebral fusion cage structure and preparation method thereof
CN111227994A (en) * 2018-11-28 2020-06-05 财团法人金属工业研究发展中心 Porous biomedical implant and method for producing same
CN113084555A (en) * 2021-04-29 2021-07-09 宁波兆盈医疗器械有限公司 Method for processing interbody fusion cage
CN113413250A (en) * 2021-07-01 2021-09-21 四川大学 Spine repair system for actively inducing bone tissue regeneration fusion and manufacturing method thereof
IT202000014569A1 (en) * 2020-06-18 2021-12-18 Sps S R L INTERSOMATIC CAGE FOR VERTEBRAL STABILIZATION
WO2021244922A3 (en) * 2020-06-04 2022-02-17 Ngmedical Gmbh Monolithic cervical or lumbar implant body
CN116275122A (en) * 2023-03-30 2023-06-23 维度(西安)生物医疗科技有限公司 3D printing porous TC4 titanium alloy fusion device and surface layer grain refinement method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385489A1 (en) * 2000-08-15 2002-02-21 John S. Thalgott Improved disc prosthesis
CN201529176U (en) * 2009-11-17 2010-07-21 北京天新福医疗器材有限公司 Embedded bone trabecula intervertebral fusion device used for anastomosing vertebra
CN102293693A (en) * 2011-06-01 2011-12-28 中国人民解放军第四军医大学 Porous titanium alloy human cervical interbody fusion cage with bioactivity and preparation method thereof
CN203263594U (en) * 2013-04-16 2013-11-06 创生医疗器械（中国）有限公司 Multi-hole interbody fusion cage
CN105581860A (en) * 2016-01-11 2016-05-18 李鹏 3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2385489A1 (en) * 2000-08-15 2002-02-21 John S. Thalgott Improved disc prosthesis
CN201529176U (en) * 2009-11-17 2010-07-21 北京天新福医疗器材有限公司 Embedded bone trabecula intervertebral fusion device used for anastomosing vertebra
CN102293693A (en) * 2011-06-01 2011-12-28 中国人民解放军第四军医大学 Porous titanium alloy human cervical interbody fusion cage with bioactivity and preparation method thereof
CN203263594U (en) * 2013-04-16 2013-11-06 创生医疗器械（中国）有限公司 Multi-hole interbody fusion cage
CN105581860A (en) * 2016-01-11 2016-05-18 李鹏 3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
黄海: ""多孔钛合金表面HA涂层改性及大动物体内骨修复研究"", 《中国优秀博硕士学位论文全文数据库(博士) 医疗卫生科技辑》 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108670504B (en) * 2018-04-16 2021-04-30 华中科技大学同济医学院附属同济医院 Personalized artificial vertebral body implant based on additive manufacturing and design method thereof
CN108670504A (en) * 2018-04-16 2018-10-19 华中科技大学同济医学院附属同济医院 Personalized artificial vertebral body implant based on additive manufacturing and design method thereof
CN108888389A (en) * 2018-09-14 2018-11-27 北京爱康宜诚医疗器材有限公司 Articular surface fusion device
CN111227994A (en) * 2018-11-28 2020-06-05 财团法人金属工业研究发展中心 Porous biomedical implant and method for producing same
CN109730814A (en) * 2018-12-20 2019-05-10 西安铂力特增材技术股份有限公司 A kind of porous fusion device of titanium alloy and its processing method
CN109925102A (en) * 2019-04-12 2019-06-25 北京大学第三医院 Lumbar Fusion prosthese
CN109966027B (en) * 2019-04-28 2021-02-19 华南协同创新研究院 Gradient unit for bone repair, porous scaffold and preparation method
CN109966028A (en) * 2019-04-28 2019-07-05 华南协同创新研究院 A kind of recombiner unit, porous support and preparation method for bone implant
CN109966027A (en) * 2019-04-28 2019-07-05 华南协同创新研究院 A kind of Bone Defect Repari Gradient Unit, porous support and preparation method
CN110584845A (en) * 2019-10-10 2019-12-20 广东省新材料研究所 Human body intervertebral fusion cage structure and preparation method thereof
CN110584845B (en) * 2019-10-10 2023-09-15 广东省新材料研究所 Human body interbody fusion cage structure and preparation method thereof
WO2021244922A3 (en) * 2020-06-04 2022-02-17 Ngmedical Gmbh Monolithic cervical or lumbar implant body
IT202000014569A1 (en) * 2020-06-18 2021-12-18 Sps S R L INTERSOMATIC CAGE FOR VERTEBRAL STABILIZATION
EP3925576A1 (en) * 2020-06-18 2021-12-22 S.P.S. S.r.l. Intersomatic cage for vertebral stabilization
US11679001B2 (en) 2020-06-18 2023-06-20 Sps S.R.L. Intersomatic cage for vertebral stabilization
CN113084555A (en) * 2021-04-29 2021-07-09 宁波兆盈医疗器械有限公司 Method for processing interbody fusion cage
CN113084555B (en) * 2021-04-29 2022-02-22 宁波兆盈医疗器械有限公司 Method for processing interbody fusion cage
CN113413250A (en) * 2021-07-01 2021-09-21 四川大学 Spine repair system for actively inducing bone tissue regeneration fusion and manufacturing method thereof
CN116275122A (en) * 2023-03-30 2023-06-23 维度(西安)生物医疗科技有限公司 3D printing porous TC4 titanium alloy fusion device and surface layer grain refinement method thereof

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