CN111227994A - Porous biomedical implant and method for producing same - Google Patents
Porous biomedical implant and method for producing same Download PDFInfo
- Publication number
- CN111227994A CN111227994A CN201811437015.9A CN201811437015A CN111227994A CN 111227994 A CN111227994 A CN 111227994A CN 201811437015 A CN201811437015 A CN 201811437015A CN 111227994 A CN111227994 A CN 111227994A
- Authority
- CN
- China
- Prior art keywords
- porous
- manufacturing
- biomedical implant
- process parameter
- solid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2002/4435—Support means or repair of the natural disc wall, i.e. annulus, e.g. using plates, membranes or meshes
Abstract
A manufacturing method of a porous biomedical implant comprises the steps of providing a support frame, wherein the support frame is provided with a bearing surface, forming the porous biomedical implant on the bearing surface in a lamination manufacturing mode, the porous biomedical implant is provided with a solid part and a porous part, the solid part is combined with the bearing surface of the support frame, the porous part is combined with the solid part, the solid part and the porous part are formed in the lamination manufacturing of the same layer, and after the lamination manufacturing of the porous biomedical implant is completed, the support frame is removed.
Description
Technical Field
The present invention relates to a biomedical implant, and more particularly, to a porous biomedical implant and a method for manufacturing the same.
Background
In modern medicine, the medical action of placing a biomedical implant into a living body to replace the original joint, intervertebral disc or tooth root … is a well-established technology, and therefore, the research on the structure and materials of various biomedical implants is one of the development focuses in the field of current dentistry. Please refer to taiwan patent application No. 102144752, "intervertebral implant and method for making the same", which utilizes porous hydroxyapatite as a scaffold model, and fills metal powder into gaps between the scaffold model, and then sinters and forms the porous intervertebral implant of the partially degradable hydroxyapatite/metal block material, although the prior art can form the porous intervertebral implant by using composite material, the manufacturing process is divided into sintering of degradable biological material, filling of metal powder, sintering and subsequent processing and forming, which results in a complex manufacturing process of the prior art biomedical implant.
Disclosure of Invention
The main objective of the present invention is to form a porous biomedical implant by lamination, wherein the porous biomedical implant comprises a solid portion and a porous portion, so that the solid portion provides sufficient supporting force and bone cells can grow through the porous portion, and the solid portion and the porous portion are formed in lamination, and the porous biomedical implant is manufactured after the scaffold is removed, thereby greatly reducing the complexity of the manufacturing process of the biomedical implant.
The manufacturing method of the porous biomedical implant comprises the steps of providing a support frame, wherein the support frame is provided with a bearing surface; forming a porous biomedical implant on the bearing surface by lamination, the porous biomedical implant having a solid portion and a porous portion, the solid portion being bonded to the bearing surface of the scaffold, the porous portion being bonded to the solid portion, wherein the solid portion and the porous portion are formed in lamination; and removing the support frame after completing the lamination manufacture of the porous biomedical implant.
In the method for manufacturing the porous biomedical implant, the solid portion is formed by a first manufacturing process parameter, and the porous portion is formed by a second manufacturing process parameter, wherein the first manufacturing process parameter is different from the second manufacturing process parameter.
In the above method for manufacturing a porous biomedical implant, the first process parameter and the second process parameter are energy density, respectively.
In the above method for manufacturing a porous biomedical implant, the energy density of the first manufacturing process parameter is between 0.15J/mm and 0.30J/mm, and the energy density of the second manufacturing process parameter is between 0.10J/mm and 0.12J/mm.
In the method for manufacturing a porous biomedical implant, the heat source in the lamination manufacturing is an electron beam.
In the above method for manufacturing a porous biomedical implant, the first manufacturing process parameter and the second manufacturing process parameter respectively have a voltage, a current and a heat source scanning speed.
The voltage of the first manufacturing process parameter is 60000V, the current of the first manufacturing process parameter is between 12mA and 20mA, the heat source scan speed of the first manufacturing process parameter is between 4000mm/s and 10000mm/s, the voltage of the second manufacturing process parameter is 60000V, the current of the second manufacturing process parameter is between 3mA and 5mA, and the heat source scan speed of the second manufacturing process parameter is between 1000mm/s and 3000 mm/s.
In the above method for manufacturing a porous biomedical implant, in the lamination manufacturing of the same layer, the solid portion located in the layer is formed first, and then the porous portion of the layer is formed.
In the above method for manufacturing a porous biomedical implant, after the solid portion of the layer is formed, the porous overlapping region of the porous portion is overlapped (overlapped) on the solid overlapping region of the solid portion when the porous portion of the layer is formed.
The present invention provides a porous biomedical implant, comprising: a solid part manufactured by lamination of a first manufacturing process parameter; and a porous portion manufactured by lamination of a second manufacturing process parameter, wherein the porous portion is combined with the solid portion, a cross section of the porous biomedical implant along a lamination direction thereof forms the solid portion and the porous portion, and the first manufacturing process parameter for forming the solid portion and the second manufacturing process parameter for forming the porous portion are different.
In the aforementioned porous biomedical implant, in the lamination manufacturing of the same layer, the solid portion located in the layer is formed first, and then the porous portion located in the layer is formed.
The porous biomedical implant described above, wherein the solid portion has a solid overlap region and the porous portion has a porous overlap region, and the solid overlap region and the porous overlap region overlap (overlap).
By means of the technical scheme, the invention at least has the following advantages and effects:
the porous biomedical implant is manufactured by lamination manufacturing, because the porous biomedical implant is provided with the solid part and the porous part, the solid part can provide enough mechanical support, bone cells can enter and grow through pores of the porous part, and in addition, because the solid part and the porous part can be directly manufactured by lamination manufacturing, the complexity of the subsequent manufacturing process can be greatly reduced.
The foregoing description is only an overview of the technical solutions of the present invention, and in order to make the technical means of the present invention more clearly understood, the present invention may be implemented in accordance with the content of the description, and in order to make the above and other objects, features, and advantages of the present invention more clearly understood, the following preferred embodiments are described in detail with reference to the accompanying drawings.
Drawings
FIG. 1: according to an embodiment of the present invention, a method for manufacturing a porous biomedical implant is provided.
FIG. 2: according to an embodiment of the present invention, the supporting frame is schematically illustrated.
FIG. 3: according to an embodiment of the present invention, a porous biomedical implant is formed on the supporting frame.
FIG. 4: according to one embodiment of the present invention, the porous biomedical implant is a cross-sectional view.
FIG. 5: according to an embodiment of the present invention, the porous biomedical implant is shown after the support frame is removed.
[ description of main element symbols ]
10: method for manufacturing porous biomedical implant 11: provide a support frame
12: forming the porous biomedical implant 13 by lamination: remove the support frame
100: the support frame 110: bearing surface
200: porous biomedical implant 210: solid part
211: solid overlap region 220: porous part
221: porous overlap region
Detailed Description
Please refer to fig. 1, which is a flowchart of a method 10 for manufacturing a porous biomedical implant according to an embodiment of the present invention, and the method includes providing a support 11, forming a porous biomedical implant 12 by lamination manufacturing, and removing a support 13, in this embodiment, steps 11 and 12 are performed by lamination manufacturing using an electron beam as a heat source, or in other embodiments, laser or plasma can be used as a heat source for lamination manufacturing, since electron beam lamination manufacturing is a well-developed 3D printing technology, conventional steps such as modeling, vacuum pumping, powder laying, ventilation, and powder recycling … in lamination manufacturing are not repeated in this disclosure.
Referring to fig. 1 and 2, in step 11, a support frame 100 is provided, in this embodiment, the support frame 100 is manufactured on a lifting platform by lamination manufacturing, and the support frame 100 can move along with the lifting platform to facilitate layer-by-layer forming of the lamination manufacturing, wherein the support frame 100 has a bearing surface 110, and the bearing surface 110 is used for bearing a subsequently formed biomedical implant.
Referring to fig. 1 and 3, in step 12, a porous biomedical implant 200 is formed on the bearing surface 110 of the scaffold 100 by lamination, the porous biomedical implant 200 has a solid portion 210 and a porous portion 220, wherein the solid portion 210 has a relatively high sintering density to provide mechanical support such as compression, torsion and fatigue …, the solid portion 210 is formed on the bearing surface 110 of the scaffold 100, the porous portion 220 has a plurality of pores for bone cells to grow into the pores after implantation, preferably, the pores are through pores, and the porous portion 220 does not need to be supported by the scaffold 100 due to the relatively low sintering density of the porous portion 220, and the porous portion 220 is formed and bonded to the solid portion 210. In this embodiment, the porous biomedical implant 200 is a lumbar fusion cage, and is provided with sufficient support and pores for the self-growth of living organisms.
Referring to fig. 4, a cross-sectional view of the porous biomedical implant 200 along a lamination direction is schematically shown, the solid portion 210 and the porous portion 220 are formed on the cross-section of the porous biomedical implant 200 along the lamination direction, and since the solid portion 210 and the porous portion 220 are formed in the same lamination manufacturing process and the sintering densities of the solid portion 210 and the porous portion 220 are different, although the solid portion 210 and the porous portion 220 are formed in the same lamination manufacturing process, the first manufacturing process parameter for forming the solid portion 210 and the second manufacturing process parameter for forming the porous portion 220 are different, and the solid portion 210 and the porous portion 220 having a good supporting force can be formed in the same lamination manufacturing process.
In the present embodiment, the first manufacturing process parameter for forming the solid portion 210 and the second manufacturing process parameter for forming the porous portion 220 are energy densities, and preferably, the energy density of the first manufacturing process parameter is between 0.15J/mm and 0.30J/mm, and the energy density of the second manufacturing process parameter is between 0.10J/mm and 0.12J/mm, so that the solid portion 210 and the porous portion 220 having holes for bone cell growth can be formed in a lamination process of the same layer.
In the present embodiment, the energy density of the first and second process parameters is controlled by the voltage of the electron beam, the current of the first process parameter is 60000V, the current of the first process parameter is between 12mA and 20mA, the scan speed of the heat source of the first process parameter is between 4000mm/s and 10000mm/s, the voltage of the second process parameter is 60000V, the current of the second process parameter is between 3mA and 5mA, and the scan speed of the heat source of the second process parameter is between 1000mm/s and 3000 mm/s.
Referring to fig. 4, preferably, in the lamination manufacturing of the same layer, the solid portion 210 of the layer is formed first, and then the porous portion 220 of the layer is formed, and the porous overlapping region 221 of the porous portion 220 is overlapped (overlapped) on the solid overlapping region 211 of the solid portion 210 when the porous portion 220 of the layer is formed, that is, the solid portion 210 and the porous portion 220 are modeled, the porous overlapping region 221 of the porous portion 220 is overlapped on the solid overlapping region 211 of the solid portion 210, so that the solid overlapping region 211 of the solid portion 210 is scanned once more by the heat source for forming the porous portion 220 in the lamination manufacturing, which does not affect the formed solid portion 210, and can ensure the firm bonding between the porous portion 220 and the solid portion 210.
Referring to fig. 1 and 5, since the solid portion 210 and the porous portion 220 can be directly manufactured by lamination, after the porous implant 200 is manufactured by lamination, the porous implant 200 can be manufactured by removing the support frame 100.
The porous biomedical implant 200 is manufactured by lamination manufacturing, since the porous biomedical implant 200 has the solid part 210 and the porous part 220, the solid part 210 can provide sufficient mechanical support, and bone cells can enter and grow through the pores of the porous part 220, and in addition, since the solid part 210 and the porous part 220 can be directly manufactured by lamination manufacturing, the complexity of the whole manufacturing process can be greatly reduced.
Although the present invention has been described with reference to a preferred embodiment, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (12)
1. A method for manufacturing a porous biomedical implant, comprising:
providing a support frame, wherein the support frame is provided with a bearing surface;
forming a porous biomedical implant in additive manufacturing, the porous biomedical implant having a solid portion and a porous portion, the solid portion bonding to the bearing surface of the scaffold, the porous portion bonding to the solid portion, wherein the solid portion and the porous portion are formed in the same layer of additive manufacturing; and
after the laminated manufacturing of the porous biomedical implant is completed, the support frame is removed.
2. The method of manufacturing a porous biomedical implant according to claim 1, characterized in that: wherein in the formation of the porous biomedical implant by additive manufacturing, the solid portion is formed with a first manufacturing process parameter, and the porous portion is formed with a second manufacturing process parameter, the first manufacturing process parameter being different from the second manufacturing process parameter.
3. The method of manufacturing a porous biomedical implant according to claim 2, characterized in that: wherein the first process parameter and the second process parameter are energy density, respectively.
4. The method of manufacturing a porous biomedical implant according to claim 3, characterized in that: wherein the energy density of the first process parameter is between 0.15J/mm and 0.30J/mm, and the energy density of the second process parameter is between 0.10J/mm and 0.12J/mm.
5. The method of manufacturing a porous biomedical implant according to claim 4, wherein: wherein the heat source in the additive layer manufacturing is an electron beam.
6. The method of manufacturing a porous biomedical implant according to claim 5, wherein: wherein the first and second process parameters have voltage, current, and heat source scanning speed, respectively.
7. The method of manufacturing a porous biomedical implant according to claim 6, characterized in that: wherein the voltage of the first manufacturing process parameter is 60000V, the current of the first manufacturing process parameter is between 12mA and 20mA, the heat source scan rate of the first manufacturing process parameter is between 4000mm/s and 10000mm/s, the voltage of the second manufacturing process parameter is 60000V, the current of the second manufacturing process parameter is between 3mA and 5mA, and the heat source scan rate of the second manufacturing process parameter is between 1000mm/s and 3000 mm/s.
8. The method of manufacturing a porous biomedical implant according to claim 1, characterized in that: wherein in the lamination of the same layer, the solid portion of the layer is formed first and then the porous portion of the layer is formed.
9. The method of manufacturing a porous biomedical implant according to claim 8, characterized in that: wherein after forming the solid portion of the layer, overlapping a porous overlapping region of the porous portion on a solid overlapping region of the solid portion when forming the porous portion of the layer.
10. A porous biomedical implant, characterized in that it comprises:
a solid part manufactured by lamination of a first manufacturing process parameter; and
a porous portion fabricated by lamination of a second fabrication process parameter, wherein the porous portion is combined with the solid portion, a cross section of the porous biomedical implant in a lamination direction thereof forms the solid portion and the porous portion, and the first fabrication process parameter forming the solid portion and the second fabrication process parameter forming the porous portion are different.
11. The porous biomedical implant of claim 10, wherein: wherein in the lamination of the same layer, the solid portion is formed in the layer and then the porous portion is formed in the layer.
12. The porous biomedical implant according to claim 10 or 11, wherein: wherein the solid portion has a solid overlap region and the porous portion has a porous overlap region, the solid overlap region and the porous overlap region overlapping each other.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811437015.9A CN111227994A (en) | 2018-11-28 | 2018-11-28 | Porous biomedical implant and method for producing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811437015.9A CN111227994A (en) | 2018-11-28 | 2018-11-28 | Porous biomedical implant and method for producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111227994A true CN111227994A (en) | 2020-06-05 |
Family
ID=70874050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811437015.9A Pending CN111227994A (en) | 2018-11-28 | 2018-11-28 | Porous biomedical implant and method for producing same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111227994A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100042218A1 (en) * | 2008-08-13 | 2010-02-18 | Nebosky Paul S | Orthopaedic implant with porous structural member |
| CN105581860A (en) * | 2016-01-11 | 2016-05-18 | 李鹏 | 3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof |
| CN105662660A (en) * | 2016-01-13 | 2016-06-15 | 李鹏 | 3D printing bionic bone trabecular structure lumbar vertebra fusion device, manufacturing method and application |
| CN105748177A (en) * | 2016-04-20 | 2016-07-13 | 华南理工大学 | Personalized spine implantation prosthesis with bionic micropores and manufacturing method thereof |
| CN107049566A (en) * | 2017-05-04 | 2017-08-18 | 西安赛隆金属材料有限责任公司 | A kind of human body sacral prosthesis fusion device and preparation method thereof |
| CN107349034A (en) * | 2017-07-31 | 2017-11-17 | 深圳维度生物医疗科技有限公司 | A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof |
| US20170348464A1 (en) * | 2014-07-22 | 2017-12-07 | Ceramtec Gmbh | Components for fusing vertebral bodies |
| CN107693172A (en) * | 2017-10-23 | 2018-02-16 | 中国人民解放军第四军医大学 | A kind of 3D printing personalized customization artificial vertebral body and preparation method thereof |
| CN108685627A (en) * | 2018-06-15 | 2018-10-23 | 陕西东望科技有限公司 | A kind of spinal prostheses and preparation method thereof based on 3D printing |
-
2018
- 2018-11-28 CN CN201811437015.9A patent/CN111227994A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100042218A1 (en) * | 2008-08-13 | 2010-02-18 | Nebosky Paul S | Orthopaedic implant with porous structural member |
| US20170348464A1 (en) * | 2014-07-22 | 2017-12-07 | Ceramtec Gmbh | Components for fusing vertebral bodies |
| CN105581860A (en) * | 2016-01-11 | 2016-05-18 | 李鹏 | 3D print type artificial bone trabecula structure cervical fusion device and preparing method and application thereof |
| CN105662660A (en) * | 2016-01-13 | 2016-06-15 | 李鹏 | 3D printing bionic bone trabecular structure lumbar vertebra fusion device, manufacturing method and application |
| CN105748177A (en) * | 2016-04-20 | 2016-07-13 | 华南理工大学 | Personalized spine implantation prosthesis with bionic micropores and manufacturing method thereof |
| CN107049566A (en) * | 2017-05-04 | 2017-08-18 | 西安赛隆金属材料有限责任公司 | A kind of human body sacral prosthesis fusion device and preparation method thereof |
| CN107349034A (en) * | 2017-07-31 | 2017-11-17 | 深圳维度生物医疗科技有限公司 | A kind of POROUS TITANIUM cervical vertebral fusion cage with HA coatings and preparation method thereof |
| CN107693172A (en) * | 2017-10-23 | 2018-02-16 | 中国人民解放军第四军医大学 | A kind of 3D printing personalized customization artificial vertebral body and preparation method thereof |
| CN108685627A (en) * | 2018-06-15 | 2018-10-23 | 陕西东望科技有限公司 | A kind of spinal prostheses and preparation method thereof based on 3D printing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105877874B (en) | Porous bone ware of Bionic Design class bone and preparation method thereof | |
| US20180256341A1 (en) | Metallic structures having porous regions from imaged bone at pre-defined anatomic locations | |
| US8992825B2 (en) | Rapid manufacturing of porous metal prostheses | |
| US9192475B2 (en) | Reinforced biocompatible ceramic implant and manufacturing method thereof | |
| US9364896B2 (en) | Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology | |
| JP5052506B2 (en) | Artificial bone manufacturing method | |
| US7113841B2 (en) | Implant forming method | |
| EP1683593A3 (en) | Laser produced porous structure | |
| CN201200499Y (en) | Grid-shaped metal implantation body of orthopaedics | |
| JPWO2008026316A1 (en) | Composite bone | |
| CN107805066A (en) | The processing method of bioceramic part based on selective laser sintering | |
| EP2384775A3 (en) | Method for producing an artificial bone and artifical bone produced by the method | |
| CN110393610B (en) | Three-layer composite bone implant prosthesis and preparation method thereof | |
| Hayashi et al. | Selective laser sintering method using titanium powder sheet toward fabrication of porous bone substitutes | |
| CN111227994A (en) | Porous biomedical implant and method for producing same | |
| US20200164439A1 (en) | Porous biomedical implant and manufacturing method thereof | |
| TW202014163A (en) | Porous biomedical-implant and method of making the same | |
| CN212165957U (en) | Manufacturing system of bone structure prosthesis | |
| KR102149329B1 (en) | Method for forming a porous coating layer on the surface of the implant inserted body | |
| KR20220072071A (en) | Bio-insertion implant with porous coating layer | |
| CN112419473A (en) | Bone trabecula porous structure generation model and method for preparing bone trabecula porous structure | |
| Wysocki et al. | Porous titanium scaffold fabrication for bone tissue engineering by SLM (selective laser melting) method | |
| CN117226118B (en) | Additive manufacturing method of zirconium-niobium alloy implant | |
| CN105798305A (en) | Method for preparing artificial porous bone structure | |
| Caragiuli et al. | Preliminary Considerations on the Design of Multi-layered Bone Scaffold for Laser-Based Printing |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200605 |