CN107334807A - A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof - Google Patents
A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof Download PDFInfo
- Publication number
- CN107334807A CN107334807A CN201710576229.3A CN201710576229A CN107334807A CN 107334807 A CN107334807 A CN 107334807A CN 201710576229 A CN201710576229 A CN 201710576229A CN 107334807 A CN107334807 A CN 107334807A
- Authority
- CN
- China
- Prior art keywords
- lucidum
- ganoderma lucidum
- radix tetrastigme
- lung cancer
- pulvis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 240000008397 Ganoderma lucidum Species 0.000 title claims abstract description 70
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims abstract description 70
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims abstract description 35
- 201000005202 lung cancer Diseases 0.000 title claims abstract description 34
- 208000020816 lung neoplasm Diseases 0.000 title claims abstract description 34
- 230000000694 effects Effects 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 45
- 238000000605 extraction Methods 0.000 claims abstract description 34
- 238000005238 degreasing Methods 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 14
- 238000007670 refining Methods 0.000 claims abstract description 14
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 8
- 238000001694 spray drying Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 230000008030 elimination Effects 0.000 claims description 5
- 238000003379 elimination reaction Methods 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 239000003595 mist Substances 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000002512 chemotherapy Methods 0.000 abstract description 8
- 239000000284 extract Substances 0.000 abstract description 7
- 238000000227 grinding Methods 0.000 abstract description 5
- 238000001959 radiotherapy Methods 0.000 abstract description 5
- 206010006895 Cachexia Diseases 0.000 abstract description 4
- 230000000259 anti-tumor effect Effects 0.000 abstract description 4
- 201000002364 leukopenia Diseases 0.000 abstract description 4
- 230000005855 radiation Effects 0.000 abstract description 4
- 238000009098 adjuvant therapy Methods 0.000 abstract description 3
- 208000022531 anorexia Diseases 0.000 abstract description 3
- 230000005809 anti-tumor immunity Effects 0.000 abstract description 3
- 206010061428 decreased appetite Diseases 0.000 abstract description 3
- 230000036737 immune function Effects 0.000 abstract description 3
- 239000003176 neuroleptic agent Substances 0.000 abstract description 3
- 230000000701 neuroleptic effect Effects 0.000 abstract description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 2
- 238000000746 purification Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 235000009508 confectionery Nutrition 0.000 description 4
- 238000003809 water extraction Methods 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000021760 high fever Diseases 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 241000222336 Ganoderma Species 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000118 anti-neoplastic effect Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- TWOWSRSKGJSZHZ-VRHDFFKNSA-N bouvardin Chemical compound C1=CC(OC)=CC=C1C[C@H](N(C)C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N(C1=O)C)C2)C(=O)N[C@@H](C)C(=O)N(C)[C@H]1[C@@H](O)C(C=C1)=CC=C1OC1=CC2=CC=C1O TWOWSRSKGJSZHZ-VRHDFFKNSA-N 0.000 description 1
- BNOCDYMCAVSRBT-UHFFFAOYSA-N bouvardin Natural products COc1ccc(CC2N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C3Cc4ccc(O)c(Oc5cccc(c5)C(O)C(N(C)C(=O)C(C)NC2=O)C(=O)N3C)c4)cc1 BNOCDYMCAVSRBT-UHFFFAOYSA-N 0.000 description 1
- 108010047824 bouvardin Proteins 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000011132 hemopoiesis Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof.By weight, its each group is divided into：5 parts of Ganodenna Lucidum P.E, 60 parts of refining ganoderam lucidum spore powder, 35 parts of radix tetrastigme micro powder.Process route extracts for Ganodenna Lucidum P.E（Ultramicro grinding supercritical fluid extraction degreasing purification process ultrasonic wave extraction）Lucidum spore powder purifying broken wall radix tetrastigme ultramicro grinding mixing sterilizing finished product.Using Ganodenna Lucidum P.E, lucidum spore powder, radix tetrastigme antitumor efficacy, three be combined with each other not only certain adjuvant treatment effect to lung cancer, improve patients with lung cancer to chemotherapy and the tolerance of radiation treatment；Mitigate the side effect such as Neuroleptic Leukocytopenia, anorexia caused by chemotherapy and radiotherapy；Improve the cachexia of patients with lung cancer, strengthen constitution；The immunologic function of patients with lung cancer is improved, strengthens the antitumor immunity of body.
Description
Technical field
The invention belongs to the preparation field of health products, and in particular to a kind of ganoderma lucidum radix tetrastigme powder with treatment lung cancer effect
Agent and preparation method thereof.
Background technology
At present, the incidence of disease of lung cancer remains high, and it is still the global problem for perplexing medical field that it, which is treated,.Chinese medicine because of it not
It is only inhibited to tumour, and drug resistance is not likely to produce, the damage and adverse reaction to body are also smaller, have become and control
Treat the important means of tumour.From traditional Chinese medicine find efficiently, low toxicity antineoplastic turn into antineoplastic research and
The important component of new drug development.
Ganodenna Lucidum P.E (also referred to as ganoderma lucidum essence powder) is the ripe new fresh sporophore of timely collecting, and hot water extraction is used after drying
The technique such as (or alcoholic extraction), vacuum concentration, spray drying, obtained glossy ganoderma extract powder, it is that the concentration of glossy ganoderma powder high power forms
Ganoderma lucidum elite.Ganodenna Lucidum P.E has certain adjuvant treatment effect to lung cancer, and its Therapeutic Characteristics is as follows：Patients with lung cancer is improved to changing
Learn the tolerance for the treatment of and radiation treatment；Mitigate Neuroleptic Leukocytopenia, anorexia etc. caused by chemotherapy and radiotherapy
Side effect；Improve the cachexia of patients with lung cancer, strengthen constitution；The immunologic function of patients with lung cancer is improved, strengthens the anticancer of body
Immunity.
Lucidum spore powder is the seed of ganoderma lucidum, is the essential part of ganoderma lucidum.Lucidum spore powder has obvious suppression to lung carcinoma cell
Make and use.For coordinating radiotherapy, the chemotherapy of patients with lung cancer, the tolerance of patient can be strengthened, mitigate side effect, improve marrow hemopoiesis
Function, increase transfer, the recurrence of leucocyte, strengthen immunocompetence, promote rehabilitation.
Radix tetrastigme (is commonly called as gold thread hoist), and rare plant in imminent danger is listed in Chinese Medicine treasure-house, has anti-inflammatory, resists
It is viral, antitumor and other effects.To various heat symptom-complexs (high fever is fainted from fear, the high fever of unknown cause), various oedema (various inflammatory edemas,
Snakebite) there is the effect of uniqueness, it is that Western medicine is irreplaceable " bouvardin ", economic value is very high.Clinically it is used for controlling
Treat the diseases such as children with high fever induced convulsions, pneumonia.
The content of the invention
The present invention provides a kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof.Its process route
Extracted for Ganodenna Lucidum P.E（Ultramicro grinding -- supercritical fluid extraction degreasing purification process -- ultrasonic wave extraction）-- ganoderma lucidum
Conidia powder purifies broken wall -- radix tetrastigme ultramicro grinding -- mixing -- sterilizing -- finished product.Utilize Ganodenna Lucidum P.E, ganoderma lucidum spore
Sub- powder, the antitumor efficacy of radix tetrastigme, three be combined with each other not only certain adjuvant treatment effect to lung cancer, improves lung cancer and suffers from
Person is to chemotherapy and the tolerance of radiation treatment；Mitigate Neuroleptic Leukocytopenia, appetite caused by chemotherapy and radiotherapy
The side effects such as decline；Improve the cachexia of patients with lung cancer, strengthen constitution；The immunologic function of patients with lung cancer is improved, strengthens body
Antitumor immunity.
To realize the purpose of the present invention, adopt the following technical scheme that：
A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect, its each component are calculated as by weight:Ganodenna Lucidum P.E 0.01 ~
10 parts, 30 ~ 90 parts of refining ganoderam lucidum spore powder, 20 ~ 50 parts of radix tetrastigme micro powder.
More excellent, the ganoderma lucidum radix tetrastigme pulvis, by weight, each group is divided into：5 parts of Ganodenna Lucidum P.E, Reishi sporule
60 parts of powder, 35 parts of radix tetrastigme.
The preparation method of ganoderma lucidum radix tetrastigme pulvis, comprises the following steps：
（1）Ganodenna Lucidum P.E：Cap is chosen more than 8 centimetres, within 2 centimetres of stem, dries, add without the ganoderma lucidum coarse crushing gone mouldy
Work, it is 20 ~ 60 mesh to ganoderma lucidum fineness；Then the REISH of 20 ~ 60 mesh is crushed to granularity as 200 with micron ultra shifter again
~ 300 mesh, obtain ganoderma lucidum fruitbody micropowder；Ganoderma lucidum fruitbody micropowder is used into supercritical CO2Fluid extraction technology carries out degreasing
Processing, extracting pressure 30Mpa, 40 DEG C of extraction temperature, CO2Flow 20L/h, extraction time 120min；Then it is auxiliary in ultrasonic wave
Help down, with the ganoderma lucidum fruitbody micropowder after flooding degreasing, 60 DEG C of Extracting temperature, solid-liquid ratio 1:20, extraction time 40min,
Ultrasonic power 70W；Centrifuging and taking supernatant, is concentrated under reduced pressure, and spray drying, produces Ganodenna Lucidum P.E；
（2）Lucidum spore powder is purified, crosses 120 mesh sieves, and control moisture is processed in 2wt% ~ 6wt% broken walls, sporoderm-broken rate requirement 98%,
Refining ganoderam lucidum spore powder is made；
（3）Radix tetrastigme picks up net impurity elimination and drying, and it is 200 ~ 300 mesh to be then crushed to granularity with micron ultra shifter, obtains radix tetrastigme
Micro mist；
（4）By Ganodenna Lucidum P.E, refining ganoderam lucidum spore powder, the well mixed simultaneously ultraviolet sterilization of radix tetrastigme micro powder, the ganoderma lucidum is made
Radix tetrastigme pulvis.
The present invention has advantages below compared with the prior art：
1st, a kind of ganoderma lucidum radix tetrastigme pulvis and preparation method thereof with treatment lung cancer effect of the present invention, using " three surpassing technology " come
Extract the active ingredient in ganoderma lucidum.Three surpass technology and refer to that superfine communication technique, supercritical liquid extraction technique and ultrasonic wave carry
Take technology.Although this three technology is had been widely used in Chinese medicine and natural drug pharmaceutical field, but be essentially all individual event
Independent utility, the present invention superfine communication technique, supercritical liquid extraction technique and ultrasonic wave extraction are efficiently combined into
" three surpassing technology " extracts the active ingredient in ganoderma lucidum.By ganoderma lucidum by ultramicro grinding, supercritical fluid extraction degreasing purifying at
Reason, three big step of ultrasonic wave extraction carry out effective component extracting, not only can at a lower temperature be extracted, will not destroy ganoderma lucidum
In active ingredient, extraction is complete, and active constituent content is high, can also avoid using chemical reagent degreasing to raw material and environment
Pollution is brought, method is simply, easily and fast and safely.
2nd, the present invention provides a kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof.Utilize ganoderma lucidum
Extract, lucidum spore powder, the antitumor efficacy of radix tetrastigme, three be combined with each other not only certain auxiliary treatment effect to lung cancer
Fruit, patients with lung cancer is improved to chemotherapy and the tolerance of radiation treatment；Mitigate white caused by chemotherapy and radiotherapy
The side effects such as Leukopenia, anorexia；Improve the cachexia of patients with lung cancer, strengthen constitution；Improve the immune of patients with lung cancer
Function, strengthen the antitumor immunity of body.
Embodiment
For the further open rather than limitation present invention, below in conjunction with example, the present invention is described in further detail.
Embodiment 1
A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect, each component are calculated as by weight:5 parts of Ganodenna Lucidum P.E, essence
60 parts of lucidum spore powder processed, 35 parts of radix tetrastigme micro powder.
Its preparation method, comprise the following steps：
（1）Ganodenna Lucidum P.E：Cap is chosen more than 8 centimetres, within 2 centimetres of stem, dries, add without the ganoderma lucidum coarse crushing gone mouldy
Work, it is 20 ~ 60 mesh to ganoderma lucidum fineness；Then the REISH of 20 ~ 60 mesh is crushed to granularity as 200 with micron ultra shifter again
~ 300 mesh, obtain ganoderma lucidum fruitbody micropowder；Ganoderma lucidum fruitbody micropowder is used into supercritical CO2Fluid extraction technology carries out degreasing
Processing, extracting pressure 30Mpa, 40 DEG C of extraction temperature, CO2Flow 20L/h, extraction time 120min；Then it is auxiliary in ultrasonic wave
Help down, with the ganoderma lucidum fruitbody micropowder after flooding degreasing, 60 DEG C of Extracting temperature, solid-liquid ratio 1:20, extraction time 40min,
Ultrasonic power 70W；Centrifuging and taking supernatant, is concentrated under reduced pressure, and spray drying, produces Ganodenna Lucidum P.E；
（2）Lucidum spore powder is purified, crosses 120 mesh sieves, and control moisture is processed in 2wt% ~ 6wt% broken walls, sporoderm-broken rate requirement 98%,
Refining ganoderam lucidum spore powder is made；
（3）Radix tetrastigme picks up net impurity elimination and drying, and it is 200 ~ 300 mesh to be then crushed to granularity with micron ultra shifter, obtains radix tetrastigme
Micro mist；
（4）By Ganodenna Lucidum P.E, refining ganoderam lucidum spore powder, the well mixed simultaneously ultraviolet sterilization of radix tetrastigme micro powder, the ganoderma lucidum is made
Radix tetrastigme pulvis.
Embodiment 2
A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect, each component are calculated as by weight:3 parts of Ganodenna Lucidum P.E, essence
65 parts of lucidum spore powder processed, 32 parts of radix tetrastigme micro powder.
Its preparation method, comprise the following steps：
（1）Ganodenna Lucidum P.E：Cap is chosen more than 8 centimetres, within 2 centimetres of stem, dries, add without the ganoderma lucidum coarse crushing gone mouldy
Work, it is 20 ~ 60 mesh to ganoderma lucidum fineness；Then the REISH of 20 ~ 60 mesh is crushed to granularity as 200 with micron ultra shifter again
~ 300 mesh, obtain ganoderma lucidum fruitbody micropowder；Ganoderma lucidum fruitbody micropowder is used into supercritical CO2Fluid extraction technology carries out degreasing
Processing, extracting pressure 30Mpa, 40 DEG C of extraction temperature, CO2Flow 20L/h, extraction time 120min；Then it is auxiliary in ultrasonic wave
Help down, with the ganoderma lucidum fruitbody micropowder after flooding degreasing, 60 DEG C of Extracting temperature, solid-liquid ratio 1:20, extraction time 40min,
Ultrasonic power 70W；Centrifuging and taking supernatant, is concentrated under reduced pressure, and spray drying, produces Ganodenna Lucidum P.E；
（2）Lucidum spore powder is purified, crosses 120 mesh sieves, and control moisture is processed in 2wt% ~ 6wt% broken walls, sporoderm-broken rate requirement 98%,
Refining ganoderam lucidum spore powder is made；
（3）Radix tetrastigme picks up net impurity elimination and drying, and it is 200 ~ 300 mesh to be then crushed to granularity with micron ultra shifter, obtains radix tetrastigme
Micro mist；
（4）By Ganodenna Lucidum P.E, refining ganoderam lucidum spore powder, the well mixed simultaneously ultraviolet sterilization of radix tetrastigme micro powder, the ganoderma lucidum is made
Radix tetrastigme pulvis.
Embodiment 3
A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect, each component are calculated as by weight:2 parts of Ganodenna Lucidum P.E, spirit
58 parts of Ganoderma lucidum spore powder, 40 parts of radix tetrastigme.
Its preparation method, comprise the following steps：
（1）Ganodenna Lucidum P.E：Cap is chosen more than 8 centimetres, within 2 centimetres of stem, dries, add without the ganoderma lucidum coarse crushing gone mouldy
Work, it is 20 ~ 60 mesh to ganoderma lucidum fineness；Then the REISH of 20 ~ 60 mesh is crushed to granularity as 200 with micron ultra shifter again
~ 300 mesh, obtain ganoderma lucidum fruitbody micropowder；Ganoderma lucidum fruitbody micropowder is used into supercritical CO2Fluid extraction technology carries out degreasing
Processing, extracting pressure 30Mpa, 40 DEG C of extraction temperature, CO2Flow 20L/h, extraction time 120min；Then it is auxiliary in ultrasonic wave
Help down, with the ganoderma lucidum fruitbody micropowder after flooding degreasing, 60 DEG C of Extracting temperature, solid-liquid ratio 1:20, extraction time 40min,
Ultrasonic power 70W；Centrifuging and taking supernatant, is concentrated under reduced pressure, and spray drying, produces Ganodenna Lucidum P.E；
（2）Lucidum spore powder is purified, crosses 120 mesh sieves, and control moisture is processed in 2wt% ~ 6wt% broken walls, sporoderm-broken rate requirement 98%,
Refining ganoderam lucidum spore powder is made；
（3）Radix tetrastigme picks up net impurity elimination and drying, and it is 200 ~ 300 mesh to be then crushed to granularity with micron ultra shifter, obtains radix tetrastigme
Micro mist；
（4）By Ganodenna Lucidum P.E, refining ganoderam lucidum spore powder, the well mixed simultaneously ultraviolet sterilization of radix tetrastigme micro powder, the ganoderma lucidum is made
Radix tetrastigme pulvis.
2nd, clinical test
1. clinical data：The lung cancer patient that 120 are taken with ganoderma lucidum radix tetrastigme pulvis carries out clinical observation, male 48, women
72, max age 74 years old, minimal ages more than 20.
2. treatment method：Medicine of the present invention is taken, daily oral meal at twice, each taking 4 grams, 7 days are a course for the treatment of,
6 courses for the treatment of are taken altogether.
3. treatment results：120 lung cancer patients, oral 90 days of ganoderma lucidum radix tetrastigme pulvis, complete incidence graph 42, part are slow
Solution 50, stablize 16, be in progress 12, alleviate and part alleviates totally 92, total effective rate 76.67%.
Detected using the extract solution three surpassed obtained by technology, measurement result is that Thick many candies concentration is 50. 68mg/mL, table
Bright method therefor recovery rate of the present invention is higher.The Ganodenna Lucidum P.E of the present invention is extracted with the ganoderma lucidum obtained using hot water extraction method
Thing carries out the com-parison and analysis of soluble Thick many candies content.As a result the soluble Thick many candies three surpassed in extract of the present invention are shown
(40.0%) the soluble Thick many candies content (29.45%) obtained compared with hot water extraction method in Ganodenna Lucidum P.E is high.For this
The Ganodenna Lucidum P.E of invention, using the acidified chloroform extraction method of classics, therefrom extraction separation obtains total triterpene acid constituents, put down
Equal yield is 9.37%, and use total triterpene acid constituents average yield in the Ganodenna Lucidum P.E that hot water extraction method obtains for
6.43%。
The foregoing is only presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification, it should all belong to the covering scope of the present invention.
Claims (4)
- A kind of 1. ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect, it is characterised in that：It is each in the ganoderma lucidum radix tetrastigme pulvis Component is calculated as by weight:0.01 ~ 10 part of Ganodenna Lucidum P.E, 30 ~ 90 parts of refining ganoderam lucidum spore powder, 20 ~ 50 parts of radix tetrastigme micro powder.
- A kind of 2. ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect according to claim 1, it is characterised in that：It is described Each component is calculated as by weight in ganoderma lucidum radix tetrastigme pulvis:5 parts of Ganodenna Lucidum P.E, 60 parts of refining ganoderam lucidum spore powder, radix tetrastigme is micro- 35 parts of powder.
- A kind of 3. ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect according to claim 1 or 2, it is characterised in that： Described Ganodenna Lucidum P.E is made by following steps：1）Cap is chosen more than 8 centimetres, within 2 centimetres of stem, is dried, without the ganoderma lucidum coarse crushing processing gone mouldy, it is thin to ganoderma lucidum Spend for 20 ~ 60 mesh；2）Then it is 200 ~ 300 mesh the REISH of 20 ~ 60 mesh to be crushed into granularity with micron ultra shifter again, and it is real to obtain ganoderma lucidum Body micropowder；3）Ganoderma lucidum fruitbody micropowder is used into supercritical CO2Fluid extraction technology carries out ungrease treatment, extracting pressure 30Mpa, extraction Take 40 DEG C of temperature, CO2Flow 20L/h, extraction time 120min；4）Then under ultrasonic assistant, with the ganoderma lucidum fruitbody micropowder after flooding degreasing, 60 DEG C of Extracting temperature, solid-liquid ratio 1:20, extraction time 40min, ultrasonic power 70W；5）Centrifuging and taking supernatant, is concentrated under reduced pressure, and spray drying, produces Ganodenna Lucidum P.E.
- 4. a kind of method for preparing the ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect as claimed in claim 1 or 2, it is special Sign is：Comprise the following steps：（1）Ganodenna Lucidum P.E：Cap is chosen more than 8 centimetres, within 2 centimetres of stem, dries, add without the ganoderma lucidum coarse crushing gone mouldy Work, it is 20 ~ 60 mesh to ganoderma lucidum fineness；Then the REISH of 20 ~ 60 mesh is crushed to granularity as 200 with micron ultra shifter again ~ 300 mesh, obtain ganoderma lucidum fruitbody micropowder；Ganoderma lucidum fruitbody micropowder is used into supercritical CO2Fluid extraction technology carries out degreasing Processing, extracting pressure 30Mpa, 40 DEG C of extraction temperature, CO2Flow 20L/h, extraction time 120min；Then it is auxiliary in ultrasonic wave Help down, with the ganoderma lucidum fruitbody micropowder after flooding degreasing, 60 DEG C of Extracting temperature, solid-liquid ratio 1:20, extraction time 40min, Ultrasonic power 70W；Centrifuging and taking supernatant, is concentrated under reduced pressure, and spray drying, produces Ganodenna Lucidum P.E；（2）Lucidum spore powder is purified, crosses 120 mesh sieves, and control moisture is processed in 2wt% ~ 6wt% broken walls, sporoderm-broken rate requirement 98%, Refining ganoderam lucidum spore powder is made；（3）Radix tetrastigme picks up net impurity elimination and drying, and it is 200 ~ 300 mesh to be then crushed to granularity with micron ultra shifter, obtains radix tetrastigme Micro mist；（4）By Ganodenna Lucidum P.E, refining ganoderam lucidum spore powder, the well mixed simultaneously ultraviolet sterilization of radix tetrastigme micro powder, the ganoderma lucidum is made Radix tetrastigme pulvis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710576229.3A CN107334807A (en) | 2017-07-14 | 2017-07-14 | A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710576229.3A CN107334807A (en) | 2017-07-14 | 2017-07-14 | A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107334807A true CN107334807A (en) | 2017-11-10 |
Family
ID=60219286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710576229.3A Pending CN107334807A (en) | 2017-07-14 | 2017-07-14 | A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107334807A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853355A (en) * | 2018-08-09 | 2018-11-23 | 黔西南州长霖种植农民专业合作社 | A kind of antitumor radix tetrastigme Chinese materia medica preparation and preparation method thereof |
| CN113144107A (en) * | 2020-05-25 | 2021-07-23 | 浙江知元健康产业有限公司 | Traditional Chinese medicine for treating lung cancer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904876A (en) * | 2010-08-12 | 2010-12-08 | 毛景华 | Method for extracting total triterpenoids in lucid ganoderma as lucid ganoderma anticancer component by tower-type gradient percolation |
-
2017
- 2017-07-14 CN CN201710576229.3A patent/CN107334807A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904876A (en) * | 2010-08-12 | 2010-12-08 | 毛景华 | Method for extracting total triterpenoids in lucid ganoderma as lucid ganoderma anticancer component by tower-type gradient percolation |
Non-Patent Citations (4)
| Title |
|---|
| 任武生等: "双灵固本散联合放疗治疗恶性肿瘤疗效观察(附232例)", 《现代肿瘤医学》 * |
| 夏征农 主编: "《辞海 医学卫生分册》", 31 March 1989, 上海辞书出版社 * |
| 朴香兰编著: "《民族药物提取分离新技术》", 31 October 2011, 中央民族大学出版社 * |
| 骆仙芳主编: "《健康之路从肺开始》", 31 January 2014, 浙江科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853355A (en) * | 2018-08-09 | 2018-11-23 | 黔西南州长霖种植农民专业合作社 | A kind of antitumor radix tetrastigme Chinese materia medica preparation and preparation method thereof |
| CN113144107A (en) * | 2020-05-25 | 2021-07-23 | 浙江知元健康产业有限公司 | Traditional Chinese medicine for treating lung cancer and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103768534B (en) | A kind of Chinese medicine composition with antitumor activity | |
| CN104263790B (en) | A kind of saline cistanche polypeptide extract, preparation method and its usage | |
| WO2012097577A1 (en) | Pharmaceutical composition for relieving fatigue and preparation method therefor | |
| CN105079046A (en) | Whole ganoderma lucidum anti-tumor soft capsules and preparation method thereof | |
| US9662349B2 (en) | Dietary composition having mixed polysaccharides derived from lucid ganoderma, lycium barbarum and polygonatum sibiricum and method of its preparation | |
| CN103432193A (en) | Microwave-assisted aqueous two-phase extraction and separation method of kudzu root total flavones | |
| CN103073651A (en) | Ganoderan extraction method and ganoderan use | |
| CN107334807A (en) | A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof | |
| CN112057546A (en) | Propolis ganoderma lucidum spore powder composition and preparation method and application thereof | |
| CN108567820A (en) | A kind of Chinese medicine composition and preparation method thereof for oncotherapy | |
| CN104031156A (en) | Selfheal polysaccharide zinc chelate as well as preparation method and application thereof to anti-cancer drug | |
| CN109528807A (en) | A kind of Chinese medicine composition and its preparation method and application enhanced human immunity | |
| CN108210547A (en) | The preparation method and its preparation of a kind of Extracts from Leaves of Phyllanthus emblica L and anti-Ai Yingyong | |
| CN104013733B (en) | Chitosan composition for prevention and treatment of chemical liver injury and preparation method thereof | |
| CN106728208A (en) | A kind of ginseng and lucid ganoderma polysaccharide triterpene preparation and preparation method thereof | |
| CN104436150A (en) | Traditional Chinese medicine composition used for treating rhinitis | |
| CN104474099A (en) | Strigose hydrangea leaf cough-relieving syrup and preparation method thereof | |
| CN106619827A (en) | Herba taraxaci essence cream and method for preparing same | |
| CN114365844A (en) | Bamboo fungus compound health food for regulating intestinal flora and improving intestinal immunity and preparation method thereof | |
| CN104825783B (en) | Chinese medicine composition with antitumor activity and its preparation method and application | |
| CN100444862C (en) | Health composition for strengthening women's immunity and its preparing method | |
| CN106834403A (en) | The extracting method of ganoderma lucidum polypeptide | |
| CN105440148A (en) | Process for producing astragalus polysaccharide by using water extraction technology | |
| CN110423284A (en) | Lucid ganoderma spore powder polysaccharide has effects that auxiliary inhibits the application in the functional food of colon cancer in preparation | |
| CN104004049A (en) | Method for extracting holotoxin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171110 |
|
| RJ01 | Rejection of invention patent application after publication |