CN113144107A - Traditional Chinese medicine for treating lung cancer and preparation method thereof - Google Patents

Traditional Chinese medicine for treating lung cancer and preparation method thereof Download PDF

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CN113144107A
CN113144107A CN202010451795.3A CN202010451795A CN113144107A CN 113144107 A CN113144107 A CN 113144107A CN 202010451795 A CN202010451795 A CN 202010451795A CN 113144107 A CN113144107 A CN 113144107A
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陈志坚
傅姗媩
胡云波
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Zhejiang Zhiyuan Health Industry Co ltd
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Abstract

The invention discloses a traditional Chinese medicine for treating lung cancer and a preparation method thereof, wherein the traditional Chinese medicine comprises the following components: the Chinese medicine composition comprises radix tetrastigme powder, lucid ganoderma extract, wall-broken lucid ganoderma spore powder, wall-broken pine pollen, taxus chinensis var mairei, edible tulip, Chinese actinidia root, corydalis amabilis, phyllanthus emblica and reed rhizome.

Description

Traditional Chinese medicine for treating lung cancer and preparation method thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating lung cancer and a preparation method thereof.
Background
The traditional Chinese medicine is one of the essentials which are passed down in thousands of years in China, is a unique tradition of China, the whole system comprises a prescription, Chinese herbal medicines and a production process, the Chinese herbal medicines can be drunk only by decocting for a certain duration and time, the Chinese herbal medicines are hundreds of and thousands of, and different categories have different curative effects, but China is still lack of a good traditional Chinese medicine formula in the aspect of treating tumors, particularly high-incidence lung cancer, and as is well known, the incidence of lung cancer always ranks first in China, besides radiotherapy and chemotherapy and targeted therapy adopted in modern hospitals, the subsequent treatment is the first choice of traditional Chinese medicine, but at present, the modern medicine generally considers that the traditional Chinese medicine is used for assisting western medicine treatment, and in most cases, the traditional Chinese medicine is used for assisting treatment, particularly, the immunity improvement after radiotherapy and chemotherapy is preferred, but most of traditional Chinese medicines on the market have treatment effects in publicity.
Disclosure of Invention
The invention aims to solve the technical problem of providing the traditional Chinese medicine for treating the lung cancer, which has good effects of assisting and improving the immunity after radiotherapy and chemotherapy and has the effects of strengthening the body resistance, consolidating the constitution and inhibiting tumor cells.
In order to solve the problems, the invention adopts the following technical scheme: a traditional Chinese medicine for treating lung cancer comprises the following components: radix tetrastigme powder, lucid ganoderma extract, wall-broken lucid ganoderma spore powder, wall-broken pine pollen, taxus chinensis var mairei, edible tulip, Chinese actinidia root, corydalis amabilis, phyllanthus emblica and reed rhizome.
Further, the Chinese medicinal materials comprise the following components in percentage by mass: the traditional Chinese medicine comprises the following components in percentage by mass: 20-30 parts of radix tetrastigme powder, 5-8 parts of lucid ganoderma extract, 5-8 parts of wall-broken lucid ganoderma spore powder, 4-6 parts of wall-broken pine pollen, 10-13 parts of taxus chinensis var mairei, 8-12 parts of edible tulip, 8-13 parts of Chinese actinidia root, 5-10 parts of corydalis amabilis, 5-8 parts of emblic leafflower fruit and 10-13 parts of reed rhizome.
Further, the Chinese medicinal materials comprise the following components in percentage by mass: 27 parts of radix tetrastigme powder, 6 parts of lucid ganoderma extract, 7 parts of wall-broken lucid ganoderma spore powder, 6 parts of wall-broken pine pollen, 10 parts of taxus chinensis, 10 parts of edible tulip, 10 parts of Chinese actinidia root, 8 parts of corydalis amabilis, 6 parts of emblic leafflower fruit and 10 parts of reed rhizome.
A preparation method of a traditional Chinese medicine for treating lung cancer comprises the following steps:
1) decocting Taxus chinensis var mairei, Pseudobulbus Cremastrae seu pleiones, radix Actinidiae chinensis, rhizoma corydalis Decumbentis, fructus Phyllanthi, and rhizoma Phragmitis for 2 times, and collecting decoction;
2) mixing the decoctions obtained by 2 times, and concentrating to obtain extract;
3) mixing the extracts with 4 powders of radix Apioris Fortunei powder, Ganoderma extract, cell wall-broken Ganoderma spore powder, and cell wall-broken pollen Pini, and making into pill.
The invention has the beneficial effects that: the traditional Chinese medicine bag for treating lung cancer comprises radix tetrastigme powder, a lucid ganoderma extract, wall-broken lucid ganoderma spore powder, wall-broken pine pollen, taxus chinensis, edible tulip, actinidia chinensis root, corydalis amabilis, phyllanthus emblica and reed rhizome, and the adopted traditional Chinese medicine components have the effects of improving immunity and inhibiting tumor cells, particularly the radix tetrastigme powder is found to have good effects of treating lung diseases and inhibiting disease development through careful research.
Detailed Description
The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention and to clearly and unequivocally define the scope of the present invention.
Example one
A traditional Chinese medicine for treating lung cancer comprises the following components: 20 parts of radix tetrastigme powder, 8 parts of lucid ganoderma extract, 8 parts of wall-broken lucid ganoderma spore powder, 6 parts of wall-broken pine pollen, 12 parts of taxus chinensis, 10 parts of edible tulip, 12 parts of Chinese actinidia root, 8 parts of corydalis amabilis, 5 parts of emblic leafflower fruit and 11 parts of reed rhizome.
Example two
A traditional Chinese medicine for treating lung cancer comprises the following components: 27 parts of radix tetrastigme powder, 6 parts of lucid ganoderma extract, 7 parts of wall-broken lucid ganoderma spore powder, 6 parts of wall-broken pine pollen, 10 parts of taxus chinensis, 10 parts of edible tulip, 10 parts of Chinese actinidia root, 8 parts of corydalis amabilis, 6 parts of emblic leafflower fruit and 10 parts of reed rhizome.
EXAMPLE III
A traditional Chinese medicine for treating lung cancer comprises the following components: 30 parts of radix tetrastigme powder, 5 parts of lucid ganoderma extract, 6 parts of wall-broken lucid ganoderma spore powder, 5 parts of wall-broken pine pollen, 10 parts of taxus chinensis, 10 parts of edible tulip, 10 parts of Chinese actinidia root, 8 parts of corydalis amabilis, 6 parts of emblic leafflower fruit and 10 parts of reed rhizome.
Wall-broken ganoderma lucidum spore powder:
(1) the anticancer effect is as follows: the ganoderma lucidum spore powder can destroy cancer cell telomerase by 1005; directly stimulate the proliferation of lymphocytes, antagonize and inhibit the growth and spread of cancer cells; inhibiting cell chromosome aberration, inhibiting generation of tumor cell free radicals, and protecting DNA; inhibiting the destruction of tumor cells to surrounding tissues and the growth of tumor cells; improving the tolerance of tumor patients to radiotherapy, chemotherapy and operation.
(2) Immunization: the Ganoderma spore powder can activate phagocytic function of macrophage, and has antagonistic effect on glucocorticoid; can improve the proliferation capacity of spleen lymphocytes, improve the activity of NK cells, improve the anti-volume numerical value of serum hemolysin and improve the phagocytosis rate of macrophages! It is indicated that it has effect in enhancing immunity.
Curative effect of ganoderma lucidum spore powder with lower surface wall breaking for improving subjective symptoms of cancer patients undergoing radiotherapy and chemotherapy
Figure BDA0002507851780000041
Radix tetrastigme powder: radix tetrastigme is listed as an endangered rare species in national medical treasury and has the effects of resisting inflammation, viruses, tumors and the like. Has unique curative effect on various heat symptoms (febrile convulsion, fever of unknown reason) and various edemas (inflammatory edema and traumatic injury), and is a 'plant antibiotic' which can not be replaced by western medicines. Poetry is the evidence: febrile convulsion with marked wonder, viral inflammation with no trace; treating hepatitis, brain lymph nodes, furunculosis, snake injury, and traumatic injury. Radix Apioris Fortunei contains radix Apioris Fortunei flavone, and the material has anti-inflammatory, antipyretic and anti-tumor effects. The active ingredients of radix tetrastigme comprise alkaloid, reducing sugar, amino acid, quercetin, kaempferol and flavonoid substances.
(1) Anti-tumor effect
The radix tetrastigme flavone can obviously inhibit the growth of SGC-7901 gastric cancer cells and SMM C-7721 liver cancer cells; the radix tetrastigme extract can inhibit the proliferation of human colon cancer HT-29 cells, HepG2 cells, lung cancer cells A549, human colon cancer cell lines RKO cells, leukemia K562 cells and leukemia HL60 cells.
Tests prove that the golden silk and ground beetle capsule which takes the radix tetrastigme as the main component has obvious effects on inhibiting the growth of Lewis lung tumor cells, SMMC-7721 liver tumor cells, HL-60 human lymphoblastic leukemia cells, SCG-7901 stomach tumor cells and HCT-116 colon tumor cells.
(2) Regulating immunity
The radix tetrastigme extract has effect in correcting intestinal tract local and systemic immunity disorder caused by scald. The radix tetrastigme can also obviously improve the immune function of mice and indexes of TNF-Ot (serum tumor necrosis factor-01) and IFN-y (haemointerferon-1), and the ethyl acetate extract of the radix tetrastigme can regulate the immune function of I-CR mice.
Weikemin professor obtained from Wuyi labour medal of China of national grade famous traditional Chinese medicine of Zhejiang institute of traditional Chinese medicine completes experimental research on anti-tumor action mechanism of radix tetrastigme of traditional Chinese medicine based on the administration of traditional Chinese medicine in Zhejiang province for eight years. Clinical observation is carried out on 120 malignant tumor patients taking the radix tetrastigme preparation from 3 months 2006 to 3 months 2007, and the curative effect is judged. The statistics of the therapeutic effect judgment standard of the World Health Organization (WHO) on malignant tumors are referred to: 120 malignant tumor patients, the radix tetrastigme preparation is orally taken for 90 days, 52 cases are completely relieved, 42 cases are partially relieved, 18 cases are stabilized, 8 cases are progressed, 94 cases are relieved and partially relieved, and the total effective rate is 78.33%.
Emblic leafflower fruit: (1) the anti-cancer effect is as follows: the emblic leafflower fruit extract can block the synthesis of a strong carcinogen N-nitroso compound in vivo or in vitro, the blocking rate is over 90 percent and is 3 to 5 times higher than that of Vc with the same concentration, and the emblic leafflower fruit extract has an anti-cancer effect. The phenolic acid component of the emblic leafflower fruit can inhibit the proliferation of a human cancer cell strain K562 in vitro.
Anti-inflammatory action: the emblic leafflower fruit can obviously inhibit the agar footpad swelling of a rat and the ear rim swelling of the mouse caused by dimethylbenzene, and obviously inhibit the capillary permeability enhancement and the leucocyte exudation caused by histamine, which shows that the emblic leafflower fruit has obvious anti-inflammatory and anti-exudation effects, and the anti-inflammatory effect is enhanced along with the increase of the dosage.
Rhizoma corydalis Decumbentis powder: the analgesic effect is as follows: rhizoma corydalis Decumbentis has significant analgesic and anti-inflammatory effects on pain caused by chemical stimulation and electrical stimulation: rhizoma corydalis Decumbentis has good inhibitory effects on rat plantar inflammation caused by carrageenan and egg white, mouse ear shell swelling caused by xylene and rat subcutaneous paper granuloma hyperplasia, and has good anti-inflammatory effects.
And (3) taxus mairei: (1) wide antitumor effect: experiments prove that the taxol can reduce the tumor incidence, interfere the metabolism of tumor cells, inhibit the proliferation of the tumor cells and induce the death of the tumor cells. (2) Taxol also has anti-leukemia effect. (2) Enhancing the immunity of the organism: the alkaloid can improve sleep; the yew flavone can improve peripheral blood T lymphocyte activity, enhance NK cell killing ability, thereby enhancing organism immunity and improving anticancer effect. (4) Diminishing inflammation and easing pain: a large amount of tannin in Taxus chinensis can reduce inflammation mediator release, improve complicated inflammation of cancer patients, and relieve pain.
And (3) edible tulip: the anti-tumor effect is as follows: col in Pseudobulbus Cremastrae Seu pleiones and its colchicamide derivative have inhibitory effect on various animal transplantation tumors.
Chinese actinidia root: modern pharmacological research shows that the Chinese actinidia root has an inhibiting effect on the growth of various tumor cells, and the extract of the Chinese actinidia root has obvious antitumor activity. Li Shi et al, show that it has strong inhibitory effect on gastric cancer cells by using an ethyl acetate extract of Actinidia chinensis planch root and adopting MTT method research. Studies of Sunshi, etc. find that the extract of radix Actinidiae chinensis with ethyl acetate has the effect of inhibiting lung cancer in vivo and in vitro. Studies such as Zhang's and the like show that after 3 drug concentrations of the n-butyl alcohol extract of the Chinese actinidia root act on 24 h, 48 h and 72h of Eca-109 cells, obvious apoptosis characteristics are displayed. Bellevis and the like have studied on cervical cancer cell lines Hela, neurotumor cell lines NG10815, gastric cancer cell lines SG7901 and the like which act on the Chinese actinidia roots by adopting methods such as an MTT colorimetric method, a colony formation method and the like, and as a result, the Chinese actinidia roots have different degrees of inhibition effects on the growth of different tumor cells. Yao's et al have discussed the growth of high metastatic human lung cancer cell (PG) and influence of expression level of protein Cx43 of the gap junction of cells of compound radix Actinidiae chinensis preparation, the result indicates, compound radix Actinidiae chinensis preparation PG cell has growth inhibiting effects.
The above description is only for the specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that are not thought of through the inventive work should be covered by the protection scope of the present invention.

Claims (4)

1. A traditional Chinese medicine for treating lung cancer is characterized in that: the traditional Chinese medicine comprises the following components: radix tetrastigme powder, lucid ganoderma extract, wall-broken lucid ganoderma spore powder, wall-broken pine pollen, taxus chinensis var mairei, edible tulip, Chinese actinidia root, corydalis amabilis, phyllanthus emblica and reed rhizome.
2. The traditional Chinese medicine for treating lung cancer and the preparation method thereof according to claim 1, wherein the traditional Chinese medicine is characterized in that: the traditional Chinese medicine comprises the following components in percentage by mass: 20-30 parts of radix tetrastigme powder, 5-8 parts of lucid ganoderma extract, 5-8 parts of wall-broken lucid ganoderma spore powder, 4-6 parts of wall-broken pine pollen, 10-13 parts of taxus chinensis var mairei, 8-12 parts of edible tulip, 8-13 parts of Chinese actinidia root, 5-10 parts of corydalis amabilis, 5-8 parts of emblic leafflower fruit and 10-13 parts of reed rhizome.
3. The traditional Chinese medicine for treating lung cancer and the preparation method thereof according to claim 2, characterized in that: the traditional Chinese medicinal materials comprise the following components in percentage by mass: 27 parts of radix tetrastigme powder, 6 parts of lucid ganoderma extract, 7 parts of wall-broken lucid ganoderma spore powder, 6 parts of wall-broken pine pollen, 10 parts of taxus chinensis, 10 parts of edible tulip, 10 parts of Chinese actinidia root, 8 parts of corydalis amabilis, 6 parts of emblic leafflower fruit and 10 parts of reed rhizome.
4. The preparation method of the traditional Chinese medicine for treating lung cancer according to claim 1, characterized in that: the method comprises the following steps:
1) decocting Taxus chinensis var mairei, Pseudobulbus Cremastrae seu pleiones, radix Actinidiae chinensis, rhizoma corydalis Decumbentis, fructus Phyllanthi, and rhizoma Phragmitis for 2 times, and collecting decoction;
2) mixing the decoctions obtained by 2 times, and concentrating to obtain extract;
3) mixing the extracts with 4 powders of radix Apioris Fortunei powder, Ganoderma extract, cell wall-broken Ganoderma spore powder, and cell wall-broken pollen Pini, and making into pill.
CN202010451795.3A 2020-05-25 2020-05-25 Traditional Chinese medicine for treating lung cancer and preparation method thereof Pending CN113144107A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113599460A (en) * 2021-09-24 2021-11-05 广州颐寿达生物科技有限公司 Ganoderma lucidum composition for assisting in inhibiting tumors and preparation method thereof
CN114272308A (en) * 2022-02-19 2022-04-05 姚远平 A Chinese medicinal composition for treating cancer, and its preparation method

Citations (1)

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN107334807A (en) * 2017-07-14 2017-11-10 武夷山元生泰生物科技有限公司 A kind of ganoderma lucidum radix tetrastigme pulvis with treatment lung cancer effect and preparation method thereof

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王承儒: "岩舒注射液联合化疗治疗晚期非小细胞肺癌36例疗效观察", 中国实用医药, vol. 08, no. 12, pages 40 - 41 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113599460A (en) * 2021-09-24 2021-11-05 广州颐寿达生物科技有限公司 Ganoderma lucidum composition for assisting in inhibiting tumors and preparation method thereof
CN114272308A (en) * 2022-02-19 2022-04-05 姚远平 A Chinese medicinal composition for treating cancer, and its preparation method

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Application publication date: 20210723