CN107319552A - A kind of three red sweet shaddock ped chewable tablets and preparation method thereof - Google Patents
A kind of three red sweet shaddock ped chewable tablets and preparation method thereof Download PDFInfo
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- CN107319552A CN107319552A CN201710538372.3A CN201710538372A CN107319552A CN 107319552 A CN107319552 A CN 107319552A CN 201710538372 A CN201710538372 A CN 201710538372A CN 107319552 A CN107319552 A CN 107319552A
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- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
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Abstract
The invention discloses a kind of three red sweet shaddock ped chewable tablets and preparation method thereof.The chewable tablets includes following raw material：Three red sweet pummelo peel extracts, peppermint oil, Fructus Monordicae extract；Also include the component of following parts by weight：80 150 parts of radix polygonati officinalis, 90 130 parts of the tuber of dwarf lilyturf, 75 120 parts of balloonflower root, 50 100 parts of waxgourd seed, 70 100 parts of xylitol, 30 50 parts of hydroxypropyl methyl cellulose, 10 15 parts of sodium carboxymethyl starch, 5 10 parts of microcrystalline cellulose.The chewable tablets is prepared by steps such as extraction, granulation, drying, whole grain, tablettings.The chewable tablets can reduce the food for sticking to dental surface residual by chewing, and remove oral peculiar smell, protect the health of one's teeth.The chewable tablets have expelling phlegm and arresting coughing, qi-regulating dissipating bind, it is aid digestion the effects such as, it is easy to carry, using safety, have no toxic side effect.
Description
Technical field
The invention belongs to field of health care food, it is related to a kind of chewable tablets and preparation method thereof, more particularly to one kind three is red
Sweet shaddock ped chewable tablets and preparation method thereof.
Background technology
The sweet shaddock bud mutations of three red sweet You Shi Guanxi small streams are into the new varieties of bud mutation, the series of Shu Yu Guanxi small streams honey shaddock again after Red-fleshed Sweet Pomelo
Kind, its fruit crust is more singularly presented rose pink in the case where accordingly hiding leaf, and the subcutaneous spongy layer of fruit is pink, and pulp is in
Rose, thus gains the name " three is red ".Three red sweet shaddocks are rich in a variety of micro-elements, and with regulation human metabolism, hypotensive is relaxed
The heart, eliminating the phlegm moistening lung, help digestion and sober up, diuresis defaecation, the alimentary health-care function such as reducing blood lipid, blood glucose and fall fire anti-inflammatory, and also health care seeks
Support solely that its is peculiar, can promote and protect the lycopene of prostatic function rich in high anti-oxidation power, can promote rich in anti-oxidant and
Protection microcirculation, the beta carotene for safeguarding the functions such as skin and mucosal health.In addition, containing physiological activator skin glucoside,
The viscosity of blood can be reduced, the formation of thrombus is reduced, so to cranial vascular disease, such as cerebral thrombus, apoplexy also have preferably
Prevention effect.And fresh shaddock meat is due to the ultimate food of the composition containing similar insulin, even more diabetic.Theory of traditional Chinese medical science is recognized
For, shaddock is sweet sour, cool in nature, with regulating qi-flowing for eliminating phlegm, moistening lung gut purge, enrich blood invigorating the spleen the effects such as, can control deficiency of food, mouth it is light, digest not
It is good to wait disease, it can help digest, eliminating phlegm is quenched the thirst, qi-regulating dissipating bind.
China's shaddock annual production will produce 400,000 tons or so of pomelo peel, due to shaddock leatherware every year more than 2,000,000 tons
There is loose structure and rich in nutritional ingredient etc., current pomelo peel is used as adsorbent or is processed into food and extracts therein
Active component etc..Three red sweet shaddocks are in addition to the pulp of edible portion, and also there is very high value its pericarp part, extensively
It is general to be applied in terms of food, medical treatment.Three red sweet shaddock peds are small available for controlling rich in protein, organic acid, vitamin and calcium etc.
Youngster's pneumonia, treatment pernio etc., also with eliminating the unusual smell, mosquito proof the effects such as.The current research for three red sweet shaddock peds is also in reality
Test the stage, many technical problems are urgently to be resolved hurrily, how bitter taste is removed when being such as processed into food, it is how excellent when extracting active component
Change extraction process etc., therefore, three red sweet shaddock peds have good potentiality to be exploited, three discarded red sweet shaddock peds are re-worked into profit
With not only economizing on resources, moreover it is possible to environmental protection, have far-reaching significance.
Chewable tablets refers to the tablet that clothes make piece swallow after dissolving, tablet surface area increasing after chewing are chewed or suck in oral cavity
Greatly, the dissolving and absorption of medicine in vivo can be promoted, it is convenient to take, it can swallow, chew containing sucking or being taken after water-dispersible, especially
It is adapted to old man, child, paralytic, the patient for swallowing difficult and gastrointestinal function difference, it is possible to reduce burden of the medicine to intestines and stomach.
The present invention is based on this, three red sweet shaddock peds is re-used chewable tablets is made, at present, there is not been reported.In addition, Chinese medicine is for I
The distinctive traditional Chinese medical theory of state and the product of practice, aboundresources are with a long history, are the pure natural organic things that the mankind apply earliest
Matter.
(1) Momordica grosvenori, is Meng Lu sections plant Momordica grosvenori Siraitia grosvenorii (Swingle) C Jeffrey ex
A.M.Luet Z.Y.Zhang dry fruit.Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, it is cool.Return lung,
Large intestine channel.【Function is with curing mainly】Clearing heat and moistening lung, relieving sore-throat opens sound, laxation defaecation.For lung-heat type cough, pharyngalgia aphonia, dry constipation of intestines.
(2) peppermint, is labiate peppermint Mentha haplocalyx Briq. dry aerial parts.Record in
《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is pungent, it is cool.Return lung, Liver Channel.【Function is with curing mainly】Dispelling wind and heat from the body, head clearing,
Relieving sore-throat, promoting eruption, soothing the liver promoting the circulation of qi.For anemopyretic cold, wind-warm syndrome is from the beginning of, headache, hot eyes, larynx numbness, aphtha, rubella, and measles, chest side of body is swollen
It is vexed.
(3) radix polygonati officinalis, is liliaceous plant radix polygonati officinalis Polygonatum odoratum (MilL) Druce dry rhizome.Receive
It is loaded in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is sweet, it is slightly cold.Attach to the lung and stomach meridians.【Function is with curing mainly】Nourishing yin to moisten dryness, it is raw
Quench the thirst in Tianjin.For lung stomach impairment of yin, cough caused by dryness-heat, dry throat and mouth, Heat Diabetes.
(4) tuber of dwarf lilyturf, is liliaceous plant tuber of dwarf lilyturf Ophiopogon japonicus<L.f) Ker-GawL dried root.
Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】Sweet, slight bitter, is slightly cold.The thoughts of returning home, lung, stomach.【Function is with curing mainly】Support
Yin and promoting production of body liquid, moistening lung clears away heart-fire.For dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, intestines
Dry constipation.
(5) balloonflower root, is Campanulaceae balloonflower root Plat ycodon, grandiflorum (Jacq.) A.DC. dry root.
Record in《Chinese Pharmacopoeia》Version in 2015：【Nature and flavor and channel tropism】It is bitter, pungent, put down.Return lung is passed through.【Function is with curing mainly】Facilitaing lung, relieving sore-throat is dispelled
Phlegm, apocenosis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia sound is mute, lung carbuncle pyemesis.
(6) waxgourd seed, is the seed of cucurbitaceous plant wax gourd.With moistening lung for removing phlegm, the carbuncle that disappears Li Shui.Control phlegm-heat cough, lung
Carbuncle, acute appendicitis, gonorrhoea, oedema.
The disclosure of background above technology contents is only used for inventive concept and the technical scheme that auxiliary understands the present invention, and it is not
The prior art of present patent application is necessarily belonged to, the applying date of the above in present patent application is being shown without tangible proof
In the case of disclosed, above-mentioned background technology should not be taken to evaluate the novelty and creativeness of the application.
The content of the invention
It is an object of the invention to provide a kind of three red sweet shaddock ped chewable tablets and preparation method thereof, to solve in the prior art
Exist：The problems such as wasting of resources that the three red sweet shaddock peds largely abandoned are caused, environmental pollution.
The present invention is turned waste into wealth by recycling three red sweet shaddock peds, it is to avoid the wasting of resources and environmental pollution.The present invention
Chewable tablets by chew can reduce stick to dental surface food remain, remove oral peculiar smell, protect the health of one's teeth；Also have
Have expelling phlegm and arresting coughing, qi-regulating dissipating bind, it is aid digestion the effects such as, it is easy to carry, using safety, have no toxic side effect.
To solve the above problems, the technical solution adopted by the present invention is as follows：
A kind of three red sweet shaddock ped chewable tablets, including following raw material：Three red sweet pummelo peel extracts, peppermint oil, Momordica grosvenori are extracted
Thing.
Above-described three red sweet shaddock ped chewable tablets, includes the component of following parts by weight：80-150 parts of radix polygonati officinalis, the tuber of dwarf lilyturf
90-130 parts, 75-120 parts of balloonflower root, 50-100 parts of waxgourd seed, 70-100 parts of xylitol, 30-50 parts of hydroxypropyl methyl cellulose,
10-15 parts of sodium carboxymethyl starch, 5-10 parts of microcrystalline cellulose.
Above-described three red sweet shaddock ped chewable tablets, the preparation method of three red sweet pummelo peel extracts is：Take three red sweet shaddock peds
200-280 parts plus 5-10 times of water immersion 12-24h, be heated to 70-90 DEG C of refluxing extraction 0.5-1h, filter, filtrate pressure (-
Paste is condensed under 0.06MPa)-(- 0.08MPa), three red sweet pummelo peel extracts are produced.
Above-described three red sweet shaddock ped chewable tablets, the preparation method of peppermint oil is：Take 150-200 parts plus 1-2 times of peppermint
Water immersion 0.5-1h is measured, the peppermint soaked supercritical carbon dioxide extraction apparatus is placed in, extracting pressure is 5-15MPa, extracted
It is 40-60 DEG C to take temperature, and CO2 flows are 20-30L/h, extract 1-2h, produce the peppermint oil.
Above-described three red sweet shaddock ped chewable tablets, the preparation method of Fructus Monordicae extract is：Take 100-130 parts of Momordica grosvenori
60 mesh are crushed to, are placed in flash extracter, 20-25 times is added and measures water, temperature is 5-10 DEG C, and voltage is 130-140V, is extracted
2-5min, produces the Fructus Monordicae extract.
The preparation method of three red sweet shaddock ped chewable tablets described in more than one, comprises the following steps：
S1. three red sweet pummelo peel extracts are prepared：Three red sweet shaddock ped 200-280 parts plus 5-10 times of water immersion 12-24h are taken, plus
Heat is to 70-90 DEG C, and refluxing extraction 0.5-1h, filtering, filtrate is condensed into thick paste under pressure (- 0.06MPa)-(- 0.08MPa)
Shape, obtains three red sweet pummelo peel extracts, standby；
S2. peppermint oil is prepared：Take 150-200 parts plus 1-2 times of peppermint to measure water immersion 0.5-1h, the peppermint soaked is placed in
Supercritical carbon dioxide extraction apparatus, extracting pressure is 5-15MPa, and extraction temperature is 40-60 DEG C, and CO2 flows are 20-30L/h,
1-2h is extracted, peppermint oil is obtained, it is standby；
S3. Fructus Monordicae extract is prepared：Take 100-130 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add
20-25 times is measured water, and temperature is 5-10 DEG C, and voltage is 130-140V, extracts 2-5min, obtains Fructus Monordicae extract, standby；
S4. radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed is taken to crush 100 mesh sieves respectively, it is standby；
S5. component is weighed by following parts by weight：80-150 parts of radix polygonati officinalis, tuber of dwarf lilyturf 90-130 part, 75-120 parts of balloonflower root, waxgourd seed
50-100 parts, 70-100 parts of xylitol, 30-50 parts of hydroxypropyl methyl cellulose, 10-15 parts of sodium carboxymethyl starch, microcrystalline cellulose
It is plain 5-10 parts；
S6. take hydroxypropyl methyl cellulose to be dissolved in 120-200 parts of ethanol and hydroxypropyl methyl cellulose Diluted Alcohol is made
Solution；
S7. the three red sweet shaddock peds for taking radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed, xylitol, sodium carboxymethyl starch, step S1 to prepare
Fructus Monordicae extract prepared by extract, the peppermint oil of step S2 preparations, step S3 is placed in mixer, is stirring evenly and then adding into
Softwood is made in the hydroxypropyl methyl cellulose Diluted Alcohol solution that step S6 is made, stirring 10-15min；The granulation of 20 mesh sieves is crossed, is done
It is dry, 50 mesh sieve whole grains are crossed, dry particl after whole grain is obtained；
S8. take dry particl after step S7 whole grains to be placed in high efficient mixer, add microcrystalline cellulose, mix 30min, pressure
Piece, produces described three red sweet shaddock ped chewable tablets.
Further, the concentration of alcohol described in step S6 is 65%；Drying temperature described in step S7 is 60-80 DEG C, is done
The dry time is 10-12h, gained dry particl moisture≤10%.
Compared with prior art, beneficial effects of the present invention are as follows：
1. the chewable tablets of the present invention can reduce the food for sticking to dental surface residual by chewing, oral peculiar smell is removed,
Protect the health of one's teeth.
2. the chewable tablets of the present invention have expelling phlegm and arresting coughing, qi-regulating dissipating bind, it is aid digestion the effects such as, it is easy to carry, using safety,
Have no toxic side effect.
3. the present invention is turned waste into wealth by recycling three red sweet shaddock peds, it is to avoid the wasting of resources and environmental pollution.
Embodiment
With reference to specific embodiment, the invention will be further described, but do not limit the scope of the invention and apply
Scope：
First, chewable tablets auxiliary material conditional filtering
1. the selection of disintegrant
The species and consumption of disintegrant are most important to the disintegration of chewable tablets, result of extraction, are the factors for first having to consider.
The disintegrant commonly used in chewable tablets has sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, PVPP, cross-linked carboxymethyl fine
Plain sodium of dimension etc..Using hydroxypropyl methyl cellulose as adhesive, microcrystalline cellulose is glidant, respectively to sodium carboxymethyl starch, friendship
Join PVP, low-substituted hydroxypropyl cellulose, 4 kinds of disintegrants of Ac-Di-Sol and carry out Selection experiment, with outward appearance, collapse
Evaluation index is limited to during solution and carries out overall merit, to determine disintegrant species optimal in chewable tablets.It the results are shown in Table 1.
The optimization test result table of the disintegrant of table 1
It was found from the result of the test in table 1：It is smooth using sodium carboxymethyl starch tablet surface made from disintegrant, and disintegration
Time limit is preferable, therefore present invention selection sodium carboxymethyl starch is disintegrant.
2. adhesive is selected
The present invention compared for the tabletting again of compressing dry granulation, wet granulation, and compressing dry granulation is bad using conventional tablet machines effect, right
Equipment requirement is high, therefore the present invention uses wet granulation tabletting again.Chewable tablets uses the particle that hydrophilic adhesive is made, surface tool
Moisture is easily moistened after hydrophily, tabletting, is penetrated into, beneficial to disintegration of tablet.Water, 65% ethanol solution, hydroxypropyl have been investigated in experiment
65% ethanol solution of methylcellulose makees adhesive, is carried out using the situation of pelletizing, tablet appearance, disintegration time limited as evaluation index comprehensive
Close and evaluate, the results are shown in Table 2.
The adhesive of table 2 investigates result table
It was found from the result of the test in table 2：The present invention uses the 65% ethanol solution granulation feelings of hydroxypropyl methyl cellulose
Condition, tablet appearance, disintegration time limited are best, therefore invention adhesives select 65% ethanol solution of hydroxypropyl methyl cellulose.
3. the selection of glidant
Powder flowbility is a critical nature in solid pharmaceutical preparation technique.Microcrystalline cellulose, magnesium stearate are normal
Glidant, can effectively improve the mobility of particle or powder in pelletizing press sheet or direct powder compression.It is right in experiment
1% microcrystalline cellulose, 1% magnesium stearate, 1% magnesium stearate-microcrystalline cellulose (1: 1) are compared as glidant, during being disintegrated
Between and hardness be inspection target, carry out overall merit.It the results are shown in Table 3.
The glidant of table 3 investigates result table
Result of the test in table 3：1% microcrystalline cellulose is best as glidant effect, therefore the present invention selects 1%
Microcrystalline cellulose is as glidant.
2nd, the preparation of three red sweet shaddock ped chewable tablets
Embodiment 1
A kind of preparation method of three red sweet shaddock ped chewable tablets, comprises the following steps：
S1. three red sweet pummelo peel extracts are prepared：Three red sweet 280 parts plus 10 times water immersion 24h of shaddock ped are taken, 90 DEG C are heated to,
Refluxing extraction 1h, filtering, filtrate is condensed into paste under pressure -0.08MPa, obtains three red sweet pummelo peel extracts, standby；
S2. peppermint oil is prepared：200 parts plus 2 times amount water immersion 1h of peppermint are taken, the peppermint soaked is placed in overcritical dioxy
Change carbon extraction equipment, extracting pressure is 15MPa, and extraction temperature is 60 DEG C, and CO2 flows are 30L/h, extract 2h, obtain peppermint oil, standby
With；
S3. Fructus Monordicae extract is prepared：Take 130 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add 25 times
Water is measured, temperature is 10 DEG C, and voltage is 140V, extracts 5min, obtains Fructus Monordicae extract, standby；
S4. radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed is taken to crush 100 mesh sieves respectively, it is standby；
S5. component is weighed by following parts by weight：150 parts of radix polygonati officinalis, 130 parts of the tuber of dwarf lilyturf, 120 parts of balloonflower root, 100 parts of waxgourd seed, wood
100 parts of sugar alcohol, 50 parts of hydroxypropyl methyl cellulose, 15 parts of sodium carboxymethyl starch, 10 parts of microcrystalline cellulose；
S6. take hydroxypropyl methyl cellulose to be dissolved in 200 part of 65% ethanol and hydroxypropyl methyl cellulose Diluted Alcohol is made
Solution；
S7. the three red sweet shaddock peds for taking radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed, xylitol, sodium carboxymethyl starch, step S1 to prepare
Fructus Monordicae extract prepared by extract, the peppermint oil of step S2 preparations, step S3 is placed in mixer, is stirring evenly and then adding into
Softwood is made in the hydroxypropyl methyl cellulose Diluted Alcohol solution that step S6 is made, stirring 15min；The granulation of 20 mesh sieves is crossed, in temperature
12h is dried at 80 DEG C, 50 mesh sieve whole grains are crossed, dry particl after whole grain is obtained, it is 8% to survey moisture；
S8. take dry particl after step S7 whole grains to be placed in high efficient mixer, add microcrystalline cellulose, mix 30min, pressure
Piece, produces described three red sweet shaddock ped chewable tablets.
Embodiment 2
A kind of preparation method of three red sweet shaddock ped chewable tablets, comprises the following steps：
S1. three red sweet pummelo peel extracts are prepared：Three red sweet 200 parts plus 5 times water immersion 12h of shaddock ped are taken, 70 DEG C is heated to, returns
Stream extracts 0.5h, filters, filtrate is condensed into paste under pressure -0.06MPa, obtains three red sweet pummelo peel extracts, standby；
S2. peppermint oil is prepared：150 parts plus 1 times amount water immersion 0.5h of peppermint are taken, the peppermint soaked is placed in overcritical two
Carbonoxide extraction equipment, extracting pressure is 5MPa, and extraction temperature is 40 DEG C, and CO2 flows are 20L/h, extract 1h, obtain peppermint oil,
It is standby；
S3. Fructus Monordicae extract is prepared：Take 100 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add 20 times
Water is measured, temperature is 5 DEG C, and voltage is 130V, extracts 2min, obtains Fructus Monordicae extract, standby；
S4. radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed is taken to crush 100 mesh sieves respectively, it is standby；
S5. component is weighed by following parts by weight：80 parts of radix polygonati officinalis, 90 parts of the tuber of dwarf lilyturf, 75 parts of balloonflower root, 50 parts of waxgourd seed, xylitol
70 parts, 30 parts of hydroxypropyl methyl cellulose, 10 parts of sodium carboxymethyl starch, 5 parts of microcrystalline cellulose；
S6. take hydroxypropyl methyl cellulose to be dissolved in 120 part of 65% ethanol and hydroxypropyl methyl cellulose Diluted Alcohol is made
Solution；
S7. the three red sweet shaddock peds for taking radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed, xylitol, sodium carboxymethyl starch, step S1 to prepare
Fructus Monordicae extract prepared by extract, the peppermint oil of step S2 preparations, step S3 is placed in mixer, is stirring evenly and then adding into
Softwood is made in the hydroxypropyl methyl cellulose Diluted Alcohol solution that step S6 is made, stirring 10min；The granulation of 20 mesh sieves is crossed, in temperature
10h is dried at 60 DEG C, 50 mesh sieve whole grains are crossed, dry particl after whole grain is obtained, it is 6% to survey moisture；
S8. take dry particl after step S7 whole grains to be placed in high efficient mixer, add microcrystalline cellulose, mix 30min, pressure
Piece, produces described three red sweet shaddock ped chewable tablets.
Embodiment 3
A kind of preparation method of three red sweet shaddock ped chewable tablets, comprises the following steps：
S1. three red sweet pummelo peel extracts are prepared：Three red sweet 220 parts plus 6 times water immersion 16h of shaddock ped are taken, 75 DEG C is heated to, returns
Stream extracts 0.8h, filters, filtrate is condensed into paste under pressure -0.065MPa, obtains three red sweet pummelo peel extracts, standby；
S2. peppermint oil is prepared：160 parts plus 1 times amount water immersion 0.8h of peppermint are taken, the peppermint soaked is placed in overcritical two
Carbonoxide extraction equipment, extracting pressure is 8MPa, and extraction temperature is 45 DEG C, and CO2 flows are 25L/h, extract 1.2h, obtain peppermint
Oil, it is standby；
S3. Fructus Monordicae extract is prepared：Take 110 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add 22 times
Water is measured, temperature is 8 DEG C, and voltage is 135V, extracts 3min, obtains Fructus Monordicae extract, standby；
S4. radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed is taken to crush 100 mesh sieves respectively, it is standby；
S5. component is weighed by following parts by weight：100 parts of radix polygonati officinalis, 100 parts of the tuber of dwarf lilyturf, 90 parts of balloonflower root, 70 parts of waxgourd seed, xylose
80 parts of alcohol, 35 parts of hydroxypropyl methyl cellulose, 12 parts of sodium carboxymethyl starch, 8 parts of microcrystalline cellulose；
S6. take hydroxypropyl methyl cellulose to be dissolved in 150 part of 65% ethanol and hydroxypropyl methyl cellulose Diluted Alcohol is made
Solution；
S7. the three red sweet shaddock peds for taking radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed, xylitol, sodium carboxymethyl starch, step S1 to prepare
Fructus Monordicae extract prepared by extract, the peppermint oil of step S2 preparations, step S3 is placed in mixer, is stirring evenly and then adding into
Softwood is made in the hydroxypropyl methyl cellulose Diluted Alcohol solution that step S6 is made, stirring 12min；The granulation of 20 mesh sieves is crossed, in temperature
11h is dried at 65 DEG C, 50 mesh sieve whole grains are crossed, dry particl after whole grain is obtained, it is 5% to survey moisture；
S8. take dry particl after step S7 whole grains to be placed in high efficient mixer, add microcrystalline cellulose, mix 30min, pressure
Piece, produces described three red sweet shaddock ped chewable tablets.
Embodiment 4
A kind of preparation method of three red sweet shaddock ped chewable tablets, comprises the following steps：
S1. three red sweet pummelo peel extracts are prepared：Three red sweet 250 parts plus 7 times water immersion 18h of shaddock ped are taken, 80 DEG C is heated to, returns
Stream extracts 0.6h, filters, filtrate is condensed into paste under pressure -0.07MPa, obtains three red sweet pummelo peel extracts, standby；
S2. peppermint oil is prepared：170 parts plus 2 times amount water immersion 0.6h of peppermint are taken, the peppermint soaked is placed in overcritical two
Carbonoxide extraction equipment, extracting pressure is 10MPa, and extraction temperature is 50 DEG C, and CO2 flows are 27L/h, extract 1-2h, obtain peppermint
Oil, it is standby；
S3. Fructus Monordicae extract is prepared：Take 125 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add 23 times
Water is measured, temperature is 6 DEG C, and voltage is 132V, extracts 4min, obtains Fructus Monordicae extract, standby；
S4. radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed is taken to crush 100 mesh sieves respectively, it is standby；
S5. component is weighed by following parts by weight：120 parts of radix polygonati officinalis, 110 parts of the tuber of dwarf lilyturf, 110 parts of balloonflower root, 80 parts of waxgourd seed, xylose
90 parts of alcohol, 40 parts of hydroxypropyl methyl cellulose, 13 parts of sodium carboxymethyl starch, 7 parts of microcrystalline cellulose；
S6. take hydroxypropyl methyl cellulose to be dissolved in 160 part of 65% ethanol and hydroxypropyl methyl cellulose Diluted Alcohol is made
Solution；
S7. the three red sweet shaddock peds for taking radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed, xylitol, sodium carboxymethyl starch, step S1 to prepare
Fructus Monordicae extract prepared by extract, the peppermint oil of step S2 preparations, step S3 is placed in mixer, is stirring evenly and then adding into
Softwood is made in the hydroxypropyl methyl cellulose Diluted Alcohol solution that step S6 is made, stirring 13min；The granulation of 20 mesh sieves is crossed, in temperature
10h is dried at 70 DEG C, 50 mesh sieve whole grains are crossed, dry particl after whole grain is obtained, it is 6% to survey moisture；
S8. take dry particl after step S7 whole grains to be placed in high efficient mixer, add microcrystalline cellulose, mix 30min, pressure
Piece, produces described three red sweet shaddock ped chewable tablets.
Embodiment 5
A kind of preparation method of three red sweet shaddock ped chewable tablets, comprises the following steps：
S1. three red sweet pummelo peel extracts are prepared：Three red sweet 270 parts plus 9 times water immersion 20h of shaddock ped are taken, 85 DEG C is heated to, returns
Stream extracts 0.9h, filters, filtrate is condensed into paste under pressure -0.075MPa, obtains three red sweet pummelo peel extracts, standby；
S2. peppermint oil is prepared：180 parts plus 1.5 times amount water immersion 0.6h of peppermint are taken, the peppermint soaked are placed in overcritical
Carbon dioxide extraction apparatus, extracting pressure is 12MPa, and extraction temperature is 55 DEG C, and CO2 flows are 29L/h, extract 1.8h, obtain thin
Lotus oil, it is standby；
S3. Fructus Monordicae extract is prepared：Take 128 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add 24 times
Water is measured, temperature is 7 DEG C, and voltage is 138V, extracts 3.5min, obtains Fructus Monordicae extract, standby；
S4. radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed is taken to crush 100 mesh sieves respectively, it is standby；
S5. component is weighed by following parts by weight：140 parts of radix polygonati officinalis, 120 parts of the tuber of dwarf lilyturf, 115 parts of balloonflower root, 90 parts of waxgourd seed, xylose
95 parts of alcohol, 45 parts of hydroxypropyl methyl cellulose, 14 parts of sodium carboxymethyl starch, 6 parts of microcrystalline cellulose；
S6. take hydroxypropyl methyl cellulose to be dissolved in 180 part of 65% ethanol and hydroxypropyl methyl cellulose Diluted Alcohol is made
Solution；
S7. the three red sweet shaddock peds for taking radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed, xylitol, sodium carboxymethyl starch, step S1 to prepare
Fructus Monordicae extract prepared by extract, the peppermint oil of step S2 preparations, step S3 is placed in mixer, is stirring evenly and then adding into
Softwood is made in the hydroxypropyl methyl cellulose Diluted Alcohol solution that step S6 is made, stirring 14min；The granulation of 20 mesh sieves is crossed, in temperature
11h is dried at 75 DEG C, 50 mesh sieve whole grains are crossed, dry particl after whole grain is obtained, it is 7% to survey moisture；
S8. take dry particl after step S7 whole grains to be placed in high efficient mixer, add microcrystalline cellulose, mix 30min, pressure
Piece, produces described three red sweet shaddock ped chewable tablets.
3rd, the quality evaluation of three red sweet shaddock ped chewable tablets
1. determine disintegration time limited
Using Chinese Pharmacopoeia version " disintegration time limited inspection technique " (general rule 0921) in 2015, Example 1-5 samples and Shen
Please publication No. detected for CN102960601A application for a patent for invention embodiment 1-3 sample, disintegration time limited is recorded respectively,
It the results are shown in Table 4.
The disintegration time mensuration situation of table 4
As can be seen from Table 4, sample disintegration time of the sample than CN102960601A that prepared by the present invention shortens, and shows
It absorbs very fast.
2. determine dissolution rate
Using Chinese Pharmacopoeia version " dissolution rate and drug release determination method " first method (general rule 0931), Example 1- in 2015
5 samples and application publication number are detected that sample contains for CN102960601A application for a patent for invention embodiment 1-3 sample
Measure and determine to use ultraviolet spectrophotometry, using rutin as reference substance, absorbance is determined at 335nm, dissolution is then calculated
Degree, the results are shown in Table 5.
The dissolution determination situation of table 5
| Embodiment | Dissolution rate (%) |
| Embodiment 1 | 97 |
| Embodiment 2 | 98 |
| Embodiment 3 | 97 |
| Embodiment 4 | 99 |
| Embodiment 5 | 97 |
| CN102960601 embodiments 1 | 87 |
| CN102960601 embodiments 2 | 89 |
| CN102960601 embodiments 3 | 88 |
As can be known from Table 5, the sample that prepared by the present invention is substantially higher than the sample dissolution rate of CN102960601A embodiment, table
Its bright bioavilability is higher.
The specific implementation of the invention is not to be limited to these illustrations for above content, is led for technology belonging to the present invention
For the those of ordinary skill in domain, without departing from the inventive concept of the premise, some simple deduction or replace can also be made,
The scope of patent protection that the present invention is determined by the claims submitted should be all considered as belonging to.
Claims (10)
1. a kind of three red sweet shaddock ped chewable tablets, it is characterised in that including following raw material：Three red sweet pummelo peel extracts, peppermint oil, sieve
Chinese berry extract.
2. three red sweet shaddock ped chewable tablets according to claim 1, it is characterised in that also include the component of following parts by weight：
80-150 parts of radix polygonati officinalis, tuber of dwarf lilyturf 90-130 part, 75-120 parts of balloonflower root, 50-100 parts of waxgourd seed, 70-100 parts of xylitol, hydroxypropyl first
30-50 parts of base cellulose, 10-15 parts of sodium carboxymethyl starch, 5-10 parts of microcrystalline cellulose.
3. three red sweet shaddock ped chewable tablets according to claim 1, it is characterised in that the system of the three red sweet pummelo peel extract
Preparation Method is：Three red sweet shaddock ped 200-280 parts plus 5-10 times of water immersion 12-24h, heating and refluxing extraction 0.5-1h are taken, are filtered, filter
Liquid is concentrated under reduced pressure into paste, produces three red sweet pummelo peel extracts.
4. three red sweet shaddock ped chewable tablets according to claim 3, it is characterised in that the system of the three red sweet pummelo peel extract
Heating-up temperature is to 70-90 DEG C in Preparation Method, and the pressure being concentrated under reduced pressure is (- 0.06MPa)-(- 0.08MPa).
5. three red sweet shaddock ped chewable tablets according to claim 1, it is characterised in that the preparation method of the peppermint oil is：
Take 150-200 parts plus 1-2 times of peppermint to measure water immersion 0.5-1h, the peppermint soaked is placed in supercritical carbon dioxide extracting dress
Put, extracting pressure is 5-15MPa, extraction temperature is 40-60 DEG C, and CO2 flows are 20-30L/h, extract 1-2h, produce described thin
Lotus oil.
6. three red sweet shaddock ped chewable tablets according to claim 1, it is characterised in that the preparation side of the Fructus Monordicae extract
Method is：Take 100-130 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add 20-25 times and measure water, temperature is 5-10
DEG C, voltage is 130-140V, extracts 2-5min, produces the Fructus Monordicae extract.
7. a kind of preparation method of three red sweet shaddock ped chewable tablets according to claim any one of 1-6, it is characterised in that bag
Include following steps：
S1. three red sweet pummelo peel extracts are prepared：Three red sweet shaddock ped 200-280 parts plus 5-10 times of water immersion 12-24h are taken, are heated to
70-90 DEG C, refluxing extraction 0.5-1h, filtering, filtrate is condensed into paste under pressure (- 0.06MPa)-(- 0.08MPa), obtained
Three red sweet pummelo peel extracts, it is standby；
S2. peppermint oil is prepared：Take 150-200 parts plus 1-2 times of peppermint to measure water immersion 0.5-1h, the peppermint soaked is placed in super face
Boundary's carbon dioxide extraction apparatus, extracting pressure is 5-15MPa, and extraction temperature is 40-60 DEG C, and CO2 flows are 20-30L/h, extraction
1-2h, obtains peppermint oil, standby；
S3. Fructus Monordicae extract is prepared：Take 100-130 parts of Momordica grosvenori to be crushed to 60 mesh, be placed in flash extracter, add 20-
25 times of amount water, temperature is 5-10 DEG C, and voltage is 130-140V, extracts 2-5min, obtains Fructus Monordicae extract, standby；
S4. radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed is taken to crush 100 mesh sieves respectively, it is standby；
S5. component is weighed by following parts by weight：80-150 parts of radix polygonati officinalis, tuber of dwarf lilyturf 90-130 part, 75-120 parts of balloonflower root, waxgourd seed 50-
100 parts, 70-100 parts of xylitol, 30-50 parts of hydroxypropyl methyl cellulose, 10-15 parts of sodium carboxymethyl starch, microcrystalline cellulose 5-
10 parts；
S6. take hydroxypropyl methyl cellulose to be dissolved in 120-200 parts of ethanol and hydroxypropyl methyl cellulose Diluted Alcohol solution is made；
S7. the three red sweet shaddock peds for taking radix polygonati officinalis, the tuber of dwarf lilyturf, balloonflower root, waxgourd seed, xylitol, sodium carboxymethyl starch, step S1 to prepare are extracted
Fructus Monordicae extract prepared by thing, the peppermint oil of step S2 preparations, step S3 is placed in mixer, is stirring evenly and then adding into step
Softwood is made in the hydroxypropyl methyl cellulose Diluted Alcohol solution that S6 is made, stirring 10-15min；The granulation of 20 mesh sieves is crossed, is dried, mistake
50 mesh sieve whole grains, obtain dry particl after whole grain；
S8. dry particl after step S7 whole grains is taken to be placed in high efficient mixer, addition microcrystalline cellulose, mixing 30min, tabletting, i.e.,
Obtain the three red sweet shaddock ped chewable tablets.
8. the preparation method of three red sweet shaddock ped chewable tablets according to claim 7, it is characterised in that the second described in step S6
Determining alcohol is 65%.
9. the preparation method of three red sweet shaddock ped chewable tablets according to claim 7, it is characterised in that dry described in step S7
Dry temperature is 60-80 DEG C, and drying time is 10-12h.
10. the preparation method of three red sweet shaddock ped chewable tablets according to claim 7, it is characterised in that dry obtained by step S7
Granule moisture level≤10%.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596938A (en) * | 2004-07-22 | 2005-03-23 | 沈阳市东陵药物研究所 | Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method |
| CN102960601A (en) * | 2012-11-28 | 2013-03-13 | 覃楚越 | Shaddock peel chewable tablet and preparation method thereof |
| CN103168994A (en) * | 2013-03-27 | 2013-06-26 | 中山大学 | Weight reducing health-care composition and preparation method thereof |
| CN103637045A (en) * | 2013-12-11 | 2014-03-19 | 罗永祺 | Platycodon grandiflorum, radix polygonati officinalis and radix pseudostellariae chewable tablet and preparation method thereof |
| CN103719863A (en) * | 2014-01-07 | 2014-04-16 | 威海环翠楼红参科技有限公司 | Preparation method of red ginseng chewable tablets |
-
2017
- 2017-07-04 CN CN201710538372.3A patent/CN107319552A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596938A (en) * | 2004-07-22 | 2005-03-23 | 沈阳市东陵药物研究所 | Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method |
| CN102960601A (en) * | 2012-11-28 | 2013-03-13 | 覃楚越 | Shaddock peel chewable tablet and preparation method thereof |
| CN103168994A (en) * | 2013-03-27 | 2013-06-26 | 中山大学 | Weight reducing health-care composition and preparation method thereof |
| CN103637045A (en) * | 2013-12-11 | 2014-03-19 | 罗永祺 | Platycodon grandiflorum, radix polygonati officinalis and radix pseudostellariae chewable tablet and preparation method thereof |
| CN103719863A (en) * | 2014-01-07 | 2014-04-16 | 威海环翠楼红参科技有限公司 | Preparation method of red ginseng chewable tablets |
Non-Patent Citations (3)
| Title |
|---|
| 周旺主编: "《烹饪营养学第2版》", 30 June 2007, 中国轻工业出版社 * |
| 赵余庆等: "《食疗与保健食品原料功能因子手册》", 31 March 2013, 中国医药科技出版社 * |
| 郑俊民主编: "《药用高分子材料学》", 30 April 1993, 中国医药科技出版社 * |
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