CN107296628B - Real-time detection system and real-time detection device for internal fistula thrombus and detection method for blood flow velocity of internal fistula thrombus - Google Patents
Real-time detection system and real-time detection device for internal fistula thrombus and detection method for blood flow velocity of internal fistula thrombus Download PDFInfo
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Abstract
The invention relates to a real-time detection system and a real-time detection device for internal fistula thrombus based on an ultrasonic Doppler effect and a detection method for blood flow velocity thereof, wherein the real-time internal fistula detection system comprises: the ultrasonic probe comprises a main control module, an ultrasonic probe driving module, a dual-mode ultrasonic probe module, a display module, a wireless transmission module and a storage module, wherein the display module, the storage module, the ultrasonic probe driving module and the wireless transmission module are directly connected with the main control module, the ultrasonic probe driving module is additionally connected with the dual-mode ultrasonic probe module, the wireless transmission module carries out remote data transmission through wireless signals, and a power supply module supplies power for each module. The invention effectively eliminates the problem that the Doppler included angle is difficult to determine in the practical application of measuring the blood flow velocity by utilizing different placing modes and two different working modes of the ultrasonic probe, and simultaneously solves the problem of fuzzy flow velocity gradient.
Description
Technical Field
The invention belongs to the field of intelligent wearable electronic medical equipment, and particularly relates to a real-time detection system and a real-time detection device for internal fistula thrombus and a detection method for blood flow velocity of the internal fistula thrombus.
Background
Autologous arteriovenous fistulas (AVFs) are common vascular access for maintaining the life of hemodialysis patients. The hospitalization number caused by the stenosis of a vascular access or the embolism of an arteriovenous internal fistula after the arteriovenous fistulation operation accounts for 15 to 24 percent of the total hospitalization number of dialysis patients. AVF dysfunction is one of the leading causes of death in long-term dialysis patients. The international kidney disease foundation blood vessel access clinical practice guidance provides that the dynamic monitoring of the hemodynamic parameters can monitor the health condition of the blood vessel access in time, and the timely intervention of the growth of thrombus can reduce the occurrence probability of access embolism and prolong the service life of the access when early thrombus is generated, thereby maintaining the life cycle and the life quality of patients.
So far, the following detection methods are available for detecting the thrombus of the autologous arteriovenous internal fistula: ultrasonic dilution method, ultrasonic imaging technology and the like are available based on ultrasonic technology; a technology for detecting tremor and noise of a venous end with an internal fistula based on a piezoelectric technology; based on near-infrared light technology, a method for detecting the change of light absorption amount during the vascular tremor based on the Lambert beer theorem is provided; an angiography method.
The ultrasonic dilution method is the internationally accepted most accurate thrombus determination method. During detection, blood vessel puncture is needed, and a diluent solvent is injected to detect the blood flow, so that whether an internal fistula thrombus exists is judged. The ultrasonic dilution method instrument is generally available in a large-scale special medical place, and because the instrument is an invasive detection section and cannot detect the physiological parameters of the internal fistula site of a patient at any time and any place, the patient is inconvenient to see a doctor.
The ultrasonic imaging technology is a relatively accurate examination method, puncture is not needed, the internal fistula condition of a patient is displayed in real time by using an ultrasonic imaging algorithm, and a doctor can make a judgment by only looking at a picture. However, the ultrasonic imaging instrument is expensive, and the patient also needs to go to a hospital to be detected, which causes inconvenience in treatment.
The piezoelectric technology-based solution is to utilize the fact that after thrombus is generated, venous-end vascular tremor and noise of the internal arteriovenous fistula of the body become weak, and therefore signals sent by a piezoelectric sensor for detecting the vascular tremor and the noise change. The near-infrared light detection technical solution based on the lambert beer theorem has the principle that whether thrombus is likely to be generated or not is judged based on the change of light absorption amount during the vascular tremor and also based on the principle of the vascular tremor. The two methods have the defects of easy interference of daily behaviors and environments of a wearer, so that the detection is not accurate enough, and the skin deformation of a patient can cause great interference.
The angiography method is also an accurate internal fistula thrombus detection method, and the thrombus formation condition is obtained by injecting a contrast agent into a blood vessel and utilizing a method that X-rays cannot penetrate the contrast agent. The method can observe the thrombus condition of the internal fistula more intuitively. However, this method is an invasive method, requires blood vessel puncture, cannot be monitored in real time, requires a special developing device, and is inconvenient for patients to see a doctor.
The method has the advantages that the portability of the wearable electronic product and the characteristic that the ultrasonic detection means is not easily interfered by the environment are combined, and the problem of the method can be well solved. The patent with application number 201521035242.0 discloses a hand ring for self-testing of uremia hemodialysis internal fistula, but the patent does not provide a detailed design scheme and a key technical method of an ultrasonic system, and the patent drawings show that the ultrasonic detection equipment adopts a method of setting one receiving and one sending double probes, so that the detection equipment can only detect a narrow measurement area at a specific angle, not only is the data not accurate enough, but also the detection equipment can only be used for detecting the thrombus of the internal fistula on the superficial layer, and the detection range is narrow.
Disclosure of Invention
The present invention is directed to solve at least one of the above problems, and the present invention provides a system and a device for real-time detection of an internal fistula thrombus, and a method for detecting a blood flow rate thereof, which combine the portability of a wearable electronic product with the feature that an ultrasonic detection means is not easily interfered, and accurately monitor a doppler shift of a blood flow velocity by using a novel layout and a novel working mode of an ultrasonic probe, so as to further determine the blood flow velocity. The technical scheme of the invention is realized as follows.
According to one aspect of the present invention, there is provided a system for real-time detection of internal fistula thrombus, comprising: the ultrasonic probe comprises a main control module, an ultrasonic probe driving module, a dual-mode ultrasonic probe module, a display module, a wireless transmission module and a storage module.
The dual-mode ultrasonic probe module is provided with two working modes of point detection and surface detection, is used for sending an ultrasonic signal, receiving a scattering signal scattered back by red blood cells, converting the scattering signal into an electric signal and sending the electric signal to the ultrasonic drive module.
And the ultrasonic probe driving module is connected with the dual-mode ultrasonic probe module and used for driving the dual-mode ultrasonic probe module to work according to a required working mode, converting the echo signal into Doppler frequency shift original data and sending the Doppler frequency shift original data to the main control module.
The main control module is connected with the double-group ultrasonic probe driving module and used for controlling the ultrasonic probe driving module to select different ultrasonic probe working modes according to requirements, receiving and processing Doppler frequency shift original data transmitted by the ultrasonic probe driving module and generating blood flow rate.
The display module is connected with the main control module and used for receiving a user instruction and displaying the blood flow rate and the growth condition of the internal fistula thrombus.
The storage module is connected with the main control module, exchanges data with the main control module, is used for storing blood flow rate data, establishing a local database of arteriovenous fistula health record, or sends the stored blood flow rate data to the main control module, and then controls the wireless transmission module to send the stored blood flow rate data to the upper computer end of the background processor through the main control module to perform later analysis and operation.
The wireless transmission module is connected with the main control module and the wireless signal and used for data exchange.
The dual-mode ultrasonic probe module comprises a first transmitter, at least two second transmitters and at least two receivers, wherein the at least two receivers are in signal connection with the ultrasonic driving module.
A first transmitter cooperates with at least two receivers to form a point detection mode of operation for detecting a point region of ultrasound waves emitted by the first transmitter that falls vertically into the blood stream to be detected.
The at least two second transmitters are matched with the at least two receivers to form a surface detection working mode, and ultrasonic waves with incidence angles of beta, which are respectively emitted by the at least two second transmitters, are detected in surface areas overlapped in the blood flow to be detected.
Beta is more than or equal to 15 degrees and less than or equal to 30 degrees, the included angle between the transmitting route of the first transmitter and the receiving route of each corresponding receiver is alpha, alpha is more than or equal to 10 degrees and less than or equal to 74 degrees, the first transmitter comprises 8-32 transmitting units, and the frequency of the emitted ultrasonic waves is 5-12 MHz.
The included angle between the transmitting route of each second transmitter and the receiving route of the corresponding receiver is alpha ', alpha' is more than or equal to 10 degrees and less than or equal to 74 degrees, at least two second transmitters comprise 8-32 transmitting units, and the frequency of the emitted ultrasonic waves is 8-10 MHz.
Wherein β ═ 15 ° and α ═ α', and the at least two second transmitters comprise 16 or 32 transmission units.
The ultrasonic probe driving module comprises a probe driving circuit unit, a working mode selection unit and an original data acquisition unit, and the main control module comprises a task management and peripheral control unit and a data processing unit.
The task management and peripheral control unit is in bidirectional communication with the wireless transmission module, the display module and the storage module, and is in unidirectional communication with the working mode selection unit, the probe driving circuit unit and the dual-mode ultrasonic probe module in sequence, and the data processing unit is in bidirectional communication with the task management and peripheral control unit and the storage module respectively, and is in unidirectional communication with the original data acquisition unit and the dual-mode ultrasonic probe module in sequence.
Wherein, the real-time detection system of internal fistula thrombus still includes power module, and power module adopts rechargeable battery power supply, and rechargeable battery charges through wireless or wired mode.
According to another aspect of the invention, a real-time fistula thrombus detection device is provided, the real-time fistula thrombus detection device is provided with a detection component, the detection component is provided with a dual-mode ultrasonic probe, the detection surface of the dual-mode ultrasonic probe is provided with a first transmitting probe, two second transmitting probes and two receiving probes which are arranged in a straight line, the first transmitter is positioned in the first transmitting probe, the second transmitter is positioned in the second transmitting probe, and the receiver is positioned in the receiving probes.
The detection part is also provided with a flexible cushion block, the real-time detection device is also provided with a wrist strap, the dual-mode ultrasonic probe is embedded in a first side face of the flexible cushion block, a detection face is exposed, and a second side face, opposite to the first side face, of the flexible cushion block is fixedly connected with the surface of the wrist strap;
the first transmitting probe is located in the center of the linear arrangement, the two receiving probes are located at two ends of the linear arrangement respectively, the distance between the adjacent transmitting probes is 2-8 mm, and the distance between the second transmitting probe and the adjacent receiving probes is 2-5 mm.
According to a third aspect of the present invention, there is provided a method for detecting a blood flow rate by using the real-time detection system, specifically comprising:
the main control module controls the ultrasonic drive module to drive the dual-mode ultrasonic probe module to work according to different working modes; the dual-mode ultrasonic probe module transmits ultrasonic signals, converts the received ultrasonic signals scattered back by the red blood cells into electric signals and sends the electric signals to the ultrasonic driving module; the ultrasonic driving module converts the electric signals into required original data for the main control module to read; the main control module reads the original data to process to obtain Doppler frequency shift related to the blood flow velocity, and the blood flow velocity is calculated according to the relation between the Doppler frequency shift and the movement velocity of the measured object.
Wherein, when the physique of disease is thin partially, and when making fistula position venous end blood vessel is lighter, control the dual mode ultrasonic probe module of ultrasonic drive module drive through host system and carry out some and survey the mode, the disease physique is fat partially, subcutaneous fat is thicker, or when making fistula position venous end blood vessel is darker, control the dual mode ultrasonic probe module of ultrasonic drive module drive through host system and carry out a face and survey the mode.
1. The real-time detection system and the detection device for the internal fistula thrombus effectively solve the problem that a Doppler included angle is difficult to determine in the practical application of measuring the blood flow velocity by utilizing different placing modes and working modes of the ultrasonic probe, and simultaneously solve the problem of fuzzy flow velocity gradient.
2. The surface detection working mode of the invention mainly aims at measuring the blood flow velocity in the deep internal fistula vein, and allows certain error of the incident angle of ultrasonic waves through a surface detection area formed by a cross vector intersection method, thereby ensuring that the result is more accurate.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:
FIG. 1 shows a schematic diagram of a system for real-time detection of internal fistula thrombus in accordance with an embodiment of the invention;
FIG. 2 is a schematic diagram illustrating a point detection mode of operation of a dual mode ultrasound probe module of a system for real-time detection of internal fistula thrombus, in accordance with an embodiment of the present invention;
FIG. 3 is a schematic view illustrating a face detection mode of operation of a dual mode ultrasound probe module of a system for real-time detection of internal fistula thrombus, in accordance with an embodiment of the present invention;
FIG. 4 shows a front view of a real-time detection device according to an embodiment of the invention;
fig. 5 shows a side view of a real-time detection device according to an embodiment of the invention.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
In order to achieve the required functions, the invention provides a real-time detection system and a detection method of internal fistula thrombus based on an ultrasonic Doppler effect.
As shown in fig. 1, the system includes: the ultrasonic probe comprises a main control module, an ultrasonic probe driving module, a dual-mode ultrasonic probe module, a display module, a wireless transmission module, a storage module, a power module and upper computer end software, wherein the display module, the storage module, the ultrasonic probe driving module and the wireless transmission module are directly connected with the main control module, the ultrasonic probe driving module is additionally connected with the dual-mode ultrasonic probe module, the wireless transmission module is connected with the upper computer software through a 2.4GHz wireless signal, and the power module supplies power for each module.
The functions of each module of the system are as follows:
the dual-mode ultrasonic probe module is provided with two working modes of point detection and surface detection, is used for sending an ultrasonic signal, receiving a scattering signal scattered back by red blood cells, converting the scattering signal into an electric signal and sending the electric signal to the ultrasonic drive module.
And the ultrasonic probe driving module is used for driving the dual-mode ultrasonic probe module to work according to a required working mode, converting the echo signal into Doppler frequency shift original data related to the blood flow velocity and sending the Doppler frequency shift original data to the main control module.
The main control module is the core of the whole system, and the tasks of the main control module comprise: and controlling the ultrasonic driving module to select different ultrasonic probe working modes, data sampling and processing and task control according to requirements, wherein the task control comprises data storage, sending, receiving and executing external commands, and data exchange between the control display module and the wireless transmission and storage module. The data sampling and processing comprises reading original data in an A/D converter of the driving module, filtering and characteristic information extraction through a built-in DSP processor to obtain effective data, and calculating by using a Doppler frequency shift formula to obtain the blood flow velocity.
The display module comprises a plurality of selectable interfaces and functions, a user can control the whole system to work through the touch screen, the display of the internal fistula thrombus information comprises the current blood flow state, and whether the initial thrombus is generated and the growth state of the thrombus is given by the blood flow speed change value in a plurality of periods of time. And drawing dynamic thrombus growth and blood flow change dynamic curves.
The wireless data transmission module and the storage module, the module contains a low energy consumption Bluetooth (BLE) module and a Wi-Fi module. Thereby internal fistula thrombus check out test set can be connected to each other through bluetooth and host computer and carry out data exchange. Or directly connected with a wireless router and the like through Wi-Fi to carry out remote data exchange.
The storage module is an SD card or other storage media, can send the processing result to an upper computer and can also store the result data on the SD card as an arteriovenous internal fistula health record local database.
As shown in fig. 2, the dual mode ultrasonic probe module is composed of two sets of ultrasonic probes, each set of ultrasonic probes is composed of an ultrasonic transmitter and a receiver, one set of ultrasonic probes includes a first transmitter and two receivers, and the other set of ultrasonic probes includes two second transmitters and two receivers. The total number of the ultrasonic probes is five, wherein three transmitters are provided, and two receivers are provided. And the two groups of probes share the ultrasonic receiver, and the two groups of probes do not work simultaneously.
The dual-mode ultrasonic probe module is set to be in two working modes of point detection and surface detection, and each group of ultrasonic probes works as one mode. The point detection working mode aims at a shallow part of a blood vessel, and uses a first transmitter and two receivers, wherein the first transmitter comprises 8-32 transmitting units, and the frequency of ultrasonic waves is 5-12 MHz.
The incident angle of the first emitter is 90 degrees, the first emitter is perpendicular to blood flow to be measured, the included angle between the receiver and the first emitter relative to a measured target is more than or equal to 10 degrees and less than or equal to 74 degrees, the ideal included angle is 10-15 degrees, and the distance between a path through which ultrasonic wave is emitted and a path through which the ultrasonic wave is reflected is approximately the same. The ideal frequency of the ultrasonic wave of the first transmitter is 8-10 MHz.
Referring again to FIG. 2, 1 is a dual mode ultrasound probe module, with black shading for the first transmitter and white for the receiver. Alpha is an included angle between a transmitting route of the first transmitter and a receiving route of the receiver, the included angles between the transmitting route of the first transmitter and the receiving routes of the two receivers are approximately the same, the angle range is 10-74 degrees, and the ideal angle is 10-15 degrees. 2 is the ultrasonic emission route of the transmitter, perpendicular to the blood flow to be measured, and 3 is the ultrasonic trajectory scattered and received by the receiver.
And in the surface detection working mode, aiming at the flow velocity detection of a deeper blood vessel, the sound waves emitted by the two second emitters form a detection area falling on the blood flow to be detected. If the region has a part which is overlapped with the blood flow, the frequency of the reflected ultrasonic wave of the part is changed, and the blood flow velocity to be measured can be obtained.
In the surface detection working mode, the incident angle of the second transmitter is 15-30 degrees, the number of the incident units of the second transmitter is 8-32, the average measurement error of the transmitter formed by 16 or 32 incident units is the minimum by adopting the 15-degree incident angle, and the detection precision is high.
As shown in fig. 3, 1 is a dual mode ultrasonic probe module. The black shading in 1 is the second emitter and white is the receiver. Beta is an incident angle, the angle range is 10-30 degrees, the ideal angle range is 15-30 degrees, alpha' is an included angle between the emitter and the receiver, the included angle range is 10-74 degrees, and the ideal included angle range is 10-15 degrees. 4 is the incident track of sound wave, 6 is the track of ultrasonic wave received by the receiver, and 5 is the diamond-shaped coverage area formed in the surface detection working mode, therefore, under the same condition, the method has larger detection coverage area and detection depth, and the position has certain error when measurement is allowed.
The detection area of the point detection working mode is small, if the single wave beam is not directly incident on blood flow, the blood flow parameters cannot be acquired, the surface detection working mode provides a large allowable incidence error range, blood flow data can be acquired more conveniently, and according to experimental results, the working mode is higher in accuracy compared with the point detection working mode of a traditional receiving and sending mode. Therefore, if the body of the patient is thin and the vein vessel at the venous end of the fistulization part is shallow, a point detection working mode can be selected; if the patient is fat in physique, the subcutaneous fat is thick, or the vein end of the fistulization part is deep, the surface detection working mode can be selected.
As shown in fig. 4, the present application also relates to a real-time detection device with a real-time detection system, wherein 100 is a dual-mode ultrasonic probe comprising a dual-mode ultrasonic probe module 1, 100 is a first transmitting probe in which a first transmitter is located, 8 and 10 are second transmitting probes in which a second transmitter is located, 7 and 11 are receiving probes in which a receiver is located, and the two receiving probes are common, and the transmitting probe 9 and the receiving probes 7 and 11 operate in a point detection operation mode. The transmitting probes 8, 10 and the receiving probes 7, 11 are operated in a surface probing mode of operation. The distance between two adjacent probes between the emission probes 8, 9 and 10 is 2-8 mm, and the distance between the emission probes 8 and 10 and the adjacent receivers 7 and 11 is 2-5 mm.
As shown in fig. 5, in a specific embodiment, the real-time fistula thrombus detection device is in a shape of a wristwatch and comprises a wrist strap 13, a display screen and a detection component 12, wherein the detection component 12 comprises a dual-mode ultrasonic probe and a flexible cushion block, the dual-mode ultrasonic probe is embedded in a first side surface of the flexible cushion block, a detection surface is exposed, and a second side surface of the flexible cushion block, which is opposite to the first side surface, is fixedly connected with the surface of the wrist strap, so that the detection surface protrudes out of the surface of the wrist strap 13, and the requirement of an ultrasonic incident angle can be guaranteed. The wrist band 13 is made of elastic material, and the generated elastic force can provide certain pressure for the probe to contact the skin and ensure that the blood vessel is not pressed.
In addition, the detection system of the invention specifically comprises the following steps:
the main control module controls the ultrasonic driving module to drive the ultrasonic transmitter and the ultrasonic receiver to work according to different working modes, the ultrasonic receiver receives ultrasonic signals scattered back by red blood cells and converts the ultrasonic signals into electric signals to be sent to the ultrasonic driving module, the driving module converts the electric signals into required original data to be read by the main control module, the main control module reads the original data to process the original data to obtain Doppler frequency shift related to blood flow speed, blood flow speed is calculated according to the relation between the Doppler frequency shift and the movement speed of a measured object, and the data is stored to give a system structure schematic diagram shown in figure 1.
In conclusion, the invention has the following beneficial effects:
(1) the portability of intelligent wearable electronic products and the accuracy of ultrasonic fluid detection based on the Doppler effect are combined, and the defect that the conventional internal fistula thrombus detection method cannot realize daily real-time detection and invasive detection is overcome.
(2) Novel ultrasonic probe overall arrangement and multiple working mode provide detection angle on a large scale and solved wearing formula ultrasonic testing scheme measuring depth in the past and be difficult for adjusting and be difficult for satisfying specific incident or reflection angle's shortcoming to the result is more accurate, through detecting, under second kind working mode, with 15 incident angle tests, survey the subcutaneous blood vessel model that the target depth is 14mm, the measured depth is 14.96mm, error range is less than 1mm, and the measured depth that the mode that adopts traditional one to launch one to receive under same condition was surveyed is 15.28 mm. And the mode two can form the coverage area, and this area has the coincidence with the blood flow and can detect the blood flow parameter, has avoided single beam detection scope too narrow and incident inaccurate the measuring of causing can't arrive actual blood flow condition.
(3) The main control module and an algorithm carried by upper computer software acquire Doppler frequency shift parameters related to blood flow velocity by using an ultrasonic Doppler effect, and obtain current blood flow velocity parameters through data processing and analysis, so that early warning and reference are provided for the growth condition of the internal fistula thrombus.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (7)
1. Real-time detection system of internal fistula thrombus, its characterized in that, real-time detection system of internal fistula thrombus includes: the ultrasonic probe comprises a main control module, an ultrasonic probe driving module, a dual-mode ultrasonic probe module, a display module, a wireless transmission module and a storage module;
the dual-mode ultrasonic probe module is provided with two working modes of point detection and surface detection, is used for sending an ultrasonic signal, receiving a scattering signal scattered back by red blood cells, converting the scattering signal into an electric signal and sending the electric signal to the ultrasonic probe driving module;
the ultrasonic probe driving module is connected with the dual-mode ultrasonic probe module and used for driving the dual-mode ultrasonic probe module to work according to a required working mode, converting an echo signal into Doppler frequency shift original data and sending the Doppler frequency shift original data to the main control module;
the main control module is connected with the ultrasonic probe driving module and used for controlling the ultrasonic probe driving module to select different ultrasonic probe working modes according to requirements, receiving and processing Doppler frequency shift original data transmitted by the ultrasonic probe driving module and generating blood flow rate; the display module is connected with the main control module and used for receiving a user instruction and displaying the blood flow rate and the growth condition of the internal fistula thrombus;
the storage module is connected with the main control module, exchanges data with the main control module, and is used for storing blood flow rate data, establishing a local database of arteriovenous fistula health records, or sending the stored blood flow rate data to the main control module, and then controlling the wireless transmission module to send the data to an upper computer end through the main control module to perform later analysis and operation;
the wireless transmission module is connected with the main control module and the wireless signal and used for data exchange;
wherein the dual-mode ultrasonic probe module comprises a first transmitter, two second transmitters and two receivers, and the two receivers are in signal connection with the ultrasonic probe driving module;
the first transmitter is matched with the two receivers to form a point detection working mode, and a point area which is vertically covered by ultrasonic waves of blood flow to be detected and is sent by the first transmitter is detected;
the two second transmitters are matched with the two receivers to form a surface detection working mode, and ultrasonic waves with an incidence angle beta, which are respectively sent by the two second transmitters, are detected in a surface area overlapped in the blood flow to be detected;
the first transmitter is positioned in the middle, the two second transmitters are respectively positioned at two sides of the first transmitter, and the two receivers are respectively positioned at the outer sides of the two second transmitters in a one-to-one correspondence manner; the first transmitter comprises 8-32 transmitting units, and the two second transmitters comprise 8-32 transmitting units, wherein beta is 15 degrees.
2. The system for real-time detection of internal fistula thrombus of claim 1,
an included angle between a transmitting route of the first transmitter and a receiving route of each corresponding receiver is alpha, alpha is more than or equal to 10 degrees and less than or equal to 74 degrees, and the frequency of ultrasonic waves emitted by the first transmitter is 5-12 MHz;
an included angle between a transmitting route of each second transmitter and a receiving route of the corresponding receiver is alpha ', alpha' is more than or equal to 10 degrees and less than or equal to 74 degrees, and the frequency of ultrasonic waves emitted by the two second transmitters is 8-10 MHz.
3. The system for real-time detection of internal fistula thrombus of claim 2,
α ═ α', the two second transmitters comprising 16 or 32 transmission units.
4. The system for real-time detection of internal fistula thrombus of claim 1,
the ultrasonic probe driving module comprises a probe driving circuit unit, a working mode selection unit and an original data acquisition unit, and the main control module comprises a task management and peripheral control unit and a data processing unit;
the task management and peripheral control unit is in two-way communication with the wireless transmission module, the display module and the storage module and is in one-way communication with the working mode selection unit, the probe driving circuit unit and the dual-mode ultrasonic probe module in sequence, and the data processing unit is in two-way communication with the task management and peripheral control unit and the storage module respectively and is in one-way communication with the original data acquisition unit and the dual-mode ultrasonic probe module in sequence.
5. The system for real-time detection of internal fistula thrombus of claim 1,
the real-time detection system of internal fistula thrombus still includes power module, power module adopts rechargeable battery power supply, rechargeable battery charges through wireless or wired mode.
6. Real-time detection apparatus comprising a real-time detection system according to any one of claims 1 to 5,
the real-time detection device is provided with a detection component, the detection component is provided with a dual-mode ultrasonic probe comprising the dual-mode ultrasonic probe module, a detection surface of the dual-mode ultrasonic probe is provided with a first transmitting probe, two second transmitting probes and two receiving probes which are linearly arranged, the first transmitter is positioned in the first transmitting probe, the second transmitter is positioned in the second transmitting probe, and the receiver is positioned in the receiving probes.
7. The real-time detection apparatus of claim 6,
the detection component is also provided with a flexible cushion block, the real-time detection device is also provided with a wrist strap, the dual-mode ultrasonic probe is embedded in a first side face of the flexible cushion block, a detection face is exposed, and a second side face, opposite to the first side face, of the flexible cushion block is fixedly connected with the surface of the wrist strap;
the first transmitting probe is located at the center of the linear arrangement, the two receiving probes are located at two ends of the linear arrangement respectively, the distance between every two adjacent transmitting probes is 2-8 mm, and the distance between the second transmitting probe and the adjacent receiving probes is 2-5 mm.
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| US11717255B2 (en) | 2016-08-05 | 2023-08-08 | Cimon Medical As | Ultrasound blood-flow monitoring |
| ES2903403T3 (en) | 2016-08-05 | 2022-04-01 | Cimon Medical As | Ultrasound blood flow monitoring |
| CN107789009A (en) * | 2017-11-20 | 2018-03-13 | 广东里田科技有限公司 | Based on the blood flow detection system and blood flow detection method being wirelessly transferred |
| EP3505071B1 (en) * | 2017-12-28 | 2022-03-16 | Przedsiebiorstwo Wdrozeniowo-Produkcyjne Sonomed sp. z o. o. | Ultrasound probe for continuous wave doppler device and use of thereof |
| CN108938006A (en) * | 2018-06-12 | 2018-12-07 | 李宏博 | A kind of vascular surgery blood flow speed detector |
| CN110037742B (en) * | 2019-04-08 | 2024-02-20 | 深圳市贝斯曼精密仪器有限公司 | Ultrasonic blood flow detection probe and detection device |
| CN110522471A (en) * | 2019-10-09 | 2019-12-03 | 业成科技（成都）有限公司 | Wearable physiologic information measuring device |
| CN112998754B (en) * | 2021-02-20 | 2022-07-19 | 苏州大学 | Noninvasive blood flow detection method, detection system and detection equipment |
| CN113243903A (en) * | 2021-04-16 | 2021-08-13 | 顺德职业技术学院 | Device and system are protected to ease heart of arteriovenous fistula |
| CN113786211B (en) * | 2021-09-17 | 2022-11-22 | 云南大学 | Ultrasonic erythrocyte aggregation degree detection and regulation system |
| CN114504345A (en) * | 2022-02-24 | 2022-05-17 | 南充市中心医院 | Convenient wearing detection ring capable of monitoring internal fistula function of dialysis patient in daily life |
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| CN2125370U (en) * | 1992-07-18 | 1992-12-23 | 孙立 | Continuous ultrasonic wave doppler searching unit |
| US20070167798A1 (en) * | 2005-11-23 | 2007-07-19 | Cai Anming H | Contrast agent augmented ultrasound therapy system with ultrasound imaging guidance for thrombus treatment |
| JP2015066219A (en) * | 2013-09-30 | 2015-04-13 | セイコーエプソン株式会社 | Ultrasonic measuring apparatus and ultrasonic measuring method |
| CN205251574U (en) * | 2015-12-12 | 2016-05-25 | 梁静 | Be used for uremia hemodialysis internal fistula bracelet of testing oneself |
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