CN107281443A - 一种散寒活血止痛的药物组合物及其制备方法和用途 - Google Patents

一种散寒活血止痛的药物组合物及其制备方法和用途 Download PDF

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CN107281443A
CN107281443A CN201710487895.XA CN201710487895A CN107281443A CN 107281443 A CN107281443 A CN 107281443A CN 201710487895 A CN201710487895 A CN 201710487895A CN 107281443 A CN107281443 A CN 107281443A
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CN107281443B (zh
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董顺坤
王文雷
李多
赵光弟
王永保
邓裕全
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Nanchong Traditional Chinese Medicine Hospital
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Abstract

本发明提供了一种药物组合物，它是由下述重量配比的原料制备而成：川乌20‑50份、草乌20‑50份、姜黄20‑50份、天南星10‑40份、半夏20‑50份、莪术30‑60份、三棱30‑60份、独活30‑60份、细辛10‑40份、当归30‑60份、红花10‑40份、桃仁20‑50份、大黄30‑60份、赤芍30‑60份、自然铜10‑40份、香加皮30‑60份、续断40‑80份、骨碎补30‑60份、川牛膝30‑60份、白蔹20‑50份、栀子40‑80份、白芷40‑80份、麻黄30‑60份、泽兰40‑80份。本发明还提供了所述药物组合物的制备方法和用途。本发明药物组合物生产工艺简单，便于携带，散寒活血止痛疗效确切、无毒副作用。

Description

一种散寒活血止痛的药物组合物及其制备方法和用途
技术领域
本发明涉及一种散寒活血止痛的药物组合物及其制备方法和用途，属于药物领域。
技术背景
寒湿痹痛多因风寒湿三气杂至，致气血瘀滞，证见身重而痛，四肢拘挛，甚则走注疼痛，或手足麻木等。是外邪侵袭经络，气血闭阻不畅，引起关节、肢体等处出现酸、痛、麻、重及屈伸不利等症状。风、寒、湿之邪往往相互为虐，方能成病。风为阳邪开发腠理，又具穿透之力，寒借此力内犯，风又借寒凝之积，使邪附病位，而成伤人致病之基。湿邪借风邪的疏泄之力，寒邪的收引之能，而入侵筋骨肌肉，风寒又借湿邪之性，黏着、胶固于肢体而不去。
风、寒、湿病邪留注肌肉、筋骨、关节，造成经络壅塞，气血运行不畅，肢体筋脉拘急、失养为本病的基本病机。但风寒湿病邪为患，各有侧重，风邪甚者，病邪流窜，病变游走不定；寒邪甚者，肃杀阳气，疼痛剧烈；湿邪甚者，黏着凝固，病变沉着不移。痹病日久不愈，气血津液运行不畅之病变日甚，血脉瘀阻，津液凝聚，痰瘀互结，闭阻经络，深入骨骱，出现皮肤瘀斑、关节肿胀畸形等症，甚至深入脏腑，出现脏腑痹的证候。初病属实，久病必耗伤正气而虚实夹杂，伴见气血亏虚，肝肾不足的证候。
现有报道治疗淤血肿痛，寒湿痹痛等病症的药物大多用药量大，药物服用时间较长，制备工艺复杂。
发明内容
本发明的目的在于提供一种散寒活血止痛的药物组合物。
本发明的另一目的是提供所述组合物的制备方法和用途。
本发明提供了一种药物组合物，它是由下述重量配比的原料制备而成：生川乌20-50份、生草乌20-50份、生天南星10-40份、生半夏20-50份、莪术30-60份、三棱30-60份、姜黄20-50份、独活30-60份、细辛10-40份、当归30-60份、红花10-40份、桃仁20-50份、大黄30-60份、赤芍30-60份、自然铜10-40份、香加皮30-60份、续断40-80份、骨碎补30-60份、川牛膝30-60份、白蔹20-50份、栀子40-80份、白芷40-80份、麻黄30-60份、泽兰40-80份。
优选地，所述的药物组合物是由下述重量配比的原料制备而成：生川乌33份、生草乌33份、生天南星22份、生半夏33份、莪术45份、三棱45份、姜黄33份、独活45份、细辛22份、当归45份、红花22份、桃仁33份、大黄45份、赤芍45份、自然铜22份、香加皮45份、续断67份、骨碎补45份、川牛膝45份、白蔹33份、栀子67份、白芷67份、麻黄45份、泽兰67份。
其中，所述药物组合物是由所述原料的原生药粉，或者水或有机溶剂提取物为活性成分，加上药学上可接受的辅料或者辅助性成分制备而成制剂。
其中，所述辅料为植物油或矿物油。
其中，所述所述制剂是外用制剂。
其中，所述外用制剂是散剂、搽剂、软膏剂、糊剂、贴剂或散剂。
本发明提供了所述药物组合物的制备方法，包括如下步骤：
a)称取各重量配比的原料药；
b)粉碎成细粉，过筛，混匀，即得。
本发明提供了所述药物组合物在制备治疗风湿痹痛的药物中的用途。
具体的，本发明提供了所述药物组合物在制备肢体疼痛、肿胀和/或晨僵的药物中的用途。
本发明药物组合物是由生川乌、生草乌、生天南星、生半夏、莪术、三棱、姜黄、独活、细辛、当归、红花、桃仁、大黄、赤芍、自然铜、香加皮、续断、骨碎补、川牛膝、白蔹、栀子、白芷、麻黄、泽兰二十四味原料药组成。本发明所述组合物中：生川乌、生草乌温通经脉，祛风散寒除湿，生天南星、生半夏辛温，能消肿散结止痛，共为君药。莪术、三棱破血祛瘀，消肿止痛，姜黄破血行气，通经止痛。独活祛风渗湿，散寒止痛，细辛温经散寒，共以祛风散寒，温经止痛。当归、红花、桃仁、大黄、赤芍补血活血，行气化瘀，共为臣药。香加皮、川牛膝、续断、骨碎补、自然铜补肾强筋，活血散瘀，续骨疗伤。白蔹、栀子苦、寒，既可清热解毒、消肿散结，又可佐制诸辛热之品。麻黄、泽兰、白芷辛香走窜，发汗散寒，利水消肿、止痛共为佐、使药。诸药合用共收活血祛瘀，消肿止痛，温经散寒之功效。
本发明药物具有活血祛瘀，消肿止痛，温经散寒的功效，采用外敷的方式，克服了患者服药困难的技术难点，并且能够迅速起效。本发明药物组合物制备工艺简单，使用方便。
根据本发明的上述内容，按照本发明相关领域的普通技术知识和惯用手段，在不脱离本发明上述基本技术思想前提下，还可以做出其它多种形式的修改、替换或变更。
具体实施方式
实施例1本发明药物组合物的制备
1.原料：生川乌33g、生草乌33g、生天南星22g、生半夏33g、莪术45g、三棱45g、姜黄33g、独活45g、细辛22g、当归45g、红花22g、桃仁33g、大黄45g、赤芍45g、自然铜22g、香加皮45g、续断67g、骨碎补45g、川牛膝45g、白蔹33g、栀子67g、白芷67g、麻黄45g、泽兰67g。
2.制备方法：a)称取各重量配比的原料药；b)粉碎成细粉，过筛，混匀，即得。
3.使用方法：外用，用植物油或矿物油调敷患处。
实施例2本发明药物组合物的制备
1.原料：生川乌20g、生草乌20g、生天南星10g、生半夏20g、莪术30g、三棱30g、姜黄20g、独活30g、细辛10g、当归30g、红花10g、桃仁20g、大黄30g、赤芍30g、自然铜10g、香加皮30g、续断40g、骨碎补30g、川牛膝30g、白蔹20g、栀子40g、白芷40g、麻黄30g、泽兰40g。
2.制备方法：制备方法：a)称取各重量配比的原料药；b)粉碎成细粉，过筛，混匀，即得。
3.使用方法：外用，用植物油或矿物油调敷患处。
实施例3本发明药物组合物的制备
1.原料：生川乌50g、生草乌50g、生天南星30g、生半夏50g、莪术60g、三棱60g、姜黄50g、独活60g、细辛40g、当归60g、红花40g、桃仁50g、大黄60g、赤芍60g、自然铜40g、香加皮60g、续断80g、骨碎补60g、川牛膝60g、白蔹50g、栀子80g、白芷80g、麻黄60g、泽兰80g。
2.制备方法：制备方法：a)称取各重量配比的原料药；b)粉碎成细粉，过筛，混匀，即得。
3.使用方法：外用，用植物油或矿物油调敷患处。
以下通过具体临床试验证明本发明的有益效果：
试验例1：本发明组合物的临床疗效
1、临床资料
1.1诊断标准：
肢体疼痛，肿胀，晨僵
1.2纳入标准
符合1.1节诊断标准的病例均纳入。
2、治疗方法
实验组：给予本发明实施例1的药物。
具体给药方法为：给予本发明实施例1的使用方法。
3、疗效观察
3.1疗效标准：
治愈：肢体疼痛、肿胀消失，活动功能正常，实验室检查正常。
好转：肢体疼痛、肿胀减轻，活动功能好转，实验室检查有改善。
未愈：肢体疼痛、肿胀及实验室检查无变化。
3.2治疗结果
如表1所示：
组别 治愈 好转 未愈 有效率
实验组(200人) 182 14 4 98％
临床结果表明，本发明对肢体疼痛，肿胀，晨僵有良好的治疗效果，200例用药组中治愈182例，好转14例，未愈4例，总有效率达到98％，未见不良反应。
本发明药物组合物生产工艺简单，便于携带，散寒活血止痛疗效确切、无毒副作用。

Claims (9)

1.一种药物组合物，其特征在于：它是由下述重量配比的原料制备而成：川乌20-50份、草乌20-50份、天南星10-40份、半夏20-50份、莪术30-60份、三棱30-60份、姜黄20-50份、独活30-60份、细辛10-40份、当归30-60份、红花10-40份、桃仁20-50份、大黄30-60份、赤芍30-60份、自然铜10-40份、香加皮30-60份、续断40-80份、骨碎补30-60份、川牛膝30-60份、白蔹20-50份、栀子40-80份、白芷40-80份、麻黄30-60份、泽兰40-80份。
2.根据权利要求1所述药物组合物，其特征在于；它是由下述重量配比的原料制备而成：川乌33份、草乌33份、天南星22份、半夏33份、莪术45份、三棱45份、姜黄33份、独活45份、细辛22份、当归45份、红花22份、桃仁33份、大黄45份、赤芍45份、自然铜22份、香加皮45份、续断67份、骨碎补45份、川牛膝45份、白蔹33份、栀子67份、白芷67份、麻黄45份、泽兰67份。
3.根据权利要求1或2任意一项所述的药物组合物，其特征在于：所述川乌、草乌、天南星、半夏为生川乌、生草乌、生天南星、生半夏。
4.根据权利要求1-3任意一项所述的药物组合物，其特征在于：它是由所述原料的原生药粉，或水或有机溶剂提取物为活性成分，加上药学上可接受的辅料或者辅助性成分制备而成的制剂。
5.根据权利要求4所述药物组合物，其特征在于：所述制剂是外用制剂。
6.根据权利要求5所述药物组合物，其特征在于：所述外用制剂是散剂、搽剂、软膏剂、糊剂、贴剂或散剂。
7.权利要求1-6任意一项所述药物组合物的制备方法，包括如下步骤：
a)称取各重量配比的原料药；
b)粉碎成细粉，过筛，混匀，即得。
8.权利要求1-6任意一项所述的药物组合物在制备治疗风湿痹痛的药物中的用途。
9.权利要求1-6任意一项所述的药物组合物在制备肢体疼痛、肿胀和/或晨僵的药物中的用途。
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