CN107281253B - Composition for remarkably improving anti-aging and beautifying functions, preparation method and application thereof - Google Patents
Composition for remarkably improving anti-aging and beautifying functions, preparation method and application thereof Download PDFInfo
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- CN107281253B CN107281253B CN201710538622.3A CN201710538622A CN107281253B CN 107281253 B CN107281253 B CN 107281253B CN 201710538622 A CN201710538622 A CN 201710538622A CN 107281253 B CN107281253 B CN 107281253B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a composition for remarkably improving anti-aging, beautifying and health-care functions, a preparation method and application thereof. The composition consists of 24-48% of haematococcus pluvialis solid dispersion, 12-21% of donkey-hide gelatin, 29-39% of poria cocos and 16-20% of blueberries in percentage by mass. Wherein the haematococcus pluvialis solid dispersion astaxanthin accounts for 2.0-3.0% by weight; melting the donkey-hide gelatin, and adding beta-cyclodextrin according to the mass ratio (m/m) of 50:10-30 to prepare donkey-hide gelatin instant powder; extracting tuckahoe with water and depositing tuckahoe with alcohol to obtain tuckahoe extract containing tuckahoe water soluble polysaccharide in 1.5-2.5 wt%; the blueberries are dehydrated and crushed to prepare the blueberry fruit powder. Experiments show that the composition can obviously reduce the MDA content in each organ tissue of a rat, obviously increase the activities of SOD and GSH-Px enzymes, effectively improve the oxidation resistance of the rat with D-galactose senescence, and has the functions of high-efficiency anti-senescence, beauty and health care.
Description
Technical Field
The invention relates to a composition for remarkably improving anti-aging, beautifying and health-care functions. In particular to a haematococcus pluvialis solid dispersion, donkey-hide gelatin instant powder, tuckahoe extract and blueberry powder compatible composition, a preparation method and application thereof.
Technical Field
Senescence (Agmg), which is the degeneration of cells, tissues and organs of an organism in structure and function, is a process that remains in evolution and is affected by both genetic and environmental factors. With the rapid development of modern genetics, molecular biology, cell biology, molecular immunology and other subjects, people put forward a plurality of theories on aging, wherein the theory of free radicals is one of the most convincing theories of aging. At present, life, work environment, staying up all night, anxiety, diet and the like all aggravate aging and diseases. Slowing down aging, and even extending the life of humans, is of increasing concern.
Haematococcus pluvialis meal has obtained FDA approval in the united states to enter the health care market as a new dietary ingredient; japan also approves its application in the food and feed industries; the european union also has haematococcus pluvialis-related product registration. The Ministry of health in China approved Haematococcus pluvialis as a new resource food (Notification No. 17 in 2010) in 10 months in 2010, and from then on, the heat tide of domestic system research, development and application of Haematococcus pluvialis was raised. The invention discloses a haematococcus pluvialis solid dispersion, a preparation method and application thereof (patent number: 201710302999.9) applied by Yunnan De Cao biological medicine science and technology Limited company, and discloses a preparation method and application of the haematococcus pluvialis solid dispersion. The haematococcus pluvialis solid dispersion is prepared by subjecting haematococcus pluvialis to CO2Supercritical extracted dry algae residue, Haematococcus pluvialis CO2The supercritical extract is composed of microcapsule powder prepared by inclusion microencapsulation and solid dispersion carrier. The patent also provides a preparation method and application of the haematococcus pluvialis solid dispersion.
Donkey-hide gelatin, as a traditional substance of homology of medicine and food, was originally recorded in Shen nong's herbal Jing and listed as the top grade, is a nourishing famous and precious Chinese medicinal material which inherits more than 3000 years and is honored by doctors of all ages as a blood-enriching holy medicine. The donkey-hide gelatin has reputation of beauty treatment and face care since ancient times, and the Ming dynasty Jiangnan famous Hejun Shengzan donkey-hide gelatin can tonify qi and nourish blood, nourish yin and moisten dryness and is beneficial to yin and longevity.
Poria cocos, as a traditional medicine and food homologous substance, has a history of being eaten for more than two thousand years in China, and is listed as the "superior product" in Shen nong Ben Cao Jing, which is called as "long-term taking of Anhui spirit-nourishing, no hunger and prolonging life".
The blueberry has fine pulp, moderate sweetness and sourness and extremely rich nutrition, has the reputation of the king of berries, is a fruit with higher nutritive value and economic value, has positive effects on the prevention and treatment of various diseases, and is more and more concerned by people in recent years.
The invention aims to prepare the specific composition of the invention by combining the haematococcus pluvialis solid dispersion prepared by the patent technology of Yunnan De Cao Tang biological medicine science and technology Limited company, namely haematococcus pluvialis solid dispersion, a preparation method and application thereof (patent number: 201710302999.9), with donkey-hide gelatin, poria cocos and blueberries according to a specific proportion, a specific process and a specific quality control technology. Experiments show that: compared with the composition prepared from the specific composition substances and the specific composition substances which are not in the composition proportion, the composition provided by the invention can obviously enhance the in-vivo oxidation resistance of the rats with the D-galactose senescence, and has the efficient anti-senescence, beauty and health care functions.
Disclosure of Invention
The invention aims to provide a composition for remarkably improving the anti-aging, beautifying and health-care functions and a preparation method thereof. The second purpose is to provide the application of the composition.
The first object of the present invention is achieved by the following technical means.
Firstly, the invention provides a composition for remarkably improving the anti-aging, beautifying and health-care functions, which consists of 24-48% of haematococcus pluvialis solid dispersion, 12-21% of donkey-hide gelatin, 29-39% of poria cocos and 16-20% of blueberries in percentage by mass.
Preferably, the composition consists of 27-42% of haematococcus pluvialis solid dispersion, 19-21% of donkey-hide gelatin, 29-31% of poria cocos and 17-19% of blueberries in percentage by mass.
Most preferably, the composition consists of 30-36% of haematococcus pluvialis solid dispersion, 21% of donkey-hide gelatin, 29% of poria cocos and 18% of blueberries in percentage by mass.
Secondly, the haematococcus pluvialis solid dispersion system is prepared by adopting the technology of the patent of haematococcus pluvialis solid dispersion, the preparation method and the application thereof (patent number: 201710302999.9) applied by Yunnan Delphaea biological medicine science and technology Limited company. Wherein the mass percentage content of the astaxanthin is 2.0-3.0%; preferably 2.2% -2.8%; most preferably 2.4-2.6%.
Thirdly, the donkey-hide gelatin is prepared into the donkey-hide gelatin instant powder by the process steps of crushing, adding a proper amount of cold water, heating, melting, adding a saturated aqueous solution of beta-cyclodextrin, spray drying and the like. The method specifically comprises the following process steps:
step 1: the mass ratio (m/m) of the donkey-hide gelatin to the beta-cyclodextrin is 50: 10-30; preferably 50: 15-25; further preferably 50: 18-22; most preferably 50: 19 to 21.
Step 2: crushing colla Corii Asini, adding appropriate amount of cold water, heating and melting to relative density of 1.10 (measured at 60 deg.C), and keeping the temperature at 60 deg.C; beta-cyclodextrin is added with hot water of 60 ℃ to prepare saturated aqueous solution. Mixing the above two solutions uniformly to obtain a 60 deg.C mixed solution.
And step 3: transferring the mixed solution of 60 ℃ prepared in the step 2 to spray drying equipment, setting the inlet temperature to be 165 ℃, the liquid supply speed to be 15 percent and the compressed air flow to be 45 L.h-1. And starting the machine to preheat to specified parameters, then carrying out spray drying, and collecting powder to obtain the finished product.
In addition, the poria cocos needs to be sliced, added with water with the mass-to-volume ratio (m/v) of 1:6, soaked for 3 hours, heated, refluxed and extracted for 3 times, and the time is 3 hours, 2 hours and 1 hour respectively. Mixing the extractive solutions for 3 times, filtering to remove insoluble impurities, adding equal volume of 95% ethanol under stirring, standing for 12 hr, centrifuging, collecting precipitate, adding water, boiling for dissolving, adjusting with 95% ethanol until the ethanol content reaches 80%, standing, precipitating brown precipitate, filtering, drying at low temperature, pulverizing, and sieving with 80 mesh sieve to obtain Poria extract. Wherein, the mass percentage of the water-soluble polysaccharide in the extract is 1.5-2.5%; preferably 1.7 to 2.3 percent; more preferably 1.9% to 2.1%.
Finally, the blueberry is blueberry powder which is prepared by adopting fresh blueberries artificially planted and harvested, dehydrating, drying, crushing and sieving with a 80-mesh sieve.
Weighing haematococcus pluvialis solid dispersoid, donkey-hide gelatin, poria cocos and blueberries according to the mass percentage and the preferable mass percentage. The composition is prepared by preparing donkey-hide gelatin and poria cocos into donkey-hide gelatin instant powder and poria cocos extracts according to the method, placing the donkey-hide gelatin instant powder and the poria cocos extracts in a clean stainless steel container, adding haematococcus pluvialis solid dispersoid and blueberries, and fully stirring and uniformly mixing the mixture.
The second purpose of the invention is realized by adopting the following technical scheme:
firstly, the composition has the functions/efficacies of anti-aging and beautifying, and can be used as a raw material for researching and developing medicines, health-care foods, functional common foods, special medical foods and special dietary foods.
Secondly, the composition can be further prepared into solid oral preparations such as powder, granules, tablets, hard capsules and the like with or without adding acceptable auxiliary materials of medicines, health-care foods, functional common foods, special medical foods and special dietary foods according to the requirements.
Detailed Description
Example 1 Haematococcus pluvialis solid Dispersion and blueberry preparation
The haematococcus pluvialis solid dispersion is prepared according to the patent technology applied to haematococcus pluvialis solid dispersion, a preparation method and application thereof (patent number: 201710302999.9) by Yunnan Decolotang biological medicine science and technology limited company. The content of astaxanthin is detected to be 2.5%.
The blueberry is prepared from artificially planted and harvested fresh blueberries by dehydrating, drying, crushing and sieving with a 80-mesh sieve.
Example 2: preparation of instant powder of donkey-hide gelatin 1
According to the formula of donkey-hide gelatin: weighing colla Corii Asini and beta-cyclodextrin at a mass ratio (m/m) of 50: 10. Crushing colla Corii Asini, adding appropriate amount of cold water, heating and melting to relative density of 1.10 (measured at 60 deg.C), and keeping the temperature at 60 deg.C; beta-cyclodextrin is added with hot water of 60 ℃ to prepare saturated aqueous solution. Mixing the above two solutions uniformly to obtain a 60 deg.C mixed solution. Transferring the mixed solution to spray drying equipment, setting inlet temperature at 165 deg.C, liquid supply speed at 15%, and compressed air flow at 45 L.h-1And after the machine is started and preheated to specified parameters, carrying out spray drying and collecting powder to obtain the powder.
Example 3: preparation of instant powder of colla Corii Asini 2
According to the formula of donkey-hide gelatin: weighing colla Corii Asini and beta-cyclodextrin at a mass ratio (m/m) of 50: 15. The donkey-hide gelatin instant powder is prepared according to the example 2.
Example 4: preparation of instant powder of colla Corii Asini 3
According to the formula of donkey-hide gelatin: weighing colla Corii Asini and beta-cyclodextrin at a mass ratio (m/m) of 50: 20. The donkey-hide gelatin instant powder is prepared according to the example 2.
Example 5: preparation of instant powder of donkey-hide gelatin 4
According to the formula of donkey-hide gelatin: weighing colla Corii Asini and beta-cyclodextrin at a mass ratio (m/m) of 50: 25. The donkey-hide gelatin instant powder is prepared according to the example 2.
Example 6: preparation of Poria extract
Slicing Poria, adding water at a mass-to-volume ratio (m/v) of 1:6, soaking for 3 hr, and extracting under reflux for 3 times (3 hr, 2 hr and 1 hr respectively). Mixing the extractive solutions for 3 times, filtering to remove insoluble impurities, adding equal volume of 95% ethanol under stirring, standing for 12 hr, centrifuging, collecting precipitate, adding water, boiling for dissolving, adjusting with 95% ethanol until the ethanol content reaches 80%, standing, precipitating brown precipitate, filtering, drying at low temperature, pulverizing, and sieving with 80 mesh sieve to obtain Poria extract. Through detection, the mass percentage content of the water-soluble polysaccharide is 2.0%.
Example 7: preparation of the composition 1
238g of haematococcus pluvialis solid dispersion prepared in example 1 and 159g of blueberries were taken. Taking 119g of donkey-hide gelatin and 347g of poria cocos, wherein the donkey-hide gelatin is prepared into donkey-hide gelatin instant powder according to the embodiment 2; poria cocos wolf was prepared as in example 6 into a Poria cocos extract. Placing colla Corii Asini instant powder and Poria extract in dry and clean container, adding Haematococcus pluvialis solid dispersion and fructus Myrtilli, stirring thoroughly to mix well, and sieving with 80 mesh sieve to obtain the final product.
Example 8: preparation of the composition 2
354.6g of haematococcus pluvialis solid dispersion prepared in example 1 and 187.15g of blueberries are taken. 177.3g of donkey-hide gelatin and 344.75g of poria cocos, wherein the donkey-hide gelatin is prepared into donkey-hide gelatin instant powder according to the embodiment 3; poria cocos wolf was prepared as in example 6 into a Poria cocos extract. Placing colla Corii Asini instant powder and Poria extract in dry and clean container, adding Haematococcus pluvialis solid dispersion and fructus Myrtilli, stirring thoroughly to mix well, and sieving with 80 mesh sieve to obtain the final product.
Example 9: preparation of the composition 3
2723g of haematococcus pluvialis solid dispersion prepared in example 1 and 1532g of blueberries were taken. 1787g colla Corii Asini and 2468g Poria, wherein the instant powder of colla Corii Asini is prepared according to example 4; poria cocos poria extract was prepared as in example 6. Placing colla Corii Asini instant powder and Poria extract in dry and clean container, adding Haematococcus pluvialis solid dispersion and fructus Myrtilli, stirring thoroughly to mix well, and sieving with 80 mesh sieve to obtain the final product.
Example 10: composition preparation 4 (with the exception of specific bits)
708g of haematococcus pluvialis solid dispersion prepared in example 1 and 2301g of blueberries are taken. 2832g of donkey-hide gelatin and 944g of poria cocos are taken, wherein the donkey-hide gelatin is prepared into donkey-hide gelatin instant powder according to the embodiment 5; poria cocos poria extract was prepared as in example 6. Placing colla Corii Asini instant powder and Poria extract in dry and clean container, adding Haematococcus pluvialis solid dispersion and fructus Myrtilli, stirring thoroughly to mix well, and sieving with 80 mesh sieve to obtain the final product.
Example 11: preparation of the powder
The composition prepared in the example 9 is weighed and placed in a dry pressing machine, the proper roller pressure is adjusted for dry pressing, sieving and packaging into 8 g/bag, and the powder with the anti-aging and beautifying activities is obtained.
Example 12: preparation of granules
Weighing the composition prepared in the embodiment 9, adding a proper amount of auxiliary materials such as sugar powder, dextrin, lactose, hydroxypropyl starch and the like, granulating, drying and packaging to obtain the granules with the anti-aging and beautifying activities.
Example 13: preparation of tablets
Weighing the composition prepared in the embodiment 9, adding a proper amount of auxiliary materials such as starch, sugar powder, dextrin, microcrystalline cellulose and the like, mixing, granulating, tabletting and packaging to obtain the tablet with the anti-aging and beautifying activities.
Example 14: preparation of hard capsules
Weighing the composition prepared in the embodiment 9, adding a proper amount of auxiliary materials such as sucrose, lactose, microcrystalline cellulose, silicon dioxide, magnesium stearate and the like, mixing, granulating, filling and packaging to obtain the hard capsule with the anti-aging and beautifying activities.
In order to further illustrate the technical effects of the composition of the present invention, the haematococcus pluvialis solid dispersion prepared in example 1, the donkey-hide gelatin instant powder prepared in example 4, the poria cocos extract prepared in example 6 and the composition prepared in example 10 are selected as control samples and are numbered as (i), (ii), (iii) and (iv); the composition prepared in example 9 was selected as a test sample, numbered fifthly, and a young rat control group and an aging model control group were set to eliminate molding interference and errors. The control sample and the test sample are used for testing the MDA content, SOD enzyme activity and GSH-Px enzyme activity of each organ (such as liver, kidney, heart, brain and prostate) of the rat, and the results are as follows:
test animals and devices: wistar male rats (weight 150-; 16 months old rats of the same strain; MDA, SOD and GSH-Px determination kit (purchased from Nanjing institute of bioengineering) and D-galactose.
Dosage given: the 60kg adult human dose of the composition of the present invention (test sample (c)) was determined to be 1 g/day, which translates to a daily rat dose of 150mg/kg BW. Determining a control sample (150 mg/kg BW) in daily sample administration according to an equal-dose sample administration comparable principle, and calculating the highest daily recommended dose of haematococcus pluvialis solid dispersion, donkey-hide gelatin instant powder and poria cocos extract according to the equal-dose sample administration comparable principle and by combining with the national pharmacopoeia or related industry standards, wherein the first sample administration dose is 72.1mg/kg BW, and the second to third sample administration doses are 150mg/kg BW.
Modeling, grouping and experiment: 105 Wistar male rats with the age of 6 weeks are randomly divided into 7 groups with the weight of 150-. Another 15 rats of the same strain at 16 months of age were purchased as a normal aged control group. Model group (TNB) and test (I) -V group were fed normally with 1.5g/kg of D-galactose injected subcutaneously from the back of the neck (0.1 ml/10g) per day, aged control group (XKP) injected with the same amount of normal saline, and aged control group, and test (I) -V group received subcutaneous injection of D-galactose at the back of the neck for 30 minutes, and then fed with samples numbered (I) -V by one-time gavage. Repeating the above operations 1 time per dayAfter completion of the feeding, all rats in all groups had free access to water and were fed continuously for 5 months. At the end of the test, anesthetizing the rats of the young control group, the model control group and the aged control group by using ether, fully exposing the abdomen, taking blood from the inferior vena cava, and measuring the content of Malondialdehyde (MDA) in the blood and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the blood; model control group and test first-fifth group, rat liver, kidney, heart, brain and prostate are sacrificed and separated, and each organ homogenate is prepared and Malondialdehyde (MDA) content, SOD enzyme activity and GSH-Px enzyme activity are measured. The test results are shown in tables 1, 2, 3 and 4. Table 1: serum MDA content and blood SOD and GSH-Px activity
Table 2: the content of MDA in different organ tissues is nmol/m
Table 3: SOD enzyme activity NU/mg pro in different organ tissues
Table 4: GSH-Px enzymatic activity NU/mg pro in different organ tissues
Tables 1-4 show that:
compared with the young control, the serum MDA content of the model group is obviously increased, the activities of blood SOD and GSH-Px enzymes are obviously reduced (P is less than 0.01), and the change trend of the model group is consistent with that of the normal aged group (see table 1), which indicates that the model group rat aging model is successfully established.
Compared with a model control group and samples, the samples (the fifth group) have obviously reduced MDA content, obviously increased SOD enzyme activity and obviously increased GSH-Px enzyme activity (P is less than 0.01) in different organ tissues, which shows that the composition (the fifth group) can effectively reduce the MDA production of each organ tissue of a rat organism, enhance the activities of SOD and GSH-Px enzyme, effectively improve the oxidation resistance of a D-galactose-induced senile rat, and has the functions of high-efficiency anti-senility, beauty and health care.
Claims (6)
1. An anti-aging beauty and health care functional composition is characterized in that: the composition is prepared from 24-48% of haematococcus pluvialis solid dispersoid with the mass percentage of astaxanthin of 2.0-3.0%, donkey-hide gelatin instant powder prepared from 12-21% of donkey-hide gelatin with the mass percentage, 29-39% of poria cocos, 1.5-2.5% of poria cocos extract with the mass percentage of water-soluble polysaccharide and 16-20% of blueberries with the mass percentage; the donkey-hide gelatin instant powder is prepared by crushing donkey-hide gelatin, adding a proper amount of cold water, heating and melting to 60 ℃, determining the relative density to be 1.10, and preserving heat at 60 ℃, wherein the mass ratio of the added donkey-hide gelatin to the added donkey-hide gelatin is 10-30: 50 beta-cyclodextrin at 60 deg.C, inlet temperature 165 deg.C, liquid supply rate 15%, and compressed air flow rate 45 L.h-1Spray drying under the condition to obtain; the poria cocos extract is prepared by slicing poria cocos, adding water with a mass-volume ratio of 1:6, soaking for 3 hours, heating and refluxing for 3 times, wherein each time is 3 hours, 2 hours and 1 hour respectively, combining extracting solutions, filtering, adding equal volume of 95% ethanol while stirring, standing for 12 hours, centrifuging, collecting precipitate, adding water, boiling for dissolving, adjusting the ethanol content to 80% with 95% ethanol, standing for separating brown precipitate, filtering, drying at low temperature, pulverizing, and sieving with a 80-mesh sieveObtaining; the blueberry is blueberry powder prepared by adopting fresh blueberries which are artificially planted and harvested, dehydrating, drying, crushing and sieving with a 80-mesh sieve.
2. The composition of claim 1, wherein: the composition is prepared from 27-42% of haematococcus pluvialis solid dispersoid, 2.2-2.8% of astaxanthin and 19-21% of donkey-hide gelatin prepared donkey-hide gelatin instant powder by mass, 29-31% of poria cocos, 1.7-2.3% of poria cocos extract by mass and 17-19% of blueberries by mass.
3. The composition of claim 1, wherein: the composition is prepared from 30-36% by mass of haematococcus pluvialis solid dispersion with 2.4-2.6% by mass of astaxanthin, 21% by mass of donkey-hide gelatin prepared donkey-hide gelatin instant powder, 29% by mass of poria cocos, 1.9-2.1% by mass of water-soluble polysaccharide and 18% by mass of blueberries.
4. The composition according to any one of claims 1 to 3, wherein: the mass ratio of the beta-cyclodextrin addition amount to the donkey-hide gelatin in the preparation of the donkey-hide gelatin instant powder is 15-25: 50.
5. the composition of claim 4, wherein: the mass ratio of the beta-cyclodextrin addition amount to the donkey-hide gelatin in the preparation of the donkey-hide gelatin instant powder is 18-22: 50.
6. the composition according to any one of claims 1 to 3, wherein: the composition is used for preparing anti-aging and beautifying health-care food and functional common food; optionally adding health food and functional common food acceptable adjuvants, and further making into powder, granule, tablet, and hard capsule.
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