CN107279369A - A kind of preparation method of hypoglycemic yellow tea - Google Patents
A kind of preparation method of hypoglycemic yellow tea Download PDFInfo
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- CN107279369A CN107279369A CN201710423277.9A CN201710423277A CN107279369A CN 107279369 A CN107279369 A CN 107279369A CN 201710423277 A CN201710423277 A CN 201710423277A CN 107279369 A CN107279369 A CN 107279369A
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- yellow tea
- polyphenols
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- alcohol
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- 235000020338 yellow tea Nutrition 0.000 title claims abstract description 135
- 230000002218 hypoglycaemic effect Effects 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
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- 210000004369 blood Anatomy 0.000 claims abstract description 57
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
- A23F3/18—Extraction of water soluble tea constituents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Alternative & Traditional Medicine (AREA)
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Abstract
The invention discloses a kind of preparation method of hypoglycemic yellow tea, belong to hypoglycemia healthcare food field.The present invention prepares hypoglycemic yellow tea method after reconfiguring yellow tea polysaccharose substance and yellow tea polyphenols.It is characterized in that using yellow tea as raw material, by hot-water soak, Ultrasonic Wave-Assisted Extraction, polysaccharose substance and polyphenols in separation of ethanol water extract, and by polysaccharose substance and polyphenols according to parts by weight 1:(0.2 6) compounding prepares new hypoglycemic yellow tea again, and the yellow tea of preparation can reduce postprandial blood sugar, and effect is better than former tea extraction material, and yellow tea polysaccharose substance and yellow tea polyphenols of the former tea extract after separation of ethanol.It is raw material that the present invention, which chooses commercially available yellow tea, and raw material sources are extensive, safety, and the novel blood sugar lowing yellow tea prepared according to this method reduces postprandial blood sugar effect substantially, is adapted to use postprandial blood sugar sensitive group.
Description
Technical field
The present invention relates to a kind of preparation method of hypoglycemic yellow tea, belong to hypoglycemia healthcare food field.
Background technology
Blood glucose value is hyperglycaemia higher than normal range (NR)；Fasting blood-glucose>6.1mmol/L, after the meal two hours blood glucose value>
7.8mmol/L, referred to as hyperglycaemia.Under normal circumstances, maintain internal blood glucose steady by hormone control and nerve modulation in body
Surely in normal range (NR)；Inherent cause (if any family's diabetic history) and environmental factor (high fat high-carbohydrate diet, it is unsound
Life style is such as smoked excessive drinking) collective effect under, two big regulating systems get muddled in body, cause blood glucose value to raise,
There is hyperglycaemia.
It is chronically in the case of hyperglycaemia, it is very harmful to body, body tissue organ lesion, inducing acute is occurred
The exhaustion of the generation of chronic complicating diseases, such as pancreas function, dehydration, body electrolyte imbalance, malnutrition, resistance decline, kidney
Exhaustion etc..Therefore control body blood glucose balance stablizes most important.
At present, the method that diabetes are not effected a radical cure is directed to, pancreas islet either can only be injected by oral hypoglycemic drug
Element method come control blood glucose be in stable state, and long-term taking antidiabetic drug either insulin injection easily body pancreas is occurred
Island element sensitiveness reduction, so that need to increase dosage, and heavy dose can trigger drug safety using medicine, harm is strong
Health.
In recent years, the effects such as numerous studies show to drink tea with Weight-reducing and lipid-lowering, anti-oxidant, regulation blood glucose.Although having reported
Road discloses Huang great Cha has a significant function of blood sugar reduction compared with green tea, black tea, and is that any component is either in tealeaves actually
Ratio change between different component has leading role still unknown to hypoglycemic.
Although there are reports has using many polyphenol extracts of green tea tea and green tea tea polysaccharide extract or the two is common
Effect reduction blood glucose in diabetic mice, but these methods generally require under very high concentration just it is effective (under normal circumstances,
Be not up to so high concentration), blood sugar decreasing effect have it is to be reinforced, need to buy commercialization polysaccharide or polyphenol substance etc. and ask
Topic.At present, report still not on yellow tea extract combination.
The content of the invention
In view of the above-mentioned problems, the invention provides reconfigure preparation between a kind of extraction of yellow tea tea component and composition
The method of novel blood sugar lowing yellow tea.Present invention discover that by the polyphenols extracted from yellow tea and polysaccharose substance according to certain
After proportioning is mixed, with good blood sugar decreasing effect, and toxicological experiment proves that mixture is nontoxic.
First purpose of the present invention is to provide a kind of preparation method of hypoglycemic yellow tea, and methods described is first from yellow tea water
The polysaccharose substance of the polyphenols of isolated alcohol-soluble and alcohol precipitation in extract solution, then by obtained Polyphenols thing
Matter and polysaccharose substance are according to weight ratio 1:(0.2~6) is mixed to get.
In one embodiment, the yellow tea water extract solution, is that first will crush yellow tea, with hot-water soak, ultrasound
Processing, filtering, then take filter residue and repeat hot-water soak, ultrasonically treated, filtration step 1~5 time, and merging filtrate removes filtrate
In suspended particulate be to obtain yellow tea water extract solution.
In one embodiment, the preparation of the yellow tea water extract solution, be specifically：The yellow tea after crushing is taken, according to
Material-water ratio 1:8~1:12 add 70~100 DEG C of 5~15min of hot-water soak, then ultrasonically treated 3~8min, then soak 5~
15min；Then it is collected by filtration filtrate, and filter residue is repeated into hot-water soak, ultrasonically treated, filtration step 1~5 time；Merging filtrate,
Flocculant is added in filtrate, removes after suspended particulate, obtains yellow tea water extract solution.
In one embodiment, the polyphenols of the alcohol-soluble, is to steam yellow tea water extract solution vacuum rotating
Hair concentration, adds the absolute ethyl alcohol of certain volume in yellow tea flooding extract after concentration, it is agitated, stand, it is isolated on
Clear liquid, supernatant concentrates, is dried to obtain the polyphenols of alcohol-soluble through rotary evaporation in vacuo.
In one embodiment, the rotary evaporation in vacuo concentration is carried out under -0.1MP vacuums.
In one embodiment, the addition volume of the absolute ethyl alcohol is 2~6 times of yellow tea flooding extract.
In one embodiment, drying is dried or vacuum freeze drying in vacuum drying chamber.
In one embodiment, the polysaccharose substance of the alcohol precipitation, is to steam yellow tea water extract solution vacuum rotating
Hair concentration, adds the absolute ethyl alcohol of certain volume in yellow tea flooding extract after concentration, it is agitated, stand, it is isolated heavy
Form sediment, precipitate the polysaccharose substance through being dried to obtain alcohol precipitation.
In one embodiment, the preparation method, specifically includes following steps：
(1) yellow tea after 100g crushing is taken to be put into 1000mL water, 90 DEG C of immersion 10min, ultrasonically treated 5 minutes, room temperature
Soak 10min；Then with three layers of filtered through gauze, filtrate is taken, filter residue is preserved；
(2) gained filter residue in step (1) is taken, hot-water soak and ultrasonic processing technique is repeated, then with three layers of filtered through gauze,
Filter residue is lost, filtrate is taken and merges with the filtrate in step (1)；
(3) flocculant is added in filtrate, removes after suspended particulate, obtains yellow tea water extract solution；
(4) by yellow tea water extract solution under -0.1MP vacuums, rotary evaporation is concentrated, then yellow tea water after concentration
The absolute ethyl alcohol of 4 times of volumes is added in extract, 10min is stirred；After stratification, separation supernatant and precipitation；
(5) supernatant is rotated into evaporation and concentration under -0.1MP vacuum, and concentrate is done in vacuum drying chamber
It is dry into powder, obtain the yellow tea polyphenols powder of alcohol-soluble；
(6) vacuum freeze drying at -45 DEG C will be deposited in and, into powder, obtain the yellow tea polysaccharose substance powder of alcohol precipitation；
(7) the yellow tea polysaccharose substance powder that the yellow tea polyphenols powder and step (6) obtained step (5) is obtained according to
Weight compares 1:(0.2~6) is mixed, that is, obtains hypoglycemic yellow tea.
In one embodiment, flocculant is organic or inorganic flocculant in the step (3).
In one embodiment, in the hypoglycemic yellow tea yellow tea polysaccharose substance and yellow tea polyphenols weight
Than for 1:2~1:6.
In one embodiment, the weight ratio of yellow tea polysaccharose substance and yellow tea polyphenols is 1:0.2、1:0.5、
1:1、1:2、1:4 or 1:6.
In one embodiment, the hypoglycemic yellow tea is configured to the solution that concentration is 12mg/mL~500mg/mL.
In one embodiment, the yellow tea raw material is to originate from the Huang that your Zhong Xiu companies production is embraced by Huoshan County of Anhui Province
Tea.
In one embodiment, the yellow tea can be Huang little Cha or Huang great Cha.
In one embodiment, the preparation technology of the yellow tea：Fresh leaf → withering → finishes → kneaded, and → vexed Huang → is dry
It is dry.
In one embodiment, the specific preparation technology of the yellow tea is：By taking Huang great Cha as an example, manufacturing procedure is divided into stir-fry
Tea, just baking, accumulation, baking.
In one embodiment, the yellow big tea process：(1) tea frying：Mitogenetic pot, two blue or green pots, three steps of ripe pot
Suddenly.Raw pot mainly plays fixing, the activity of destructive enzyme；Two blue or green pots mainly play a part of tentatively to rub bar and continue to finish；Ripe pot
Mainly further do bar；(2) just dry：Quick high-temp is bakeed after stir-fry, and temperature is 120 DEG C or so, throw leaf amount be per hand-held basketwork brazier 2~
2.5kg, every 2~3 minutes turned over baking once, are dried about 30 minutes, and up to doing very likely, breaking for tea stalk folding, is appropriateness；(3) accumulate：
Tealeaves is filled to basket while hot after lower baking or is piled up in circle seat and is slightly compressed, high about 1m is placed in dry drying room, utilizes drying room
Heat promote xanthochromia.Depending on old tender, the tea base water content size of the accumulation time visual fresh leaf of length and xanthochromia degree, 5 are typically required
~7 days；Leaf color xanthochromia is stacked into, fragrance is revealed as moderately, and as reactor startup is bakeed；(4) bakee：It is further using high temperature
Promote the conversion of xanthochromia and endoplasm, it is fragrant to form the yellow big distinctive crispy rice of tea in Huoshan.
Second object of the present invention is to provide the hypoglycemic yellow tea prepared according to the method described above.
Third object of the present invention is to provide a kind of hypoglycemic medicine composition or health food, the drug regimen
Thing or health food are using the hypoglycemic yellow tea of the present invention as principle active component.
In one embodiment, described pharmaceutical composition also includes pharmaceutically acceptable excipients.It is described pharmaceutically
Acceptable excipients refer to any diluent, adjuvant and/or carrier available for pharmaceutical field.
In one embodiment, the hypoglycemic yellow tea can be applied in combination with other active components, as long as they are not
Produce other unfavorable effects, such as allergic reaction.
In one embodiment, described pharmaceutical composition can be configured to several formulation, wherein containing in pharmaceutical field
Some conventional excipient；For example, oral formulations (such as tablet, capsule, solution or suspension)；The preparation of injectable (such as may be used
The solution or suspension of injection, or injectable dried powder, before the injection add water for injection can use immediately)；Office
Portion's preparation (such as ointment or solution).
In one embodiment, the carrier for the pharmaceutical composition of the present invention is available common in pharmaceutical field
Type, including：It is the adhesives of oral formulations, lubricant, disintegrant, cosolvent, diluent, stabilizer, suspending agent, colourless
Element, flavouring etc.；Preservative, solubilizer, stabilizer of injectable formulation etc.；Matrix, diluent, the lubrication of topical formulations
Agent, preservative etc..Pharmaceutical preparation can by oral administration or parenteral (such as intravenous, subcutaneous, intraperitoneal or local) administration,
If some drugses are unstable under the conditions of stomach, enteric coated tablets can be configured to.
The present invention also provides application of the hypoglycemic yellow tea in terms of blood sugar reducing preparation is prepared.
Beneficial effects of the present invention：
The present invention uses the polyphenols powder in yellow tea and the allotment of polysaccharose substance powder, with good hypoglycemic work(
Can, and yellow tea polyphenols powder or yellow tea polysaccharose substance powder is used alone without blood sugar decreasing effect.And yellow tea polyphenol
Class material and yellow tea polysaccharose substance are all from yellow tea tealeaves, and the toxicological experiment of material proves that mixture is nontoxic after allotment.
Brief description of the drawings
Fig. 1 is the hypoglycemic effect of different formulations yellow tea.
Embodiment
The invention discloses a kind of preparation method of novel blood sugar lowing yellow tea.Those skilled in the art can be by this paper
Hold, be suitably modified Extraction technique realization.In particular, all similar replacements and change to the skill of this area
It is it will be apparent that they are considered as being included in the present invention for art personnel.Method of the present invention and combinations thereof application is
Illustrate explanation by preferable case study on implementation, related personnel substantially can be not departing from present invention, in spirit and scope to this
Methods and applications described in text are modified or suitably change is with combining, to realize and apply the technology of the present invention.
Prepared by the novel blood sugar lowing yellow tea that the present invention is provided raw materials used is commercially available.With reference to specific implementation
Case, is expanded on further the present invention：
Embodiment 1：The preparation method of hypoglycemic yellow tea
The yellow tea after 100g crushing is taken to be put into 1000mL deionized waters, 90 DEG C of immersion 10min, ultrasonically treated 5 minutes, room
Temperature immersion 10min.Then with three layers of filtered through gauze, filtrate is taken, filter residue is preserved.Filter residue is repeated into hot-water soak and ultrasonically treated work
Skill, then with three layers of filtered through gauze, abandons filter residue, obtains filtrate, and merge with first step filtrate.Then flocculation is added in filtrate
Agent, removes after suspended particulate, obtains yellow tea water extract solution.By yellow tea water extract solution under -0.1MP vacuums, rotation is steamed
Hair concentration, then adds the absolute ethyl alcohol of 4 times of volumes in yellow tea flooding extract after concentration, stir 10min.Stratification
Afterwards, isolated supernatant and precipitation.Supernatant is rotated into evaporation and concentration under -0.1MP vacuum, and by concentrate true
Powder is dried in empty drying box, the yellow tea polyphenols powder of alcohol-soluble is obtained.To be deposited at -45 DEG C vacuum freeze drying into
Powder, obtains the yellow tea polysaccharose substance powder of alcohol precipitation.
1 parts by weight yellow tea polysaccharose substance and 0.2 parts by weight yellow tea polyphenols are mixed to prepare novel blood sugar lowing yellow
Tea.
Embodiment 2
The preparation method of novel blood sugar lowing yellow tea is substantially the same manner as Example 1, differs only in：
1 parts by weight yellow tea polysaccharose substance and 0.5 parts by weight yellow tea polyphenols are mixed to prepare novel blood sugar lowing yellow
Tea.
Embodiment 3
The preparation method of novel blood sugar lowing yellow tea is substantially the same manner as Example 1, differs only in：
1 parts by weight yellow tea polysaccharose substance and 1 parts by weight yellow tea polyphenols are mixed to prepare novel blood sugar lowing yellow tea.
Embodiment 4
The preparation method of novel blood sugar lowing yellow tea is substantially the same manner as Example 1, differs only in：
1 parts by weight yellow tea polysaccharose substance and 2 parts by weight yellow tea polyphenols are mixed to prepare novel blood sugar lowing yellow tea.
Embodiment 5
The preparation method of novel blood sugar lowing yellow tea is substantially the same manner as Example 1, differs only in：
1 parts by weight yellow tea polysaccharose substance and 4 parts by weight yellow tea polyphenols are mixed to prepare novel blood sugar lowing yellow tea.
Embodiment 6
The preparation method of novel blood sugar lowing yellow tea is substantially the same manner as Example 1, differs only in：
1 parts by weight yellow tea polysaccharose substance and 6 parts by weight yellow tea polyphenols are mixed to prepare novel blood sugar lowing yellow tea.
Embodiment 7
The preparation method of novel blood sugar lowing yellow tea is substantially the same manner as Example 1, differs only in：
Novel blood sugar lowing yellow tea is made by 1 parts by weight yellow tea polysaccharose substance.
Embodiment 8
The preparation method of novel blood sugar lowing yellow tea is substantially the same manner as Example 1, differs only in：
Novel blood sugar lowing yellow tea is made by 1 parts by weight yellow tea polyphenols.
Embodiment 9：The function of blood sugar reduction experiment of function of blood sugar reduction yellow tea
1. experiment purpose：Hypoglycemic yellow tea of the invention is studied to mouse reducing postprandial blood glucose
2. experiment material：
Main agents：The hypoglycemic yellow tea of the present invention, glucose
Experimental animal：SPF grades of male ICR mouses, 80, body weight (30 ± 2) g
Laboratory apparatus：Blood glucose meter and blood sugar test paper, Johnson Co.
3. test method：Normal diet raised mouse after one week, and it (is respectively glucose group, yellow tea water to be randomly divided into 10 groups
Extract group, 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment, 5 groups of embodiment, 6 groups of embodiment, 7 groups of embodiment,
8 groups of embodiment；Wherein yellow tea water extract group is that the aqueous solution for obtaining tea into hot water is concentrated and dried what is obtained), mouse
After fasting 8 hours, fasting blood sugar is determined.The glucose of the oral gavage 1g pers kilogram of body weight of glucose control group, yellow tea water extraction
Thing group gavage yellow tea water extract, the every kg body weight of glucose and 0.5g of the oral gavage 1g of remaining 8 groups of difference per kg body weight
The not novel blood sugar lowing yellow tea in be the same as Example, respectively at 15 minutes after gavage, 30 minutes, 45 minutes, 60 minutes, afterbody was adopted
Blood, surveys blood glucose value.
4. blood glucose test results are characterized
Blood glucose rise index=(blood glucose value-fasting blood sugar)/fasting blood sugar
Blood glucose value-in the blood glucose value of different time points detection
Mouse blood sugar value before fasting blood sugar-gavage
5. experimental result
Wherein, such as table 1 and Fig. 1 of the blood glucose rise index after different time.
Mouse blood sugar raises index under the different experiments group of table 1
| 0min | 15min | 30min | 45min | 60min | |
| Glucose group | 0 | 1.07 | 0.86 | 0.62 | 0.51 |
| Yellow tea water extract group | 0 | 0.94 | 0.58 | 0.44 | 0.23 |
| Embodiment 1 | 0 | 1.04 | 0.73 | 0.52 | 0.27 |
| Embodiment 2 | 0 | 0.97 | 0.63 | 0.48 | 0.24 |
| Embodiment 3 | 0 | 0.92 | 0.60 | 0.36 | 0.31 |
| Embodiment 4 | 0 | 0.69 | 0.43 | 0.22 | 0.24 |
| Embodiment 5 | 0 | 0.56 | 0.30 | 0.20 | 0.07 |
| Embodiment 6 | 0 | 0.82 | 0.37 | 0.31 | 0.16 |
| Embodiment 7 | 0 | 1.12 | 0.92 | 0.68 | 0.65 |
| Embodiment 8 | 0 | 1.05 | 0.91 | 0.51 | 0.40 |
Fig. 1 and the result of table 1 show, yellow tea polysaccharose substance and Huang of the yellow tea polyphenols according to different weight than preparation
Tea is respectively provided with hypoglycemic effect, and the hypoglycemic effect of the yellow tea of embodiment 5 is best.Yellow tea tea polysaccharide class material and yellow tea tea are more
This experiment of aldehydes matter does not show blood sugar decreasing effect.
Claims (10)
1. a kind of preparation method of hypoglycemic yellow tea, it is characterised in that methods described is first to be separated from yellow tea water extract solution
The polyphenols of alcohol-soluble and the polysaccharose substance of alcohol precipitation are obtained, then by obtained polyphenols and polysaccharose substance
Compare 1 according to weight:(0.2~6) is mixed to get.
2. it is according to the method described in claim 1, it is characterised in that the polyphenols of the alcohol-soluble, by yellow tea water extraction
Thing solution rotary evaporation in vacuo is concentrated, the absolute ethyl alcohol of addition certain volume in yellow tea flooding extract after concentration, agitated,
Standing, isolated supernatant, supernatant concentrate, are dried to obtain the polyphenols of alcohol-soluble through rotary evaporation in vacuo；It is described
The polysaccharose substance of alcohol precipitation, is by the concentration of yellow tea water extract solution rotary evaporation in vacuo, yellow tea flooding extract after concentration
The middle absolute ethyl alcohol for adding certain volume, agitated, standing, isolated precipitation, precipitates the polysaccharide through being dried to obtain alcohol precipitation
Class material.
3. according to the method described in claim 1, it is characterised in that in the hypoglycemic yellow tea polyphenols of alcohol-soluble and
The weight ratio of the polysaccharose substance of alcohol precipitation is 1:2~1:6.
4. according to the method described in claim 1, it is characterised in that the polyphenols of alcohol-soluble and the polysaccharide thing of alcohol precipitation
The weight ratio of matter is 1:0.2、1:0.5、1:1、1:2、1:4 or 1:6.
5. it is according to the method described in claim 1, it is characterised in that the yellow tea water extract solution, that first will crush yellow tea,
With hot-water soak, ultrasonically treated, filtering, then take filter residue and repeat hot-water soak, ultrasonically treated, filtration step 1~5 time, close
And filtrate, the suspended particulate removed in filtrate is to obtain yellow tea water extract solution.
6. according to the method described in claim 1, it is characterised in that the preparation method specifically includes following steps：
(1) yellow tea after 100g crushing is taken to be put into 1000mL water, 90 DEG C of immersion 10min, ultrasonically treated 5 minutes, soaking at room temperature
10min；Then with three layers of filtered through gauze, filtrate is taken, filter residue is preserved；
(2) gained filter residue in step (1) is taken, hot-water soak and ultrasonic processing technique is repeated, then with three layers of filtered through gauze, loses filter
Slag, takes filtrate and merges with the filtrate in step (1)；
(3) flocculant is added in filtrate, removes after suspended particulate, obtains yellow tea water extract solution；
(4) by yellow tea water extract solution under -0.1MP vacuums, rotary evaporation is concentrated, then yellow tea flooding after concentration
The absolute ethyl alcohol of 4 times of volumes is added in thing, 10min is stirred；After stratification, separation supernatant and precipitation；
(5) supernatant is rotated into evaporation and concentration under -0.1MP vacuum, and concentrate is dried in vacuum drying chamber
Powder, obtains the yellow tea polyphenols powder of alcohol-soluble；
(6) vacuum freeze drying at -45 DEG C will be deposited in and, into powder, obtain the yellow tea polysaccharose substance powder of alcohol precipitation；
(7) the yellow tea polysaccharose substance powder that the yellow tea polyphenols powder and step (6) obtained step (5) is obtained is according to weight
Than 1:(0.2~6) is mixed, that is, obtains hypoglycemic yellow tea.
7. the hypoglycemic yellow tea prepared according to any methods described of claim 1~6.
8. a kind of hypoglycemic medicine composition or health food, it is characterised in that described pharmaceutical composition or health food
Using the hypoglycemic yellow tea described in claim 7 as principle active component.
9. pharmaceutical composition according to claim 8, it is characterised in that described pharmaceutical composition also includes pharmaceutically connecing
The excipients received.
10. application of the hypoglycemic yellow tea in terms of blood sugar reducing preparation is prepared described in claim 7.
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| CN111793660A (en) * | 2020-09-02 | 2020-10-20 | 安徽大学 | A radix et rhizoma Rhei tea polysaccharide with blood sugar lowering effect |
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Application publication date: 20171024 |