CN107271337A - A kind of human body alveolar aerosol deposition measurement experiment system - Google Patents
A kind of human body alveolar aerosol deposition measurement experiment system Download PDFInfo
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- CN107271337A CN107271337A CN201710271413.7A CN201710271413A CN107271337A CN 107271337 A CN107271337 A CN 107271337A CN 201710271413 A CN201710271413 A CN 201710271413A CN 107271337 A CN107271337 A CN 107271337A
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
Abstract
The invention discloses a kind of human body alveolar aerosol deposition measurement experiment system, standard particle generating means and air-breathing aerosol particle counter are connected by pipeline with breather cheek valve respectively；Breather cheek valve runs through the lid of transparent experiment container by pipeline with being connected the total pipeline after the pipeline of humidifier converges, it is connected with the lung acinus experimental model being arranged on inside transparent experiment container, the bottom of transparent experiment container is connected by pipeline with simulated respiration pump；Pressure gauge is provided with transparent experiment container；Expiration aerosol particle counter is connected with one-way exhaust valve and total pipeline successively by pipeline；The computer for being provided with data analysis system is electrically connected with PIV Particle-beam Tracings instrument and simulated respiration pump respectively, and PIV Particle-beam Tracing instrument is arranged on the side of transparent experiment container.The present invention can provide the in-vitro measurements of the pellet deposition under different-grain diameter, breathing pattern, ambient humidity and pathological conditions.
Description
Technical field
The invention belongs to biomedical engineering, healthy prevention epidemic prevention technology and equipment, man-machine-environment systems engineering, breathing
The technical field such as hydrodynamics and personal breathing protection, is to be related to a kind of human body alveolar aerosol deposition measurement in fact specifically
Check system.
Background technology
With the accelerated development of global industry, atmosphere pollution makes respiratory disease turn into a kind of common disease, frequently-occurring disease,
Pellet (refers to aerodynamic diameter<10 μm of airborne suspended particulate) lung deposition be main inducing it
One.Human respiratory is made up of respiratory tract (nose, pharynx, larynx, trachea-bronchial epithelial cell) and lung.The main function of respiratory tract is gas
Passage, link up lung and external environment.Pellet in air is entered after human body by respiration, part deposition
In the multistage bronchiole of the conduction portion of human respiratory, i.e. nose, pharynx, larynx, tracheae, main bronchus and intrapulmonary；Another portion
It can point then enter lung acinus area, substantial amounts of deposition makes pulmonary lesion, influence respiratory function, and penetrate further into alveolar wall to enter people
Body blood circulation system, huge injury is caused to health.
On the other hand, with being understood in depth to the disease such as PFT and asthma, pulmonary emphysema, chronic obstructive pulmonary disease, people
Recognize that inhalation is the effective means for treating above-mentioned disease.Lung suck preparation because it is easy to use, work it is rapid, avoid
The first pass effect of liver, reduces Formulations for systemic administration issuable adverse reaction and turns into wide at present the advantages of overdose is used
The method of the treatment respiratory disease of general concern.Suck preparation to enter after human body, the medicine for being deposited on the upper respiratory tract is most of
It is excreted by the motion of cilium, the medicine being only deposited in lung acinus could enter blood circulation and be absorbed.I.e.
Improve bioavilability of the inhalation in lung, it is necessary to improve its deposition in lung acinus area.Therefore, setting up lung can inhale
Enter particulate matter deposition in-vitro measurements experimental provision, with huge scientific research value and application value.
The method that upper respiratory tract particulate matter deposition can set up physical model by computer model and CT scan is surveyed
Amount analysis.Patent CN204797996 U describe the method and dress of a kind of weight method measurement human upper airway particulate matter deposition
Put, efficiently solve human upper airway particulate matter deposition analogue measurement problem, but it does not account for the upper respiratory tract to suction
The humidification of air, and the deposition of human body smalls bronchus and alveolar region can not be measured.
Lung acinus is the main region of respiration, accounts for the 90% of respiratory system volume, measures various breathings, environment, disease
Particulate matter lung acinus deposits and finds that deposition rule is very necessary under the conditions of disease influence etc..Measurement to the part is mainly adopted at present
With experimental animal or the method for volunteer's actual test, but with high costs, experimental period length, big to human body side effect.Due to lung
Acinus plot structure is complicated, size is smaller, there is no method to set up physical model by CT scan mode.Chinese patent CN 104050321
A describes a kind of computer model of alveolar particulate matter running orbit, and substantial amounts of simplification has been carried out to alveolar.But analog result is
It is based on ideal boundary condition it is assumed that belong to Computer Simulation category, obtain data and be not based on experiment gained, it usually needs
Physical model further verifies that actual application value is limited.
The A of Chinese patent CN 102750859 employ elastic silica gel material and a kind of device for simulating pulmonary ventilation have been made, and adjust
Section silica gel material modulus of elasticity is close with human lung, realizes the simulation of elasticity breathing.Although being built the patent provides one kind
The thinking of vertical elasticity lung acinus model, but it is only capable of simulation reconstruction respiratory, it is impossible to pellet is carried out in lung acinus
Area's sedimentation experiment.
The content of the invention
The purpose of the present invention is to overcome the deficiencies in the prior art there is provided a kind of human body alveolar aerosol deposition measurement experiment system
System.
Technical scheme is summarized as follows：
A kind of human body alveolar aerosol deposition measurement experiment system, including standard particle generating means 1-1 and air-breathing gas it is molten
Glue particle collector 1-2, standard particle generating means 1-1 and air-breathing aerosol particle counter 1-2 pass through pipeline and list respectively
To intake valve 1-3 connections；Breather cheek valve 1-3 is by pipeline with being connected the total pipeline 1-14 after humidifier 1-4 pipeline converges
Through transparent experiment container 1-10 lid, with the lung acinus experimental model 1-9's that is arranged on inside transparent experiment container 1-10
15 grades of bronchus 2-1 connections are simulated, 15 grades of bronchus 2-1 of simulation pass through 16 grades of bronchuses of the first Y-type three way type 2-2 and 2 simulations
2-3 connections, each simulate 16 grades of bronchus 2-3 and are connected by 17 grades of bronchus 2-5 of the second Y-type three way type 2-4 and 2 simulations, often
17 grades of bronchus 2-5 of individual simulation are connected by connecting tube 2-6 with simulated lung acinus cluster 2-7, and simulated lung acinus cluster 2-7 includes simulation
It is provided with breathing 3-4, simulation breathing 3-4 on interface 3-1, interface 3-1 outer wall and is provided with annular projection 3-2, is simulated
Lung acinus 3-3 is flexibly connected with interface 3-1 and fixed by annular projection 3-2；Transparent experiment container 1-10 bottom passes through pipe
Road is connected with simulated respiration pump 1-11；Pressure gauge 1-8 is provided with transparent experiment container 1-10；Expiration aerosol particle counter
1-6 is connected with one-way exhaust valve 1-5 and total pipeline 1-14 successively by pipeline；It is provided with the computer 1-12 of data analysis system
Electrically connected respectively with PIV Particle-beam Tracing instrument 1-13 and simulated respiration pump 1-11, PIV Particle-beam Tracing instrument 1-13 is arranged on transparent experiment
Container 1-10 side.
Advantages of the present invention：
The pellet that the present invention can be provided under different-grain diameter, breathing pattern, ambient humidity and pathological conditions sinks
The in-vitro measurements of product rate.Experimenter is expected to disclose the deposition rule and influence factor of lung acinus area particulate matter using the present invention,
Explore the optimization of the origin cause of formation of PUD D, development, prevention, targeted therapy and inhalable therapy, and be used for instead of experimental animal or
Volunteer carries out curative effect of medication analysis and novel drugs exploitation.
Brief description of the drawings
Fig. 1 is schematic diagram of the invention.
Fig. 2 is lung acinus laboratory model construction schematic diagram.
Fig. 3 is simulated lung acinotubular and simulated lung acinus partial cutaway schematic.
Embodiment
With reference to specific embodiment, the present invention is further illustrated.
Standard particle generating means of the present invention is by taking F9531 standard particle generating means as an example, and it is commercially available.But do not limit
The present invention.
Aerosol particle counter is commercially available.
It is bronchial that the present invention adjoins 15-17 grades of smalls according to 50 times of determination lung acinuses of Weibel A anatomical models amplification
Diameter, length, Branch Angle, alveolar size and J.Y.Wang alveolar biomechanical parameter set up real Human Lung acinus
Model, outfit standard particle generator, aerosol particle counter, simulated respiration pump, humidifier, PIV Particle-beam Tracing instrument etc.,
Offer is a kind of can to measure Human Lung acinus section model deposition, deposition distribution, single alveolar deposition, the measurement of Flow Field Distribution
Experimental provision.
A kind of human body alveolar aerosol deposition measurement experiment system, including standard particle generating means 1-1 and air-breathing gas it is molten
Glue particle collector 1-2, standard particle generating means 1-1 and air-breathing aerosol particle counter 1-2 pass through pipeline and list respectively
To intake valve 1-3 connections；Breather cheek valve 1-3 is by pipeline with being connected the total pipeline 1-14 after humidifier 1-4 pipeline converges
Through transparent experiment container 1-10 lid, with the lung acinus experimental model 1-9's that is arranged on inside transparent experiment container 1-10
15 grades of bronchus 2-1 connections are simulated, 15 grades of bronchus 2-1 of simulation pass through 16 grades of bronchuses of the first Y-type three way type 2-2 and 2 simulations
2-3 connections, each simulate 16 grades of bronchus 2-3 and are connected by 17 grades of bronchus 2-5 of the second Y-type three way type 2-4 and 2 simulations, often
17 grades of bronchus 2-5 of individual simulation are connected by connecting tube 2-6 with simulated lung acinus cluster 2-7, and simulated lung acinus cluster 2-7 includes simulation
It is provided with breathing 3-4, simulation breathing 3-4 on interface 3-1, interface 3-1 outer wall and is provided with annular projection 3-2, is simulated
Lung acinus 3-3 is flexibly connected with interface 3-1 and fixed by annular projection 3-2；Transparent experiment container 1-10 bottom passes through pipe
Road is connected with simulated respiration pump 1-11；Pressure gauge 1-8 is provided with transparent experiment container 1-10；Expiration aerosol particle counter
1-6 is connected with one-way exhaust valve 1-5 and total pipeline 1-14 successively by pipeline；It is provided with the computer 1-12 of data analysis system
Electrically connected respectively with PIV Particle-beam Tracing instrument 1-13 and simulated respiration pump 1-11, the PIV Particle-beam Tracings instrument 1-13 is set
In transparent experiment container 1-10 side.
Simulated lung acinus can select its modulus of elasticity, Poisson's ratio natural emulsion consistent with alveolar biomechanical parameter,
For example：Model C Y50X2, is only citing, and be not limited thereof.
Simulated lung acinus and smalls bronchus at different levels can disassemble into individual unit using being flexibly connected, and be easy to individually divide
Analysis.
Standard particle generating means is two phase flow aerosol generator, can produce concentration more than 106Individual/cm3Height list
Disperse aerosol, particle size range is 0.1 μm -8 μm, and spherical, particulate matter size and concentration can change.
Simulated respiration pump is piston type.
A kind of use of human body alveolar aerosol deposition measurement experiment system of the present invention：
Using a kind of human body alveolar aerosol deposition measurement experiment system of the present invention, pressurization determines No leakage；Open single
To intake valve 1-3, start standard particle generating means 1-1, occur monodisperse polystyrene microsphere, open air-breathing aerosol particle
Counter 1-2, measures generation concentration, until sampled concentrations are stable；Simulated respiration pump 1-11 is set to reach the pressure that experiment needs
And flow period, open simulated respiration pump 1-11, start recording breath cycle；One-way exhaust valve 1-5 is opened, expiration gas is opened molten
Glue particle collector 1-6, measurement exhalation aerosol concentration, records time cumulation number；The difference of inhaled concentration and exhalation concentration
Ratio with inhaled concentration is lung acinus experimental model 1-9 total particulate depositions.When system works, pass through humidifier 1-4
Humidified to aerosol, pressure gauge 1-8 record pressure.After experiment starts, PIV Particle-beam Tracing instrument 1-13 are opened, lung acinus is measured
Interior pellet movement velocity and flow field；After the breath cycle number of times for reaching setting, standard of closure particle is filled successively
Put 1-1, air-breathing aerosol particle counter 1-2, simulated respiration pump 1-11, breather cheek valve 1-3；Particulate matter is calculated in Human Lung
The total depositions of acinus Qu.
Simulated respiration pump is controlled by computer, simulated respiration frequency, tidal volume, residual volume(RV), pressure difference can be measured and exhaled
Flow is inhaled, and draws respiratory flow curve.
Humidifier can humidify 50%~100% to lung acinus experimental model.
PIV Particle-beam Tracings instrument is used for the movement velocity and rail for showing and calculating particulate matter each region in simulated lung acinus cluster
Mark.
The present invention can simulate real human body lung acinus area's biomethanics and respiratory characteristic, realize that Human Lung acinus area is external
Pellet movement locus is measured with deposition.
The computer 1-12 and PIV Particle-beam Tracing instrument 1-13 for being provided with data analysis system can real-time display system endoparticle
Thing movement locus, measurement kinematic parameter.
Check valve ensures that aerosol motion is unidirectional.
The lid of transparent experiment container can be opened and closed, and install experiment container when compressing structure ensures to close airtight.
During the system operatio of the present invention, by the measurement to different respiratory rates and depth of respiration, stable state breathing can obtain
The deposition conditions of pattern difference respiratory flow aerosol in a model.By changing Aerosol Properties, it can be sucked with aids drug
The distribution spread condition that therapeutic effect and medicine enter after alveolar.By changing bronchus shape and alveolar shape, size, thickness
Degree, modulus of elasticity can carry out the change of pellet deposition under the conditions of pulmonary lesion.
Claims (1)
1. a kind of human body alveolar aerosol deposition measurement experiment system, including standard particle generating means (1-1) and air-breathing gas it is molten
Glue particle collector (1-2), it is characterized in that the standard particle generating means (1-1) and air-breathing aerosol particle counter (1-
2) it is connected respectively by pipeline with breather cheek valve (1-3)；Breather cheek valve (1-3) is by pipeline with being connected humidifier (1-4)
Pipeline converge after total pipeline (1-14) run through transparent experiment container (1-10) lid, with being arranged on transparent experiment container
15 grades of bronchus (2-1) connections of simulation of (1-10) internal lung acinus experimental model (1-9), simulate 15 grades of bronchuses (2-1)
It is connected by 16 grades of bronchuses (2-3) of the first Y-type three way type (2-2) and 2 simulations, each 16 grades of bronchuses (2-3) of simulation pass through
17 grades of bronchuses (2-5) of second Y-type three way type (2-4) and 2 simulations are connected, and each 17 grades of bronchuses (2-5) of simulation pass through connection
Pipe (2-6) is connected with simulated lung acinus cluster (2-7), and simulated lung acinus cluster (2-7) includes simulation breathing (3-4), simulates alveolar
It is provided with pipe (3-4) on interface (3-1), the outer wall of interface (3-1) and is provided with annular projection (3-2), simulated lung acinus (3-3)
It is flexibly connected with interface (3-1) and fixed by annular projection (3-2)；The bottom of transparent experiment container (1-10) by pipeline with
Simulated respiration pump (1-11) is connected；Pressure gauge (1-8) is provided with transparent experiment container (1-10)；Expiration aerosol particle is counted
Device (1-6) is connected with one-way exhaust valve (1-5) and total pipeline (1-14) successively by pipeline；It is provided with the meter of data analysis system
Calculation machine (1-12) is electrically connected with PIV Particle-beam Tracings instrument (1-13) and simulated respiration pump (1-11) respectively, the PIV Particle-beam Tracings instrument
(1-13) is arranged on transparent experiment container (1-10) side.
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| CN201710271413.7A CN107271337B (en) | 2017-04-24 | 2017-04-24 | Human alveolus aerosol deposition measurement experiment system |
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| CN201710271413.7A CN107271337B (en) | 2017-04-24 | 2017-04-24 | Human alveolus aerosol deposition measurement experiment system |
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| CN107271337B CN107271337B (en) | 2023-09-15 |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109166438A (en) * | 2018-10-15 | 2019-01-08 | 西安建筑科技大学 | A kind of breathing thermal manikin and its operating method sucking exposure detection for particulate pollutant human body |
| CN110975950A (en) * | 2019-11-08 | 2020-04-10 | 哈尔滨工业大学（深圳） | Micro-fluidic alveolus chip and alveolus respiration simulation device |
| CN111257517A (en) * | 2020-03-09 | 2020-06-09 | 广东工业大学 | Device for simulating lung breathing |
| CN111489624A (en) * | 2020-04-30 | 2020-08-04 | 哈尔滨工业大学(深圳)(哈尔滨工业大学深圳科技创新研究院) | Single-alveolus three-dimensional amplification model and alveolus respiration simulation device |
| CN111595739A (en) * | 2020-05-21 | 2020-08-28 | 中国矿业大学 | Human respiratory particulate matter deposition simulation and monitoring experiment system |
| CN112345687A (en) * | 2020-11-10 | 2021-02-09 | 温州市大荣纺织仪器有限公司 | Burning dummy with smoke testing function |
| CN112577764A (en) * | 2020-11-18 | 2021-03-30 | 南京师范大学 | Method for evaluating pulmonary delivery efficiency of liquid mist aerosol |
| CN113228141A (en) * | 2019-01-15 | 2021-08-06 | 菲利普莫里斯生产公司 | Perforation structure |
| CN113465873A (en) * | 2021-05-20 | 2021-10-01 | 西安医学院第一附属医院 | Experimental device for simulating internal flow of respiratory tract |
| US20220036766A1 (en) * | 2019-04-24 | 2022-02-03 | Cipla Limited | Methods and systems for simulating deposition of inhaled drug on lungs |
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| CN112345687A (en) * | 2020-11-10 | 2021-02-09 | 温州市大荣纺织仪器有限公司 | Burning dummy with smoke testing function |
| CN112577764A (en) * | 2020-11-18 | 2021-03-30 | 南京师范大学 | Method for evaluating pulmonary delivery efficiency of liquid mist aerosol |
| CN113465873A (en) * | 2021-05-20 | 2021-10-01 | 西安医学院第一附属医院 | Experimental device for simulating internal flow of respiratory tract |
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