CN206930556U - A kind of human body alveolar aerosol deposition measurement experiment system - Google Patents
A kind of human body alveolar aerosol deposition measurement experiment system Download PDFInfo
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- CN206930556U CN206930556U CN201720433433.5U CN201720433433U CN206930556U CN 206930556 U CN206930556 U CN 206930556U CN 201720433433 U CN201720433433 U CN 201720433433U CN 206930556 U CN206930556 U CN 206930556U
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Abstract
The utility model discloses a kind of human body alveolar aerosol deposition measurement experiment system, standard particle generating means and air-breathing aerosol particle counter are connected by pipeline with breather cheek valve respectively；Breather cheek valve runs through the lid of transparent experiment container by pipeline with being connected the total pipeline after the pipeline of humidifier converges, it is connected with the lung acinus experimental model being arranged on inside transparent experiment container, the bottom of transparent experiment container is connected by pipeline with simulated respiration pump；Pressure gauge is provided with transparent experiment container；Expiration aerosol particle counter is connected with one-way exhaust valve and total pipeline successively by pipeline；The computer for being provided with data analysis system electrically connects with PIV Particle-beam Tracings instrument and simulated respiration pump respectively, and PIV Particle-beam Tracing instrument is arranged on the side of transparent experiment container.The utility model can provide the in-vitro measurements of the pellet deposition under different-grain diameter, breathing pattern, ambient humidity and pathological conditions.
Description
Technical field
The utility model belong to biomedical engineering, healthy prevention epidemic prevention technology and equipment, man-machine-environment systems engineering,
The technical field such as hydrodynamics and personal breathing protection is breathed, is to be related to a kind of human body alveolar aerosol deposition to survey specifically
Quantity experiment system.
Background technology
With the accelerated development of global industry, atmosphere pollution makes respiratory disease turn into a kind of common disease, frequently-occurring disease,
Pellet (refers to aerodynamic diameter<10 μm of airborne suspended particulate) lung deposition be main inducing it
One.Human respiratory is made up of respiratory tract (nose, pharynx, larynx, trachea-bronchial epithelial cell) and lung.The main function of respiratory tract is gas
Passage, link up lung and external environment.After pellet in air enters human body by respiration, part deposition
In the multistage bronchiole of the conduction portion of human respiratory, i.e. nose, pharynx, larynx, tracheae, main bronchus and intrapulmonary；Another portion
Lung acinus area can then be entered by dividing, and substantial amounts of deposition makes pulmonary lesion, influences respiratory function, and penetrate further into alveolar wall and enter people
Body blood circulation system, huge injury is caused to health.
On the other hand, with being understood in depth to the disease such as PFT and asthma, pulmonary emphysema, chronic obstructive pulmonary disease, people
Recognize that inhalation is the effective means for treating above-mentioned disease.Lung suck preparation because it is easy to use, work it is rapid, avoid
The first pass effect of liver, reduce the issuable adverse reaction of Formulations for systemic administration and turn into wide at present the advantages that overdose uses
The method of the treatment respiratory disease of general concern.After suction preparation enters human body, the medicine for being deposited on the upper respiratory tract is most of
It is excreted by the motion of cilium, the medicine being only deposited in lung acinus could enter blood circulation and be absorbed.I.e.
Improve bioavilability of the inhalation in lung, it is necessary to improve its deposition in lung acinus area.Therefore, establishing lung can inhale
Enter particulate matter deposition in-vitro measurements experimental provision, there is huge scientific research value and application value.
The method that upper respiratory tract particulate matter deposition can establish physical model by computer model and CT scan is surveyed
Amount analysis.Patent CN204797996 U describe a kind of method and dress of weight method measurement human upper airway particulate matter deposition
Put, efficiently solve human upper airway particulate matter deposition analogue measurement problem, but it does not account for the upper respiratory tract to suction
The humidification of air, and the deposition of human body smalls bronchus and alveolar region can not be measured.
Lung acinus is the main region of respiration, accounts for the 90% of respiratory system volume, measures various breathings, environment, disease
Particulate matter lung acinus deposits and finds that deposition rule is very necessary under the conditions of disease influence etc..Measurement to the part is mainly adopted at present
With experimental animal or the method for volunteer's actual test, but it is with high costs, and experimental period is long, big to human body side effect.Due to lung
Acinus plot structure is complicated, size is smaller, there is no method to establish physical model by CT scan mode.Chinese patent CN 104050321
A describes a kind of computer model of alveolar particulate matter running orbit, and substantial amounts of simplification has been carried out to alveolar.But analog result is
It is based on ideal boundary condition it is assumed that belong to Computer Simulation category, obtain data and be not based on experiment gained, it usually needs
Physical model further verifies that actual application value is limited.
The A of Chinese patent CN 102750859 employ elastic silica gel material and a kind of device for simulating pulmonary ventilation have been made, and adjust
Section silica gel material modulus of elasticity is close with human lung, realizes the simulation of elasticity breathing.To be built although the patent provides one kind
The thinking of elastic lung acinus model is found, but it is only capable of simulation reconstruction respiratory, can not carry out pellet in lung acinus
Area's sedimentation experiment.
Utility model content
The purpose of this utility model is overcome the deficiencies in the prior art, there is provided a kind of human body alveolar aerosol deposition measurement is real
Check system.
The technical solution of the utility model is summarized as follows：
A kind of human body alveolar aerosol deposition measurement experiment system, including standard particle generating means 1-1 and air-breathing gas it is molten
Glue particle collector 1-2, standard particle generating means 1-1 and air-breathing aerosol particle counter 1-2 pass through pipeline and list respectively
To intake valve 1-3 connections；Breather cheek valve 1-3 is by pipeline with being connected the total pipeline 1-14 after humidifier 1-4 pipeline converges
Through transparent experiment container 1-10 lid, with the lung acinus experimental model 1-9's that is arranged on inside transparent experiment container 1-10
15 grades of bronchus 2-1 connections are simulated, 15 grades of bronchus 2-1 of simulation pass through 16 grades of bronchuses of the first Y-type three way type 2-2 and 2 simulations
2-3 connections, each simulate 16 grades of bronchus 2-3 and be connected by 17 grades of bronchus 2-5 of the second Y-type three way type 2-4 and 2 simulations, often
17 grades of bronchus 2-5 of individual simulation are connected by connecting tube 2-6 with simulated lung acinus cluster 2-7, and simulated lung acinus cluster 2-7 includes simulation
Interface 3-1 is provided with breathing 3-4, simulation breathing 3-4, annular projection 3-2 is provided with interface 3-1 outer wall, is simulated
Lung acinus 3-3 is flexibly connected with interface 3-1 and fixed by annular projection 3-2；Transparent experiment container 1-10 bottom passes through pipe
Road is connected with simulated respiration pump 1-11；Pressure gauge 1-8 is provided with transparent experiment container 1-10；Expiration aerosol particle counter
1-6 is connected with one-way exhaust valve 1-5 and total pipeline 1-14 successively by pipeline；It is provided with the computer 1-12 of data analysis system
Electrically connected respectively with PIV Particle-beam Tracing instrument 1-13 and simulated respiration pump 1-11, PIV Particle-beam Tracing instrument 1-13 is arranged on transparent experiment
Container 1-10 side.
The advantages of the utility model：
The utility model can provide the inhalable particles under different-grain diameter, breathing pattern, ambient humidity and pathological conditions
The in-vitro measurements of thing deposition.Experimenter is expected to disclose the deposition rule and shadow of lung acinus area particulate matter using the utility model
The factor of sound, the optimization of the origin cause of formation of PUD D, development, prevention, targeted therapy and inhalable therapy is explored, and for replacing experiment
Animal or volunteer carry out curative effect of medication analysis and novel drugs exploitation.
Brief description of the drawings
Fig. 1 is schematic diagram of the present utility model.
Fig. 2 is lung acinus laboratory model construction schematic diagram.
Fig. 3 is simulated lung acinotubular and simulated lung acinus partial cutaway schematic.
Embodiment
The utility model is further described with reference to specific embodiment.
For the utility model standard particle generating means by taking F9531 standard particle generating means as an example, it is commercially available.But not
Limit the utility model.
Aerosol particle counter is commercially available.
The utility model amplifies 50 times according to Weibel A anatomical models and determines that lung acinus adjoins 15-17 level smalls branch gas
The diameter of pipe, length, Branch Angle, alveolar size and J.Y.Wang alveolar biomechanical parameter establish real Human Lung
Acinus model, outfit standard particle generator, aerosol particle counter, simulated respiration pump, humidifier, PIV Particle-beam Tracings
Instrument etc., there is provided one kind can measure Human Lung acinus section model deposition, deposition distribution, single alveolar deposition, Flow Field Distribution
Measurement experiment device.
A kind of human body alveolar aerosol deposition measurement experiment system, including standard particle generating means 1-1 and air-breathing gas it is molten
Glue particle collector 1-2, standard particle generating means 1-1 and air-breathing aerosol particle counter 1-2 pass through pipeline and list respectively
To intake valve 1-3 connections；Breather cheek valve 1-3 is by pipeline with being connected the total pipeline 1-14 after humidifier 1-4 pipeline converges
Through transparent experiment container 1-10 lid, with the lung acinus experimental model 1-9's that is arranged on inside transparent experiment container 1-10
15 grades of bronchus 2-1 connections are simulated, 15 grades of bronchus 2-1 of simulation pass through 16 grades of bronchuses of the first Y-type three way type 2-2 and 2 simulations
2-3 connections, each simulate 16 grades of bronchus 2-3 and be connected by 17 grades of bronchus 2-5 of the second Y-type three way type 2-4 and 2 simulations, often
17 grades of bronchus 2-5 of individual simulation are connected by connecting tube 2-6 with simulated lung acinus cluster 2-7, and simulated lung acinus cluster 2-7 includes simulation
Interface 3-1 is provided with breathing 3-4, simulation breathing 3-4, annular projection 3-2 is provided with interface 3-1 outer wall, is simulated
Lung acinus 3-3 is flexibly connected with interface 3-1 and fixed by annular projection 3-2；Transparent experiment container 1-10 bottom passes through pipe
Road is connected with simulated respiration pump 1-11；Pressure gauge 1-8 is provided with transparent experiment container 1-10；Expiration aerosol particle counter
1-6 is connected with one-way exhaust valve 1-5 and total pipeline 1-14 successively by pipeline；It is provided with the computer 1-12 of data analysis system
Electrical connection is electrically connected with PIV Particle-beam Tracing instrument 1-13 and simulated respiration pump 1-11 respectively, the PIV Particle-beam Tracings instrument 1-13 is set
In transparent experiment container 1-10 side.
Simulated lung acinus can select its modulus of elasticity, Poisson's ratio natural emulsion consistent with alveolar biomechanical parameter,
Such as：Model C Y50X2, only it is citing, and is not limited thereof.
Simulated lung acinus and smalls bronchus at different levels can disassemble into individual unit using being flexibly connected, and be easy to individually divide
Analysis.
Standard particle generating means is two phase flow aerosol generator, can produce concentration more than 106Individual/cm3Height
Monodisperse aerosol, particle size range are 0.1 μm -8 μm, and spherical, particulate matter size and concentration can change.
Simulated respiration pump is piston type.
A kind of use of human body alveolar aerosol deposition measurement experiment system of the utility model：
Using a kind of human body alveolar aerosol deposition measurement experiment system of the present utility model, pressurization determines No leakage；Beat
Opening one-way intake valve 1-3, start standard particle generating means 1-1, monodisperse polystyrene microsphere occurs, open air-breathing aerosol
Particle collector 1-2, generation concentration is measured, until sampled concentrations are stable；Simulated respiration pump 1-11 is set to reach experiment needs
Pressure and flow period, open simulated respiration pump 1-11, start recording breath cycle；One-way exhaust valve 1-5 is opened, opens and exhales
Aerosol particle counter 1-6, measurement exhalation aerosol concentration, records time cumulation number；Inhaled concentration and exhalation concentration
The ratio of difference and inhaled concentration is lung acinus experimental model 1-9 total particulate depositions.When system works, pass through humidifier
1-4 humidifies to aerosol, pressure gauge 1-8 record pressure.After experiment starts, PIV Particle-beam Tracing instrument 1-13 are opened, measure lung gland
Pellet movement velocity and flow field in bubble；After the breath cycle number for reaching setting, standard of closure particle occurs successively
Device 1-1, air-breathing aerosol particle counter 1-2, simulated respiration pump 1-11, breather cheek valve 1-3；Particulate matter is calculated in human body
The total depositions of lung acinus Qu.
Simulated respiration pump is controlled by computer, simulated respiration frequency, tidal volume, residual volume(RV), pressure difference can be measured and exhaled
Flow is inhaled, and draws respiratory flow curve.
Humidifier can humidify 50%~100% to lung acinus experimental model.
PIV Particle-beam Tracings instrument is used for the movement velocity and rail for showing and calculating particulate matter each region in simulated lung acinus cluster
Mark.
The utility model can simulate real human body lung acinus area's biomethanics and respiratory characteristic, realize Human Lung acinus area
External pellet movement locus measures with deposition.
The computer 1-12 and PIV Particle-beam Tracing instrument 1-13 for being provided with data analysis system can real-time display system endoparticle
Thing movement locus, measurement kinematic parameter.
Check valve ensures that aerosol motion is unidirectional.
The lid of transparent experiment container can open and close, and experiment container is airtight when installation compressing structure ensures to close.
During system operatio of the present utility model, by the measurement to different respiratory rates and depth of respiration, stable state can obtain
The deposition conditions of breathing pattern difference respiratory flow aerosol in a model., can be with aids drug by changing Aerosol Properties
The distribution spread condition that Inhalation in Treating effect and medicine enter after alveolar.By change bronchus shape and alveolar shape, size,
Thickness, modulus of elasticity can carry out the change of pellet deposition under the conditions of pulmonary lesion.
Claims (1)
1. a kind of human body alveolar aerosol deposition measurement experiment system, including standard particle generating means (1-1) and air-breathing gas it is molten
Glue particle collector (1-2), it is characterized in that the standard particle generating means (1-1) and air-breathing aerosol particle counter (1-
2) it is connected respectively by pipeline with breather cheek valve (1-3)；Breather cheek valve (1-3) is by pipeline with being connected humidifier (1-4)
Pipeline converge after total pipeline (1-14) run through transparent experiment container (1-10) lid, with being arranged on transparent experiment container
15 grades of bronchus (2-1) connections of simulation of (1-10) internal lung acinus experimental model (1-9), simulate 15 grades of bronchuses (2-1)
It is connected by 16 grades of bronchuses (2-3) of the first Y-type three way type (2-2) and 2 simulations, each simulates 16 grades of bronchuses (2-3) and pass through
17 grades of bronchuses (2-5) of second Y-type three way type (2-4) and 2 simulations are connected, and each simulate 17 grades of bronchuses (2-5) and pass through connection
Pipe (2-6) is connected with simulated lung acinus cluster (2-7), and simulated lung acinus cluster (2-7) includes simulation breathing (3-4), simulates alveolar
Interface (3-1) is provided with pipe (3-4), annular projection (3-2), simulated lung acinus (3-3) are provided with the outer wall of interface (3-1)
It is flexibly connected with interface (3-1) and fixed by annular projection (3-2)；The bottom of transparent experiment container (1-10) by pipeline with
Simulated respiration pump (1-11) connects；Pressure gauge (1-8) is provided with transparent experiment container (1-10)；Expiration aerosol particle counts
Device (1-6) is connected with one-way exhaust valve (1-5) and total pipeline (1-14) successively by pipeline；It is provided with the meter of data analysis system
Calculation machine (1-12) electrically connects with PIV Particle-beam Tracings instrument (1-13) and simulated respiration pump (1-11) respectively, the PIV Particle-beam Tracings instrument
(1-13) is arranged on transparent experiment container (1-10) side.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720433433.5U CN206930556U (en) | 2017-04-24 | 2017-04-24 | A kind of human body alveolar aerosol deposition measurement experiment system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720433433.5U CN206930556U (en) | 2017-04-24 | 2017-04-24 | A kind of human body alveolar aerosol deposition measurement experiment system |
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| CN206930556U true CN206930556U (en) | 2018-01-26 |
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| CN201720433433.5U Withdrawn - After Issue CN206930556U (en) | 2017-04-24 | 2017-04-24 | A kind of human body alveolar aerosol deposition measurement experiment system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107271337A (en) * | 2017-04-24 | 2017-10-20 | 中国人民解放军军事医学科学院卫生装备研究所 | A kind of human body alveolar aerosol deposition measurement experiment system |
-
2017
- 2017-04-24 CN CN201720433433.5U patent/CN206930556U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107271337A (en) * | 2017-04-24 | 2017-10-20 | 中国人民解放军军事医学科学院卫生装备研究所 | A kind of human body alveolar aerosol deposition measurement experiment system |
| CN107271337B (en) * | 2017-04-24 | 2023-09-15 | 中国人民解放军军事医学科学院卫生装备研究所 | Human alveolus aerosol deposition measurement experiment system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20180126 Effective date of abandoning: 20230915 |
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| AV01 | Patent right actively abandoned |
Granted publication date: 20180126 Effective date of abandoning: 20230915 |