CN107259580B - The preparation method of one kind of multiple minerals vitamin preparations - Google Patents
The preparation method of one kind of multiple minerals vitamin preparations Download PDFInfo
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- CN107259580B CN107259580B CN201710581517.8A CN201710581517A CN107259580B CN 107259580 B CN107259580 B CN 107259580B CN 201710581517 A CN201710581517 A CN 201710581517A CN 107259580 B CN107259580 B CN 107259580B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 66
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 47
- 239000011707 mineral Substances 0.000 title claims abstract description 47
- 229940088594 vitamin Drugs 0.000 title claims abstract description 28
- 229930003231 vitamin Natural products 0.000 title claims abstract description 28
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 28
- 239000011782 vitamin Substances 0.000 title claims abstract description 28
- 150000003722 vitamin derivatives Chemical class 0.000 title claims abstract description 26
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 49
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 49
- 239000011710 vitamin D Substances 0.000 claims abstract description 49
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 49
- 150000003710 vitamin D derivatives Chemical class 0.000 claims abstract description 49
- 229940046008 vitamin d Drugs 0.000 claims abstract description 49
- 235000010755 mineral Nutrition 0.000 claims abstract description 46
- 239000002245 particle Substances 0.000 claims abstract description 25
- 239000000463 material Substances 0.000 claims abstract description 11
- 239000011248 coating agent Substances 0.000 claims description 73
- 239000000243 solution Substances 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 39
- 238000000576 coating method Methods 0.000 claims description 38
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 28
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000011572 manganese Substances 0.000 claims description 22
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 20
- 229910052748 manganese Inorganic materials 0.000 claims description 20
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 16
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 14
- 239000000853 adhesive Substances 0.000 claims description 14
- 230000001070 adhesive effect Effects 0.000 claims description 14
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 14
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 14
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 14
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- 229940099596 manganese sulfate Drugs 0.000 claims description 12
- 239000011702 manganese sulphate Substances 0.000 claims description 12
- 235000007079 manganese sulphate Nutrition 0.000 claims description 12
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical group [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 12
- 239000008213 purified water Substances 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 9
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 9
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 9
- 229940083466 soybean lecithin Drugs 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 6
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 6
- 229960002079 calcium pantothenate Drugs 0.000 claims description 6
- 238000010790 dilution Methods 0.000 claims description 6
- 239000012895 dilution Substances 0.000 claims description 6
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 6
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 6
- 239000004222 ferrous gluconate Substances 0.000 claims description 6
- 235000013924 ferrous gluconate Nutrition 0.000 claims description 6
- 229960001645 ferrous gluconate Drugs 0.000 claims description 6
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims description 6
- 239000000395 magnesium oxide Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 239000011781 sodium selenite Substances 0.000 claims description 6
- 235000015921 sodium selenite Nutrition 0.000 claims description 6
- 229960001471 sodium selenite Drugs 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 6
- 235000012756 tartrazine Nutrition 0.000 claims description 6
- 239000004149 tartrazine Substances 0.000 claims description 6
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 claims description 6
- 229960000943 tartrazine Drugs 0.000 claims description 6
- 239000004408 titanium dioxide Substances 0.000 claims description 6
- 239000011670 zinc gluconate Substances 0.000 claims description 6
- 235000011478 zinc gluconate Nutrition 0.000 claims description 6
- 229960000306 zinc gluconate Drugs 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 claims description 3
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims description 3
- CEZCCHQBSQPRMU-UHFFFAOYSA-L chembl174821 Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-UHFFFAOYSA-L 0.000 claims description 3
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 3
- 229940097275 indigo Drugs 0.000 claims description 3
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims description 3
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 5
- 235000015097 nutrients Nutrition 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 235000013402 health food Nutrition 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 11
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 235000012343 cottonseed oil Nutrition 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000005095 gastrointestinal system Anatomy 0.000 description 2
- AMWRITDGCCNYAT-UHFFFAOYSA-L hydroxy(oxo)manganese;manganese Chemical compound [Mn].O[Mn]=O.O[Mn]=O AMWRITDGCCNYAT-UHFFFAOYSA-L 0.000 description 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011574 phosphorus Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention relates to the preparation methods of one kind of multiple minerals vitamin preparations, belong to nutritional health food field.Specific steps include the pretreatment of vitamin D, the preparation of vitamin D embedded particles, the pretreatment of divalent manganesetion, the preparation of divalent manganesetion embedded particles, the pretreatment of mineral matter element and preparation synthesis；The several mineral materials vitamin preparation prepared by this method, vitamin D and divalent manganesetion therein is made to be effectively isolated with the other multi mineral prime elements added in product, avoid interference of the external environment to drug simultaneously, effectively enhance the stability of preparation, give full play to its pharmaceutical properties, multi mineral prime element is added, ensures that human body takes in enough required nutrients.
Description
Technical field
The invention belongs to nutritional health food field, specifically, being related to the system of one kind of multiple minerals vitamin preparations
Preparation Method.
Background technology
With the development of science and technology and the raising of people's health consciousness, daily active nutritive health-care food for supplementing have been formed
A kind of new trend takes in nutrient deficiency or the certain diseases of prevention to supplement three meals in a day.Numerous studies show vitamin, mineral
Matter and it can effectively prevent disease with their nutrient prime replenishers as main component, vitamin and mineral is maintenance flesh
Body eubolism and the essential important substance of health, the two are to form the important composition of a variety of coenzyme and hormone, are lacked
Reactive volt-ampere hour can lead to dysbolism, and cause a variety of diseases.
Several mineral materials vitamin preparation, containing multi mineral prime element and vitamin, can be supplemented as nutritional supplement
The deficiency of body vitamin and micro macroelement, for preventing the various diseases caused by vitamin and indispensable element lack
Disease.Wherein vitamin D is a very unique member in all bioactive substances, has a variety of effects, not only to human body
Alcium and phosphor metabolization and sclerotin calcification play an important role, and each histocyte has wide application to whole body, with various important diseases
Have substantial connection, but since vitamin D influences other materials in illumination, air, humidity and product, in process of production and
The product made in products-supply using the method for conventional formulation, vitamin D are influenced by factors above, and content significantly drops
It is low, make people's vitamin D intake deficiency that the due effect of nutritional supplement be not achieved, and air, humidity are to trace element manganese
And other materials influence in product, easily make bivalent manganese cycling of elements into manganese dioxide, the manganese during manufactured products-supply
Element is influenced by factors above, and product appearance character is caused black splotch easily occur, the quality of product by Different Effects,
It is unfavorable for absorption of human body.
Therefore, it is necessary to improve the stability of vitamin D in several mineral materials vitamin preparation, human body is improved in product
The absorption rate of vitamin D；It is necessary to protect divalent manganesetion in nutritional preparation, it is avoided to be oxidized to two under alkaline condition
Manganese oxide is influenced so as to product quality.
Invention content
In order to solve the problems, such as background technology, the present invention provides the systems of one kind of multiple minerals vitamin preparations
Preparation Method by carrying out embedding treatment to vitamin D and divalent manganesetion, makes itself and other several mineral materials for being added in product
Element is effectively isolated, and effectively enhances the stability of preparation.
To achieve the above object, the present invention is achieved through the following technical solutions：
The preparation method of one kind of multiple minerals vitamin preparations, includes the following steps：
1) pretreatment of vitamin D：Microcrystalline cellulose is given birth to dimension into the piller of 10 mesh with 3%HPMC solution mixing systems
95% alcohol 100 of plain D oil solutions:Spray is done on piller, treating that piller fully absorbs vitamin D to saturation state after 1 dilution
It is dry for use；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, is coated the piller for absorbing vitamin D, dried for standby；
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, it is dry further by mixture A and adhesive 3%HPMC solution mixing systems into 10 mesh pillers
For use；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent B with water is uniformly mixed, is made
The coating solution of solid content 15% is coated 10 mesh piller of bivalent manganese, dried for standby；
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) preparation synthesizes：By the vitamin D embedded particles of 160-180 parts by weight, the divalent manganesetion packet of 10-15 parts by weight
Bury particle, the mineral matter element pretreatment piller of 30-35 parts by weight is uniformly mixed, tabletting or encapsulated use.
Further, coating agent A described in step 2) be the titanium dioxide of 10-15 parts by weight, the soybean phosphorus of 5-10 parts by weight
Fat, the Sunset yellow aluminum lake of 3-8 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, the talcum powder of 10-20 parts by weight, 5-10 weights
Measure the polyethylene glycol of part, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight indigo aluminum lake.
Further, coating agent B described in step 4) be the titanium dioxide of 10-15 parts by weight, the brilliant blue aluminium color of 3-8 parts by weight
Shallow lake, the soybean lecithin of 5-10 parts by weight, the copper sulphate of 2-5 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, 10-20 parts by weight
Talcum powder, the polyethylene glycol of 5-10 parts by weight, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight Fancy red aluminum lake.
Beneficial effects of the present invention：
The present application is handled vitamin D and divalent manganesetion by packaging technique, effective protection vitamin D and
Divalent manganesetion is not illuminated by the light, in air, humidity and product other materials influence；Soybean lecithin is added in, makes coating agent uniform
Densification, covered effect is good, while soybean lecithin can promote human metabolism, promotes the suction of vitamin D and each nutrient
It receives；Several mineral materials vitamin preparation by Cotton seeds, make vitamin D and bivalent manganese from added in product it is other more
Kind mineral matter element is effectively isolated, while avoid interference of the external environment to drug, effectively enhances the stability of preparation, fully
Play its pharmaceutical properties；Multi mineral prime element is added, ensures that human body takes in enough required nutrients.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the embodiment of the present invention is clearly and completely described,
Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work, all
Belong to the scope of protection of the invention.
The preparation method of one kind of multiple minerals vitamin preparations, includes the following steps：
1) pretreatment of vitamin D：Microcrystalline cellulose is given birth to dimension into the piller of 10 mesh with 3%HPMC solution mixing systems
95% alcohol 100 of plain D oil solutions:Spray is done on piller, treating that piller fully absorbs vitamin D to saturation state after 1 dilution
It is dry for use；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, is coated the piller for absorbing vitamin D, dried for standby；
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, it is dry further by mixture A and adhesive 3%HPMC solution mixing systems into 10 mesh pillers
For use；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent B with water is uniformly mixed, is made
The coating solution of solid content 15% is coated 10 mesh piller of bivalent manganese, dried for standby；
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby；
6) preparation synthesizes：By the vitamin D embedded particles of 160-180 parts by weight, the divalent manganesetion packet of 10-15 parts by weight
Bury particle, the mineral matter element pretreatment piller of 30-35 parts by weight is uniformly mixed, tabletting or encapsulated use.
Further, coating agent A described in step 2) be the titanium dioxide of 10-15 parts by weight, the soybean phosphorus of 5-10 parts by weight
Fat, the Sunset yellow aluminum lake of 3-8 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, the talcum powder of 10-20 parts by weight, 5-10 weights
Measure the polyethylene glycol of part, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight indigo aluminum lake.
Further, coating agent B described in step 4) be the titanium dioxide of 10-15 parts by weight, the brilliant blue aluminium color of 3-8 parts by weight
Shallow lake, the soybean lecithin of 5-10 parts by weight, the copper sulphate of 2-5 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, 10-20 parts by weight
Talcum powder, the polyethylene glycol of 5-10 parts by weight, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight Fancy red aluminum lake.
Further, the mass ratio of microcrystalline cellulose and 3%HPMC solution is 3.5-4 in step 1):1；It is mixed in step 3)
The mass ratio 3.5-4 of object A and adhesive 3%HPMC solution:1.
Further, the art for coating condition in step 2) be 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure
2.0bar, coating pan rotating speed 5rpm, coating flow velocity 80-100g/min.
Further, the art for coating condition in step 4) be 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure
2.0bar, coating pan rotating speed 8rpm, coating flow velocity 100-120g/min.
Embodiment 1
One kind of multiple minerals vitamin preparations and preparation method thereof, specific preparation process is as follows：
1) pretreatment of vitamin D：It is 3.5 in mass ratio by microcrystalline cellulose and 3%HPMC solution:1 is mixed and made into 10
Purpose piller, by 95% alcohol 100 of vitamin D oil solution:1 dilution after spray on piller, treat piller fully absorb dimension life
Plain D is to saturation state, dried for standby；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, in 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
The piller for absorbing vitamin D is coated under conditions of coating flow velocity 80-100g/min, dried for standby, coating agent A's
Composition is as shown in table 1：
The composition of 1 coating agent A of table
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, further by mixture A and adhesive 3%HPMC solution in mass ratio 3.5:1 is mixed
10 mesh pillers, dried for standby；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent with water is uniformly mixed, is made solid
The coating solution of content 15%, in 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed
10 mesh piller of bivalent manganese is coated under conditions of 8rpm, coating flow velocity 100-120g/min, dried for standby, coating agent B
Composition it is as shown in table 2：
The composition of 2 coating agent B of table
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) preparation synthesizes：By the vitamin D embedded particles of 160 parts by weight, 10 parts by weight divalent manganesetion embedded particles,
The mineral matter element pretreatment piller of 30 parts by weight is uniformly mixed, and one kind of multiple minerals vitamins are made in tabletting or encapsulated
Preparation.
Embodiment 2
One kind of multiple minerals vitamin preparations and preparation method thereof, specific preparation process is as follows：
1) pretreatment of vitamin D：It is 3.8 in mass ratio by microcrystalline cellulose and 3%HPMC solution:1 is mixed and made into 10
Purpose piller, by 95% alcohol 100 of vitamin D oil solution:1 dilution after spray on piller, treat piller fully absorb dimension life
Plain D is to saturation state, dried for standby；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, in 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
The piller for absorbing vitamin D is coated under conditions of coating flow velocity 80-100g/min, dried for standby, coating agent A's
Composition is as shown in table 1：
The composition of 1 coating agent A of table
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, further by mixture A and adhesive 3%HPMC solution in mass ratio 3.8:1 is mixed
10 mesh pillers, dried for standby；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent with water is uniformly mixed, is made solid
The coating solution of content 15%, in 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed
10 mesh piller of bivalent manganese is coated under conditions of 8rpm, coating flow velocity 100-120g/min, dried for standby, coating agent B
Composition it is as shown in table 2：
The composition of 2 coating agent B of table
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) by the vitamin D embedded particles of 170 parts by weight, the divalent manganesetion embedded particles of 12 parts by weight, 33 parts by weight
Mineral matter element pretreatment piller be uniformly mixed, one kind of multiple minerals vitamin preparations are made in tabletting or encapsulated.
Embodiment 3
One kind of multiple minerals vitamin preparations and preparation method thereof, specific preparation process is as follows：
1) pretreatment of vitamin D：It is 4 in mass ratio by microcrystalline cellulose and 3%HPMC solution:1 is mixed and made into 10 mesh
Piller, by 95% alcohol 100 of vitamin D oil solution:Spray is on piller, treating that piller fully absorbs vitamin D after 1 dilution
To saturation state, dried for standby；
2) preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, in 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
The piller for absorbing vitamin D is coated under conditions of coating flow velocity 80-100g/min, dried for standby, coating agent A's
Composition is as shown in table 1：
The composition of 1 coating agent A of table
3) pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio
2:Mixture A is obtained after 1 mixing, further by mixture A and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10
Mesh piller, dried for standby；
4) preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent with water is uniformly mixed, is made solid
The coating solution of content 15%, in 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed
10 mesh piller of bivalent manganese is coated under conditions of 8rpm, coating flow velocity 100-120g/min, dried for standby, coating agent B
Composition it is as shown in table 2：
The composition of 2 coating agent B of table
5) pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, 30-40 parts by weight ferrous gluconate,
The zinc gluconate of 20-30 parts by weight, the sodium selenite of 0.01-0.03 parts by weight, the magnesia mixing of 10-15 parts by weight are equal
It is even, mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers,
Dried for standby.
6) preparation synthesizes：By the vitamin D embedded particles of 180 parts by weight, 15 parts by weight divalent manganesetion embedded particles,
The mineral matter element pretreatment piller of 35 parts by weight is uniformly mixed, and one kind of multiple minerals vitamins are made in tabletting or encapsulated
Preparation.
Effect analysis：
Adult's gastrointestinal system is from the food of the 1mg containing manganese to radiolabeled54The uptake of Mn, adult male and women
It is (1.35 ± 0.51) % and (3.55 ± 2.11) % respectively.Young woman takes in after 0.3mg manganese within 10d storing for manganese in vivo
Amount is about (5.0 ± 3.1) %.And in the present invention, several mineral materials vitamin preparation of the gastrointestinal system from the 1mg containing manganese of being grown up
In to radiolabeled54The uptake of Mn, adult male and women be respectively (2.65 ± 0.53) % and (5.55 ±
2.01) %.
The present application first pre-processes vitamin D and divalent manganesetion, then is coated operation, in pretreatment
The HPMC of proper proportion is added in, makes the piller shape to be formed uniform, surface rounding；Using HPMC as film forming in conventional coating agents
Agent, but it is larger as the clothing film porosity that film forming agent is formed using HPMC, and barrier property is relatively poor, and film forming agent polyethylene
Alcohol viscosity is larger, and form a film clothing film cracky, and production is difficult to control, the present invention first with HPMC to vitamin D and divalent manganesetion into
Row pretreatment, then be polyvinyl alcohol with film forming agent and coating solution containing soybean lecithin is coated, soybean lecithin has fine
Emulsifiability, dispersion performance, wettability and pick resistance, the addition of proper proportion soybean lecithin improves polyvinyl alcohol
The viscosity problem of coating solution, while make each component of coating agent is fabulous to be dispersed in solution system, form point of stable homogeneous
System is dissipated, sedimentation, the layering of coating agent in coating process is avoided, is coated the problems such as uneven；Since polyvinyl alcohol and HPMC have pole
Good compatibility cementability, piller first pass through HPMC pretreatments and are coated operation again, and fabulous enhances coating agent and piller
Compatibility, make coating stable and firm, it is not easily to fall off；Iron and calcium can hinder the absorption of manganese to a certain extent, in the coating agent of manganese
The copper of proper proportion is added in component, the defect can be overcome, promote the absorption of manganese；Several mineral materials dimension by Cotton seeds
Raw element preparation, makes vitamin D and divalent manganesetion are effectively isolated with the other multi mineral prime elements added in product, keeps away simultaneously
Exempt from interference of the external environment to drug, effectively enhance the stability of preparation, give full play to its pharmaceutical properties；Add multi mineral
Prime element ensures that human body takes in enough required nutrients.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (4)
1. the preparation method of one kind of multiple minerals vitamin preparations, which is characterized in that the several mineral materials vitamin system
The preparation method of agent includes the following steps：
1）The pretreatment of vitamin D：By microcrystalline cellulose with 3%HPMC solution mixing systems into the piller of 10 mesh, by vitamin D oil
95% alcohol 100 of solution:Spray on piller, treating that piller fully absorbs vitamin D to saturation state, treat by drying after 1 dilution
With；
2）The preparation of vitamin D embedded particles：Using purified water as solvent, coating agent A with water is uniformly mixed, solid content is made
15% coating solution is coated the piller for absorbing vitamin D, dried for standby；
3）The pretreatment of divalent manganesetion：The bivalent manganese is manganese sulfate, by microcrystalline cellulose and manganese sulfate in mass ratio 2:1 is mixed
Mixture A is obtained after conjunction, further by mixture A and adhesive 3%HPMC solution mixing systems into 10 mesh pillers, dried for standby；
4）The preparation of divalent manganesetion embedded particles：Using purified water as solvent, coating agent B with water is uniformly mixed, is made and contains admittedly
The coating solution of amount 15%, is coated 10 mesh piller of bivalent manganese, dried for standby；
5）The pretreatment of mineral matter element：By the calcium pantothenate of 40-50 parts by weight, the ferrous gluconate of 30-40 parts by weight, 20-
The zinc gluconate of 30 parts by weight, the sodium selenite of 0 .01-0 .03 parts by weight, 10-15 parts by weight magnesia be uniformly mixed,
Mixture B is formed, further by mixture B and adhesive 3%HPMC solution in mass ratio 4:1 is mixed and made into 10 mesh pillers, dry
For use；
6）Preparation synthesizes：By the divalent manganesetion embedding of the vitamin D embedded particles of 160-180 parts by weight, 10-15 parts by weight
Grain, 30-35 parts by weight mineral matter element pretreatment piller be uniformly mixed, tabletting or encapsulated use；
Wherein, step 2）Described in coating agent A for the titanium dioxide of 10-15 parts by weight, the soybean lecithin of 5-10 parts by weight, 3-8
The Sunset yellow aluminum lake of parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, the talcum powder of 10-20 parts by weight, 5-10 parts by weight
Polyethylene glycol, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight indigo aluminum lake；
Step 4）Described in coating agent B for the titanium dioxide of 10-15 parts by weight, the Brilliant blue aluminum lake of 3-8 parts by weight, 5-10 weight
Part soybean lecithin, the copper sulphate of 2-5 parts by weight, the tartrazine aluminum lake of 3-8 parts by weight, 10-20 parts by weight talcum powder, 5-
The polyethylene glycol of 10 parts by weight, the polyvinyl alcohol of 8-15 parts by weight, 3-8 parts by weight Fancy red aluminum lake.
2. the preparation method of one kind of multiple minerals vitamin preparations according to claim 1, which is characterized in that step 1）
The mass ratio of middle microcrystalline cellulose and 3%HPMC solution is 3.5-4:1；Step 3）Middle mixture A and adhesive 3%HPMC solution
Mass ratio 3.5-4:1.
3. the preparation method of one kind of multiple minerals vitamin preparations according to claim 1, which is characterized in that step 2）
In art for coating condition for 60 DEG C of inlet air temperature, 38-42 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 5rpm,
It is coated flow velocity 80-100g/min.
4. the preparation method of one kind of multiple minerals vitamin preparations according to claim 1, which is characterized in that step 4）
In art for coating condition for 90 DEG C of inlet air temperature, 40-45 DEG C of piece bed tempertaure, atomizing pressure 2.0bar, coating pan rotating speed 8rpm,
It is coated flow velocity 100-120g/min.
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| CN111870584A (en) * | 2020-08-25 | 2020-11-03 | 无限极（中国）有限公司 | Composition beneficial to bone health promotion and application thereof |
| CN113368068B (en) * | 2021-05-21 | 2022-08-02 | 北京斯利安药业有限公司 | Embedded particles and preparation method and application thereof |
| CN113180245A (en) * | 2021-06-07 | 2021-07-30 | 湖北人缘堂医药生物工程有限公司 | Production method of multi-vitamin mineral tablets |
| CN115006363A (en) * | 2022-06-23 | 2022-09-06 | 上海信谊万象药业股份有限公司 | Oyster calcium carbonate chewable tablets and preparation method thereof |
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