CN107252111A - It is a kind of to aid in health food of diabetic's rehabilitation and preparation method thereof - Google Patents
It is a kind of to aid in health food of diabetic's rehabilitation and preparation method thereof Download PDFInfo
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- CN107252111A CN107252111A CN201710375078.5A CN201710375078A CN107252111A CN 107252111 A CN107252111 A CN 107252111A CN 201710375078 A CN201710375078 A CN 201710375078A CN 107252111 A CN107252111 A CN 107252111A
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- Prior art keywords
- cortex eucommiae
- bark
- folium cortex
- weight
- mulberry leaf
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- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 25
- 235000013402 health food Nutrition 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 240000000249 Morus alba Species 0.000 claims abstract description 41
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 41
- 241000208689 Eucommia ulmoides Species 0.000 claims abstract description 39
- 239000000284 extract Substances 0.000 claims abstract description 39
- 239000006041 probiotic Substances 0.000 claims abstract description 25
- 235000018291 probiotics Nutrition 0.000 claims abstract description 25
- 238000000855 fermentation Methods 0.000 claims abstract description 20
- 230000004151 fermentation Effects 0.000 claims abstract description 20
- 238000000605 extraction Methods 0.000 claims abstract description 19
- 240000001046 Lactobacillus acidophilus Species 0.000 claims abstract description 5
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims abstract description 5
- 241000194017 Streptococcus Species 0.000 claims abstract description 5
- 238000011081 inoculation Methods 0.000 claims abstract description 5
- 210000000936 intestine Anatomy 0.000 claims abstract description 5
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 33
- 230000008595 infiltration Effects 0.000 claims description 22
- 238000001764 infiltration Methods 0.000 claims description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 18
- 239000012141 concentrate Substances 0.000 claims description 15
- 239000012530 fluid Substances 0.000 claims description 15
- 230000001954 sterilising effect Effects 0.000 claims description 14
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 13
- 239000002609 medium Substances 0.000 claims description 13
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 12
- 239000008103 glucose Substances 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 239000001888 Peptone Substances 0.000 claims description 9
- 108010080698 Peptones Proteins 0.000 claims description 9
- 235000015278 beef Nutrition 0.000 claims description 9
- 235000019319 peptone Nutrition 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 241000208688 Eucommia Species 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 239000001963 growth medium Substances 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000011068 loading method Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000009630 liquid culture Methods 0.000 claims description 2
- 206010013786 Dry skin Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 abstract description 6
- 238000009395 breeding Methods 0.000 abstract description 4
- 230000001488 breeding effect Effects 0.000 abstract description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 abstract description 4
- 239000001527 calcium lactate Substances 0.000 abstract description 4
- 229960002401 calcium lactate Drugs 0.000 abstract description 4
- 235000011086 calcium lactate Nutrition 0.000 abstract description 4
- 230000002218 hypoglycaemic effect Effects 0.000 abstract description 4
- 108010010998 polyactin A Proteins 0.000 abstract description 4
- 239000003390 Chinese drug Substances 0.000 abstract description 3
- 230000000975 bioactive effect Effects 0.000 abstract description 3
- 230000035558 fertility Effects 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000000295 complement effect Effects 0.000 abstract description 2
- 238000012216 screening Methods 0.000 abstract description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 235000013305 food Nutrition 0.000 description 7
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 230000001186 cumulative effect Effects 0.000 description 6
- 230000036541 health Effects 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
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- 230000001580 bacterial effect Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
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- 238000012856 packing Methods 0.000 description 3
- 230000000529 probiotic effect Effects 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
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- 230000035900 sweating Effects 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- -1 Phenylpropanoid Glycosides Chemical class 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
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- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
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- 210000004153 islets of langerhan Anatomy 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
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- 230000001502 supplementing effect Effects 0.000 description 2
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- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 description 1
- 206010066786 Diabetic keratopathy Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 239000006143 cell culture medium Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
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- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000000091 immunopotentiator Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 230000001717 pathogenic effect Effects 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
- A23V2400/225—Faecalis
Abstract
The present invention provides a kind of health food of auxiliary diabetic's rehabilitation and preparation method thereof, is made by the inoculation probiotics fermention culture of traditional Chinese drug inspissation extract, the traditional Chinese drug inspissation extract is by Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf with 1：2：3 weight is concentrated to give than carrying out extraction.The present invention is determined from the Lactobacillus acidophilus in probiotics member and intestines streptococcus by screening, it is subject to scientific formula and deep drainpipe fermentation, nutritional ingredient in Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf meets the demand of growth of probiotics breeding and significantly improves the fertility of probiotics, generate substantial amounts of soluble calcium lactate and mannatide, probiotics further degrades the bioactive ingredients contained by Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf simultaneously, have complementary advantages, so as to play hypoglycemic healthcare function.
Description
Technical field
The invention belongs to diabetic health care technical field, and in particular to a kind of health food of auxiliary diabetic rehabilitation
And preparation method thereof.
Background technology
Statistics shows that whole world diabetic's number there are about 100,012,000, and diabetes are in global hair
Sick rate has the trend increased year by year, and current China diabetic number there are about 30,000,000, be classified as after cardiovascular and cerebrovascular disease and
The third-largest disease after tumour.A variety of chronic complicating diseases that diabetes are produced on the basis of artery sclerosis and microangiopathies,
Such as diabetic cardiomyopathy, diabetic acromelic gangrene, diabetic cerebrovascular disease, nephrosis, diabetic keratopathy view
Film lesion and DPN etc., are to the maximum harm of human health.
Diabetes are a kind of multiple diseases, and its pathogenic factor is that defect of insulin secretion or other biological effect are impaired,
Or both have concurrently and cause.The diet of diabetic should not eat the high food of various sugar contents, should not eat high containing cholesterol
Food and animal tallow, should not drink, the staple food rich in vitamin B and food fiber such as five cereals can only be eaten.At present
Most of Western medicine for treating diabetes are all to control blood glucose on surface, the repairing islet cells not from source, this
Also exactly why blood glucose remains high and generation complication always.
Publication No. CN105168400A Chinese patent disclose it is a kind of be used for prevent and treat diabetes Chinese medicinal capsule and its
Preparation method, its capsule filler particles are 1 by weight ratio:1 traditional Chinese drug inspissation medicinal extract and auxiliary material powdered glucose is made, the Chinese medicine
Concentrated extract steams through ultramicro grinding, high temperature successively by raw material folium cortex eucommiae, mulberry leaf and moutan bark, soak concentration is made, and this is special
The principle of profit is that hypoglycemic effect is played using the active component extracted from folium cortex eucommiae, mulberry leaf and moutan bark, but this
A little molecules of active components amounts are big, and absorption of human body is extremely limited, and these active components can not still repair pancreas islet from source
Cell, can only maintain blood sugar level stable, can not make diabetic's rehabilitation.
The content of the invention
The present invention for problems of the prior art there is provided it is a kind of aid in diabetic's rehabilitation health food and
Its preparation method.The present invention determines, from the Lactobacillus acidophilus in probiotics member and intestines streptococcus, to be subject to section by screening
Learn the need that the nutritional ingredient in formula and deep drainpipe fermentation, Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf meets growth of probiotics breeding
Seek and significantly improve the fertility of probiotics, generate substantial amounts of soluble calcium lactate and two kinds of mannatide it is new into
Point, while probiotics further degrades the bioactive ingredients contained by Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf, have complementary advantages, so that
Play probiotics be good for stomach, bark of eucommia strengthen immunity and with mulberry leaf cooperation hypotensive, hypoglycemic healthcare function.
The present invention is adopted the following technical scheme that：
The preparation method of the health food of above-mentioned auxiliary diabetic rehabilitation, comprises the following steps：
A) prepared by seed liquor
The composition of seed liquid culture medium used is as follows when prepared by seed liquor：
By weight percentage, peptone 1 ~ 4%, beef extract 0.1 ~ 0.5%, glucose or lactose 1 ~ 4%, sodium chloride 0.1 ~ 0.5%,
Eucommia leaf extract 1 ~ 4%, calcium carbonate 1 ~ 2%, surplus is pure water；The eucommia leaf extract is made by water extraction, by the bark of eucommia
Leaf is with 1：After 1 ~ 2 weight ratio mixes infiltration with pure water 1 ~ 3 hour, extracted twice, with 1 when extracting for the first time：5 ~ 7
Weight is than adding pure water, with 1 during second of extraction：3 ~ 5 weight is than adding pure water, and the temperature extracted twice is 70 DEG C
~ 80 DEG C, the time is 0.5 ~ 1.5 hour, is concentrated after extraction, spray drying is made；
Each raw material is weighed by said ratio and is added in the pure water of part, is heated to whole dissolvings, pH is to 6.5 ~ 6.8 for adjustment,
Remaining pure water is supplied, is sterilized after stirring evenly, sterilising temp is 110 DEG C ~ 130 DEG C, and then 20 ~ 40min of sterilization time is inoculated with institute
State probiotics to be cultivated, cultivation temperature is 35 DEG C ~ 39 DEG C, incubation time is 22 ~ 24 hours；
B) culture is expanded
The composition of fermentation medium used is as follows when expanding culture：
By weight percentage, peptone 1-2%, beef extract 0.1-0.2%, glucose or lactose 1-2%, sodium chloride 0.1-0.2%,
0.5-1.0% calcium carbonate, surplus is that folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf extract concentrate；The folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf
Extract concentrate to be made by water extraction, specific preparation method is as follows：
1）The pretreatment of raw material：Bark of Eucommia Ulmoides is stripped annual 4 ~ June, scrapes off tertia, and it is in puce to bank up " sweating " to endothelium, is crushed
Dry in flakes；The folium cortex eucommiae annual summer, two season of autumn branches and leaves it is luxuriant when pluck, dry or low temperature drying；Plucked after the annual first frost of mulberry leaf,
Removal of impurities, dry standby；
2）Infiltration：Take 3 parts of 1 part of Bark of Eucommia Ulmoides, 2 parts of folium cortex eucommiae and mulberry leaf respectively by weight and respectively with 1：1 ~ 2 weight ratio with
Pure water mixing infiltration, Bark of Eucommia Ulmoides infiltrates 6 ~ 10 hours, and folium cortex eucommiae infiltrates 1 ~ 3 hour, and mulberry leaf infiltrate 2 ~ 6 hours；
3）Extract：Bark of Eucommia Ulmoides after infiltration is extracted twice, with 1 when extracting for the first time：3 ~ 5 weight is purer than adding
Water, with 1 during second of extraction：3 ~ 5 weight is than adding pure water, and the temperature extracted twice is 95 DEG C ~ 105 DEG C, and the time is equal
For 0.5 ~ 1.5 hour；Folium cortex eucommiae after infiltration is extracted twice, with 1 when extracting for the first time：5 ~ 7 weight is purer than adding
Water purification, with 1 during second of extraction：3 ~ 5 weight is than adding pure water, and the temperature extracted twice is 70 DEG C ~ 80 DEG C, and the time is equal
For 0.5 ~ 1.5 hour；Mulberry leaf after infiltration are extracted twice, the same folium cortex eucommiae of extraction conditions；
4）Concentration：The extract solution that above-mentioned Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf are extracted twice is well mixed, and is concentrated under reduced pressure, dense
Contracting temperature is 65 DEG C ~ 75 DEG C, and vacuum is 0.06 ~ 0.08MPa, finally gives folium cortex eucommiae, Bark of Eucommia Ulmoides that proportion is 1.10 ~ 1.20
Concentrate is extracted with mulberry leaf；Proportion refers to that the ratio of the quality of concentrate and the synthermal pure water quality of same volume is represented；
Each raw material is weighed by said ratio, remaining raw material in addition to the calcium carbonate is mixed, whole dissolvings are heated to, adjustment pH is extremely
6.5 ~ 6.8, calcium carbonate is added, is sterilized after stirring evenly, sterilising temp is 110 DEG C ~ 130 DEG C, sterilization time is 20 ~ 40min, then
Seed liquor obtained by inoculation step a) is fermented, and fermentation temperature is 35 DEG C ~ 39 DEG C, as the zymotic fluid pH in the fermentation medium
When value reaches 3.8 ~ 4.2, fermentation is completed, and tabletting or loading capsule softgel shell produce the health care food after obtained zymotic fluid is dried
Product.
Preferably, the probiotics includes Lactobacillus acidophilus and intestines streptococcus.
The health food that the preparation method of the health food of above-mentioned auxiliary diabetic's rehabilitation is prepared.
Beneficial effects of the present invention are as follows：
The age of diabetes patient is universal higher, and hypoimmunity, is perplexed by multiple complications, and the present invention is directed to diabetes
The physical feature of people, probiotics is inoculated into Bark of Eucommia Ulmoides, folium cortex eucommiae and Mori folium extract, the micro member enriched in extract solution
The need for the nutritional ingredients such as element, amino acid, carbohydrate disclosure satisfy that growth of probiotics breeding, promote the breeding of probiotics,
So that the fertility of probiotics increases decades of times, probiotics adjustment gut flora balance, while suppress the corrupt bacteria growing of enteron aisle,
Ensure the good health status of human gastrointestinal tract, be the normal performance of each organ of human body and bone and stably serve good rehabilitation
And health-care effect, fully demonstrate and radicallyed reform, return the ecological dietotherapy theory of natural green；Generated in fermentation process substantial amounts of
Soluble calcium lactate and mannatide, soluble calcium lactate trap are high, and calcium supplementing effect is notable, it is adaptable to age higher sugar
The demand of replenishing the calcium of patient is urinated, mannatide can effectively improve the immunity of organisms of diabetes patient as immunopotentiator,
Spontaneous elimination complication from inside to outside, so that strengthening the bones and muscles, filling liver kidney, the function of repairing cartilaginous tissue damaged cell are reached, from
Fundamentally repairing islet cells；The wooden lipidol class of bioactive ingredients in Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf, Phenylpropanoid Glycosides class, cyclenes
A variety of secondary metabolites such as ether terpene, flavonoids, rutin, can further be degraded, be more beneficial for absorption of human body, fully hair
Wave its hypoglycemic effect.
Number of viable contrast table
Embodiment
In order that the technical purpose of the present invention, technical scheme and beneficial effect are clearer, with reference to specific embodiment
Technical scheme is further illustrated.
Embodiment one
First, the preparation of seed liquor, comprises the following steps：
（1）The preparation of culture medium：Weigh peptone 20g, beef extract 10g, sodium chloride 6g, eucommia leaf extract 20g, lactose 20g,
Precipitated calcium carbonate 20g（Slant medium and detection live probiotic bacterial content culture medium separately add 30 ~ 40g of agar）；
The eucommia leaf extract is by folium cortex eucommiae with 1：After 1 weight ratio mixes infiltration with pure water 2 hours, carried twice
Take, with 1 when extracting for the first time：6 weight is than adding pure water, with 1 during second of extraction：4 weight is than adding pure water, two
The temperature of secondary extraction is 70 DEG C ~ 80 DEG C, and the time is 1 hour, is concentrated after extraction, spray drying is made；
Remaining raw material in addition to the calcium carbonate is put in a heating container, first added after 1500mL pure water, heating for dissolving with weight
HCl adjustment pH to 6.5 ~ 6.8 of the fraction for 20% NaOH or 2mol/L is measured, supplementing remaining pure water to cumulative volume is
2000mL, then adds calcium carbonate and stirs, packing slant tube 6mL/ branch × 8, one-level test tube 9mL/ branch × 8,
Two grades of 175mL/ × 8 bottles of triangular flasks, remaining 400mL, packing detection health food live probiotic bacterial content blake bottle
100mL/ × 4 bottles, every bottle of another Ensure Liquid agar 1.5g and precipitated calcium carbonate 1g dispenses packaging of being jumped a queue respectively after finishing, is placed in
Sterilized in electrothermal pressure sterilizer, set 115 DEG C of sterilising temp, sterilization time 25min, 8 slant tubes set inclined-plane while hot,
It is down to after room temperature, refrigerator cold-storage is put together standby；
（2）First cell culture medium and secondary medium culture：Superclean bench of the step operation in clean area is carried out, and is taken original
Probiotics strain（The probiotics includes Lactobacillus acidophilus and intestines streptococcus, comes from Chinese microorganism strain collection）1
Prop up → be seeded in the fluid nutrient medium of 2 one-level test tubes → put constant incubator：35 DEG C ~ 39 DEG C cultures are activated for 22 ~ 24 hours
Put constant incubator → in the solid medium for lining slant tube using oese from the one-level test tube after activation again →：
The good inclined-plane of 35 DEG C ~ 39 DEG C cultures, 22 ~ 24 hours → growth selection, transfers in the fluid nutrient medium of one-level test tube, puts perseverance
Warm incubator：The fluid nutrient medium of the good one-level test tube of 35 DEG C ~ 39 DEG C cultures, 22 ~ 24 hours → growth selection is transferred in two grades
In the fluid nutrient medium of triangular flask, constant incubator is put：35 DEG C ~ 39 DEG C cultures, 22 ~ 24 hours → bis- grades triangular flask fermented and cultureds
Obtained zymotic fluid is as seed liquor, for follow-up expansion culture.
2nd, expand culture, comprise the following steps：
The composition of fermentation medium used is as follows when the 1st, expanding culture：
By weight percentage, peptone 90g, beef extract 9g, sodium chloride 9g, glucose 90g, precipitated calcium carbonate 90g, surplus is
Folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf extract concentrate；The folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf extract the preparation method of concentrate such as
Under：
1）The pretreatment of raw material：Bark of Eucommia Ulmoides is stripped annual 4 ~ June, scrapes off tertia, and it is in puce to bank up " sweating " to endothelium, is crushed
Dry in flakes；The folium cortex eucommiae annual summer, two season of autumn branches and leaves it is luxuriant when pluck, dry or low temperature drying；Plucked after the annual first frost of mulberry leaf,
Removal of impurities, dry standby；
2）Infiltration：Bark of Eucommia Ulmoides 1.5kg, folium cortex eucommiae 3kg and mulberry leaf 4.5kg are taken respectively and respectively with 1：1 weight ratio and pure water
Mixing infiltration, Bark of Eucommia Ulmoides infiltrates 8 hours, and folium cortex eucommiae infiltrates 2 hours, and mulberry leaf infiltrate 4 hours；
3）Extract：Bark of Eucommia Ulmoides after infiltration is extracted twice, with 1 when extracting for the first time：6 weight ratio adds pure water,
With 1 during second of extraction：4 weight is than adding pure water, and the temperature extracted twice is 98 DEG C ~ 100 DEG C, and the time is 1 small
When；Folium cortex eucommiae after infiltration is extracted twice, with 1 when extracting for the first time：6 weight is carried for the second time than adding pure water
With 1 when taking：4 weight is than adding pure water, and the temperature extracted twice is 70 DEG C ~ 80 DEG C, and the time is 1 hour；After infiltration
Mulberry leaf extracted twice, the same folium cortex eucommiae of extraction conditions；
4）Concentration：The extract solution that above-mentioned Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf are extracted twice is well mixed, and decompression is carried out after filtering dense
Contracting, thickening temperature is 65 DEG C ~ 75 DEG C, and vacuum is 0.06 ~ 0.08MPa, and it is that 8000mL, proportion are 1.10 to be concentrated into cumulative volume
Folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf extract concentrate；
Collect above-mentioned concentrate to put in a clean molten device of stainless steel, add peptone, beef extract, sodium chloride and glucose, plus
Heat adjusts pH to 6.5 ~ 6.8 for 20% NaOH or 2mol/L HCl with weight fraction, supplements pure water to after being completely dissolved
It is 9000mL to cumulative volume, is then sub-packed in the clean three-level round-bottomed flask that 3 volumes are 5000mL, every packing
3000mL, then respectively to addition precipitated calcium carbonate 30g in every bottle, sealing, which is jumped a queue, is placed in electrified regulation in electrothermal pressure sterilizer
Air bleeding valve is closed after 10min, steam discharge decompression zero after 118 ~ 121 DEG C of sterilising temp, sterilizing 30min is set, wears asbestos gloves
Open and covered on electrothermal pressure sterilizer, 3 round-bottomed flasks are gently transferred to superclean bench, are down to after room temperature, according to sterile
Operation sequence, the seed liquor fermented in two grades of triangular flasks of step one is inoculated in 3 three-level round-bottomed flasks respectively, in time will
The precipitated calcium carbonate for being deposited in bottom of bottle has uniformly shaken and is transferred to automatic constant-temperature culture shaking table, sets cultivation temperature 37 DEG C ~ 39
DEG C, 105 ~ 110 times/min of wobble frequency, cultivation and fermentation 16 ~ 18 hours, it has been observed that bottom of bottle calcium carbonate is wholly absent, zymotic fluid
Color from depth to shallow and smell micro-perfume, is then freeze-dried；The cumulative volume 9000mL of 3 three-level round-bottomed flasks, uniform point
Loaded in 10 stainless steel lyophilized plate, every disk 900mL, setting freeze-drying relevant parameter, less than -30 DEG C pre-freezes 120 minutes →
Once distillation → parsing-desiccation → defrost discharges → seals stored refrigerated, can tabletting or load capsule softgel shell health food is made.
Embodiment two
The preparation be the same as Example one of the seed liquor of embodiment two, the expansion incubation of embodiment two is as follows：
The composition of fermentation medium used is as follows when the 1st, expanding culture：
By weight percentage, peptone 300g, beef extract 30g, sodium chloride 30g, glucose 300g, precipitated calcium carbonate 300g,
Surplus is that folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf extract concentrate；The folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf extract the preparation side of concentrate
Method is as follows：
1）The pretreatment of raw material：Bark of Eucommia Ulmoides is stripped annual 4 ~ June, scrapes off tertia, and it is in puce to bank up " sweating " to endothelium, is crushed
Dry in flakes；The folium cortex eucommiae annual summer, two season of autumn branches and leaves it is luxuriant when pluck, dry or low temperature drying；Plucked after the annual first frost of mulberry leaf,
Removal of impurities, dry standby；
2）Infiltration：Bark of Eucommia Ulmoides 5kg, folium cortex eucommiae 10kg and mulberry leaf 15kg are taken respectively and respectively with 1：1 weight ratio is mixed with pure water
Infiltration is closed, Bark of Eucommia Ulmoides infiltrates 10 hours, and folium cortex eucommiae infiltrates 3 hours, and mulberry leaf infiltrate 6 hours；
3）Extract：Bark of Eucommia Ulmoides after infiltration is extracted twice, with 1 when extracting for the first time：6 weight ratio adds pure water,
With 1 during second of extraction：4 weight is than adding pure water, and the temperature extracted twice is 98 DEG C ~ 100 DEG C, and the time is 1 small
When；Folium cortex eucommiae and mulberry leaf after infiltration is carried out to same extraction twice respectively, with 1 when extracting for the first time：6 weight is than adding
Pure water, with 1 during second of extraction：4 weight is than adding pure water, and the temperature extracted twice is 75 DEG C ~ 80 DEG C, and the time is equal
For 1 hour；
4）Concentration：The extract solution that above-mentioned Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf are extracted twice is well mixed, and decompression is carried out after filtering dense
Contracting, thickening temperature is 65 DEG C ~ 75 DEG C, and vacuum is 0.06 ~ 0.08MPa, and it is Du that 28L, proportion are 1.20 to be concentrated into cumulative volume
Zhong Ye, Bark of Eucommia Ulmoides and mulberry leaf extract concentrate；
The stainless steel fermentation tank charge door that specification is 50L is opened, 28L obtained above folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf is transferred to
Concentrate is extracted, peptone, beef extract, sodium chloride and glucose is added, is heated to after being completely dissolved, is 20% with weight fraction
NaOH or 2mol/L HCl adjustment pH to 6.5 ~ 6.8, supplement pure water to cumulative volume be 30L, then into fermentation tank add
Precipitated calcium carbonate 300g, closes charge door, starts electrical heating, sets after 118 DEG C ~ 121 DEG C of sterilising temp, sterilizing 30min, opens
Cooling water valve, when temperature in fermentation tank is down into 37 DEG C ~ 39 DEG C, lights alcohol pyrosphere, opens inoculation mouth, inoculation kind used
Sub- liquid can select embodiment one obtained by three-level round-bottomed flask zymotic fluid（Inoculum concentration is 10%）, then close rapidly and connect
Kind of mouth, sets 37 DEG C ~ 39 DEG C of fermentation temperature, when zymotic fluid pH reaches 3.8 ~ 4.2, zymotic fluid color from depth to shallow, smell micro-perfume,
It is determined as fermentation termination（Corresponding fermentation time is 18 ~ 20 hours）, then it is freeze-dried, and set relevant parameter,
Distillation → parsing-desiccation → defrost the discharging of less than -30 DEG C pre-freezes 120 minutes → once, seal stored refrigerated, can tabletting or loading
Health food is made in capsule softgel shell.
Embodiment three
The difference of embodiment three and embodiment one is that three pairs of gained zymotic fluids of embodiment use spray drying process, set air intake
160 DEG C ~ 180 DEG C of temperature, 65 DEG C ~ 75 DEG C of leaving air temp, collects dry powder in time, can tabletting or load capsule softgel shell be made health care food
Product.
Example IV
The difference of example IV and embodiment two is that example IV uses spray drying process to gained zymotic fluid, sets air intake
160 DEG C ~ 180 DEG C of temperature, 65 DEG C ~ 75 DEG C of leaving air temp, collects dry powder in time, can tabletting or load capsule softgel shell be made health care food
Product.
To the component testing result of the health food prepared by embodiment two and four, number of live bacteria of probiotics therein is by implementing
Detection live probiotic bacterial content culture medium prepared by example one, which is detected, to be drawn, as shown in table 1：
The component testing result of health food prepared by the embodiment two and four of table 1
It is supplied to 57 diabetics to try out the health food prepared by embodiment two, wherein 48 blood glucose are down to normal water
Put down, and complication is substantially mitigated or eliminated, significantly, table 2 gives three model cases to effect：
The model case of table 2
It should be noted last that：Above-described embodiment is merely to illustrate the technical scheme being not intended to limit the present invention, any to this hair
The equivalent substitution of bright progress and the modification or local replacement for not departing from spirit and scope of the invention, it all should cover in present invention power
Within the scope of profit is claimed.
Claims (3)
1. a kind of preparation method of the health food of auxiliary diabetic's rehabilitation, it is characterised in that comprise the following steps：
It is prepared by seed liquor
The composition of seed liquid culture medium used is as follows when prepared by seed liquor：
By weight percentage, peptone 1 ~ 4%, beef extract 0.1 ~ 0.5%, glucose or lactose 1 ~ 4%, sodium chloride 0.1 ~ 0.5%,
Eucommia leaf extract 1 ~ 4%, calcium carbonate 1 ~ 2%, surplus is pure water；The eucommia leaf extract is by folium cortex eucommiae with 1：1 ~ 2 weight
After amount is than mixing infiltration with pure water 1 ~ 3 hour, extracted twice, with 1 when extracting for the first time：5 ~ 7 weight is purer than adding
Water purification, with 1 during second of extraction：3 ~ 5 weight is than adding pure water, and the temperature extracted twice is 70 DEG C ~ 80 DEG C, and the time is equal
For 0.5 ~ 1.5 hour, concentrated after extraction, spray drying is made；
Each raw material is weighed by said ratio, remaining raw material in addition to the calcium carbonate is added in the pure water of part, is heated to complete
Portion dissolves, and pH is to 6.5 ~ 6.8 for adjustment, supplies remaining pure water, adds calcium carbonate, is sterilized after stirring evenly, sterilising temp is 110
DEG C ~ 130 DEG C, then 20 ~ 40min of sterilization time is inoculated with the probiotics and is cultivated, and cultivation temperature is 35 DEG C ~ 39 DEG C, culture
Time is 22 ~ 24 hours；
Expand culture
The composition of fermentation medium used is as follows when expanding culture：
By weight percentage, peptone 1-2%, beef extract 0.1-0.2%, glucose or lactose 1-2%, sodium chloride 0.1-0.2%,
0.5-1.0% calcium carbonate, surplus is that folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf extract concentrate；The folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf
The preparation method for extracting concentrate is as follows：
1）Infiltration：Take 3 parts of 1 part of Bark of Eucommia Ulmoides, 2 parts of folium cortex eucommiae and mulberry leaf respectively by weight and respectively with 1：1 ~ 2 weight ratio with
Pure water mixing infiltration, Bark of Eucommia Ulmoides infiltrates 6 ~ 10 hours, and folium cortex eucommiae infiltrates 1 ~ 3 hour, and mulberry leaf infiltrate 2 ~ 6 hours；
2）Extract：Bark of Eucommia Ulmoides after infiltration is extracted twice, with 1 when extracting for the first time：3 ~ 5 weight is purer than adding
Water, with 1 during second of extraction：3 ~ 5 weight is than adding pure water, and the temperature extracted twice is 95 DEG C ~ 105 DEG C, and the time is equal
For 0.5 ~ 1.5 hour；Folium cortex eucommiae after infiltration is extracted twice, with 1 when extracting for the first time：5 ~ 7 weight is purer than adding
Water purification, with 1 during second of extraction：3 ~ 5 weight is than adding pure water, and the temperature extracted twice is 70 DEG C ~ 80 DEG C, and the time is equal
For 0.5 ~ 1.5 hour；Mulberry leaf after infiltration are extracted twice, the same folium cortex eucommiae of extraction conditions；
3）Concentration：The extract solution that above-mentioned Bark of Eucommia Ulmoides, folium cortex eucommiae and mulberry leaf are extracted twice is well mixed, and is concentrated under reduced pressure, dense
Contracting temperature is 65 DEG C ~ 75 DEG C, and vacuum is 0.06 ~ 0.08MPa, finally gives folium cortex eucommiae, Bark of Eucommia Ulmoides and mulberry leaf and extracts concentrate；
Each raw material is weighed by said ratio, remaining raw material in addition to the calcium carbonate is mixed, whole dissolvings are heated to, adjustment pH is extremely
6.5 ~ 6.8, calcium carbonate is added, is sterilized after stirring evenly, sterilising temp is 110 DEG C ~ 130 DEG C, sterilization time is 20 ~ 40min, then
Seed liquor obtained by inoculation step a) is fermented, and fermentation temperature is 35 DEG C ~ 39 DEG C, as the zymotic fluid pH in the fermentation medium
When value reaches 3.8 ~ 4.2, fermentation is completed, and obtained zymotic fluid takes tabletting after two kinds of methods dryings of freeze-drying or spray drying
Or loading capsule softgel shell produces the health food.
2. the preparation method of the health food of auxiliary diabetic's rehabilitation according to claim 1, it is characterised in that institute
Stating probiotics includes Lactobacillus acidophilus and intestines streptococcus.
What 3. the preparation method of the health food of auxiliary diabetic's rehabilitation according to claim 1 or 2 was prepared
Health food.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110810684A (en) * | 2018-08-07 | 2020-02-21 | 三门峡金测质量技术检验检测有限责任公司 | Beverage prepared by fermenting folium Eucommiae and fructus Lycii with lactobacillus and its preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550754A (en) * | 2013-11-25 | 2014-02-05 | 三株福尔制药有限公司 | Probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as preparation method and application of composition |
| CN105168400A (en) * | 2015-09-29 | 2015-12-23 | 河南海丝克生物科技股份有限公司 | Traditional Chinese medicine capsule for preventing and treating diabetes and preparation method thereof |
| CN106617097A (en) * | 2017-03-06 | 2017-05-10 | 邹吉祥 | Health-care food and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550754A (en) * | 2013-11-25 | 2014-02-05 | 三株福尔制药有限公司 | Probiotic fermented traditional Chinese medicinal compound composition for assisting in reducing blood sugar as well as preparation method and application of composition |
| CN105168400A (en) * | 2015-09-29 | 2015-12-23 | 河南海丝克生物科技股份有限公司 | Traditional Chinese medicine capsule for preventing and treating diabetes and preparation method thereof |
| CN106617097A (en) * | 2017-03-06 | 2017-05-10 | 邹吉祥 | Health-care food and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110810684A (en) * | 2018-08-07 | 2020-02-21 | 三门峡金测质量技术检验检测有限责任公司 | Beverage prepared by fermenting folium Eucommiae and fructus Lycii with lactobacillus and its preparation method |
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