CN107251757A - A kind of eutrophy element Cordyceps militaris chewable tablets and preparation method and application - Google Patents
A kind of eutrophy element Cordyceps militaris chewable tablets and preparation method and application Download PDFInfo
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- CN107251757A CN107251757A CN201710439325.3A CN201710439325A CN107251757A CN 107251757 A CN107251757 A CN 107251757A CN 201710439325 A CN201710439325 A CN 201710439325A CN 107251757 A CN107251757 A CN 107251757A
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Abstract
The invention discloses a kind of eutrophy element Cordyceps militaris chewable tablets and preparation method and application.The present invention utilizes multi-nutrition beneficiation technologies, realizes that Cordyceps militaris is once cultivated, rich in various nutrient elements, including trace elements of selenium, iron, zinc, the human body benefit active such as macroelement calcium, and cordycepin, adenosine, cordycepic acid, bata-carotene.Eutrophy element Cordyceps militaris chewable tablets is made by primary raw material of the eutrophy element Cordyceps militaris; it is instant, glossy; both it is direct-edible; also it may be dissolved in drinking water and drink; chewable tablets carries portable, can save and not degenerate for a long time, simultaneously containing abundant nutrition element; and also there is the strong kidney qi-restoratives of Cordyceps militaris, protection liver, body immunity, the effects such as enhancing human tolerance, the fatigue that disappears, anti-aging, promotion digest is improved.
Description
Technical field
The present invention relates to a kind of eutrophy element Cordyceps militaris chewable tablets and preparation method and application.
Background technology
Nutrient be body survive, grow, physical exertion and health and food form intake one
Need material.China is a typical country based on plant food, and diet structure is relatively simple, micronutrient member
Element lacks more obvious, and wherein calcium, iron, zinc, selenium, vitamin E and bata-carotene lack more serious.Calcium content in human body
Abundant, it is in the activation of nerve and cell, in terms of the transmission of nerve impulse, the maintenance of the heartbeat rhythm and pace of moving things, blood clotting
Play an important role.By inquiry so hypertension sufferer, internal serious calcium deficiency.Adult needs calcium constituent 600-1000mg in one day,
Diet is only supplied 50-60%, calcium generally existing insufficiency of intake.Ferro element is to constitute the essential trace element of human body
One, iron deficiency influences whether health and the development of human body, and maximum influence is hypoferric anemia.The application form of the World Health Organization
Bright, hypoferric anemia can occur for about 50% young girl, 20% adult female, 40% pregnant woman.It is by food to mend iron
Or pharmaceutical methods be human body additionally supplement necessary, appropriate inorganic iron or organoiron compound so that supplement ferro element with up to
To the process of physical fitness, prevention or adjuvant treatment of diseases purpose.Zinc is the trace element of human body daily need, and trophism zinc lacks
Weary also known as zinc dificiency, due to insufficiency of intake, it is necessary to measure increase, caused by meals zinc bioavailability is low.Selenium element is people and dynamic
One of indispensable trace element in thing vital movement, is sulphur hydrogen reduction protease in organism, de- iodine enzyme, glutathione mistake
The required component of a variety of selenoenzyme albumen such as oxidizing ferment, and participate in human body multiple metabolic pathways.Research is found, when body lacks
During selenium element, immunologic mechanism can be weakened, the resistance to disease is reduced, various corresponding shortage symptoms occur.
Cordyceps militaris (Cordyceps militaris) also known as northern Chinese caterpillar Fungus, it is that sac fungus is sub- to belong on biology point is learned
Door, ergot Zoopagales, Clavicipitaceae, Cordyceps.Cordyceps militaris is a kind of medicine-food two-purpose fungi, and health ministry adds Cordyceps militaris
Enter into the Chinese medicine list ranks of medicine-food two-purpose.Research shows the protein that Cordyceps militaris contains up to 30%, by 17 kinds of amino
Acid is constituted, and has the essential amino acid that the A wide selection of colours and designs for accounting for total amino acid content 35.47%, quantity are sufficient, ratio is appropriate；Together
Shi Hanyou VA, VB2, VE, VC, VBP, Vd, VB6 etc..Cordyceps militaris is also containing abundant beta carotene, cordycepic acid, cordycepin, ammonia
Base acid, adenosine class, Cordyceps sinensis polysaccharide, mannitol, SOD enzymes and ergot mercaptan isoreactivity composition, and there is significant pharmacological action, such as
Calm hypnosis, anti-oxidant, preventing and treating aging, antifatigue, antitumor, resist oxygen lack, strengthen immunity, enhancement, antitumor and protection
The effects such as cardiopulmonary tissue.Fungi has stronger accumulation ability to trace element, and external source battalion is added during cordyceps militaris plantation
Element is supported, so that the nutrient of fructification enriched, is easy to while the inorganic selenium of external source can be converted into by Cordyceps militaris
The organic form selenium that absorption of human body is utilized.Can be by the accumulation of exogenous nutrition element absorption in body using eutrophy element Cordyceps militaris
It is interior, so that as efficient, safe, natural nutrient meal supplement form.
In the nowadays living environment of high rhythm, people increasingly pay close attention to self health status.At present, in the market supplement people
The product of body nutrient is generally single nutrient piece, it is impossible to fully supplement the various nutrients of needed by human body；Minority contains
There is the nutrient piece of two or more composition, because component content is less, it is also difficult to reach abundant extra-nutrition element
Purpose.And some nutrient medicines, in order to reach sanatory purpose, its content is mostly higher, should not be as daily
Nutrient replenishers.
The content of the invention
It is an object of the invention to provide chewable tablets prepared by a kind of utilization eutrophy element Cordyceps militaris, preparation method includes
Eutrophy element Cordyceps militaris is subjected to ultramicro grinding, then into lubricant raw material adds sweetener, wet grain is made, by drying,
After whole grain, add tabletting after lubricant and form.Nutrient in eutrophy element Cordyceps militaris of the present invention include trace elements of selenium,
The human body benefit actives such as zinc, iron, macroelement calcium, and cordycepin, adenosine, cordycepic acid, vitamin E, beta carotene.
, as raw material, to produce the Cordyceps militaris tablet containing multi-nutrition element rich in various nutrient elements Cordyceps militaris, to reach health care
With the purpose of comprehensive supplement human nutrition element.
To achieve the above object, present invention firstly provides a kind of eutrophy element cordyceps culturing method, including by pupa worm
Careless strain, which is inoculated on culture medium for cultivating, carries out the culture of bacterium germination annesl and fructification culture；
The bacterium germination annesl culture includes：Culture medium can be covered with prior to being cultivated under lucifuge, obstructed wind environment to mycelia (typically
Culture 4-7 days) after, then illumination cultivation, it is ensured that light irradiation time >=12h daily, after culture to white hypha can change yellowly or
Crocus (general culture 3-5 days)；Wherein, 15-18 DEG C of cultivation temperature, relative air humidity 60-65%；
The fructification culture includes：Full exposure culture, 18-22 DEG C of temperature, culture to ripe (the general culture of fructification
40-50 days).
When fructification grows into 5-7cm or so, top is expanded, and shows that fruiting bodies of cordyceps militaris is ripe, you can harvesting, drying.
The culture medium for cultivating includes 10-40 parts by weight rice, 10-40 parts by weight PD culture mediums；The culture medium for cultivating
In the also calcium citrate containing 5-50mg/g, 2-50mg/g ferrous gluconate, 1-30mg/g zinc citrate, 2-100mg/
Kg nanometer selenium.
Usually, the part by weight of rice and PD culture mediums is 1 in the culture medium for cultivating:1-1.5.
Specifically, the culture medium for cultivating includes 20 parts by weight rice, 20 parts by weight PD culture mediums；The culture medium for cultivating
In calcium citrate also containing 5,40 or 50mg/g, 2,40 or 50mg/g ferrous gluconate, 1,20 or 30mg/g lemon
Sour zinc, 2,60 or 100mg/kg nanometer selenium.
Specifically, the culture medium for cultivating includes 10 parts by weight rice, 10 parts by weight PD culture mediums；The culture medium for cultivating
In the also calcium citrate containing 5mg/g, 2mg/g ferrous gluconate, 1mg/g zinc citrate, 2mg/kg nanometer selenium.
Specifically, the culture medium for cultivating includes 20 parts by weight rice, 20 parts by weight PD culture mediums；The culture medium for cultivating
In the also calcium citrate containing 20mg/g, 20mg/g ferrous gluconate, 10mg/g zinc citrate, 40mg/kg nanometer
Selenium.
Specifically, the culture medium for cultivating includes 40 parts by weight rice, 40 parts by weight PD culture mediums；The culture medium for cultivating
In the also calcium citrate containing 50mg/g, 50mg/g ferrous gluconate, 30mg/g zinc citrate, 100mg/kg nanometer
Selenium.
The PD Nutrient mediums are the PDA culture medium without agar.The general PD Nutrient mediums per 1000ml are by potato (peeling)
200g, glucose 20g is made, its pH 7.0 or so.
The nanometer selenium can be made by chemistry or biological method；Also it can be prepared by following any literature method：
CN201410520106.4 (the nanometer selenium particle size range of synthesis be 30-300nm), CN201510047365.4,
CN201610566900.1、CN 201610952997.X、CN 201610946230.6、CN 201610946282.3。
Further, nanometer selenium footpath scope is 30-300nm.
Further, nanometer selenium effective content >=70%, preferably >=90%.
Above-mentioned culture medium for cultivating can be prepared by existing conventional method, for example, mix each component by proportioning, and sterilizing is (general
121 DEG C of high pressure steam sterilization 30min), it is standby after cooling.
Strain is commercially available buys for Cordyceps militaris (Cordyceps militaris) of the present invention.
Cordyceps militaris strain can also be inoculated on culture medium for cultivating and carry out by the present invention by solid cordyceps militars strain
The culture of bacterium germination annesl and fructification culture.Solid cordyceps militars strain, liquid spawn can be prepared by this area conventional method.
By the eutrophy element Cordyceps militaris (water content≤5%, similarly hereinafter) of harvesting, yield, pupa with normal cultivation Cordyceps militaris
Cordyceps sinensis growthform and spore amount are contrasted (Fig. 2), find rich multi-nutrition element Cordyceps militaris in cultivation to its yield,
Cordyceps militaris form, production spore ability are unaffected, so as to ensure the yield and quality of rich multi-nutrition element Cordyceps militaris.Using electricity
Feel selenium, iron, zinc and the calcium in the rich multi-nutrition element Cordyceps militaris of method analysis of Coupled Plasma-Mass Spectroscopy (ICP-MS)；Using height
The rich multi-nutrition element Cordyceps militaris beneficial organism active ingredient cordycepin of method analysis of effect liquid phase chromatogram (HPLC), adenosine, worm
Oxalic acid, beta carotene.Analysis result show selenium in eutrophy cordyceps sinensis, iron, zinc, the content of calcium be respectively 2.8-362mg/kg,
2.5-100g/kg, 2.1-50g/kg, 5.8-100g/kg, the human body beneficial activity such as cordycepin, adenosine, cordycepic acid, beta carotene
Content of material is respectively 6-12mg/kg, 2.5-5mg/kg, 20-100g/kg, 1-3g/kg；Compared with common Cordyceps militaris, eutrophy
Cordyceps militaris selenium, iron, zinc, calcium, cordycepin, adenosine, cordycepic acid, the content beta-carotene of the per kilogram of element Cordyceps militaris be respectively
5-900,2-800,2-780,10-850,1-2.5,1.2-2.5,1-3,1-2 times of common Cordyceps militaris.
The present invention is low relative to conventional method inorganic selenium (selenate, selenite) toxicity from nanometer selenium, reduces latent
Risk；By rationally controlling the particle diameter and content of nanometer selenium in culture medium for cultivating, cordyceps sinensis growth is neither influenceed to make training again
Support the nanometer selenium 100% in base be converted into Organic Selenium in fruiting bodies of cordyceps militaris, the culture medium after cultivation without nanometer selenium and
Inorganic selenium is free of in the selenium-enriched cordceps militaris fructification obtained；In addition, the inventive method does not influence Cordyceps militaris itself effect not only
The synthesis of composition cordycepin, adenosine, amino acid etc., also substantially increases the content of cordycepin, effectively improves Cordyceps militaris
Quality.
Present invention additionally comprises above-mentioned culture medium for cultivating.
Present invention additionally comprises the eutrophy element Cordyceps militaris that the above method is obtained.
Present invention additionally comprises the food prepared containing above-mentioned eutrophy element Cordyceps militaris or by the Cordyceps militaris, health food,
Medicine, feed etc..
Food, health food, medicine, feeding are being prepared present invention additionally comprises the eutrophy element Cordyceps militaris of above method culture
Application in terms of material.
Specifically, the present invention provides a kind of eutrophy Cordyceps militaris chewable tablets, is made up of above-mentioned eutrophy element Cordyceps militaris.
Preferably, its active component of the eutrophy Cordyceps militaris chewable tablets is (aqueous including above-mentioned eutrophy element Cordyceps militaris
Amount≤5%) 25-40 parts by weight, royal jelly dried powder 10-15 parts by weight, lemon powder 10-15 parts by weight, Bee Pollen 8-15 parts by weight；
It is further preferred that its active component of the eutrophy Cordyceps militaris chewable tablets includes above-mentioned eutrophy element Cordyceps militaris
35-40 parts by weight, royal jelly dried powder 10-12 parts by weight, lemon powder 10-12 parts by weight, Bee Pollen 8-10 parts by weight；
It is preferred that its active component of the eutrophy Cordyceps militaris chewable tablets includes the above-mentioned weight of eutrophy element Cordyceps militaris 35
Part, the parts by weight of royal jelly dried powder 10, the parts by weight of lemon powder 12, the parts by weight of Bee Pollen 8.
Its raw material of above-mentioned eutrophy Cordyceps militaris chewable tablets also includes pharmaceutically available auxiliary material, such as beta-schardinger dextrin, white sand
Sugar, starch, maltodextrin, magnesium stearate, salt etc., consumption can be adjusted according to actual needs.
In a detailed embodiment, the parts by weight of beta-schardinger dextrin 2, white sand are contained in the eutrophy Cordyceps militaris chewable tablets
Sugared 5 parts by weight, the parts by weight of starch 5, the parts by weight of maltodextrin 2, the parts by weight of magnesium stearate 2, the parts by weight of salt 2.
The present invention also provides the preparation method of above-mentioned eutrophy Cordyceps militaris chewable tablets, including：
1) each raw material is taken by proportioning；
2) by eutrophy Cordyceps militaris (water content≤5%) ultramicro grinding (such as 10000 revs/min), 300 mesh sieves are crossed,
It is well mixed with other supplementary materials outside magnesium stearate, is slowly added to appropriate 70% edible alcohol solution, softwood is made；System
Grain, whole grain, add magnesium stearate lubricant, after mixing tabletting.
The reasonable science of eutrophy element Cordyceps militaris formula of chewable tablets of the present invention, nutrition is daily intaked according to each adult
Element calcium 200-1000mg, iron 5-20mg, zinc 3-15mg, beta carotene 60-800 μ g, Organic Selenium 55-400 μ g are standardized
Design, makes each nutrient calcium, iron, zinc, beta carotene, the content of Organic Selenium in every eutrophy element Cordyceps militaris exist respectively
50-400mg, 1-10mg, 2-50mg, 20-100 μ g, 20-100 μ g.The eutrophy element Cordyceps militaris chewable tablets has both quantified nutrition
Element is again convenient, can be precisely controlled the nutrient amount that daily human body is taken in, while the health-care chewable tablet of the present invention is also rich in
A large amount of Cordyceps militaris active ingredients, have healthcare function to human body to a certain extent.
Eutrophy element Cordyceps militaris chewable tablets involved in the present invention, the nutrition supplemented with other many multi-vitamin mineral matter pieces lacks
Fall into, can effectively improve the physiological function of human body.Because Cordyceps militaris has each component in various biological effect, body appropriate in itself
Ratio, the physiological action such as calmness, hypnosis, anticonvulsion, hypotensive can be produced, can effectively facilitate brain reactivity, alleviate pressure
Power, improves sleep, beauty moisturizing delays brain aging function, with good blood pressure reduction effect, at the same promote kidney Fitness improvement and
Protective effect.It can be adjusted on product taste of the present invention, be swallowed without being coated, obtain the satisfaction in the sense of taste, do not take
The sensation of medicine.The present invention not only shortens numerous and diverse production technology, saves growth cost.The present invention improve nutrient and
The matched method of Cordyceps militaris, can improve coordination absorption efficiency of the human body to nutrient.
It is eutrophy element Cordyceps militaris chewable tablets instant prepared by the present invention, glossy, it is both direct-edible, it is also solvable
Solution is drunk in drinking water, and chewable tablets carries portable, can save and not degenerate for a long time, simultaneously containing abundant nutrition element, Yi Jiye
Strong kidney qi-restoratives with Cordyceps militaris, protection liver, raising body immunity, strengthen human tolerance, disappear fatigue, anti-aging, promotion
The effects such as digestion.
Brief description of the drawings
Fig. 1 is that eutrophy element Cordyceps militaris cultivates Cordyceps militaris with silkworm chrysalis；
Fig. 2 represents that eutrophy element produced from Cordyceps militaris L spore is analyzed.
Fig. 3 represents different disposal group biomass in experimental example.
Fig. 4 represents in experimental example nutritive element content in different disposal group Cordyceps militaris.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.It is unreceipted specific in embodiment
Technology or condition person, are carried out according to the technology or condition described by document in the art, or according to product description.It is used
Reagent or the unreceipted production firm person of instrument, are the conventional products that can be commercially available by regular distributor.
1) solid culture matrix manufacturing
200g potatoes are cleaned into peeling stripping and slicing, 1000ml water is added, boils just broken to gently being pressed with spoon, uses multilayer filtered through gauze,
20g glucose is added into filtrate, 20g agar powders are settled to 1000ml with 1 water, adjust pH 7.0.After packing, autoclaving is used
121 DEG C of pot, 30min sterilizings are standby after cooling.
2) strain makes
The wild cordyceps militaris (Cordyceps militaris) of collection are cleaned up, and use 75% alcohol disinfecting, will be divided
Raw sporophore is cut into small pieces, and is placed on above-mentioned solid medium culture, lucifuge, and 21 DEG C of cultures select the vigorous progress of mycelia after 7 days
Tube, the test tube Cord blood after tube is standby.
3) prepared by liquid spawn
500ml conical flasks are taken to add 200ml liquid PD culture mediums, the cordyceps that access step 2 makes after sterilizing cooling
Plant or commercially available Cordyceps militaris (Cordyceps militaris) strain, be placed in isothermal vibration incubator 18-22 DEG C,
150rpm, is cultivated 3-5 days, obtains Cordyceps militaris strain.
The PD Nutrient mediums are the PDA culture medium without agar, its pH 7.0 or so.Preparation method and PDA culture medium class
Seemingly.
Nanometer selenium footpath used below scope is 30nm-300nm, and the nanometer selenium effective content is 90%.
Embodiment 1
A kind of eutrophy element Cordyceps militaris (Cordyceps militaris) cultural method, comprises the following steps：
1) it is inoculated with
10g rice is added in 300ml culture bottles, 10g PD culture mediums add calcium citrate, ferrous gluconate, lemon
Lemon acid zinc and nanometer selenium cause their concentration respectively 5mg/g, 2mg/g, 1mg/g, 2mg/kg, after being sealed with sealed membrane
In 121 DEG C of sterilizing 30min of high-pressure sterilizing pot.Room temperature is cooled to after end subject to sterilization, super-clean bench is put in, uviol lamp sterilizing is opened
30min.Liquid spawn is diluted after 10 times respectively toward inoculation 5ml strains in every bottle.
2) bacterium germination annesl
The culture bottle for having connect bacterium is placed in lucifuge, stuffy, temperature control at 15-18 DEG C, relative air humidity control exists
60-65%, is cultivated 4-7 days, mycelia can cover with culture medium.Mycelia opens illumination after covering with, it is ensured that daily light irradiation time 12h, raw
After long 3-5 days, white hypha can change yellowly.
3) grow
After mycelia is completely reformed into crocus, daily continuous light 24h continued in 18-22 DEG C of culture to 40-50 days.
4) harvest and dry
When fructification grows into 5-7cm or so, top is expanded, and shows that fruiting bodies of cordyceps militaris is ripe, you can harvesting (Fig. 1).
Fruiting bodies of cordyceps militaris is scooped up from root using the small iron spoon of elbow, dries or dries.
Attributional analysis：
By the rich multi-nutrition element Cordyceps militaris of harvesting and the yield of normal cultivation Cordyceps militaris, Cordyceps militaris growthform and
Spore amount is contrasted (Fig. 2), finds rich multi-nutrition element Cordyceps militaris in cultivation to its yield, Cordyceps militaris form, production spore
Ability is unaffected, so as to ensure the yield and quality of rich multi-nutrition element Cordyceps militaris.Using inductively coupled plasma matter
Compose selenium, iron, zinc and the calcium in the rich multi-nutrition element Cordyceps militaris of method analysis of (ICP-MS)；Using high performance liquid chromatography
(HPLC) the rich multi-nutrition element Cordyceps militaris beneficial organism active ingredient cordycepin of method analysis, adenosine, cordycepic acid, β-Hu Luo
Bu Su.Selenium, iron in analysis result display eutrophy cordyceps sinensis, zinc, the content of calcium are respectively 2.8mg/kg, 2.5g/kg, 2.1g/
Kg, 5.8g/kg, the human body benefit active content such as cordycepin, adenosine, cordycepic acid, beta carotene is respectively 6mg/kg,
2.5mg/kg, 20g/kg, 1g/kg.
Embodiment 2
A kind of eutrophy element Cordyceps militaris (Cordyceps militaris) cultural method, the difference with embodiment 1 only exists
In the culture medium for cultivating includes 20 parts by weight rice, 20 parts by weight PD culture mediums；Also contain in the culture medium for cultivating
20mg/g calcium citrate, 20mg/g ferrous gluconate, 10mg/g zinc citrate, 40mg/kg nanometer selenium.
Attributional analysis：
Using the selenium in the rich multi-nutrition element Cordyceps militaris of method analysis of inductive coupling plasma mass spectrometry (ICP-MS),
Iron, zinc and calcium；Using the rich multi-nutrition element Cordyceps militaris beneficial organism activity of the method analysis of high performance liquid chromatography (HPLC) into
Part cordycepin, adenosine, cordycepic acid, beta carotene.Selenium, iron in analysis result display eutrophy cordyceps sinensis, zinc, the content point of calcium
Not Wei 82.5mg/kg, 40.3g/kg, 30.2g/kg, 40.5g/kg, the human body such as cordycepin, adenosine, cordycepic acid, beta carotene has
Beneficial activity substance content is respectively 11.8mg/kg, 3.1mg/kg, 70.9g/kg, 2.8g/kg.
Embodiment 3
A kind of eutrophy element Cordyceps militaris (Cordyceps militaris) cultural method, the difference with embodiment 1 only exists
In the culture medium for cultivating includes 40 parts by weight rice, 40 parts by weight PD culture mediums；Also contain in the culture medium for cultivating
50mg/g calcium citrate, 50mg/g ferrous gluconate, 30mg/g zinc citrate, 100mg/kg nanometer selenium.
Attributional analysis：
Using the selenium in the rich multi-nutrition element Cordyceps militaris of method analysis of inductive coupling plasma mass spectrometry (ICP-MS),
Iron, zinc and calcium；Using the rich multi-nutrition element Cordyceps militaris beneficial organism activity of the method analysis of high performance liquid chromatography (HPLC) into
Part cordycepin, adenosine, cordycepic acid, beta carotene.Selenium, iron in analysis result display eutrophy cordyceps sinensis, zinc, the content point of calcium
Wei not 362mg/kg, 100g/kg, 50g/kg, 100g/kg, the beneficial work of human body such as cordycepin, adenosine, cordycepic acid, beta carotene
Property content of material is respectively 6.8mg/kg, 4.9mg/kg, 99.9g/kg, 1.0g/kg.
Embodiment 4
A kind of eutrophy Cordyceps militaris chewable tablets, its raw material includes：Eutrophy element Cordyceps militaris prepared by embodiment 3 is (aqueous
Amount≤5%) 35 parts by weight, the parts by weight of royal jelly dried powder 10, the parts by weight of lemon powder 12, the parts by weight of Bee Pollen 8, weight of beta-schardinger dextrin 2
Measure part, the parts by weight of white granulated sugar 5, the parts by weight of starch 5, the parts by weight of maltodextrin 2, the parts by weight of magnesium stearate 2, the parts by weight of salt 2.
Preparation method comprises the following steps：
1) pretreatment of raw material
The eutrophy element Cordyceps militaris that embodiment 3 is cultivated is dried to water content 5%, using 10000 revs/min of super powder
Broken machine carries out ultramicro grinding, then is sieved with 300 eye mesh screens, extracting screen underflow, carries out ultramicro grinding again to oversize and is surpassed
Micro mist.
2) get the raw materials ready
According to parts by weight, eutrophy element Cordyceps militaris Ultramicro-powder, royal jelly dried powder, lemon powder, Bee Pollen, β-ring are weighed
Dextrin, white granulated sugar, starch, maltodextrin, magnesium stearate, it is standby.
3) softwood processed is mixed
First eutrophy element Cordyceps militaris powder is well mixed with beta-schardinger dextrin, royal jelly dried powder, lemon powder, peak is then added
Pollen, white granulated sugar, starch, maltodextrin, add proper amount of edible salt, are placed in mixer, and middling speed mixing 30min, mixing is equal
Appropriate 70% edible alcohol solution is slowly added to after even, is stirred when being added dropwise, softwood is made.
4) granulation, whole grain
The softwood prepared is placed in oscillating granulator wet grain is first made, then by the wet grain obtained more at 50-60 DEG C
18 mesh sieve whole grains are crossed after lower dry particle to water content 3%, dry particle is obtained.
5) tabletting
Magnesium stearate lubricant is added into dry particle, after mixing tabletting.
Embodiment 5
A kind of eutrophy Cordyceps militaris chewable tablets, its raw material includes：Eutrophy element Cordyceps militaris prepared by embodiment 3 is (aqueous
Amount≤5%) 25 parts by weight, the parts by weight of royal jelly dried powder 10, the parts by weight of lemon powder 10, the parts by weight of Bee Pollen 8, weight of beta-schardinger dextrin 2
Measure part, the parts by weight of white granulated sugar 5, the parts by weight of starch 5, the parts by weight of maltodextrin 2, the parts by weight of magnesium stearate 2, the parts by weight of salt 2.
Preparation method is same as Example 4.
Embodiment 6
A kind of eutrophy Cordyceps militaris chewable tablets, its raw material includes：Eutrophy element Cordyceps militaris prepared by embodiment 3 is (aqueous
Amount≤5%) 40 parts by weight, the parts by weight of royal jelly dried powder 15, the parts by weight of lemon powder 15, the parts by weight of Bee Pollen 15, weight of beta-schardinger dextrin 2
Measure part, the parts by weight of white granulated sugar 5, the parts by weight of starch 5, the parts by weight of maltodextrin 2, the parts by weight of magnesium stearate 2, the parts by weight of salt 2.
Preparation method is same as Example 4.
Experimental example
(1) experiment material and equipment
Cordyceps militaris (Cordyceps militaris) strain, rice, potato, glucose, calcium citrate, gluconic acid are sub-
Iron, zinc citrate, nanometer selenium；Selenium, calcium, iron, Zinc standard solution.
Between shaking table, balance, autoclave, super-clean bench, culture bottle, cultivation, inductive coupling plasma mass spectrometry (ICP-MS).
(2) experimental procedure
20g rice is added in 300ml culture bottles, 20g PD culture mediums add calcium citrate, ferrous gluconate, lemon
Lemon acid zinc and nanometer selenium cause their concentration to see the table below respectively：
In 121 DEG C of sterilizing 30min of high-pressure sterilizing pot after being sealed with sealed membrane.Room temperature is cooled to after end subject to sterilization, is put in
Super-clean bench, opens uviol lamp sterilizing 30min.Liquid spawn is diluted after 10 times respectively toward inoculation 5ml strains in every bottle.
The culture bottle for having connect bacterium is subjected to the culture of bacterium germination annesl and fructification culture；The bacterium germination annesl culture includes：First
It can be covered with cultivating (4-7 days) to mycelia under lucifuge, obstructed wind environment after culture medium, then illumination cultivation, it is ensured that during daily illumination
Length >=12h, yellowly or crocus can be changed after culture after (3-5 days) to white hypha；Wherein, 15-18 DEG C of cultivation temperature, sky
Gas relative humidity 60-65%；The fructification culture includes：Full exposure culture, 18-22 DEG C of temperature, culture (40-50 days) to son
Entity is ripe.
By each group fructification drying after maturation, weigh crushed after biomass respectively, each activity index to be measured.
Using the selenium in the rich multi-nutrition element Cordyceps militaris of method analysis of inductive coupling plasma mass spectrometry (ICP-MS),
Iron, zinc and calcium.
(3) experimental result
1. different disposal group biomass
In experiment process one (i.e. experimental group 1, similarly hereinafter) to each group biomass under conditions of six with the addition micro member of external source
Have notable difference.Every bottle of biomass is significantly higher than control group processing one in culture bottle under the conditions of processing two, treatment group five with
Control group processing one is compared to biomass without significant difference, and every bottle of biomass is less than control group processing one under the conditions of six groups of processing；Knot
Fruit sees Fig. 3.
2. nutrient in different disposal group Cordyceps militaris
Under conditions of experiment process one to six, with the addition Cordyceps militaris of external source trace element, calcium, iron, zinc, selenium contain
Amount in the increase of finite concentration scope inside gradient, but under the conditions of processing six microelements of calcium, iron, zinc, selenium without dramatically increasing or low
In processing five；As a result Fig. 4 is seen.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of culture medium for cultivating for cultivating eutrophy element Cordyceps militaris, it is characterised in that the culture medium for cultivating includes 10-
40 parts by weight rice, 10-40 parts by weight PD culture mediums；The also calcium citrate containing 5-50mg/g, 2- in the culture medium for cultivating
50mg/g ferrous gluconate, 1-30mg/g zinc citrate, 2-100mg/kg nanometer selenium.
2. culture medium for cultivating according to claim 1, it is characterised in that it is big that the culture medium for cultivating includes 20 parts by weight
Rice, 20 parts by weight PD culture mediums；Calcium citrate in the culture medium for cultivating also containing 5,40 or 50mg/g, 2,40 or 50mg/g
Ferrous gluconate, 1,20 or 30mg/g zinc citrate, 2,60 or 100mg/kg nanometer selenium；
Or, the culture medium for cultivating includes 10 parts by weight rice, 10 parts by weight PD culture mediums；Also contain in the culture medium for cultivating
There are 5mg/g calcium citrate, 2mg/g ferrous gluconate, 1mg/g zinc citrate, 2mg/kg nanometer selenium；
Or, the culture medium for cultivating includes 20 parts by weight rice, 20 parts by weight PD culture mediums；Also contain in the culture medium for cultivating
There are 20mg/g calcium citrate, 20mg/g ferrous gluconate, 10mg/g zinc citrate, 40mg/kg nanometer selenium；
Or, the culture medium for cultivating includes 40 parts by weight rice, 40 parts by weight PD culture mediums；Also contain in the culture medium for cultivating
There are 50mg/g calcium citrate, 50mg/g ferrous gluconate, 30mg/g zinc citrate, 100mg/kg nanometer selenium.
3. culture medium for cultivating according to claim 1 or 2, it is characterised in that rice is trained with PD in the culture medium for cultivating
The part by weight for supporting base is 1:1-1.5.
4. the culture medium for cultivating according to claim any one of 1-3, it is characterised in that the PD Nutrient mediums per 1000ml are by soil
Beans 200g, glucose 20g is made, its pH 7.0 or so；
And/or, nanometer selenium footpath scope is 30-300nm；
And/or, nanometer selenium effective content >=70%, preferably >=90%.
5. a kind of eutrophy element cordyceps culturing method, it is characterised in that including Cordyceps militaris spawn is inoculated in into claim
The culture of bacterium germination annesl and fructification culture are carried out on any one of 1-4 culture medium for cultivating；
The bacterium germination annesl culture includes：Prior to cultivating to mycelia and can cover with after culture medium under lucifuge, obstructed wind environment, then illumination
Culture, it is ensured that daily light irradiation time >=12h, yellowly or crocus can be changed after culture to white hypha；Wherein, cultivation temperature
15-18 DEG C, relative air humidity 60-65%；
The fructification culture includes：Full exposure culture, 18-22 DEG C of temperature, culture is ripe to fructification.
6. a kind of eutrophy element Cordyceps militaris, it is characterised in that its selenium, iron, zinc, the content of calcium be respectively 2.8-362mg/kg,
2.5-100g/kg、2.1-50g/kg、5.8-100g/kg；
And/or, its cordycepin, adenosine, cordycepic acid, the content of beta carotene are respectively 6-12mg/kg, 2.5-5mg/kg, 20-
100g/kg、1-3g/kg。
7. eutrophy element Cordyceps militaris described in the eutrophy element Cordyceps militaris of claim 5 methods described acquisition or claim 6
Application in terms of food, health food, medicine, feed is prepared.
8. a kind of eutrophy Cordyceps militaris chewable tablets, it is characterised in that its active component includes what claim 5 methods described was obtained
Eutrophy element Cordyceps militaris 25-40 parts by weight, royal jelly dried powder 10-15 weights described in eutrophy element Cordyceps militaris or claim 6
Measure part, lemon powder 10-15 parts by weight, Bee Pollen 8-15 parts by weight；
Preferably, its active component of the eutrophy Cordyceps militaris chewable tablets includes the eutrophy element Cordyceps militaris 35-40 weight
Part, royal jelly dried powder 10-12 parts by weight, lemon powder 10-12 parts by weight, Bee Pollen 8-10 parts by weight；
It is preferred that the eutrophy Cordyceps militaris chewable tablets its active component include the above-mentioned parts by weight of eutrophy element Cordyceps militaris 35,
The parts by weight of royal jelly dried powder 10, the parts by weight of lemon powder 12, the parts by weight of Bee Pollen 8；
And/or, the eutrophy Cordyceps militaris chewable tablets, its raw material also includes the parts by weight of beta-schardinger dextrin 2, the parts by weight of white granulated sugar 5, formed sediment
The parts by weight of powder 5, the parts by weight of maltodextrin 2, the parts by weight of magnesium stearate 2, the parts by weight of salt 2.
9. the preparation method of eutrophy Cordyceps militaris chewable tablets described in claim 8, it is characterised in that including：
1) each raw material is taken by proportioning；
2) by the eutrophy Cordyceps militaris ultramicro grinding, 300 mesh sieves is crossed, are mixed with other supplementary materials outside magnesium stearate
It is even, be slowly added to appropriate 70% edible alcohol solution, be made softwood；Granulation, whole grain, add magnesium stearate lubricant, through mixed
Tabletting after conjunction.
10. eutrophy element Cordyceps militaris chewable tablets according to claim 8 or the richness prepared by claim 9 methods described
Nutrient Cordyceps militaris chewable tablets, it is characterised in that calcium in every eutrophy element Cordyceps militaris, iron, zinc, beta carotene, organic
The content of selenium is respectively 50-400mg, 1-10mg, 2-50mg, 20-100 μ g, 20-100 μ g.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111887333A (en) * | 2020-07-31 | 2020-11-06 | 广东粤微生物科技有限公司 | Selenium-rich cordyceps militaris tablet candy and preparation method thereof |
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| CN103460994A (en) * | 2013-09-05 | 2013-12-25 | 徐州工程学院 | Cordyceps militaris nano-selenium and preparation method thereof |
| CN103704023A (en) * | 2013-12-24 | 2014-04-09 | 沈阳师范大学 | Method for cultivating functional cordyceps militaris |
| CN105010900A (en) * | 2015-08-12 | 2015-11-04 | 黑龙江天一农业科技开发有限公司 | Cordyceps militaris chewable tablet and preparation method thereof |
| CN106381271A (en) * | 2016-08-16 | 2017-02-08 | 日照市大地芝草生物科技有限公司 | Making method for selenium-rich Cordyceps militaris |
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| CN101755615A (en) * | 2009-12-31 | 2010-06-30 | 张寿禄 | Cultivation method of high trace element edible and medical fungi |
| CN103460994A (en) * | 2013-09-05 | 2013-12-25 | 徐州工程学院 | Cordyceps militaris nano-selenium and preparation method thereof |
| CN103704023A (en) * | 2013-12-24 | 2014-04-09 | 沈阳师范大学 | Method for cultivating functional cordyceps militaris |
| CN105010900A (en) * | 2015-08-12 | 2015-11-04 | 黑龙江天一农业科技开发有限公司 | Cordyceps militaris chewable tablet and preparation method thereof |
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| CN111887333A (en) * | 2020-07-31 | 2020-11-06 | 广东粤微生物科技有限公司 | Selenium-rich cordyceps militaris tablet candy and preparation method thereof |
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Effective date of registration: 20171102 Address after: 100085, B, 9 floor, No. 9, 3rd Street, Haidian District, Beijing, B1005 Applicant after: Xi Pukang (Beijing) Biological Technology Co., Ltd. Address before: 100096 Beijing Chaoyang District sun ad 15-1-602 Applicant before: Liu Jinjun |
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Application publication date: 20171017 |