CN107233522A - 一种用于治疗黄疸的汤剂药物及其制备方法 - Google Patents

一种用于治疗黄疸的汤剂药物及其制备方法 Download PDF

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CN107233522A
CN107233522A CN201710650825.1A CN201710650825A CN107233522A CN 107233522 A CN107233522 A CN 107233522A CN 201710650825 A CN201710650825 A CN 201710650825A CN 107233522 A CN107233522 A CN 107233522A
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夏瑜
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Sichuan Jintang Haina Biomedical Technology Institute
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Abstract

本发明属于中药制剂领域，目的是根据中医治疗黄疸的认识机理而提供的一种用于治疗黄疸的汤剂药物，所述药物的各个组分及其质量份比如下：米仁9～30g、车前子9～16g、瓜蒌皮15～25g、石斛6～16g、白茅根9～35g、黄芩3～10g、佩兰3～10g、鱼腥草15～26g、陈皮3～12g、防己5～10g、虎杖9～16g、茵陈6～16g、茯苓10～16g、知母6～15g、萆薢10～16g、竹茹5～10g、金银花6～16g；本发明提供的药物是一个很好的中药组方。

Description

一种用于治疗黄疸的汤剂药物及其制备方法
技术领域
本发明属于中药制剂领域，具体涉及一种用于治疗黄疸的汤剂药物，特别是供黄疸患者使用的汤剂药物及其制备方法的领域。
背景技术
祖国医学认为：黄疸是常见症状与体征，其发生是由于胆红素代谢障碍而引起血清内胆红素浓度升高所致。临床上表现为巩膜、黏膜、皮肤及其他组织被染成黄色。因巩膜含有较多的弹性硬蛋白，与胆红素有较强的亲和力，故黄疸患者巩膜黄染常先于黏膜、皮肤而首先被察觉。当血清总胆红素在17.1～34.2μmol/L，而肉眼看不出黄疸时，称隐性黄疸或亚临床黄疸；当血渍总胆红素浓度超过34.2μmol/L时，临床上即可发现黄疸，也称为显性黄疸。
那么，就如何找到一种可效治疗黄疸的中药组合物，是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展，在治疗黄疸上，人们逐渐意识到了中医治疗黄疸的优点，且在治疗过程中疗效好、见效快、毒副作用小等优势，针对现有西医治疗黄疸的现状，本发明的目的是在于提供一种用于治疗黄疸的汤剂药物，以解决黄疸患者早日恢复健康的问题。该药物是以常见的中药为原料，通过选择合理的药物及质量份比，可有效治疗上述黄疸一证。
为达到上述发明的目的，本发明所采用的技术方案为：提供一种用于治疗黄疸的汤剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁9～30g、车前子9～16g、瓜蒌皮15～25g、石斛6～16g、白茅根9～35g、黄芩3～10g、佩兰3～10g、鱼腥草15～26g、陈皮3～12g、防己5～10g、虎杖9～16g、茵陈6～16g、茯苓10～16g、知母6～15g、萆薢10～16g、竹茹5～10g、金银花6～16g。
一种用于治疗黄疸的汤剂药物及其制备方法，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁10～26g、车前子10～14g、瓜蒌皮18～22g、石斛7～14g、白茅根10～31g、黄芩5～9g、佩兰5～9g、鱼腥草18～23g、陈皮5～11g、防己6～9g、虎杖10～14g、茵陈7～14g、茯苓11～14g、知母7～13g、萆薢11～14g、竹茹6～9g、金银花7～14g。
一种用于治疗黄疸的汤剂药物及其制备方法，其特征在于，所述“最佳方案”的药物的各个组分及其质量份比如下所示：
米仁23g、车前子12g、瓜蒌皮20g、石斛12g、白茅根26g、黄芩8g、佩兰8g、鱼腥草20g、陈皮10g、防己8g、虎杖12g、茵陈12g、茯苓12g、知母12g、萆薢12g、竹茹8g、金银花12g。
一种用于治疗黄疸的汤剂药物及其制备方法，其特征在于，所述方法包括如下步骤制备而成：
A、将上述原料中药拣去杂质和粉尘后，按照质量份比分别粉碎成粗粒状包煎；
B、①将包好的原料中药放入冷开水中浸泡60min，然后再将浸泡好的药物和浸泡药物的澄清液一并放入砂锅内，注入过药60mm的冷开水进行第一次武火煎煮，待煎煮到15min时，转文火熬制40 min，滤取药液；②药渣中再次注入过药56mm的微温开水进行第二次武火煎煮，待煎煮到10min时，转文火熬制35 min，滤取药液；③将两次药液混合浓缩成50%的中药液450ml（毫升）即可。
一种用于治疗黄疸的汤剂药物及其制备方法，其特征在于，所述服用方法为：将制备好的中药液以一天服用，每日一剂，早中晚各服一次，给药量150ml（毫升）/次（小孩酌减），趁热服。15天为一个疗程，服药3～5个疗程，症状消失，病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料，充分发挥各组分的药理功效：
米仁，性味：甘、淡、凉，具有健脾、利湿、清热、排脓之功效，用于治疗泄泻、湿痹、筋脉拘挛、屈伸不利、水肿、脚气、肺痿、肺痈、肠痈、淋浊、痛经、白带等症；
车前子，性味：甘、微寒，具有清热利尿、渗湿通淋、明目、祛痰之功效，用于治疗水肿胀满、热淋涩痛、暑湿泄泻、目赤肿痛、痰热咳嗽；
瓜蒌皮，性味：苦、寒，具有润肺化痰，利气宽胸之功效，用于治疗痰热咳嗽、咽痛、胸痛、吐血、衄血、消渴、便秘、痈疮肿毒等病症；
石斛，性味：甘、微寒，具有生津益胃、滋阴清热、润肺益肾、明目强腰之功效，用于治疗热病伤津、口干烦渴、胃阴不足、胃痛干呕、肺燥干咳、虚热不退、阴伤目暗、腰膝软弱；
白茅根，性味：甘、寒，具有凉血止血、清热利尿之功效，用于治疗血热吐血、衄血、尿血、热病烦渴、黄疸、水肿、热淋涩痛、急性肾炎水肿；
黄芩，性味：苦、寒，具有清热燥湿、泻火解毒、止血、安胎之功效，用于治疗湿温、暑温胸闷呕恶、湿热痞满、泻痢、黄疸、肺热咳嗽、高热烦渴、血热吐衄、痈肿疮毒、胎动不安；
佩兰，性味：辛、平，具有芳香化湿、醒脾开胃、发表解暑之功效，用于治疗湿浊中阻、脘痞呕恶、口中甜腻、口臭、多涎、暑湿表症、头胀胸闷；
鱼腥草，性味：辛、微寒，具有清热解毒、消痈排脓、利尿通淋之功效，用于治疗肺痈吐脓、痰热喘咳、热痢、热淋、痈肿疮毒；
陈皮，性味：苦、辛、温，具有理气健脾、燥湿化痰之功效，用于治疗胸脘胀满、食少吐泻、咳嗽痰多；
防己，性味：苦、寒，具有利水消肿、祛风止痛之功效，用于治疗水肿脚气、小便不利、湿疹疮毒、风湿痹痛、高血压等症；
虎杖，性味：微苦、微寒，具有祛风利湿、散瘀定痛、止咳化痰之功效，用于治疗关节痹痛、湿热黄疸、经闭、症瘕、水火烫伤、跌扑损伤、痈肿疮毒、咳嗽痰多；
茵陈，性味：苦、辛、微寒，具有清湿热、退黄疸之功效，用于治疗黄疸尿少、湿疮瘙痒、传染性黄疸型肝炎；
茯苓，性味：甘、淡、平，具有渗湿利水、健脾和胃、宁心安神之功效，用于治疗小便不利、水肿胀满、痰饮咳逆、呕吐、脾虚食少、泄泻、心悸不安、失眠健忘、遗精白浊；
知母，性味：苦、甘、寒，具有清热泻火、生津润燥之功效，用于治疗外感热病、高热烦渴、肺热燥咳、骨蒸潮热、内热消渴、肠燥便秘等症；
萆薢，性味：性平，味苦，具有利湿去浊、祛风通痹之功效，用于治疗膏淋、白浊、白带过多、风湿痹痛、关节不利、腰膝疼痛；
竹茹，性味：甘、微寒，具有清热化痰、除烦止呕之功效，用于治疗痰热咳嗽、胆火挟痰、烦热呕吐、惊悸失眼、中风痰迷、舌强不语、胃热呕吐、妊娠恶阻、胎动不安；
金银花，性味：甘、寒，具有清热解毒、凉散风热之功效，用于治疗痈肿疔疮、喉痹、丹毒、热毒血痢、风热感冒、温病发热。
本发明药物是基于中医治疗黄疸的原则，从依据黄疸的病理机制及药理作用认为：就黄疸，本发明所提供的药物中的各原料中药药效共奏，对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述黄疸的治疗而提出的一种中药配方，采用该配方制备的药物药效好，见效快，是一个标本兼治的中药组方，特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述：
实施例1：
一种用于治疗黄疸的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁23g、车前子12g、瓜蒌皮20g、石斛12g、白茅根26g、黄芩8g、佩兰8g、鱼腥草20g、陈皮10g、防己8g、虎杖12g、茵陈12g、茯苓12g、知母12g、萆薢12g、竹茹8g、金银花12g。
实施例2：
一种用于治疗黄疸的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁26g、车前子14g、瓜蒌皮22g、石斛14g、白茅根31g、黄芩9g、佩兰9g、鱼腥草23g、陈皮11g、防己9g、虎杖14g、茵陈14g、茯苓14g、知母13g、萆薢14g、竹茹9g、金银花14g。
实施例3：
一种用于治疗黄疸的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁30g、车前子16g、瓜蒌皮25g、石斛16g、白茅根35g、黄芩10g、佩兰10g、鱼腥草26g、陈皮12g、防己10g、虎杖16g、茵陈16g、茯苓16g、知母15g、萆薢16g、竹茹10g、金银花16g。
典型病例
经临床诊断治疗黄疸患者共1450例，年龄为18岁以上的850例，只有600例为18岁以下。1450例患者中痊愈的950例，有效的355例，无效的145例。总有效率达90%。

Claims (3)

1.一种用于治疗黄疸的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁9～30g、车前子9～16g、瓜蒌皮15～25g、石斛6～16g、白茅根9～35g、黄芩3～10g、佩兰3～10g、鱼腥草15～26g、陈皮3～12g、防己5～10g、虎杖9～16g、茵陈6～16g、茯苓10～16g、知母6～15g、萆薢10～16g、竹茹5～10g、金银花6～16g。
2.根据权利要求1所述的用于治疗黄疸的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁10～26g、车前子10～14g、瓜蒌皮18～22g、石斛7～14g、白茅根10～31g、黄芩5～9g、佩兰5～9g、鱼腥草18～23g、陈皮5～11g、防己6～9g、虎杖10～14g、茵陈7～14g、茯苓11～14g、知母7～13g、萆薢11～14g、竹茹6～9g、金银花7～14g。
3.根据权利要求1至2所述的用于治疗黄疸的汤剂药物，其特征在于，所述药物的各个组分及其质量份比如下所示：
米仁23g、车前子12g、瓜蒌皮20g、石斛12g、白茅根26g、黄芩8g、佩兰8g、鱼腥草20g、陈皮10g、防己8g、虎杖12g、茵陈12g、茯苓12g、知母12g、萆薢12g、竹茹8g、金银花12g。
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