CN107233436A - 一种有效治疗牛皮癣的中药复方制剂及其制备方法 - Google Patents
一种有效治疗牛皮癣的中药复方制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种有效治疗牛皮癣的中药复方制剂及其制备方法,按重量份数计,所述中药复方制剂的原料组成为:羊蹄根提取物10~20份,牡荆鲜叶提取物5~15份,白癣皮提取物5~15份,柳枝提取物5~9份,蒲公英鲜叶提取物5~15份,生地提取物5~15份,当归提取物5~9份,土大黄根提取物5~15份,杉木油5~15份,甘草油5~9份,凡士林3~6份。本发明根据牛皮癣成因的内在机理,以清热凉血、祛风化湿、杀菌抗炎和养阴润燥为基本配伍原理,对牛皮癣起到了根治且不复发的治疗效果。
Description
技术领域
本发明属于医药领域,具体涉及一种有效治疗牛皮癣的中药复方制剂及其制备方法。
背景技术
牛皮癣是一种常见并易复发的慢性炎症性皮肤病。其病因复杂且尚不完全明确,主要有遗传学说、免疫功能紊乱学说、感染学说、代谢障碍说、精神因素说、饮食不良说等。
牛皮癣的反复难愈成为医学上的疑难症,西医的激素和抗菌治疗实难奏效,中医认为血热、血瘀、血虚、血燥是该症的主要原因,其中血热是根本性诱因,造成血热的一是内伤七情,二是外感六淫,三是代谢失节,七情内伤,五志过极,直接影响相应的内脏,使脏腑气机逆乱,功能失调而内生五邪,产生化风、化寒、化湿、化燥、化热、化火等种种病变的发生;饮食不节,脾失运化,生湿化热、湿热内蕴;外感风、寒、暑、湿、燥等各种外邪,也会郁久化火,伤阴不复,造成阴津亏虚致阴虚,阴不制阳而盛热,“阴虚生内热,阳盛生外热”《素问·调经论》,因有“五气化火”、“五志化火”之说。火热与心相应,心主血脉而藏神,故火旺则血热。火热之邪入于血分,聚于局部则为血瘀而生疮痈。血热日久而生血虚,血虚生风,风胜则皮痒。血热风燥,营卫失调,肌肤失养,肌表失荣干燥、皲裂、革化,血热妄行而见皮下出血和红皮,湿热交替而难愈。因此,治疗以清热解毒,凉血、活血、养血,润燥熄风为要。
本发明由羊蹄(Rumex japonicus)根、牡荆叶、白癣皮、柳枝、土大黄(长刺酸模Rumex trisetifer)根、蒲公英叶、生地、当归提取物,生甘草油、杉木油组成。畲药中羊蹄根清热凉血,专治癣、秃疮、疔、疖。牡荆叶苦寒,专门化湿、杀菌抗炎;蒲公英叶功专化热毒;杉木油辛、温,具有祛风散瘀去湿毒作用,《纲目拾遗》记载杉木油可“治一切顽癣”。
发明内容
本发明的目的在于针对现有技术不足,提供一种有效治疗牛皮癣的中药复方制剂及其制备方法。本发明制得的中药复方制剂是一种能够根治牛皮癣且不易复发的纯中药制剂。
为实现上述目的,本发明采用如下技术方案:
一种有效治疗牛皮癣的中药复方制剂,按重量份数计,其原料组成为:羊蹄根提取物10~20份,牡荆鲜叶提取物5~15份,白癣皮提取物5~15份,柳枝提取物5~9份,蒲公英鲜叶提取物5~15份,生地提取物5~15份,当归提取物5~9份,土大黄根提取物5~15份,杉木油5~15份,甘草油5~9份,凡士林3~6份。
优选地,一种有效治疗牛皮癣的中药复方制剂,按重量份数计,其原料组成为:羊蹄根提取物15份,牡荆鲜叶提取物10份,白癣皮提取物10份,柳枝提取物7份,蒲公英鲜叶提取物10份,生地提取物10份,当归提取物7份,土大黄根提取物10份,杉木油10份,甘草油7份,凡士林4份。
如上所述的有效治疗牛皮癣的中药复方制剂的制备方法,具体包括以下步骤:
(1)分别取羊蹄根、牡荆鲜叶、白癣皮、柳枝、蒲公英鲜叶、生地和当归,切碎,加入所取药材重量的1.5-2.0倍95wt%酒精浸泡24h,50-60℃水回流提取2-3h,重复回流提取2-3次,合并提取液,真空浓缩至浸膏,即分别制得羊蹄根提取物、牡荆鲜叶提取物、白癣皮提取物、柳枝提取物、蒲公英鲜叶提取物、生地提取物和当归提取物;
(2)取土大黄根,加入所取药材重量的1.5-2.0倍95wt%酒精浸泡24h,50-60℃水回流提取2-3h,重复回流提取2-3次,合并提取液,浓缩至浸膏,加水悬浮浸膏,加入浸膏体积的1.5-2.0倍正丁醇萃取,合并三次萃取液,真空浓缩为浸膏,即制得土大黄根提取物;
(3)取生甘草,去皮,切段0.5-1.0cm,取体积1倍纯芝麻油浸泡3-5天,滤后取油,即得到甘草油;
(4)取杉木破碎成屑,杉木屑通入水蒸气蒸馏,冷却蒸汽后,分离油水,得杉木油;
(5)将上述制得的羊蹄根提取物、牡荆鲜叶提取物、白癣皮提取物、柳枝提取物、蒲公英鲜叶提取物、生地提取物、当归提取物、土大黄根提取物、杉木油和甘草油按重量配比混合后,再加入凡士林混匀,制得所述有效治疗牛皮癣的中药复方制剂。
本发明的有益效果在于:本方取羊蹄根、牡荆叶、白癣皮、柳枝、土大黄根和蒲公英的寒凉以清热凉血;生地滋阴清热凉血,养阴生津;以白癣皮、蒲公英、杉木油祛风解毒;土大黄行瘀解毒、抗菌;生甘草油、蒲公英泄热解毒;以当归补血活血。本方清以热凉血为主,兼顾养血活血,祛风化湿,养阴润燥,功效全面,重用了羊蹄根、牡荆叶、杉木油、白癣皮专门治疗癣疮的药物,以生甘草油和蒲公英专一清解热毒,达到标本兼治的目的。
具体实施方式
以下结合具体实施例对本发明做进一步说明,但本发明不仅仅限于这些实施例。
实施例1
(1)分别取羊蹄根、牡荆鲜叶、白癣皮、柳枝、蒲公英鲜叶、生地和当归,切碎,加入所取药材重量的1.5倍95wt%酒精浸泡24h,50℃水回流提取3h,重复回流提取3次,合并提取液,真空(0.8-1.0 Pa)浓缩至浸膏,即分别制得羊蹄根提取物、牡荆鲜叶提取物、白癣皮提取物、柳枝提取物、蒲公英鲜叶提取物、生地提取物和当归提取物;
(2)取土大黄根,加入所取药材重量的1.5倍95wt%酒精浸泡24h,50℃水回流提取3h,重复回流提取3次,合并提取液,浓缩至浸膏,加水悬浮浸膏,加入浸膏体积的1.5倍正丁醇萃取,合并三次萃取液,真空(0.8-1.0 Pa)浓缩为浸膏,即制得土大黄根提取物;
(3)取生甘草,去皮,切段0.5cm,取体积1倍纯芝麻油浸泡3天,滤后取油,即得到甘草油;
(4)取杉木破碎成屑,杉木屑通入水蒸气蒸馏,冷却蒸汽后,分离油水,得杉木油;
(5)取上述制得的羊蹄根提取物10份、牡荆鲜叶提取物5份、白癣皮提取物5份、柳枝提取物6份、蒲公英鲜叶提取物5份、生地提取物7份、当归提取物5份、土大黄根提取物5份、杉木油9份和甘草油5份混合后,再加入3份凡士林混匀,制得所述有效治疗牛皮癣的中药复方制剂。
实施例2
(1)分别取羊蹄根、牡荆鲜叶、白癣皮、柳枝、蒲公英鲜叶、生地和当归,切碎,加入所取药材重量的2.0倍95wt%酒精浸泡24h, 60℃水回流提取2h,重复回流提取2次,合并提取液,真空(0.8-1.0 Pa)浓缩至浸膏,即分别制得羊蹄根提取物、牡荆鲜叶提取物、白癣皮提取物、柳枝提取物、蒲公英鲜叶提取物、生地提取物和当归提取物;
(2)取土大黄根,加入所取药材重量的2.0倍95wt%酒精浸泡24h, 60℃水回流提取2h,重复回流提取2次,合并提取液,浓缩至浸膏,加水悬浮浸膏,加入浸膏体积的1.5-2.0倍正丁醇萃取,合并三次萃取液,真空(0.8-1.0 Pa)浓缩为浸膏,即制得土大黄根提取物;
(3)取生甘草,去皮,切段1.0cm,取体积1倍纯芝麻油浸泡5天,滤后取油,即得到甘草油;
(4)取杉木破碎成屑,杉木屑通入水蒸气蒸馏,冷却蒸汽后,分离油水,得杉木油;
(5)取上述制得的羊蹄根提取物20份、牡荆鲜叶提取物15份、白癣皮提取物15份、柳枝提取物9份、蒲公英鲜叶提取物12份、生地提取物12份、当归提取物9份、土大黄根提取物9份、杉木油10份和甘草油9份混合后,再加入6份凡士林混匀,制得所述有效治疗牛皮癣的中药复方制剂。
实施例3
(1)分别取羊蹄根、牡荆鲜叶、白癣皮、柳枝、蒲公英鲜叶、生地和当归,切碎,加入所取药材重量的1.8倍95wt%酒精浸泡24h,55℃水回流提取2.5h,重复回流提取3次,合并提取液,真空(0.8-1.0 Pa)浓缩至浸膏,即分别制得羊蹄根提取物、牡荆鲜叶提取物、白癣皮提取物、柳枝提取物、蒲公英鲜叶提取物、生地提取物和当归提取物;
(2)取土大黄根,加入所取药材重量的1.8倍95wt%酒精浸泡24h,55℃水回流提取2.5h,重复回流提取3次,合并提取液,浓缩至浸膏,加水悬浮浸膏,加入浸膏体积的1.8倍正丁醇萃取,合并三次萃取液,真空(0.8-1.0 Pa)浓缩为浸膏,即制得土大黄根提取物;
(3)取生甘草,去皮,切段1.0cm,取体积1倍纯芝麻油浸泡4天,滤后取油,即得到甘草油;
(4)取杉木破碎成屑,杉木屑通入水蒸气蒸馏,冷却蒸汽后,分离油水,得杉木油;
(5)取上述制得的羊蹄根提取物15份、牡荆鲜叶提取物10份、白癣皮提取物10份、柳枝提取物7份、蒲公英鲜叶提取物10份、生地提取物10份、当归提取物7份、土大黄根提取物10份、杉木油10份和甘草油7份混合后,再加入4份凡士林混匀,制得所述有效治疗牛皮癣的中药复方制剂。
应用本膏剂治疗牛皮癣,5-7天后病灶浸润边缘清晰,皮痒显著减轻,部分银屑脱落,增厚皮肤减薄,10-15天后病灶浸润边缘消退,中心部位红斑明显减轻,没有明显银屑出现,20-25天红斑消退,皮肤恢复正常,临床治愈率71-84%。
以上所述仅为本发明的较佳实施例,凡依本发明申请专利范围所做的均等变化与修饰,皆应属本发明的涵盖范围。
Claims (3)
1.一种有效治疗牛皮癣的中药复方制剂,其特征在于:按重量份数计,所述中药复方制剂的原料组成为:羊蹄根提取物10~20份,牡荆鲜叶提取物5~15份,白癣皮提取物5~15份,柳枝提取物5~9份,蒲公英鲜叶提取物5~15份,生地提取物5~15份,当归提取物5~9份,土大黄根提取物5~15份,杉木油5~15份,甘草油5~9份,凡士林3~6份。
2.根据权利要求1所述的一种有效治疗牛皮癣的中药复方制剂,其特征在于:按重量份数计,所述中药复方制剂的原料组成为:羊蹄根提取物15份,牡荆鲜叶提取物10份,白癣皮提取物10份,柳枝提取物7份,蒲公英鲜叶提取物10份,生地提取物10份,当归提取物7份,土大黄根提取物10份,杉木油10份,甘草油7份,凡士林4份。
3.一种制备如权利要求1或2所述的中药复方制剂的方法,其特征在于:具体包括以下步骤:
(1)分别取羊蹄根、牡荆鲜叶、白癣皮、柳枝、蒲公英鲜叶、生地和当归,切碎,加入所取药材重量的1.5-2.0倍95wt%酒精浸泡24h,50-60℃水回流提取2-3h,重复回流提取2-3次,合并提取液,真空浓缩至浸膏,即分别制得羊蹄根提取物、牡荆鲜叶提取物、白癣皮提取物、柳枝提取物、蒲公英鲜叶提取物、生地提取物和当归提取物;
(2)取土大黄根,加入所取药材重量的1.5-2.0倍95wt%酒精浸泡24h,50-60℃水回流提取2-3h,重复回流提取2-3次,合并提取液,浓缩至浸膏,加水悬浮浸膏,加入浸膏体积的1.5-2.0倍正丁醇萃取,合并三次萃取液,真空浓缩为浸膏,即制得土大黄根提取物;
(3)取生甘草,去皮,切段0.5-1.0cm,取体积1倍纯芝麻油浸泡3-5天,滤后取油,即得到甘草油;
(4)取杉木破碎成屑,杉木屑通入水蒸气蒸馏,冷却蒸汽后,分离油水,得杉木油;
(5)将上述制得的羊蹄根提取物、牡荆鲜叶提取物、白癣皮提取物、柳枝提取物、蒲公英鲜叶提取物、生地提取物、当归提取物、土大黄根提取物、杉木油和甘草油按重量配比混合后,再加入凡士林混匀,制得所述有效治疗牛皮癣的中药复方制剂。
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