CN107217001A - A kind of detection of biological samples device and the gene tester based on the device - Google Patents
A kind of detection of biological samples device and the gene tester based on the device Download PDFInfo
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- CN107217001A CN107217001A CN201710621024.2A CN201710621024A CN107217001A CN 107217001 A CN107217001 A CN 107217001A CN 201710621024 A CN201710621024 A CN 201710621024A CN 107217001 A CN107217001 A CN 107217001A
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
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Abstract
The present invention relates to a kind of detection of biological samples device and the gene tester based on the device, detection of biological samples device, main structure includes Shou Yang areas 2, extract in area 5, detection zone 10, device and be connected as an entirety between each functional areas, the process of whole detection of biological samples can be completed in a device, and separate separate by interlayer between each functional areas, interlayer can be opened, can also close.Based on the gene tester of detection of biological samples device of the present invention, its method includes step：A. sample solution to be detected, is that nucleic acid extraction is carried out under closed space；B. the solution after extracting, is that constant-temperature amplification is carried out under closed space；C. sample solution it is extracted, amplification after, detected by nucleic acid test strip.Using a kind of detection of biological samples device of the present invention and the gene tester based on the device, everybody can fast, easily carry out genetic test.
Description
Technical field
The present invention relates to Measurement for Biotechnique, a kind of gene assaying device is related generally to.
The invention further relates to the method for genetic test, include the operating process such as extraction, amplification, detection of nucleic acid.
Background technology
Genetic test is the blood from human body, other body fluid or cell, detection individual DNA genetic polymorphism is extracted in organizing
Property and genotype.
Genetic test main purpose has two, and one is the diagnosis for disease, such as the diagnostic classification of leukaemia, is all needed
Carry out the genetic test of correlation；Two be the prevention for disease, exactly detects that the genotype of Healthy People and some heredity are more
The relation of state property, analysis gene and disease risks, and propose guidance in life to person under inspection, it is to avoid the generation of disease.
Although genetic test has many advantages, do not popularized at present.It is primarily due to genetic test
Operating process is excessively complicated, it is necessary to operated by professional person.Because in the process of the test of genetic test, nucleic acid can be related to
The steps such as extraction, amplification, and detection are, it is necessary to carry out liquid relief to sample solution, and filtering etc. is operated.Without professional knowledge background
People, it is difficult to operating operation test process.
It is expensive and the gene detection equipment of in the market is excessively complicated, towards subject of a sale primarily directed to doctor
Institute, clinic and study base etc..In the market lacks a kind of ruck and has the ability to buy, and exercisable detection means.Institute
The method of genetic test and biological specimen to realize this method can be fast, easily completed to invent a kind of ruck
Detection means, which just seems, to be highly desirable to, and can widely popularize the popularization of Measurement for Biotechnique.
The content of the invention
In order to overcome the defect of said gene detection method and gene detection equipment, the technical problems to be solved by the invention
It is to provide a kind of quick, simple to operate gene tester；
Corresponding to this, another technical problem to be solved of the invention, which is to provide, can realize genetic test quick, simple to operate
The detection of biological samples device of method.
A kind of detection of biological samples device, main structure includes Shou Yang areas 2, extracts area 5, amplification region 8, detection zone 10,
A number interlayer 4, No. two interlayers 6, No. three interlayers 11, each functional areas（Comprising Shou Yang areas 2, area 5, amplification region 8, detection zone are extracted
10）Between be connected as at an entirety, and each functional areas interconnection all have an interlayer（Include an interlayer 4, No. two
Interlayer 6, No. three interlayers 11）, interlayer can open, can also close.Nucleic acid rapid extraction, constant temperature can be realized on the apparatus
Amplification, and detected by nucleic acid test strip, read result.
A described interlayer 4, No. two interlayers 6, No. three interlayers 11 are all made up of two pieces of platy structures with small opening,
In external force pressurizing unit outer wall, when two small openings are overlapped, liquid enters next functional areas through small opening.When external force disappears
Lose, when two boards shape recovers origin-location, the small opening of tabular can be blocked mutually, prevent liquid when shaking up, be back to one
Functional areas, it is ensured that each functional areas possesses good seal always.
Described one end of Shou Yang areas 2 carries screw lid 1, and the other end is connected with extraction area 5 and there is an interlayer 4 junction,
The outer wall of Shou Yang areas 2 is extruded by external force, can open an interlayer 4, allows sample to enter extraction area 5.
Described one end of extraction area 5 is connected with Shou Yang areas 2, and the other end is connected with amplification region 8, and is connected with amplification region 8
There are No. two interlayers 6 at place, there is a filter membrane 7 below No. two interlayers 6, and filter membrane 7 and the extraction inwall of area 5 are closely coupled, gapless.Extract
Attachment is useful in area 5 extracts the outer wall of area 5 so that No. two interlayers 6 are opened in the nucleic acid extracting reagent for extracting nucleic acid by extruding,
The solution in area 5 is extracted after filter membrane 7, the material in addition to nucleic acid is filtered out, only remaining nucleic acid solution enters amplification region 8.
Described one end of amplification region 8 is connected with extracting area 5, and one end is connected with detection zone 10, and the outer surface of amplification region 8 is posted
Heating patch 9, the various dry powder needed for amplified reaction are contained in inside.Have No. three interlayers 11 with the connecting place of detection zone 10, No. three every
There is a guiding mouth 12 lower section of layer 11, and guiding mouth 12 is connected with the sample pad 13 of detection zone 10.Can by the outer wall for extruding amplification region 8
No. three interlayers 11 are opened, the liquid allowed after amplification enters sample pad 13 by guiding mouth 12.
Described heating patch 9 its internal composition is main includes the mixture of the synthesis such as iron, activated carbon, inorganic salts, water, can be
Occur exothermic reaction in air in the presence of oxygen, and this reaction is that since being torn heating 9 extexines of patch, it can be continuous
The heat that more than 50 ° of release, the fever time of heating patch 9 can ensure that temperature of the amplification region 8 in the nucleic acid amplification stage keeps permanent
It is fixed.
Described detection zone 10 is made up of chamber cylinder 14 and test strips 15.Chamber cylinder 14 is made up of transparent material, by test strips 15
Surround, form the space of one and atmospheric isolation, and fix a test strips 15 wherein, chamber cylinder 14 is in the display knot of test strips 15
Really that face is in dimpling type, forms a small-sized magnifying glass, is easy to sentence read result.
Described Shou Yang areas 2, extract area 5, amplification region 8 by with favorable elasticity, it is extrudable and to solution without adsorptivity
Material is constituted.
A kind of gene tester based on described detection of biological samples device, its method includes step：
A. sample solution to be detected, is that nucleic acid extraction is carried out under closed space；
B. the solution after extracting, is that constant-temperature amplification is carried out under closed space；
C. sample solution it is extracted, amplification after, detected by nucleic acid test strip；
Sample solution completes nucleic acid extraction, can be directly entered the nucleic acid amplification stage；When the sample solution completion nucleic acid amplification stage,
Can directly it carry out that the operation such as liquid relief need not be carried out in detection of nucleic acids, process of the test.
As the improvement of gene tester of the present invention, sample pad 13, coloured particle pad are included in test strips 15
16th, tunica fibrosa 17 and absorbent filter pad 18, each part mentioned above partly overlaps in adjacent, also includes detection line on tunica fibrosa 17
19 and nature controlling line 20.
Testing result judges that a. develops the color when nature controlling line 20, and detection line 19 develops the color, and represents this time to detect effective, sample solution
In contain testing gene；B. when nature controlling line 20 develops the color, detection line 19 does not develop the color, and represents this time to detect effective, in sample solution not
Contain testing gene；C. when nature controlling line 20 does not develop the color, represent that this time detection is invalid.
In summary, beneficial effects of the present invention：
Gene tester provided by the present invention, simple to operate, without carrying out extra liquid relief, filtering etc. is operated, greatly
Operating process is simplified, ruck can also fast, easily complete alone genetic test, and result can be observed directly,
Whole detection process only needs just can complete for 40 minutes.
The detection of biological samples device corresponding with the gene tester of the present invention, has used interlayer by each functional areas
To be spaced apart, in external force pressurizing unit, interlayer is opened, when external force disappears, and interlayer closure ensure that between functional areas well
Reaction solution do not flow back, each functional areas has a good seal, and solution will not cross pollution so that the testing result of device
It is more accurate, reliable.
Whole device structure is also more simple compared with biological monitor of the prior art, small volume, it is not necessary to outer
Portion's supply source, cost price is lower, with more preferable economic benefit, while very easy to use and do not need bulky auxiliary to set
It is standby, and the simplicity operated causes layman all can voluntarily be detected and sentence read result, eliminates information delay.
The detection of biological samples device of the present invention is the good disposable product of seal, eliminates the possibility of pollution.
Brief description of the drawings
Fig. 1 is a kind of overall structure figure of detection of biological samples device of the invention；
Screw lid 1
Shou Yang areas 2
Graduation mark 3
A number interlayer 4
Extract area 5
No. two interlayers 6
Filter membrane 7
Amplification region 8
Heating patch 9
Detection zone 10
No. three interlayers 11
Guiding mouth 12
Sample pad 13
Chamber cylinder 14
Test strips 15
Coloured particle pad 16
Tunica fibrosa 17
Absorbent filter pad 18
Detection line 19
Nature controlling line 20
Fig. 2 is the plan of test strips；
Fig. 3 is the plan of interlayer；
Fig. 4 is the three-dimensional structure diagram of interlayer.
Embodiment
The present invention is further illustrated below in conjunction with accompanying drawing, but not limits the present invention.
As shown in figure 1, detection bar device：Comprising Shou Yang areas 2, extract area 5, amplification region 8, detection zone 10.Rapid extraction exists
Area 5 is extracted to complete；Isothermal amplification reactions are completed in amplification region 8；Nucleic acid test strip detection mode and real-time reading result are in detection
Area 10 is completed.
The present embodiment 1 is so that alcohol-based is because of detection as an example, the activity of ADH1B genes in detection human body：
Implementation is comprised the following steps that：
1. opening screw lid 1, tested sample is added to Shou Yang areas 2（Saliva, blood）The outer wall in 200ul, Shou Yang area 2 has graduation mark
3。
2. after firmly tightening screw lid 1, then extruding the outer wall in Shou Yang areas 2, the first interlayer 4 is opened, allows sample to enter and carries
Take area 5.
3. turn upside down 1min, dissolving, which is mixed, extracts the dry state lytic reagent of attachment, Proteinase K, carrier in area 5
The nucleic acid extracting reagent dry powder such as RNA, mixes and places after 10min, and the outer wall that area 5 is extracted in extruding opens the second interlayer 6, allows liquid flow
Enter amplification region 8 after filter membrane 7.
4. turn upside down 1min, dissolving mixes the dry powder of the amplification system of attachment in amplification region 8, tears the appearance of amplification region 8
The outer membrane of the heating patch 9 in face, heating patch 9 starts to give the continuous heating of amplification region 8, it is ensured that amplification region 8 is under a constant temperature
The amplification of progress, is placed after 20min, and the outer wall of extruding amplification region 8 opens the 3rd interlayer 11, makes liquid laggard by guiding mouth 12
Enter the sample pad 13 of detection zone 10.
5. in the presence of absorbent filter pad 18, coloured particle pad can be sequentially passed through by entering the sample of sample pad 13
16th, tunica fibrosa 17, absorbent filter pad 18, detection line 19, nature controlling line 20, the detection of whole test strips 15 are completed in 5min.
6. described in coloured particle pad 16 on contain C antigens, nature controlling line 20 contain C antibody, so no matter amplification production
The whether purposeful gene of thing, nature controlling line 20 can all develop the color, and show that this result is inaccurate if do not developed the color.
Detection line 19 contains the antibody of cls gene to be checked.
7. result interpretation：
1. when nature controlling line 20 does not develop the color, then it represents that this time detection is unsuccessful；
2. in the case that nature controlling line 20 develops the color：
Detection line 19 develops the color, and represents that ADH1B is active, does not develop the color, ADH1B does not have activity.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair
The equivalent transformation that bright description is made, or other related technical fields are directly or indirectly used in, similarly it is included in
In the scope of patent protection of the present invention.
Claims (9)
1. a kind of detection of biological samples device, its structure includes Shou Yang areas（2）, extract area（5）, amplification region（8）, detection zone
（10）, it is technically characterized in that, an entirety is connected as between each functional areas in device, can be completed in a device
All there is an interlayer, interlayer can be opened, can also closed at whole gene detection process, and each functional areas interconnection
Close.
2. a kind of detection of biological samples device according to claim 1, it is characterised in that：A number interlayer (4), No. two interlayers
(6), No. three interlayers (11) are all that, when external force pressurizing unit, interlayer is opened, and solution can flow through interlayer, when the extruding of no external force
During device, interlayer is closed, and solution can not pass through interlayer.
3. a kind of detection of biological samples device according to claim 1, it is characterised in that：
Shou Yang areas（2）One end carries screw lid（1）, the other end is with extracting area（5）It is connected and there is an interlayer junction（4）, lead to
Cross external force extruding Shou Yang areas（2）Outer wall, can make an interlayer（4）Open, allow sample to enter extraction area（5）；
Extract area（5）One end and Shou Yang areas（2）It is connected, the other end and amplification region（8）It is connected, and and amplification region（8）Connecting place
There are No. two interlayers（6）, in No. two interlayers（6）There is a filter membrane lower section（7）, filter membrane（7）With extracting area（5）Inwall is closely coupled, nothing
Gap, extracts area（5）The useful nucleic acid extracting reagent to extract nucleic acid of interior attachment, area is extracted by external force extruding（5）Outer wall, makes
Obtain No. two interlayers（6）Open, extract area（5）Interior solution is through filter membrane（7）Enter amplification region afterwards（8）；
Amplification region（8）One end is with extracting area（5）It is connected, one end and detection zone（10）It is connected, amplification region（8）Outer surface post liter
Temperature patch（9）, amplification region（8）Contain the various dry powder needed for amplified reaction in inside；
Amplification region（8）With detection zone（10）Connecting place has No. three interlayers（11）, in No. three interlayers（11）There is a guiding mouth lower section
（12）, guiding mouth（12）With detection zone（10）Sample pad（13）It is connected, by extruding amplification region（8）Outer wall can open No. three
Interlayer（11）, allow amplification after liquid pass through guiding mouth（12）Into sample pad（13）.
4. a kind of detection of biological samples device according to claim 1, it is characterised in that：Heating patch（9）It is mixed inside it
Compound produces heat, is amplification region with exothermic reaction occurs in the presence of aerial oxygen（8）Continuous heating.
5. a kind of detection of biological samples device according to claim 1, it is characterised in that：Detection zone（10）By chamber cylinder（14）
And test strips（15）Composition；Chamber cylinder（14）It is made up of transparent material, by test strips（15）Surround, form one and atmospheric isolation
Space, and a test strips are fixed wherein（15）, chamber cylinder（14）In display test strips（15）As a result that face is in dimpling type, is formed
One small-sized magnifying glass, is easy to sentence read result.
6. a kind of detection of biological samples device according to claim 1, it is characterised in that：Shou Yang areas（2）, extract area (5),
Amplification region (8) is by with favorable elasticity and squeezable, the material for not possessing adsorptivity to solution is constituted.
7. a kind of gene tester of the detection of biological samples device based on described in claim 1, its method includes step：
Sample solution to be detected, is that nucleic acid extraction is carried out under closed space；
Solution after extraction, is that constant-temperature amplification is carried out under closed space；
Sample solution is extracted, after amplification, is detected by nucleic acid test strip；
Characterized in that, when sample solution completes nucleic acid extraction, the nucleic acid amplification stage can be directly entered；When sample solution is completed
In the nucleic acid amplification stage, detection of nucleic acids can be directly carried out, the operation such as liquid relief need not be carried out by drawing in testing result, process of the test.
8. a kind of method for genetic test according to claim 7, it is characterised in that：Described test strips（15）On
Include sample pad（13）, coloured particle pad（16）, tunica fibrosa（17）With absorbent filter pad（18）, each part mentioned above is in phase
Adjacent place partly overlaps, tunica fibrosa（17）On also include detection line（19）And nature controlling line（20）.
9. according to a kind of claim 7-8 method for genetic test, it is characterised in that：Testing result judges that a. works as matter
Control line（20）Colour developing, detection line（19）Colour developing, represents this time to detect effective, testing gene is contained in sample solution；B. Quality Control is worked as
Line（20）Colour developing, detection line（19）Do not develop the color, represent this time to detect effective, testing gene is not contained in sample solution；C. matter is worked as
Control line（20）When not developing the color, represent that this time detection is invalid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710621024.2A CN107217001A (en) | 2017-07-27 | 2017-07-27 | A kind of detection of biological samples device and the gene tester based on the device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710621024.2A CN107217001A (en) | 2017-07-27 | 2017-07-27 | A kind of detection of biological samples device and the gene tester based on the device |
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Family
ID=59954495
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| CN201710621024.2A Pending CN107217001A (en) | 2017-07-27 | 2017-07-27 | A kind of detection of biological samples device and the gene tester based on the device |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112538423A (en) * | 2020-12-23 | 2021-03-23 | 广州和实生物技术有限公司 | Integral nucleic acid extraction and detection device and use method thereof |
| CN112680340A (en) * | 2020-12-23 | 2021-04-20 | 广州和实生物技术有限公司 | Full-automatic nucleic acid detection device and detection method thereof |
| WO2022134153A1 (en) * | 2020-12-23 | 2022-06-30 | 广州和实生物技术有限公司 | Nucleic acid poct testing apparatus and testing method thereof |
| CN115466671A (en) * | 2022-09-28 | 2022-12-13 | 广纳达康(广州)生物科技有限公司 | Anti-scour liquid nucleic acid amplification product detection device and detection method |
| CN117761311A (en) * | 2023-12-25 | 2024-03-26 | 威尔塔斯生物工程技术(上海)有限公司 | Immunochromatography device and detection method for detecting carbapenemase in bacteria |
-
2017
- 2017-07-27 CN CN201710621024.2A patent/CN107217001A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112538423A (en) * | 2020-12-23 | 2021-03-23 | 广州和实生物技术有限公司 | Integral nucleic acid extraction and detection device and use method thereof |
| CN112680340A (en) * | 2020-12-23 | 2021-04-20 | 广州和实生物技术有限公司 | Full-automatic nucleic acid detection device and detection method thereof |
| WO2022134153A1 (en) * | 2020-12-23 | 2022-06-30 | 广州和实生物技术有限公司 | Nucleic acid poct testing apparatus and testing method thereof |
| CN112680340B (en) * | 2020-12-23 | 2024-07-16 | 广州和实生物技术有限公司 | Full-automatic nucleic acid detection device and detection method thereof |
| CN112538423B (en) * | 2020-12-23 | 2024-07-16 | 广州和实生物技术有限公司 | Integral nucleic acid extraction detection device and application method thereof |
| CN115466671A (en) * | 2022-09-28 | 2022-12-13 | 广纳达康(广州)生物科技有限公司 | Anti-scour liquid nucleic acid amplification product detection device and detection method |
| CN115466671B (en) * | 2022-09-28 | 2023-12-15 | 广纳达康(广州)生物科技有限公司 | Anti-flushing liquid nucleic acid amplification product detection device and detection method |
| CN117761311A (en) * | 2023-12-25 | 2024-03-26 | 威尔塔斯生物工程技术(上海)有限公司 | Immunochromatography device and detection method for detecting carbapenemase in bacteria |
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