CN107213275A - A kind of raise livestock anthelmintic and preparation method thereof - Google Patents
A kind of raise livestock anthelmintic and preparation method thereof Download PDFInfo
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- CN107213275A CN107213275A CN201710293231.XA CN201710293231A CN107213275A CN 107213275 A CN107213275 A CN 107213275A CN 201710293231 A CN201710293231 A CN 201710293231A CN 107213275 A CN107213275 A CN 107213275A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a kind of raise livestock anthelmintic for animals and preparation method thereof for belonging to field of medicine preparing technology.It is made up of the raw material of following parts by weight：10 20 parts of fructus ulmi extract, 10 20 parts of Fructus Carpesii extract, two 38 parts of medicine algae extracts, 15 30 parts of salt lythrum salucaria, 38 parts of filler, 35 parts of mineral matter, 12 parts of vitamin, 30 50 parts of water.Anthelmintic prepared by the present invention, for the taeniasis of livestock, nematodiasis, toxoplasmosis, piroplasmosis, Babesia Gibsoni, theileriosis, Cryptosporidiosis, Entamoeba histolytica, large intestine balantidiasis etc., with good therapeutic effect, without any toxic side effect, prepare simple, raw material sources are wide, are adapted to large-scale industrial production.
Description
Technical field
The invention belongs to field of medicine preparing technology, and in particular to a kind of raise livestock anthelmintic and its preparation side
Method.
Background technology
In the feeding process of domestic animal, parasitic disease is easily infected, common animal parasitosis has a fluke disease, taeniasis,
Nematodiasis, toxoplasmosis, piroplasmosis, Babesia Gibsoni, theileriosis, Cryptosporidiosis, Entamoeba histolytica, large intestine cilium
Parasitosis etc..Parasitosis morbidity is serious, and the death rate is high, and the economic loss caused to animal husbandry is huge, to life and the health of the mankind
Threaten very big.
Protozoon volume is small, and basic structure includes pellicle, kytoplasm and karyon.The organella moti of protozoon has pseudopodium, flagellum
And three kinds of cilium, motion mode has pseudopodial movement, flagellum movement and ciliary movement.Karyon is generally vesicular nucleus, and minority is substantive core,
The trophophase of protozoon, minority can have two or more mostly containing only a core.The morphological feature of dyed rear karyon is to differentiate doctor
Learn the important evidence of protozoon.The mode of reproduction of parasitic protozoa point asexual reproduction and zoogamy.Some protozoons are with sexual and asexual
Mode is alternateed and the reproduction referred to as alternation of generations.
The parasitic disease for treating domestic animal often uses Western medicine, such as piperazine, AVM, the phosphorus of ammonia third, organochlorine, antibioticses.
Antibiotics such as moxidectin etc. can effectively treat nematodiasis, the illness such as vermin, and still, long use can produce anti-
The property of medicine；AVM, the phosphorus of ammonia third, although the energy desinsection expelling parasite of the medicine such as organochlorine, side effect is larger, and is pernicious to people, dirty
Contaminate environment.
Patent 201310635744.6 discloses a kind of Powerful insect repellent for veterinary use and preparation method thereof.The raw material weight of use
Amount part, which constitutes, is：5~8 parts of tripterygium wilfordii, 20~30 parts of kuh-seng, 15~25 parts of the fruit of Rangoon creeper, 10~15 parts of stone-like omphalia, rheum officinale 20~30
Part, 10~15 parts of radix glycyrrhizae, 10~15 parts of beta-schardinger dextrin.Although the pharmaceutical composition can maggot, drug effect is not high, cure
Rate is low.
The content of the invention
It is an object of the invention to provide a kind of raise livestock anthelmintic and preparation method thereof.
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：10-20 parts of fructus ulmi extract, Lappula echinata
10-20 parts of extract, two 3-8 parts of medicine algae extracts, 15-30 parts of salt lythrum salucaria, 3-8 parts of filler, 3-5 parts of mineral matter,
1-2 parts of vitamin, 30-50 parts of water.
The preparation method of the fructus ulmi extract is：The blade of fructus ulmi is dried or dried, is ground, plus 3-5 times of weight
60% ethanol solution refluxing extraction of number 3 times, merging filtrate is evaporated and is made.
The preparation method of the Fructus Carpesii extract is：Lappula echinata is dried or dried, is ground, plus 3-5 times of parts by weight
60% ethanol solution refluxing extraction 3 times, merging filtrate is evaporated and is made.
The preparation method of the two medicines algae extract is：Two medicine algaes are taken, are (0.6-1) in the ratio between cooling refrigeration work consumption：1
Under the conditions of, frozen dried 13-20h is made.
The preparation method of the salt lythrum salucaria is：Salt Lythrum salicaria is dried or dried, is ground, plus 3-5 times weighs
60% ethanol solution refluxing extraction of amount number 3 times, merging filtrate is evaporated and is made.
The filler is cyclodextrin, starch, sucrose, chitosan, carboxymethyl cellulose, one kind in bean powder or it is a kind of with
On.
The mineral matter is medical stone powder, calcium carbonate, calcium dihydrogen phosphate, potassium chloride, potassium sulfate, magnesium sulfate, in ferric phosphate
One or more.
The vitamin is vitamin E, vitamin A, vitamin D, vitamin B1, vitamin B12, one in vitamin C
Plant or more than one.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 30-50 parts, 10-20 parts of fructus ulmi extract, 10-20 parts of Fructus Carpesii extract, two medicines
3-8 parts of algae extract, 15-30 parts of salt lythrum salucaria is put into emulsification pot, vacuumizes and maintain its vacuum
0.09-0.12Pa, while opening emulsification pot heat button, 80-90 DEG C is heated to emulsification pot；
(2) homogenizer button is opened, homogeneous stirs 6-10min under 8-18r/min mixing speeds；Rotating speed is improved, in 25-
10-20min is stirred under 35r/min mixing speed；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, pot will be emulsified in 40-50min
Temperature is reduced to 55-65 DEG C, adds 3-8 parts of filler, and 3-5 parts of mineral matter, 1-2 parts of vitamin stirs 10-20min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 23-28 DEG C, is applied preservative film, seals 24- up for safekeeping
30h, is produced.
Beneficial effects of the present invention：Raise livestock anthelmintic prepared by the present invention, for the taeniasis of livestock, nematode
Disease, toxoplasmosis, piroplasmosis, Babesia Gibsoni, theileriosis, Cryptosporidiosis, Entamoeba histolytica, large intestine balantidiasis
Deng with good therapeutic effect, without any toxic side effect, preparing simple, raw material sources are wide, are adapted to large-scale industry metaplasia
Production.
Embodiment
With reference to specific embodiment, the present invention will be further described.
In following embodiments：
The preparation method of the fructus ulmi extract is：The blade of fructus ulmi is dried or dried, is ground, plus 3-5 times of weight
60% ethanol solution refluxing extraction of number 3 times, merging filtrate is evaporated and is made.
The preparation method of the Fructus Carpesii extract is：Lappula echinata is dried or dried, is ground, plus 3-5 times of parts by weight
60% ethanol solution refluxing extraction 3 times, merging filtrate is evaporated and is made.
The preparation method of the two medicines algae extract is：Two medicine algaes are taken, are (0.6-1) in the ratio between cooling refrigeration work consumption：1
Under the conditions of, frozen dried 13-20h is made.
The preparation method of the salt lythrum salucaria is：Salt Lythrum salicaria is dried or dried, is ground, plus 3-5 times weighs
60% ethanol solution refluxing extraction of amount number 3 times, merging filtrate is evaporated and is made.
Embodiment 1
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：15 parts of fructus ulmi extract, Lappula echinata is extracted
15 parts of thing, two 6 parts of medicine algae extracts, 22 parts of salt lythrum salucaria, 3 parts of cyclodextrin, 2 parts of chitosan, 4 parts of medical stone powder, dimension
Raw E0.2 parts of element, 0.2 part of vitamin A, 0.2 part of vitamin C, 0.4 part of vitamin D, 40 parts of water.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 40 parts, 15 parts of fructus ulmi extract, 15 parts of Fructus Carpesii extract, two medicine algae extracts 6
Part, 22 parts of salt lythrum salucaria is put into emulsification pot, vacuumizes and its vacuum is maintained 0.1Pa, while opening emulsification
Pot heat button, 85 DEG C are heated to emulsification pot；
(2) homogenizer button is opened, homogeneous stirs 8min under 12r/min mixing speeds；Rotating speed is improved, in 30r/min
Mixing speed under stir 15min；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 45min
60 DEG C are reduced to, 3 parts of cyclodextrin, 2 parts of chitosan, 4 parts of medical stone powder, 0.2 part of vitamin E, 0.2 part of vitamin A, dimension life is added
Plain C0.2 parts, 0.4 part of vitamin D stirs 15min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 25 DEG C, is applied preservative film, seals 26h up for safekeeping, i.e.,
.
Embodiment 2
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：10 parts of fructus ulmi extract, Lappula echinata is extracted
10 parts of thing, two 3 parts of medicine algae extracts, 15 parts of salt lythrum salucaria, 2 parts of starch, 1 part of sucrose, 1 part of calcium carbonate, biphosphate
1 part of calcium, 1 part of potassium chloride, 0.2 part of vitamin A, 0.4 part of vitamin D, 0.2 part of vitamin B1,0.2 part of vitamin B12, water 30
Part.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 30 parts, 10 parts of fructus ulmi extract, 10 parts of Fructus Carpesii extract, two medicine algae extracts 3
Part, 15 parts of salt lythrum salucaria is put into emulsification pot, vacuumizes and its vacuum is maintained 0.09Pa, while opening breast
Change pot heat button, 80 DEG C are heated to emulsification pot；
(2) homogenizer button is opened, homogeneous stirs 6min under 8r/min mixing speeds；Rotating speed is improved, 25r/min's
10min is stirred under mixing speed；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 40min
55 DEG C are reduced to, 2 parts of starch, 1 part of sucrose, 1 part of calcium carbonate, 1 part of calcium dihydrogen phosphate, 1 part of potassium chloride, vitamin A 0.2 is added
Part, 0.4 part of vitamin D, 0.2 part of vitamin B1,0.2 part of vitamin B12 stirs 10min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 23 DEG C, is applied preservative film, seals 24h up for safekeeping, i.e.,
.
Embodiment 3
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：20 parts of fructus ulmi extract, Lappula echinata is extracted
20 parts of thing, two 8 parts of medicine algae extracts, 30 parts of salt lythrum salucaria, 4 parts of carboxymethyl cellulose, 4 parts of bean powder, 3 parts of potassium sulfate,
1 part of magnesium sulfate, 1 part of ferric phosphate, vitamin e1 part, 1 part of vitamin C, 50 parts of water.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 50 parts, 20 parts of fructus ulmi extract, 20 parts of Fructus Carpesii extract, two medicine algae extracts 8
Part, 30 parts of salt lythrum salucaria is put into emulsification pot, vacuumizes and its vacuum is maintained 0.12Pa, while opening breast
Change pot heat button, 90 DEG C are heated to emulsification pot；
(2) homogenizer button is opened, homogeneous stirs 10min under 18r/min mixing speeds；Rotating speed is improved, in 35r/min
Mixing speed under stir 20min；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 50min
65 DEG C are reduced to, 4 parts of carboxymethyl cellulose, 4 parts of bean powder, 3 parts of potassium sulfate, 1 part of magnesium sulfate, 1 part of ferric phosphate, vitamin e1 is added
Part, 1 part of vitamin C stirs 20min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 28 DEG C, is applied preservative film, seals 30h up for safekeeping, i.e.,
.
Embodiment 4
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：15 parts of fructus ulmi extract, Lappula echinata is extracted
15 parts of thing, two 6 parts of medicine algae extracts, 22 parts of salt lythrum salucaria, 3 parts of cyclodextrin, 2 parts of chitosan, 4 parts of medical stone powder is blue or green
4 parts of metal and stone powder, 0.2 part of vitamin E, 0.2 part of vitamin A, 0.2 part of vitamin C, 0.4 part of vitamin D, 40 parts of water.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 40 parts, 15 parts of fructus ulmi extract, 15 parts of Fructus Carpesii extract, two medicine algae extracts 6
Part, 22 parts of salt lythrum salucaria is put into emulsification pot, vacuumizes and its vacuum is maintained 0.1Pa, while opening emulsification
Pot heat button, 85 DEG C are heated to emulsification pot；
(2) homogenizer button is opened, homogeneous stirs 8min under 12r/min mixing speeds；Rotating speed is improved, in 30r/min
Mixing speed under stir 15min；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 45min
60 DEG C are reduced to, 3 parts of cyclodextrin, 2 parts of chitosan, 4 parts of medical stone powder, 4 parts of lapis lazuli powder, 0.2 part of vitamin E, dimension life is added
Plain A0.2 parts, 0.2 part of vitamin C, 0.4 part of vitamin D stirs 15min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 25 DEG C, is applied preservative film, seals 26h up for safekeeping, i.e.,
.
Embodiment 5
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：10 parts of fructus ulmi extract, Lappula echinata is extracted
10 parts of thing, two 3 parts of medicine algae extracts, 15 parts of salt lythrum salucaria, short 3 parts of spy spring extract, 2 parts of starch, 1 part of sucrose, carbon
Sour 1 part of calcium, 1 part of calcium dihydrogen phosphate, 1 part of potassium chloride, 0.2 part of vitamin A, 0.4 part of vitamin D, 0.2 part of vitamin B1, dimension life
Plain 0.2 part of B12,30 parts of water.
It is described it is short visit spring extract preparation method be：The flower in short spy spring is dried or dried, is ground, plus 5 times of weights
60% ethanol solution refluxing extraction of amount number 3 times, merging filtrate is evaporated and is made.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 30 parts, 10 parts of fructus ulmi extract, 10 parts of Fructus Carpesii extract, two medicine algae extracts 3
Part, 15 parts of salt lythrum salucaria, short 3 parts of spy spring extract is put into emulsification pot, vacuumizes and maintain its vacuum
0.09Pa, while opening emulsification pot heat button, 80 DEG C are heated to emulsification pot；
(2) homogenizer button is opened, homogeneous stirs 6min under 8r/min mixing speeds；Rotating speed is improved, 25r/min's
10min is stirred under mixing speed；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 40min
55 DEG C are reduced to, 2 parts of starch, 1 part of sucrose, 1 part of calcium carbonate, 1 part of calcium dihydrogen phosphate, 1 part of potassium chloride, vitamin A 0.2 is added
Part, 0.4 part of vitamin D, 0.2 part of vitamin B1,0.2 part of vitamin B12 stirs 10min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 23 DEG C, is applied preservative film, seals 24h up for safekeeping, i.e.,
.
Comparative example 1
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：10 parts of fructus ulmi extract, Lappula echinata is extracted
10 parts of thing, 15 parts of salt lythrum salucaria, 2 parts of starch, 1 part of sucrose, 1 part of calcium carbonate, 1 part of calcium dihydrogen phosphate, 1 part of potassium chloride,
0.2 part of vitamin A, 0.4 part of vitamin D, 0.2 part of vitamin B1,0.2 part of vitamin B12,30 parts of water.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 30 parts, 10 parts of fructus ulmi extract, 10 parts of Fructus Carpesii extract, salt lythrum salucaria
15 parts, it is put into emulsification pot, vacuumizes and its vacuum is maintained 0.09Pa, while emulsification pot heat button is opened, to breast
Change pot and be heated to 80 DEG C；
(2) homogenizer button is opened, homogeneous stirs 6min under 8r/min mixing speeds；Rotating speed is improved, 25r/min's
10min is stirred under mixing speed；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 40min
55 DEG C are reduced to, 2 parts of starch, 1 part of sucrose, 1 part of calcium carbonate, 1 part of calcium dihydrogen phosphate, 1 part of potassium chloride, vitamin A 0.2 is added
Part, 0.4 part of vitamin D, 0.2 part of vitamin B1,0.2 part of vitamin B12 stirs 10min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 23 DEG C, is applied preservative film, seals 24h up for safekeeping, i.e.,
.
Comparative example 2
A kind of raise livestock anthelmintic, is made up of the raw material of following parts by weight：20 parts of fructus ulmi extract, Lappula echinata is extracted
20 parts of thing, two 8 parts of medicine algae extracts, 4 parts of carboxymethyl cellulose, 4 parts of bean powder, 3 parts of potassium sulfate, 1 part of magnesium sulfate, 1 part of ferric phosphate,
Vitamin e1 part, 1 part of vitamin C, 50 parts of water.
The preparation method of above-mentioned raise livestock anthelmintic, is carried out in accordance with the following steps：
(1) according to parts by weight, fetch water 50 parts, 20 parts of fructus ulmi extract, 20 parts of Fructus Carpesii extract, two medicine algae extracts 8
Part, it is put into emulsification pot, vacuumizes and its vacuum is maintained 0.12Pa, while emulsification pot heat button is opened, to emulsification
Pot is heated to 90 DEG C；
(2) homogenizer button is opened, homogeneous stirs 10min under 18r/min mixing speeds；Rotating speed is improved, in 35r/min
Mixing speed under stir 20min；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 50min
65 DEG C are reduced to, 4 parts of carboxymethyl cellulose, 4 parts of bean powder, 3 parts of potassium sulfate, 1 part of magnesium sulfate, 1 part of ferric phosphate, vitamin e1 is added
Part, 1 part of vitamin C stirs 20min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 28 DEG C, is applied preservative film, seals 30h up for safekeeping, i.e.,
.
Experimental example：
Take 8 week old piglet 900 to be divided into 9 groups, every group 100, respectively test blank control group, albendazole Yi Wei bacterium
Plain powder group, embodiment 1-5 and comparative example 1-2 experimental groups；Blank control group feeds chow diet, albendazole ivermectin powder group
Daily addition 10g albendazole ivermectin powders/every pig feed in feed, other each group addition 10g pest repellants/every pigs
Feed, situations such as carrying out outward appearance, body weight to pig health status is checked and is compared.
Index of assessment of curative effect：
(1) without parasitic infection rate and parasitic infection rate：Healthy (no parasitic infection)：Pig feed intake is normal or increases
Plus, body surface fur light；Parasitic infection：In the presence of obvious parasite dye sense symptom, feed intake declines, and body surface fur color and luster is not
Light；
(2) average weight gain：According to the body weight of every pig before administration and during off-test, the gain in weight of every pig of calculating, according to
This calculates every group of average weight gain；Body weight increase rate：The ratio between average weight gain by each medication group and blank control group is calculated.
Statistical result is as shown in table 1:
Table 1
As can be seen from Table 1, the anthelmintic that prepared by embodiment 1-5, parasitic infection rate is average well below blank control
Daily gain is significantly larger than blank control, it was demonstrated that anthelmintic of the invention has a good anthelminthic effect, comparative example 1, comparative example 2 with
Embodiment 2, embodiment 3 is compared, and adds two medicine algae extracts less respectively, and salt lythrum salucaria, parasitic infection rate increases,
Average daily gain is reduced, it was demonstrated that above-mentioned substance plays the effect of key, embodiment 4-5 parasite sense for the effect of anthelmintic
Dye rate is less than embodiment 1-2, and average daily gain is higher than embodiment 1-2, by comparison, adds lapis lazuli powder, the short spy spring carries more
Take thing, it was demonstrated that above-mentioned substance plays the effect of key for increasing the drug effect of anthelmintic.
Claims (9)
1. a kind of raise livestock anthelmintic, it is characterised in that be made up of the raw material of following parts by weight：Fructus ulmi extract 10-
20 parts, 10-20 parts of Fructus Carpesii extract, two 3-8 parts of medicine algae extracts, 15-30 parts of salt lythrum salucaria, 3-8 parts of filler, mineral
3-5 parts of matter, 1-2 parts of vitamin, 30-50 parts of water.
2. raise livestock anthelmintic according to claim 1, it is characterised in that the preparation method of the fructus ulmi extract
For：The blade of fructus ulmi is dried or dried, is ground, plus 3-5 times of parts by weight 60% ethanol solution refluxing extraction 3 times, close
And filtrate, it is evaporated and is made.
3. raise livestock anthelmintic according to claim 1, it is characterised in that the preparation method of the Fructus Carpesii extract
For：Lappula echinata is dried or dried, is ground, plus 3-5 times of parts by weight 60% ethanol solution refluxing extraction 3 times, merging filtrate,
It is evaporated and is made.
4. raise livestock anthelmintic according to claim 1, it is characterised in that the preparation method of the two medicines algae extract
For：Two medicine algaes are taken, are (0.6-1) in the ratio between cooling refrigeration work consumption：Under conditions of 1, frozen dried 13-20h is made.
5. raise livestock anthelmintic according to claim 1, it is characterised in that the preparation side of the salt lythrum salucaria
Method is：Salt Lythrum salicaria is dried or dried, is ground, plus 3-5 times of parts by weight 60% ethanol solution refluxing extraction 3 times, close
And filtrate, it is evaporated and is made.
6. raise livestock anthelmintic according to claim 1, it is characterised in that the filler is cyclodextrin, starch, sugarcane
One or more in sugar, chitosan, carboxymethyl cellulose, bean powder.
7. raise livestock anthelmintic according to claim 1, it is characterised in that the mineral matter is medical stone powder, carbonic acid
One or more in calcium, calcium dihydrogen phosphate, potassium chloride, potassium sulfate, magnesium sulfate, ferric phosphate.
8. raise livestock anthelmintic according to claim 1, it is characterised in that the vitamin is vitamin E, vitamin
One or more in A, vitamin D, vitamin B1, vitamin B12, vitamin C.
9. the preparation method of raise livestock anthelmintic described in claim 1, it is characterised in that carry out in accordance with the following steps：
(1) according to parts by weight, fetch water 30-50 parts, 10-20 parts of fructus ulmi extract, 10-20 parts of Fructus Carpesii extract, two medicine algaes carry
3-8 parts of thing is taken, 15-30 parts of salt lythrum salucaria is put into emulsification pot, vacuumizes and its vacuum is maintained 0.09-
0.12Pa, while opening emulsification pot heat button, 80-90 DEG C is heated to emulsification pot；
(2) homogenizer button is opened, homogeneous stirs 6-10min under 8-18r/min mixing speeds；Rotating speed is improved, in 25-35r/
10-20min is stirred under min mixing speed；
(3) cooling water is opened, and controls the speed of cooling water, is cooled down while stirring, the temperature of pot will be emulsified in 40-50min
55-65 DEG C is reduced to, 3-8 parts of filler is added, 3-5 parts of mineral matter, 1-2 parts of vitamin stirs 10-20min；
(4) material for preparing step (3) is placed in sterilization container, is cooled to 23-28 DEG C, is applied preservative film, seals 24-30h up for safekeeping,
Produce.
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Application publication date: 20170929 |