CN107208159A - 宿主dna作为克罗恩氏病的生物标记物 - Google Patents

宿主dna作为克罗恩氏病的生物标记物 Download PDF

Info

Publication number
CN107208159A
CN107208159A CN201680007943.4A CN201680007943A CN107208159A CN 107208159 A CN107208159 A CN 107208159A CN 201680007943 A CN201680007943 A CN 201680007943A CN 107208159 A CN107208159 A CN 107208159A
Authority
CN
China
Prior art keywords
subject
disease
crohn
sample
relative abundance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680007943.4A
Other languages
English (en)
Chinese (zh)
Inventor
A·切尔维诺
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
En Temu Biological Science Co Ltd
Original Assignee
En Temu Biological Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by En Temu Biological Science Co Ltd filed Critical En Temu Biological Science Co Ltd
Publication of CN107208159A publication Critical patent/CN107208159A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201680007943.4A 2015-01-30 2016-01-29 宿主dna作为克罗恩氏病的生物标记物 Pending CN107208159A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305142.0 2015-01-30
EP15305142 2015-01-30
PCT/EP2016/051989 WO2016120475A1 (en) 2015-01-30 2016-01-29 Host dna as a biomarker of crohn's disease

Publications (1)

Publication Number Publication Date
CN107208159A true CN107208159A (zh) 2017-09-26

Family

ID=52577797

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680007943.4A Pending CN107208159A (zh) 2015-01-30 2016-01-29 宿主dna作为克罗恩氏病的生物标记物

Country Status (12)

Country Link
US (2) US9873914B2 (enExample)
EP (1) EP3250710B1 (enExample)
JP (1) JP6585175B2 (enExample)
CN (1) CN107208159A (enExample)
AU (1) AU2016211113A1 (enExample)
BR (1) BR112017014978A2 (enExample)
CA (1) CA2973307A1 (enExample)
ES (1) ES2693973T3 (enExample)
IL (1) IL253327B (enExample)
MX (1) MX376501B (enExample)
PL (1) PL3250710T3 (enExample)
WO (1) WO2016120475A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114882944A (zh) * 2022-06-22 2022-08-09 珠海碳云智能科技有限公司 基于Metagenome测序的肠道微生物样品宿主性别鉴定方法、装置及应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2693973T3 (es) * 2015-01-30 2018-12-17 Enterome ADN hospedador como un biomarcador de la enfermedad de Crohn
WO2018187272A1 (en) 2017-04-03 2018-10-11 Gusto Global, Llc Rational design of microbial-based biotherapeutics
WO2019157529A1 (en) 2018-02-12 2019-08-15 10X Genomics, Inc. Methods characterizing multiple analytes from individual cells or cell populations
CN108220286A (zh) * 2018-03-28 2018-06-29 上海锐翌生物科技有限公司 粪便宿主dna甲基化检测方法
EP4495262A1 (en) 2023-07-21 2025-01-22 Luxia Scientific Host dna as a biomarker of vaginal health

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018252A2 (en) * 1999-09-08 2001-03-15 Exact Laboratories, Inc. Methods for disease detection
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
RU2313576C1 (ru) * 2006-05-29 2007-12-27 Ростовский-на-Дону научно-исследовательский противочумный институт Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека РЕКОМБИНАНТНАЯ ПЛАЗМИДА, ЭКСПРЕССИРУЮЩАЯ КЛОНИРОВАННЫЙ ГЕН Ace VIBRIO CHOLERAE И ШТАММ ESCHERICHIA COLI-ПРОДУЦЕНТ ACCESSORY CHOLERAE ENTEROTOXIN VIBRIO CHOLERAE
CN101238224A (zh) * 2005-06-06 2008-08-06 惠氏公司 炎性肠病的外周血单核细胞的表达谱
WO2012150453A1 (en) * 2011-05-05 2012-11-08 Diagnodus Limited Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
CN103003299A (zh) * 2010-04-15 2013-03-27 奥佛涅-克莱蒙第一大学 用于预防或治疗炎性肠病尤其是克罗恩病的拮抗剂
US20140186845A1 (en) * 2011-06-14 2014-07-03 Universite Paul Sabatier - Toulouse Iii Methods for determining the expression level of a gene of interest including correction of rt-qpcr data for genomic dna-derived signals
CN103911440A (zh) * 2014-03-13 2014-07-09 南京医科大学 一种与铂类化疗药物肝脏毒性相关的snp标志物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100291551A1 (en) * 2006-11-17 2010-11-18 Genizon Biosciences Inc. Genemap of the human associated with crohn's disease
CN101868729B (zh) 2007-11-20 2013-07-17 霍夫曼-拉罗奇有限公司 利用标记物组合钙防卫蛋白和血红蛋白/触珠蛋白复合物从粪便样品评价结肠直肠癌的方法
ES2693973T3 (es) * 2015-01-30 2018-12-17 Enterome ADN hospedador como un biomarcador de la enfermedad de Crohn

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001018252A2 (en) * 1999-09-08 2001-03-15 Exact Laboratories, Inc. Methods for disease detection
US20040259101A1 (en) * 2003-06-20 2004-12-23 Shuber Anthony P. Methods for disease screening
CN101238224A (zh) * 2005-06-06 2008-08-06 惠氏公司 炎性肠病的外周血单核细胞的表达谱
RU2313576C1 (ru) * 2006-05-29 2007-12-27 Ростовский-на-Дону научно-исследовательский противочумный институт Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека РЕКОМБИНАНТНАЯ ПЛАЗМИДА, ЭКСПРЕССИРУЮЩАЯ КЛОНИРОВАННЫЙ ГЕН Ace VIBRIO CHOLERAE И ШТАММ ESCHERICHIA COLI-ПРОДУЦЕНТ ACCESSORY CHOLERAE ENTEROTOXIN VIBRIO CHOLERAE
CN103003299A (zh) * 2010-04-15 2013-03-27 奥佛涅-克莱蒙第一大学 用于预防或治疗炎性肠病尤其是克罗恩病的拮抗剂
WO2012150453A1 (en) * 2011-05-05 2012-11-08 Diagnodus Limited Device and method for non-invasive collection of colorectal mucocellular layer and disease detection
US20140186845A1 (en) * 2011-06-14 2014-07-03 Universite Paul Sabatier - Toulouse Iii Methods for determining the expression level of a gene of interest including correction of rt-qpcr data for genomic dna-derived signals
CN103911440A (zh) * 2014-03-13 2014-07-09 南京医科大学 一种与铂类化疗药物肝脏毒性相关的snp标志物及其应用

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ELISEO PAPA ET AL.: ""Non-Invasive Mapping of the Gastrointestinal Microbiota Identifies Children with Inflammatory Bowel Disease"", 《PLOS ONE》 *
ERICA VILLA ET AL.: ""Identification of Subjects at Risk for Colorectal Carcinoma Through a Test Based on K-ras Determination in the Stool"", 《GASTROENTEROLOGY》 *
HENRIK LAURELL ET AL.: ""Correction of RT–qPCR data for genomic DNA-derived signals with ValidPrime"", 《NUCLEIC ACIDS RESEARCH》 *
KLAASSEN ET AL.: ""Quantification of Human DNA in Feces as a Diagnostic Test for the Presence of Colorectal Cancer"", 《CLINICAL CHEMISTRY》 *
张美玲: ""两种肠道疾病中肠道菌群结构变化的分子生态学研究"", 《中国博士学位论文全文数据库 医药卫生科技辑》 *
萧树东: "《胃肠病学和肝病学：基础理论与临床进展》", 31 October 2004, 上海世界图书出版公司 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114882944A (zh) * 2022-06-22 2022-08-09 珠海碳云智能科技有限公司 基于Metagenome测序的肠道微生物样品宿主性别鉴定方法、装置及应用
CN114882944B (zh) * 2022-06-22 2024-09-20 深圳微伴医学检验实验室 基于Metagenome测序的肠道微生物样品宿主性别鉴定方法、装置及应用

Also Published As

Publication number Publication date
MX2017009752A (es) 2017-12-07
IL253327B (en) 2020-06-30
US10793911B2 (en) 2020-10-06
MX376501B (es) 2025-03-07
US20160258017A1 (en) 2016-09-08
JP2018504909A (ja) 2018-02-22
AU2016211113A1 (en) 2017-09-07
ES2693973T3 (es) 2018-12-17
US20180251844A1 (en) 2018-09-06
BR112017014978A2 (pt) 2018-03-20
EP3250710A1 (en) 2017-12-06
CA2973307A1 (en) 2016-08-04
JP6585175B2 (ja) 2019-10-02
US9873914B2 (en) 2018-01-23
IL253327A0 (en) 2017-09-28
PL3250710T3 (pl) 2019-02-28
WO2016120475A1 (en) 2016-08-04
EP3250710B1 (en) 2018-08-22

Similar Documents

Publication Publication Date Title
US10793911B2 (en) Host DNA as a biomarker of Crohn's disease
CN106661765B (zh) 用于脓毒症的诊断
ES2906192T3 (es) Biomarcadores para una enfermedad inflamatoria del intestino
US20190203295A1 (en) Methods of predicting complication and surgery in crohn's disease
CN107541563B (zh) 一种用于早期诊断、预测脓毒血症并发急性肾损伤的分子标记物、试剂盒及应用
CN103097548A (zh) 基于多癌症侵袭相关机制的生物标记
CN106795557A (zh) 用于肺癌诊断的方法和系统
US11613782B2 (en) Method for predicting progression to active tuberculosis disease
CN106153917B (zh) 两组胰腺癌血浆诊断标志物谱及其应用
Pan Development of diagnostic methods using cell-free nucleic acids
US10078086B2 (en) Use of interleukin-27 as a diagnostic biomarker for bacterial infection in critically ill patients
US20170335399A1 (en) Detection of mineralocorticoid receptor activation and personalized antihypertensive therapy based thereon
CN108064273B (zh) 结直肠癌相关疾病的生物标志物
WO2021024856A1 (ja) 間質性肺炎のタンパク質診断バイオマーカー
WO2012059617A1 (es) Método de obtención de datos útiles para el diagnóstico del cáncer de páncreas y para evaluar la respuesta al tratamiento
US20190093164A1 (en) Biomarker for diagnosis of allergic rhinitis
CN107541564A (zh) 分子标记物tcons_00016233、试剂盒及应用
US20210165003A1 (en) Assessment of the risk of complication in a patient suspected of having an infection, having a sofa score lower than two
JP2023178332A (ja) 循環性血清無細胞ｄｎａバイオマーカー及び方法
WO2023275407A2 (en) Method for predicting a clinical response towards an immune checkpoint inhibitor based on pretreatment therewith
CN118028453A (zh) Cxcl1和tnfrsf12a在aki诊断中的应用
EP2946212A1 (en) Diagnosis of ulcerative colitis
PH12018050189A1 (en) Early diagnosis and prognosis of complicated leptospirosis using molecular markers
HK1238306A1 (en) Method and systems for lung cancer diagnosis
HK1237382B (zh) 用於脓毒症的诊断

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20170926