CN107208107B - 伤口愈合的方法 - Google Patents
伤口愈合的方法 Download PDFInfo
- Publication number
- CN107208107B CN107208107B CN201580070791.8A CN201580070791A CN107208107B CN 107208107 B CN107208107 B CN 107208107B CN 201580070791 A CN201580070791 A CN 201580070791A CN 107208107 B CN107208107 B CN 107208107B
- Authority
- CN
- China
- Prior art keywords
- wound
- lactic acid
- seq
- protein
- plasmid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Materials Engineering (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110680754.6A CN113403244B (zh) | 2014-12-23 | 2015-12-23 | 伤口愈合的方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1451658-7 | 2014-12-23 | ||
| SE1451658 | 2014-12-23 | ||
| PCT/EP2015/081146 WO2016102660A1 (en) | 2014-12-23 | 2015-12-23 | Methods for wound healing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110680754.6A Division CN113403244B (zh) | 2014-12-23 | 2015-12-23 | 伤口愈合的方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| CN107208107A CN107208107A (zh) | 2017-09-26 |
| CN107208107A8 CN107208107A8 (zh) | 2017-12-26 |
| CN107208107B true CN107208107B (zh) | 2021-07-09 |
Family
ID=55080095
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580070791.8A Active CN107208107B (zh) | 2014-12-23 | 2015-12-23 | 伤口愈合的方法 |
| CN202110680754.6A Active CN113403244B (zh) | 2014-12-23 | 2015-12-23 | 伤口愈合的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110680754.6A Active CN113403244B (zh) | 2014-12-23 | 2015-12-23 | 伤口愈合的方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10696974B2 (enExample) |
| EP (2) | EP3735979B1 (enExample) |
| JP (2) | JP6581208B2 (enExample) |
| KR (2) | KR102297619B1 (enExample) |
| CN (2) | CN107208107B (enExample) |
| AU (2) | AU2015370982B2 (enExample) |
| CA (1) | CA2971520C (enExample) |
| ES (2) | ES3048233T3 (enExample) |
| WO (1) | WO2016102660A1 (enExample) |
Families Citing this family (18)
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| EP3408378B1 (en) | 2016-01-25 | 2022-01-12 | NantCell, Inc. | Nk cells with altered cxcl12/cxcr4 signaling |
| BR112019007812A2 (pt) * | 2016-10-31 | 2019-07-16 | Kimberly Clark Co | métodos para arquivar e de recriar um microbioma. |
| CN110157733A (zh) * | 2018-02-11 | 2019-08-23 | 四川大学 | 重组mIL-22BP载体、脂质体复合物及其制备方法和用途 |
| CN117487686A (zh) * | 2018-07-24 | 2024-02-02 | 生命大地女神有限公司 | 选择和使用褪黑素支持细菌以减少婴儿绞痛 |
| MX2020014222A (es) * | 2018-07-24 | 2021-03-09 | Biogaia Ab | Metodos terapeuticos que utilizan cepas bacterianas las cuales son capaces de aumentar los niveles de adenosina. |
| CN109112155A (zh) * | 2018-08-02 | 2019-01-01 | 南昌大学 | 乳酸乳球菌mg1363的构建及其在治疗细菌性阴道炎中的应用 |
| CN109517772A (zh) * | 2018-10-30 | 2019-03-26 | 南昌大学 | 一种乳酸乳球菌mg1363的构建及其在治疗产妇乳头皲裂中的应用 |
| CN109234298A (zh) * | 2018-10-30 | 2019-01-18 | 南昌大学 | 一种卷曲乳杆菌atcc55221的构建及其在治疗产妇乳头皲裂中的应用 |
| JP7045671B2 (ja) * | 2018-11-12 | 2022-04-01 | 有限会社バイオ研 | 皮膚塗布用の皮膚創傷治癒促進組成物、その製造方法、及び創傷被覆材 |
| US20230310522A1 (en) * | 2019-06-24 | 2023-10-05 | Mendes S.R.L. | Composition with antibacterial and re-epithelializing action including probiotics |
| CN110623792B (zh) * | 2019-09-23 | 2022-05-06 | 温州医科大学附属第一医院 | 一种医学敷料及其制备方法 |
| CN114470007B (zh) * | 2020-11-13 | 2024-10-18 | 葡萄王生技股份有限公司 | 含乳酸菌发酵产物之皮肤创伤外用组合物及其用途 |
| CA3228922A1 (en) | 2021-10-11 | 2023-04-20 | Ajinomoto Co., Inc. | Bacterium modified to express heterologous tat protein |
| WO2023118327A1 (en) | 2021-12-22 | 2023-06-29 | Ilya Pharma Ab | Live bacteria as excipients for proteins |
| AU2022429649A1 (en) * | 2021-12-29 | 2024-08-08 | Ilya Pharma Ab | Treatment of therapy-induced enteropathy |
| KR102752056B1 (ko) * | 2023-07-12 | 2025-01-13 | 전남대학교 산학협력단 | 락토바실러스 루터리(Lactobacillus reuteri) NCHBL-005 균주를 포함하는 창상 예방 또는 치료, 피부 재생 촉진용 조성물 |
| GB202405882D0 (en) | 2024-04-26 | 2024-06-12 | Ilya Pharma Ab | Treatment of mdr infections |
| CN118948906B (zh) * | 2024-10-16 | 2025-02-14 | 温州医科大学附属第一医院 | 一种促进创面愈合的乳酸杆菌生物膜衍生物及其制备方法和应用 |
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| RU2008147398A (ru) | 2006-05-02 | 2010-06-10 | Актогеникс Н.В. (Be) | Доставка пептидов, связанных с ожирением, через кишечник посредством микроорганизмов |
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| EP2758512B1 (en) | 2011-09-23 | 2018-05-09 | Intrexon Actobiotics NV | Modified gram positive bacteria and uses thereof |
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-
2015
- 2015-12-23 CA CA2971520A patent/CA2971520C/en active Active
- 2015-12-23 AU AU2015370982A patent/AU2015370982B2/en active Active
- 2015-12-23 EP EP20161504.4A patent/EP3735979B1/en active Active
- 2015-12-23 CN CN201580070791.8A patent/CN107208107B/zh active Active
- 2015-12-23 US US15/538,384 patent/US10696974B2/en active Active
- 2015-12-23 KR KR1020207004865A patent/KR102297619B1/ko active Active
- 2015-12-23 KR KR1020177020505A patent/KR102081493B1/ko active Active
- 2015-12-23 WO PCT/EP2015/081146 patent/WO2016102660A1/en not_active Ceased
- 2015-12-23 CN CN202110680754.6A patent/CN113403244B/zh active Active
- 2015-12-23 EP EP15822941.9A patent/EP3237622B1/en active Active
- 2015-12-23 ES ES20161504T patent/ES3048233T3/es active Active
- 2015-12-23 ES ES15822941T patent/ES2864373T3/es active Active
- 2015-12-23 JP JP2017552233A patent/JP6581208B2/ja active Active
-
2019
- 2019-06-19 AU AU2019204290A patent/AU2019204290B2/en active Active
- 2019-08-29 JP JP2019156412A patent/JP7033109B2/ja active Active
-
2020
- 2020-06-05 US US16/893,781 patent/US11473091B2/en active Active
-
2022
- 2022-08-11 US US17/819,274 patent/US20230093013A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016102660A1 (en) | 2016-06-30 |
| US20230093013A1 (en) | 2023-03-23 |
| US20200299703A1 (en) | 2020-09-24 |
| AU2019204290A1 (en) | 2019-07-04 |
| JP2020005646A (ja) | 2020-01-16 |
| KR20170097194A (ko) | 2017-08-25 |
| AU2015370982B2 (en) | 2019-03-21 |
| CA2971520A1 (en) | 2016-06-30 |
| CN107208107A8 (zh) | 2017-12-26 |
| ES3048233T3 (en) | 2025-12-09 |
| EP3237622A1 (en) | 2017-11-01 |
| EP3237622B1 (en) | 2021-02-24 |
| ES2864373T3 (es) | 2021-10-13 |
| JP6581208B2 (ja) | 2019-09-25 |
| CN107208107A (zh) | 2017-09-26 |
| KR20200020994A (ko) | 2020-02-26 |
| EP3735979A1 (en) | 2020-11-11 |
| US11473091B2 (en) | 2022-10-18 |
| CN113403244A (zh) | 2021-09-17 |
| US20180187202A1 (en) | 2018-07-05 |
| KR102081493B1 (ko) | 2020-02-26 |
| JP7033109B2 (ja) | 2022-03-09 |
| EP3735979B1 (en) | 2025-08-13 |
| CA2971520C (en) | 2024-04-09 |
| KR102297619B1 (ko) | 2021-09-02 |
| EP3735979C0 (en) | 2025-08-13 |
| AU2015370982A1 (en) | 2017-07-13 |
| CN113403244B (zh) | 2022-08-19 |
| AU2019204290B2 (en) | 2021-12-16 |
| JP2018502600A (ja) | 2018-02-01 |
| US10696974B2 (en) | 2020-06-30 |
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