CN107207531B - 作为TGF-β抑制剂的稠合的咪唑衍生物 - Google Patents

作为TGF-β抑制剂的稠合的咪唑衍生物 Download PDF

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Publication number
CN107207531B
CN107207531B CN201580074061.5A CN201580074061A CN107207531B CN 107207531 B CN107207531 B CN 107207531B CN 201580074061 A CN201580074061 A CN 201580074061A CN 107207531 B CN107207531 B CN 107207531B
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Prior art keywords
imidazol
dihydro
pyrrolo
pyridine
methylphenyl
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Expired - Fee Related
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CN201580074061.5A
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Chinese (zh)
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CN107207531A (zh
Inventor
R·辛格
T·金赛拉
J·于
M·格尔曼
I·S·达尔维什
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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CN201580074061.5A 2014-11-21 2015-11-16 作为TGF-β抑制剂的稠合的咪唑衍生物 Expired - Fee Related CN107207531B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462082959P 2014-11-21 2014-11-21
US62/082,959 2014-11-21
US201562141509P 2015-04-01 2015-04-01
US62/141,509 2015-04-01
PCT/US2015/060872 WO2016081364A1 (en) 2014-11-21 2015-11-16 Fused imidazole derivatives as tgf-beta inhibitors

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CN107207531A CN107207531A (zh) 2017-09-26
CN107207531B true CN107207531B (zh) 2021-05-25

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US (1) US10696693B2 (https=)
EP (1) EP3221318B1 (https=)
JP (1) JP6789941B2 (https=)
CN (1) CN107207531B (https=)
ES (1) ES2895626T3 (https=)
WO (1) WO2016081364A1 (https=)

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ES2928773T3 (es) 2017-01-17 2022-11-22 Heparegenix Gmbh Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos
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US10696693B2 (en) 2020-06-30
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