CN107207493B - 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶 - Google Patents

作为布罗莫结构域抑制剂的经取代的吡咯并吡啶 Download PDF

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Publication number
CN107207493B
CN107207493B CN201580072359.2A CN201580072359A CN107207493B CN 107207493 B CN107207493 B CN 107207493B CN 201580072359 A CN201580072359 A CN 201580072359A CN 107207493 B CN107207493 B CN 107207493B
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cancer
pyrrolo
alkyl
pyridin
oxo
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Expired - Fee Related
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CN201580072359.2A
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Chinese (zh)
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CN107207493A (zh
Inventor
B·K·阿尔布雷克特
S·F·贝隆
D·J·伯迪克
A·科特
T·克劳福德
L·A·戴金
M·C·休伊特
V·萧魏徐
Y·勒布朗
S·R·马格努森
C·G·纳斯维斯查克
F·A·罗梅罗
Y·唐
A·M·泰勒
S·王
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Genentech Inc
Constellation Pharmaceuticals Inc
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Genentech Inc
Constellation Pharmaceuticals Inc
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Priority to CN202211065963.0A priority Critical patent/CN115583947A/zh
Priority to CN202310032629.3A priority patent/CN116003409A/zh
Publication of CN107207493A publication Critical patent/CN107207493A/zh
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D471/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Diabetes (AREA)
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  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201580072359.2A 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶 Expired - Fee Related CN107207493B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202211065963.0A CN115583947A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶
CN202310032629.3A CN116003409A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077703P 2014-11-10 2014-11-10
US62/077,703 2014-11-10
PCT/US2015/060003 WO2016077378A1 (en) 2014-11-10 2015-11-10 Substituted pyrrolopyrdines as inhibitors of bromodomain

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CN202211065963.0A Division CN115583947A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶
CN202310032629.3A Division CN116003409A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶

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CN107207493A CN107207493A (zh) 2017-09-26
CN107207493B true CN107207493B (zh) 2023-01-20

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CN201580072359.2A Expired - Fee Related CN107207493B (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶
CN202310032629.3A Pending CN116003409A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶
CN202211065963.0A Pending CN115583947A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶

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CN202310032629.3A Pending CN116003409A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶
CN202211065963.0A Pending CN115583947A (zh) 2014-11-10 2015-11-10 作为布罗莫结构域抑制剂的经取代的吡咯并吡啶

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US (1) US10183009B2 (https=)
EP (1) EP3218375B1 (https=)
JP (1) JP6669744B2 (https=)
CN (3) CN107207493B (https=)
MA (1) MA40943A (https=)
WO (1) WO2016077378A1 (https=)

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EP3218375A1 (en) 2017-09-20
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JP2017533248A (ja) 2017-11-09
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