CN107207489A - 作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物 - Google Patents

作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物 Download PDF

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Publication number
CN107207489A
CN107207489A CN201580074696.5A CN201580074696A CN107207489A CN 107207489 A CN107207489 A CN 107207489A CN 201580074696 A CN201580074696 A CN 201580074696A CN 107207489 A CN107207489 A CN 107207489A
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China
Prior art keywords
pyridin
thiadiazol
methoxy
nicotinamide
benzamide
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Pending
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CN201580074696.5A
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English (en)
Chinese (zh)
Inventor
P·梅钦
A·夏普
C·J·洛克
M·S·钱伯斯
A·霍奇斯
V·艾伦
J·M·埃拉德
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Jean Keogh Tex Swiss Ltd By Share Ltd
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Jean Keogh Tex Swiss Ltd By Share Ltd
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Publication of CN107207489A publication Critical patent/CN107207489A/zh
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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  • Chemical Kinetics & Catalysis (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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CN201580074696.5A 2014-12-17 2015-12-16 作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物 Pending CN107207489A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14198597.8A EP3034500A1 (en) 2014-12-17 2014-12-17 Amido thiazole derivatives as NADPH oxidase inhibitors
EP14198597.8 2014-12-17
PCT/IB2015/059659 WO2016098005A1 (en) 2014-12-17 2015-12-16 Amido thiadiazole derivatives as nadph oxidase inhibitors

Publications (1)

Publication Number Publication Date
CN107207489A true CN107207489A (zh) 2017-09-26

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Application Number Title Priority Date Filing Date
CN201580074696.5A Pending CN107207489A (zh) 2014-12-17 2015-12-16 作为nadph氧化酶抑制剂的酰氨基噻二唑衍生物

Country Status (13)

Country Link
US (2) US10130619B2 (https=)
EP (2) EP3034500A1 (https=)
JP (1) JP2017537948A (https=)
KR (1) KR20170094263A (https=)
CN (1) CN107207489A (https=)
AU (1) AU2015365465B2 (https=)
BR (1) BR112017012846A2 (https=)
CA (1) CA2971357A1 (https=)
HK (1) HK1245777A1 (https=)
IL (1) IL252928A0 (https=)
MX (1) MX2017007884A (https=)
RU (1) RU2017121044A (https=)
WO (1) WO2016098005A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110590706A (zh) * 2019-11-06 2019-12-20 四平市精细化学品有限公司 一种n-甲基吡咯烷的制备方法
CN114174273A (zh) * 2019-03-22 2022-03-11 优曼尼蒂治疗公司 化合物和其用途

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3034500A1 (en) * 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors
US11970486B2 (en) 2016-10-24 2024-04-30 Janssen Pharmaceutica Nv Compounds and uses thereof
EA201991650A1 (ru) 2017-01-06 2020-01-20 Юманити Терапьютикс, Инк. Способы лечения неврологических расстройств
CA3083000A1 (en) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Compounds and uses thereof
EP3479843A1 (en) 2017-11-01 2019-05-08 GenKyoTex Suisse SA Use of nox inhibitors for treatment of cancer
BR112020019191A2 (pt) 2018-03-23 2021-01-05 Yumanity Therapeutics, Inc. Compostos e seus usos
MX2021008903A (es) 2019-01-24 2021-11-04 Yumanity Therapeutics Inc Compuestos y usos de los mismos.
WO2020243459A1 (en) * 2019-05-31 2020-12-03 Ideaya Biosciences, Inc. Thiadiazolyl derivatives as dna polymerase theta inhibitors
EA202193251A1 (ru) 2019-06-05 2022-03-10 Эмори Юниверсити Пептидомиметики для лечения коронавирусной и пикорнавирусной инфекций
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
CN117083271A (zh) * 2020-12-02 2023-11-17 伊迪亚生物科学有限公司 作为DNA聚合酶θ抑制剂的取代的噻二唑基衍生物
TW202237595A (zh) * 2020-12-02 2022-10-01 美商愛德亞生物科學公司 作為DNA聚合酶θ抑制劑之經取代噻二唑基衍生物
TW202315618A (zh) * 2021-06-11 2023-04-16 美商愛德亞生物科學公司 作為DNA聚合酶θ抑制劑之O-聯結噻二唑基化合物
WO2023060573A1 (en) * 2021-10-15 2023-04-20 Beijing Danatlas Pharmaceutical Co., Ltd. Novel thiadiazolyl derivatives of dna polymerase theta inhibitors
KR102422881B1 (ko) * 2021-11-08 2022-07-20 (주)셀로스바이오텍 신규 옥사다이아졸 유도체 및 이의 용도
US11896719B2 (en) 2022-01-24 2024-02-13 Calliditas Therapeutics Ab Pharmaceutical compositions
WO2024182380A2 (en) * 2023-02-28 2024-09-06 Cyteir Therapeutics, Inc. Substituted thiadiazolyl compounds
AU2024251390A1 (en) * 2023-04-13 2025-11-27 Danatlas Pharmaceuticals Co., Ltd. Thiadiazolone derivatives, compositions and uses thereof
WO2026057018A1 (en) * 2024-09-12 2026-03-19 Fulcrum Therapeutics, Inc. Nox inhibitors and methods of use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041813A1 (en) * 2002-10-30 2004-05-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
WO2010086551A1 (fr) * 2009-01-28 2010-08-05 Sanofi-Aventis Dérivés de thiadiazoles et d'oxadiazoles, leur préparation et leur application en thérapeutique
WO2012170752A1 (en) * 2011-06-10 2012-12-13 Glaxo Wellcome Manufacturing Pte Ltd Novel compounds
WO2013038136A1 (en) * 2011-09-16 2013-03-21 The University Of Surrey BI-AROMATIC AND TRI-AROMATIC COMPOUNDS AS NADPH OXIDASE 2 (Nox2) INHIBITORS
WO2013068972A1 (en) * 2011-11-11 2013-05-16 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763496A (en) 1995-11-27 1998-06-09 The Research Foundation Of State University Of New York Prevention of atherosclerosis using NADPH oxidase inhibitors
EP1505068A4 (en) * 2002-04-23 2008-03-19 Shionogi & Co PYRAZOLO (1,5-a) PYRIMIDINE DERIVATIVE AND INHIBITOR OF NAD (P) H OXIDASE CONTAINING SAID DERIVATIVE
JP2006520326A (ja) 2003-02-28 2006-09-07 ハワード フローリー インスティチュート オブ エクスペリメンタル フィジオロジー アンド メディシン 治療薬
JPWO2004089412A1 (ja) 2003-04-08 2006-07-06 三菱ウェルファーマ株式会社 特異的ｎａｄ（ｐ）ｈオキシダーゼ抑制剤
FR2882654B1 (fr) 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
US20110269141A1 (en) * 2007-02-21 2011-11-03 Reverse Proteomics Research Institute Co., Ltd. Target protein and target gene for drug discovery, and screening method
CN102573487A (zh) * 2009-06-09 2012-07-11 加利福尼亚资本权益有限责任公司 Hedgehog信号传导的吡啶基-三嗪抑制剂
WO2011027359A2 (en) 2009-07-30 2011-03-10 Matrix Laboratories Ltd Novel process for the preparation of 4-hydroxy atomoxetine
EP2752196A1 (en) 2013-01-03 2014-07-09 Université Bordeaux Segalen Selective nox-1 inhibitor peptides and uses thereof
WO2014153227A1 (en) 2013-03-14 2014-09-25 Eastern Virginia Medical School Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting nox-1
EP3034500A1 (en) * 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041813A1 (en) * 2002-10-30 2004-05-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
WO2010086551A1 (fr) * 2009-01-28 2010-08-05 Sanofi-Aventis Dérivés de thiadiazoles et d'oxadiazoles, leur préparation et leur application en thérapeutique
WO2012170752A1 (en) * 2011-06-10 2012-12-13 Glaxo Wellcome Manufacturing Pte Ltd Novel compounds
WO2013038136A1 (en) * 2011-09-16 2013-03-21 The University Of Surrey BI-AROMATIC AND TRI-AROMATIC COMPOUNDS AS NADPH OXIDASE 2 (Nox2) INHIBITORS
WO2013068972A1 (en) * 2011-11-11 2013-05-16 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PATRICK MOUGENOT，ET AL.: "Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114174273A (zh) * 2019-03-22 2022-03-11 优曼尼蒂治疗公司 化合物和其用途
CN110590706A (zh) * 2019-11-06 2019-12-20 四平市精细化学品有限公司 一种n-甲基吡咯烷的制备方法
CN110590706B (zh) * 2019-11-06 2021-07-27 四平市精细化学品有限公司 一种n-甲基吡咯烷的制备方法

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