CN107206256A - 榴菌素b的多形体 - Google Patents

榴菌素b的多形体 Download PDF

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Publication number
CN107206256A
CN107206256A CN201580073723.7A CN201580073723A CN107206256A CN 107206256 A CN107206256 A CN 107206256A CN 201580073723 A CN201580073723 A CN 201580073723A CN 107206256 A CN107206256 A CN 107206256A
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CN
China
Prior art keywords
crystal form
compound
cancer
peak
certain embodiments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580073723.7A
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English (en)
Chinese (zh)
Inventor
泰罗·昆纳里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CN107206256A publication Critical patent/CN107206256A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201580073723.7A 2014-12-23 2015-12-22 榴菌素b的多形体 Pending CN107206256A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095850P 2014-12-23 2014-12-23
US62/095,850 2014-12-23
PCT/US2015/067399 WO2016106326A1 (en) 2014-12-23 2015-12-22 Polymorph of granaticin b

Publications (1)

Publication Number Publication Date
CN107206256A true CN107206256A (zh) 2017-09-26

Family

ID=56151519

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580073723.7A Pending CN107206256A (zh) 2014-12-23 2015-12-22 榴菌素b的多形体

Country Status (9)

Country Link
US (1) US10314815B2 (enExample)
EP (1) EP3237066B1 (enExample)
JP (2) JP7358029B2 (enExample)
KR (1) KR102554779B1 (enExample)
CN (1) CN107206256A (enExample)
AU (1) AU2015369707B2 (enExample)
CA (1) CA2972266C (enExample)
IL (1) IL252944B (enExample)
WO (1) WO2016106326A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3338770B1 (en) 2010-03-08 2023-06-07 Sloan-Kettering Institute For Cancer Research Cdc7 kinase inhibitors and uses thereof
TW202535351A (zh) * 2023-12-05 2025-09-16 仁新醫藥股份有限公司 Cdc7抑制劑組合療法

Citations (1)

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Publication number Priority date Publication date Assignee Title
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FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
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DE4121468A1 (de) 1991-06-28 1993-01-14 Deutsches Primatenzentrum Gmbh Antivirale substanzen und diese enthaltende arzneimittel
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
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CARL E. SNIPES ET AL.: "Biosynthesis of the Antibiotic Granaticin", 《BIOSYNTHESIS OF GRANATICIN》 *
DONGMEI LIANG ET AL.: "Phylogenetic Analysis of Antibiotic Glycosyltransferases", 《J MOL EVOL》 *
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Also Published As

Publication number Publication date
AU2015369707B2 (en) 2020-07-23
JP7358029B2 (ja) 2023-10-10
US10314815B2 (en) 2019-06-11
EP3237066A1 (en) 2017-11-01
EP3237066B1 (en) 2020-10-21
IL252944A0 (en) 2017-08-31
EP3237066A4 (en) 2018-06-27
JP2018500355A (ja) 2018-01-11
CA2972266A1 (en) 2016-06-30
IL252944B (en) 2021-02-28
WO2016106326A1 (en) 2016-06-30
US20170360746A1 (en) 2017-12-21
CA2972266C (en) 2023-05-09
KR102554779B1 (ko) 2023-07-11
KR20170097165A (ko) 2017-08-25
JP2023071705A (ja) 2023-05-23
AU2015369707A1 (en) 2017-07-13

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SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
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Application publication date: 20170926