CN107198757A - It is a kind of to treat the Chinese herbal medicine fluid that brothers bacterium catches an illness - Google Patents

It is a kind of to treat the Chinese herbal medicine fluid that brothers bacterium catches an illness Download PDF

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CN107198757A
CN107198757A CN201710518504.6A CN201710518504A CN107198757A CN 107198757 A CN107198757 A CN 107198757A CN 201710518504 A CN201710518504 A CN 201710518504A CN 107198757 A CN107198757 A CN 107198757A
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chinese herbal
brothers
herbal medicine
illness
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康国军
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/76Salicaceae (Willow family), e.g. poplar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
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  • Microbiology (AREA)
  • Medical Informatics (AREA)
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  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
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Abstract

Treat the Chinese herbal medicine fluid that brothers bacterium catches an illness the invention discloses a kind of, it as follows step be prepared from:First by 5 10 grams of alumens, 5 10 grams of fruit of summer cypress, 5 10 grams of folium artemisiae argyis, 5 10 Keshans how, be added in silo after 5 10 grams of Folium Pterocaryaes, 35 grams of myrobalans, 5 10 grams of Semen Bulbus Allii wash cleans and to be boiled soaked medicine with big fire after, use small fire instead, maintain medicine to seethe with excitement 20 30 minutes;Cold filtration obtains filtrate, is added in above-mentioned filtrate and obtains Chinese herbal medicine fluid 10 20 grams of alimentary acetic acids, 10 20 grams of salicylic acids, 35 grams of glycerine, 10 20 grams of mature vinegars.It can effectively sterilizing, remove infection, recovery from illness skin, prevent recurrence.Various brothers bacterium can effectively be cured to catch an illness, split especially for tinea of feet and hands, pin sweat, foot odour, brothers' skin(Decortication), the disease of skin such as corn and onychomycosis there is good curative effect.The present invention is easy to use, and safety is without any side effects.

Description

It is a kind of to treat the Chinese herbal medicine fluid that brothers bacterium catches an illness
Technical field
The present invention relates to a kind of Chinese herbal medicine prescription, the Chinese herbal medicine fluid that brothers bacterium catches an illness is treated more particularly, to a kind of.
Background technology
Brothers bacterium catches an illness also referred to as hand-foot skin disease, is a kind of frequently-occurring disease, common disease, is a kind of obstinate, seasonal recurrence disease, Although the consequence of paralysis, death will not be brought, often the body and mind to patient bring greatly, be difficult to the pain born, give people Work, life and rest cause to have a strong impact on.Brothers bacterium catches an illness clinically shows as tinea of feet and hands, pin sweat, foot odour, Shou Zupi more Split(Decortication), the hand-foot skin disease such as corn and onychomycosis.Hand-foot skin disease is mostly the disease caused by fungal infection hand-foot skin The reason for disease, formation, is also a lot:With race, age, regional environment, weather, occupation, heredity, health, diet and social factor etc. There is direct relation, be a kind of many because of caused disease.The treatment method and medicine of current hand-foot skin disease mainly have two major classes: One is external medication, typically need to for a long time be adhered in patient, and two be oral systemic drug treatment, is generally used for skin damage The case that scope is big, obstinate, externally applied drug is hard to work.Specific treatment method is considerably complicated, varies with each individual, there is hospital in hospital Treatment method, it is among the people also to have treatment means among the people and folk prescription, each have their own feature and curative effect.But in addition to drug therapy, patient Eat less as far as possible on diet or do not eat the food such as pan-fried, stir-fry, peppery, roasting, unhygienic food is not eaten, it is have a bath more, keep skin moderately to do It is refreshing, keep room ventilation and clothing loose, it is to avoid to be contacted with sensitive species, keep good phychology, it is objective to face, actively enter Row treatment, in addition, adheres to carrying out drug therapy in the case where doctor instructs.Hand-foot skin disease is carried out using Chinese recipe or decoction Spray coating is convenient, most economical treatment method.Existing Chinese herb medicine is also a lot, and some people are using effective in cure, but some people do not have Effective in cure or curative effect is not obvious, or recurrence, or brings some side effects, and applicability is not strong.
The content of the invention
For it is above-mentioned the problems of in the prior art, caught an illness effect the invention provides a kind of not only treatment brothers bacterium Well, do not recur, be free from side effects, and treatment is convenient, treatment time is short, the low Chinese herbal medicine fluid of medical expense.
Stride is prepared from the Chinese herbal medicine fluid that treatment brothers bacterium of the present invention catches an illness as follows:
A, first by 5-10 grams of alumen, 5-10 grams of fruit of summer cypress, 5-10 grams of folium artemisiae argyi, 5-10 Keshans how, 5-10 grams of Folium Pterocaryae, 3-5 grams scold It is added to after son, 5-10 grams of Semen Bulbus Allii wash clean in silo after soaked medicine is boiled with big fire, uses small fire instead, maintains medicine Boiling 20-30 minutes, cooled and filtered obtains filtrate;
B, 10-20 grams of alimentary acetic acid, 10-20 grams of salicylic acid, 3-5 grams of glycerine, 10-20 grams of mature vinegar be added separately to above-mentioned filter In liquid, it is sufficiently stirred for obtaining Chinese herbal medicine fluid.
The treatment method of the present invention:Brothers bacterium affected area is cleaned up, middle meadow medicament is coated in bacterium dye with absorbent cotton In sick affected areas, once in the morning and once at night, continuous 7 days, one week was a course for the treatment of, and the general 1-2 courses for the treatment of can be cured entirely;For foot Bacterium dye can use immersion way, every time immersion 20-30 minutes, once a day, even 3-4 days.During treatment, patient diet is preferably clear It is light, eat light food more, avoid eating the food such as pan-fried, stir-fry, peppery, roasting.
Alumen of the present invention is in opaque, white, cellular or spongy solid block or fine powder, nodeless mesh sample thing Matter, body lightweight pine, hand twists with the fingers frangible, sour-puckery flavor.Dissolving phlegm, eliminating dampness, antidiarrheal, hemostasis, removing toxic substances, desinsection are primarily adapted for use in, without damp and hot person Avoid clothes.
The summer cypress blastostyle is upright, multi-branched, green, and autumn is often changed into red, and sprout has a white pubescence, annual herb, It is high about 50~150 centimetres;With clearing heat and promoting diuresis, dispelling wind and arresting itching.For under difficulty and pain in micturition, pruritus vulvae band, rubella, eczema, skin scabies Itch.
The folium artemisiae argyi property is pungent, hardship, temperature;Slightly poisonous, it has rationale blood, by cold-dampness;Wen Jing, the effect of stopping blooding and be antiabortive; Cure mainly under trusted subordinate's crymodynia, diarrhea convulsion, protracted dysentery, hematemesis, lower blood, irregular menstruation, uterine bleeding, band, fetal irritability, large carbuncle, mange.
The Chinese medicine kaempferia galamga, alias husky ginger is used as medicine with rhizome, warming middle-JIAO for eliminating dampness, and promoting qi circulation and relieving pain cures mainly acute gastroenteritis, digestion It is bad, stomach cold pain, toothache, rheumatic arthritis, traumatic injury.
The Folium Pterocaryae taste bitter and cold is nontoxic, and tender leaf bitter is cool in nature, nontoxic, with clearing heat for promoting eruption, diuresis detoxicating functions;Its Pan-fried juice can treat tinea pedis, caused by beriberi infection it is red and swollen, suppurate etc..
Myrobalan's refreshing and detoxicating Chinese medicine, goes wind to relieve pain, cures mainly chronic diarrhea;Protracted dysentery;Prolapse of the anus;Tinea of feet and hands such as skin infection etc..
A kind of conventional edible flavouring in Semen Bulbus Allii, with higher nutritive value, temperature is pungent, sweet;Middle benefit gas stomach invigorating, disappears Eat qi-regulating;With strong disinfecting, anti-curing oncoma and cancer, toxin-expelling intestine-cleaning, hypoglycemic, blood pressure and cardio-cerebrovascular diseases.
The salicylic acid in fact it be it is a kind of can remove acne and help skin reduce pore composition because Salicylic liposoluble characteristic, it can be cleaned come the pore to skin by being merged with lipid, so not only will not Allow skin to be injured well, and may also help in the problem of skin timely improves pore.
The present invention mix boiling again after above-mentioned various raw materials are decocted with auxiliary material, filtered fluid as Chinese herbal medicine fluid for It is antifungal have significant synergy and assist same-action, can effectively sterilizing, remove infection, recovery from illness skin, prevent again Hair.Various brothers bacterium can effectively be cured to catch an illness, split especially for tinea of feet and hands, pin sweat, foot odour, brothers' skin(Decortication), corn There is good curative effect with the disease of skin such as onychomycosis.The present invention is easy to use, and safety is without any side effects.
Embodiment
Further illustrate the present invention by the following examples,
Embodiment 1, as follows step be prepared from:First by 7 grams of alumens, 8 grams of fruit of summer cypress, 8 grams of folium artemisiae argyis, 7 Keshans how, 8 grams It is added in silo after first soaked medicine is boiled with big fire, uses instead small after Folium Pterocaryae, 4 grams of myrobalans, 7 grams of Semen Bulbus Allii wash cleans Fire, maintains medicine to seethe with excitement 20-30 minutes;Cooled and filtered obtains filtrate, by 15 grams of alimentary acetic acids, 15 grams of salicylic acids, 3 grams it is sweet Oil, 19 grams of mature vinegars are added separately to be sufficiently stirred for can obtain this Chinese herbal medicine fluid in above-mentioned filtrate.
Embodiment 2, as follows step be prepared from:First by 10 grams of alumens, 5 grams of fruit of summer cypress, 5 grams of folium artemisiae argyis, 9 Keshans How, be added in silo after 6 grams of Folium Pterocaryaes, 3- grams of myrobalan, 15 grams of Semen Bulbus Allii wash cleans and first boiled soaked medicine with big fire Afterwards, use small fire instead, maintain medicine to seethe with excitement 20-30 minutes;Cooled and filtered obtains filtrate, by 20 grams of alimentary acetic acids, 10 grams of bigcatkin willows Acid, 5 grams of glycerine, 11 grams of mature vinegars are added separately to be sufficiently stirred for can obtain this Chinese herbal medicine fluid in above-mentioned filtrate.
Embodiment 3, as follows step be prepared from:First by 20 grams of alumens, 10 grams of fruit of summer cypress, 10 grams of folium artemisiae argyis, 5 Keshans How, be added in silo after 10 grams of Folium Pterocaryaes, 5 grams of myrobalans, 10 grams of Semen Bulbus Allii wash cleans and first boiled soaked medicine with big fire Afterwards, use small fire instead, maintain medicine to seethe with excitement 20-30 minutes;Cooled and filtered obtains filtrate, by 10 grams of alimentary acetic acids, 20 grams of bigcatkin willows Acid, 4 grams of glycerine, 15 grams of mature vinegars are added separately to be sufficiently stirred for can obtain this Chinese herbal medicine fluid in above-mentioned filtrate.Bottled sealing Save backup.
Clinical treatment case:
1st, patient, Lee, male, shows as having a large amount of red mottles, also small bulk below knee in July, 2015 at 50 one full year of life Redness, has and itches, plays white skin, wet swollen tinea pedis is diagnosed as to local hospital, treats and is treated with some folk prescriptions among the people through multiple hospitals, Though taking a favorable turn, between the beginning of spring and the Beginning of summer, it will recur, and product expands behind recurrence, characteristic of disease is aggravated.In October, 2016 to Shen Ask someone to punish and treat, be coated in bacterium with absorbent cotton with Chinese herbal medicine fluid of the present invention and catch an illness in affected areas, once in the morning and once at night, continuously 7 days, it is within one week course for the treatment of, treats 2 courses for the treatment of, be cured entirely in mid-December, 2016, to does not also recur so far.
2nd, patient, Lin, male, shows as the special-shaped grey black of toe, matt, deck week in January, 2016 at 56 one full year of life Side incompleteness is uneven, and deck surface is rough and uneven in surface, and white skin is played between instep and toe, is onychomycosis to hospital diagnosis, is killed with bright first Bacterium solution external application, it is daily to apply respectively once sooner or later, treat one month, do not cure yet.In October, 2016 uses Chinese herbal medicine fluid of the present invention, first It is secondary before use, first make mollities unguium with the immersion of 45-50 degree warm water, repair thin and strike off that chaff on nail is broken and first skin, take in the present invention 2000 grams of herbal medicine liquid soaks onychomycosis 30 minutes, and daily evening, once continuous dipping was applied daily after two weeks, then in onychomycosis Once Chinese herbal medicine fluid of the present invention, continuous to apply more than 15 days, and onychomycosis symptom disappears, and foot does not play white skin yet.To in May, 2017 Only, do not recur also.
3rd, patient, Liu, women, 55 one full year of life, symptom shows as pin sweat, foot odour, and its foul smell is unpleasant when serious, even if in the winter It also only wears silk stocking, and socks are not worn even.For a long time in family expenses folk prescription soaking therapy among the people, but therapeutic effect is less obvious.2016 Year September is introduced by Pingxiang kith and kin, is treated with Chinese herbal medicine fluid of the present invention, every time use Chinese herbal medicine fluid 1500- of the present invention 2000 grams are soaked 30 minutes, once a day, use hot blast drying after immersion immediately, in sleep hot day in the evening is exposed by pin, and winter is with thoroughly Wind gauze wrapped, then using Chinese herbal medicine fluid of the present invention is sprayed, before sleeping every night with each spraying after getting up early once, one month Afterwards, patient's foot odour is all eliminated, and is not also occurred till now.
Efficacy evaluation of the present invention and statistics
Curative effect is effective:Symptom is disappeared, and drug withdrawal is not recurred in 1 year,
Curative effect is general:Symptom is disappeared substantially, and drug withdrawal is not recurred in 1 year,
Curative effect is invalid:Symptom does not disappear, and has recurrence after drug withdrawal and aggravates,
Present invention treatment case statistics(In January, 2015-2016 year December)
Case digital display effect enabledisable recurrence total effective rate
Tinea of feet and hands 188 120 58 10 94.1%
Pin sweat foot odour 84 65 15 4 95.2%
Brothers' cracking 33 25 53 90.9%
Onychomycosis 45 30 10 41 88.9%
Shown by above-mentioned statistical analysis:Chinese herbal medicine fluid of the present invention splits for treatment tinea of feet and hands, pin sweat, foot odour, brothers' skin Being caught an illness with the brothers bacterium such as onychomycosis not only has significant curative effect, and clinical observation has no any adverse reaction, and prepares and use Convenient, price is low, strong adaptability.

Claims (2)

1. a kind of treat the Chinese herbal medicine fluid that brothers bacterium catches an illness, it is characterised in that:It as follows step be prepared from:
A, first by 5-10 grams of alumen, 5-10 grams of fruit of summer cypress, 5-10 grams of folium artemisiae argyi, 5-10 Keshans how, 5-10 grams of Folium Pterocaryae, 3-5 grams scold It is added to after son, 5-10 grams of Semen Bulbus Allii wash clean in silo after first soaked medicine is boiled with big fire, uses small fire instead, maintains medicine Thing seethes with excitement 20-30 minutes;Cooled and filtered obtains filtrate,
B, 10-20 grams of alimentary acetic acid, 10-20 grams of salicylic acid, 3-5 grams of glycerine, 10-20 grams of mature vinegar be added separately to above-mentioned filter Chinese herbal medicine fluid is can obtain in liquid.
2. it is according to claim 1 it is a kind of treat the Chinese herbal medicine fluid that brothers bacterium catches an illness, it is characterized in that:First by 7 grams of alumens, 8 Gram fruit of summer cypress, 8 grams of folium artemisiae argyis, 7 Keshans how, be added in silo after 8 grams of Folium Pterocaryaes, 4 grams of myrobalans, 7 grams of Semen Bulbus Allii wash cleans and first use After soaked medicine is boiled in big fire, small fire is used instead, maintain medicine to seethe with excitement 20-30 minutes;Cooled and filtered obtains filtrate, by 15 Gram alimentary acetic acid, 15 grams of salicylic acids, 3 grams of glycerine, 19 grams of mature vinegars are added separately to be sufficiently stirred for can obtain in above-mentioned filtrate Chinese herbal medicine fluid.
CN201710518504.6A 2017-06-30 2017-06-30 It is a kind of to treat the Chinese herbal medicine fluid that brothers bacterium catches an illness Pending CN107198757A (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1628754A (en) * 2004-08-30 2005-06-22 王传 Local externally applied itch stopping garlic paint
CN101040994A (en) * 2006-03-24 2007-09-26 沈华立 Formulation for treating beriberi
CN103933311A (en) * 2014-03-28 2014-07-23 张建民 Traditional Chinese medicine for treating barbiers
CN104173872A (en) * 2014-08-29 2014-12-03 钟书明 Traditional Chinese medicine for treating dermatophytosis
CN105079222A (en) * 2014-05-20 2015-11-25 安阳市源首生物药业有限责任公司 Beriberi treating traditional Chinese medicine liquid and preparation method thereof
CN105535725A (en) * 2015-12-30 2016-05-04 吴祖豪 Traditional Chinese medicine for treating beriberi and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1628754A (en) * 2004-08-30 2005-06-22 王传 Local externally applied itch stopping garlic paint
CN101040994A (en) * 2006-03-24 2007-09-26 沈华立 Formulation for treating beriberi
CN103933311A (en) * 2014-03-28 2014-07-23 张建民 Traditional Chinese medicine for treating barbiers
CN105079222A (en) * 2014-05-20 2015-11-25 安阳市源首生物药业有限责任公司 Beriberi treating traditional Chinese medicine liquid and preparation method thereof
CN104173872A (en) * 2014-08-29 2014-12-03 钟书明 Traditional Chinese medicine for treating dermatophytosis
CN105535725A (en) * 2015-12-30 2016-05-04 吴祖豪 Traditional Chinese medicine for treating beriberi and preparation method thereof

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健康生活图书编委会: "《疾病身体信号自查自疗手册》", 31 October 2011, 吉林科学技术出版社 *
吴德超等: "复方止痒擦剂的临床观察", 《医药产业资讯》 *
孙莹等: "手足癣临床病案分析105例", 《中国当代医药》 *
张文康: "《中西医结合医学》", 30 June 2000, 中国中医药出版社 *
石振钟: "《巧用中草药治杂病》", 31 January 2013, 人民军医出版社 *
路涛: "大蒜外用治疗皮肤科疾病", 《中医外治杂志》 *

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Application publication date: 20170926

WD01 Invention patent application deemed withdrawn after publication