CN107192588A - Glycolated hemoglobin analysis pressurizing filter system and method - Google Patents

Glycolated hemoglobin analysis pressurizing filter system and method Download PDF

Info

Publication number
CN107192588A
CN107192588A CN201710183521.9A CN201710183521A CN107192588A CN 107192588 A CN107192588 A CN 107192588A CN 201710183521 A CN201710183521 A CN 201710183521A CN 107192588 A CN107192588 A CN 107192588A
Authority
CN
China
Prior art keywords
filter
booster
glycolated hemoglobin
cavity
hemoglobin analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710183521.9A
Other languages
Chinese (zh)
Inventor
庄雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JIANGSU AUDICOM MEDICAL TECHNOLOGY Co Ltd
Original Assignee
JIANGSU AUDICOM MEDICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JIANGSU AUDICOM MEDICAL TECHNOLOGY Co Ltd filed Critical JIANGSU AUDICOM MEDICAL TECHNOLOGY Co Ltd
Priority to CN201710183521.9A priority Critical patent/CN107192588A/en
Publication of CN107192588A publication Critical patent/CN107192588A/en
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D35/00Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/02Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention discloses a kind of glycolated hemoglobin analysis pressurizing filter system, including glycolated hemoglobin analysis, there is sample introduction mechanism, chromatographic column and the colorimetric pool being sequentially connected in series by pipeline in glycolated hemoglobin analysis, and microparticle and fibrin filter and booster are sequentially connected in series in the end of pipeline, booster has the pipeline section of spiral winding;Filter has the filter body of disk like, and the center at filter body two ends sets inlet and outlet respectively, and patty filter core is filled with vivo in filter, and the filter core uses hydrophobic ultra-high molecular weight polyethylene UHMW PE, and being modified sintering through hydrophilizing agent surface forms.The present invention avoids the blocking of booster helix tube with filter, improves the reliability of small-sized glycosylated hemoglobin monitoring instrument, extend its non-maintaining cycle while bubble is suppressed using booster.

Description

Glycolated hemoglobin analysis pressurizing filter system and method
Technical field
The present invention relates to medical biochemistry detection equipment technical field, and in particular to a kind of glycolated hemoglobin analysis supercharging Filtration system and method.
Background technology
The measure to glycosylated hemoglobin mainly uses ion exchange chromatography at present, and its principle is saccharified based on hemoglobin The loss of the cation of molecular surface afterwards.When the sample containing glycosylated hemoglobin passes through cation-exchange chromatography post, saccharification Hemoglobin and both the non-glycated hemoglobin are adsorbed by cationic ion-exchange resin.Applicant leads in glycolated hemoglobin analysis Domain has obtained multinomial patent of invention, such as the gradient elution analysis method of ZL201110084781.3 glycolated hemoglobin analysis four, ZL 201110100181.1 glycolated hemoglobin analysis backwash flow path system etc..Glycosylated hemoglobin detecting instrument is solved to exist The problem of in terms of miniaturization, reliability, chromatography column life.
Applicant focuses on client feedback during product marketing, with sustained improvement product.In glycosylated hemoglobin analysis Instrument measure with elution process, in order to avoid the pressure value in conventional fluid path is less than normal and bubble that produced in optical colorimetric pond, Overcome the absorbance influence that bubble is caused, have booster in fluid path terminal tandem, booster possesses special screw extrusion structure, Avoid the presence of the dry knot of albumen, impurity, eluent after the formation of bubble, but the elution of entrance booster in sample using back pressure Crystalline substance etc., is easily adsorbed on booster duct wall, and such as cleaning easily causes blocking not in time, once booster generation clogging will Can directly it scrap.And periodically to booster carry out examination and maintenance difficulty also than larger, on the one hand due to the caliber of booster Very tiny, on the other hand its pipeline is long, and it is difficult to investigate thoroughly one by one to block section more, therefore is difficult daily to booster progress Care and maintenance.How while bubble removing is removed to elution pipeline supercharging, it is to avoid pipeline blockage, extend glycosylated hemoglobin In the non-maintaining cycle of analyzer, just turn into new technical barrier urgently to be resolved hurrily.
The content of the invention
Goal of the invention:In order to overcome the deficiencies in the prior art, the present invention provides a kind of glycosylated hemoglobin analysis Instrument pressurizing filter system and method.
Technical scheme:In order to solve the above technical problems, the glycolated hemoglobin analysis pressurizing filter system that the present invention is provided System, including glycolated hemoglobin analysis, the glycolated hemoglobin analysis have be sequentially connected in series by pipeline sample introduction mechanism, Chromatographic column and colorimetric pool, the end of the pipeline are sequentially connected in series microparticle and fibrin filter and booster, the supercharging Utensil has the pipeline section of spiral winding;The filter has a filter body of disk like, the center at filter body two ends set respectively import and Outlet, is filled with patty filter core, the filter core uses hydrophobic ultra-high molecular weight polyethylene UHMW-PE, through parent in vivo in filter Aqua surface is modified sintering and formed.
Specifically, the pipeline section of spiral winding is a flexible pipe being wound on hollow reel on booster, including is close to volume The inner ring of axle wound clockwise, and outer ring of the wrapped anti-clockwise on inner ring, inner ring winding starting point as booster stream Body entrance, outer ring winding terminal as booster fluid issuing.Winding of the flexible pipe on spool, by of inner ring to outer ring Clamp force becomes big so that the sectional area of inner ring hose inner wall is more than outer ring, produces the back pressure of crescendo.
It is in glycolated hemoglobin analysis present invention simultaneously provides a kind of boosting method of glycolated hemoglobin analysis Removal waste fluid line end, be sequentially connected in series microparticle and fibrin filter and booster, booster is one section spiral helicine The pipeline section of spiral winding, increases the resistance of Drainage pipe, by the pipe-line system of closing in its front end colorimetric pool and chromatographic column Sample and eluent produce back pressure, prevent release of the dissolved gas in sample and eluent, it is to avoid bubbing is formed Bubble is adsorbed on the tube wall of colorimetric pool light path Measurement channel, and at the same time microparticle and fibrin filter will be most Impurity is barred from filter so that the stopping state of booster greatly reduces.
Operation principle:Booster is set on the Drainage pipe of glycosylated hemoglobin detector, and booster is one section of spiral The pipeline section of the spiral winding of shape, increases the resistance of Drainage pipe, so that sample and eluent production in contrastive colours pond and chromatographic column Raw certain back pressure, prevents release of the dissolved gas in sample and eluent, it is to avoid bubbing formation bubble absorption exists On the tube wall of colorimetric pool light path Measurement channel, while a filter of being connected before waste liquid enters booster, will be most of Impurity be barred from filter so that the stopping state of booster greatly reduces.
Wherein, filter body uses the translucent PP materials of macromolecule, with good heat resistanceheat resistant and solvent resistance.Filter core can select With hydrophobic ultra-high molecular weight polyethylene UHMW-PE, it is modified sintering through hydrophilizing agent surface and forms hydrophilic polyethene micron pore size Filter material, or other polythene material micron pore sizes filter saturating material, filter antireflective film material with micron pore size etc., the material It is only used for the bulky grain thing in glycosylated hemoglobin detection analysis instrument equipment filter agent or blood sample.
This material has excellent corrosion resistance and hydrophobicity (being less than 0.01%) and health is nontoxic(With physiological inertia and Physiological adaptation).Filter method under lower pressure;More than 5 microns of impurity, filter efficiency >=99.99% can be filtered out.
Filter core is shaped as column, its cross section can for circle, sector, square, rectangle, rhombus or other do not advise Then shape.Its diameter takes 6.0mm~18.5mm, and the aperture of material takes 2.0 μm~100.00 μm, thickness take 1.00mm~ 12.00mm, weight 0.03g~0.75g, operating pressure 60kpa~2000kpa.
Beneficial effect:The present invention avoids booster helix tube with filter while bubble is suppressed using booster Blocking, improve the reliability of small-sized glycosylated hemoglobin monitoring instrument, extend its non-maintaining cycle.
Except it is above-described present invention solves the technical problem that, constitute technical scheme technical characteristic and by these technologies Outside the advantage that the technical characteristic of scheme is brought., below will knot to make the object, technical solutions and advantages of the present invention clearer The accompanying drawing in the embodiment of the present invention is closed, to other skills included in the other technologies problem of the invention that can be solved, technical scheme The advantage that art feature and these technical characteristics are brought does apparent, complete description, it is clear that described embodiment is this Invent a part of embodiment, rather than whole embodiments.Embodiments of the present invention, which are generally described and illustrated herein in the accompanying drawings Component can arrange and design with a variety of configurations.Therefore, implementation of the invention below to providing in the accompanying drawings The detailed description of example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made Every other embodiment, belongs to the scope of protection of the invention.
Brief description of the drawings
Fig. 1 is the structural representation of the embodiment of the present invention;
Fig. 2 is microparticle and the structural representation of fibrin filter in Fig. 1;
Fig. 3 is the division schematic diagram that Fig. 2 plants cavity;
Fig. 4 is Fig. 2 installation diagram;
In figure:First half-shell 1, the second half-shell 2, the first flange 4, the first cavity 5, the second flange 6, step surface 7, the second cavity 8, Filter core 9, the 3rd cavity 10, microparticle and fibrin filter 11, booster 12.
Embodiment
Embodiment:
The present embodiment is the concrete application of glycolated hemoglobin analysis pressurizing filter system and method, as shown in figure 1, being existing There are the drain line end of glycolated hemoglobin analysis, serial particle and fibrin filter 11 and booster 12, be pressurized Device 12 has the structure of spiral winding, the resistance for increasing Drainage pipe, in the pipe-line system of closing, to the ratio of its front end Sample and eluent in color pond and chromatographic column produce back pressure, prevent release of the dissolved gas in sample and eluent, keep away Exempt from bubbing to be formed, prevented bubble absorption go the tube wall of colorimetric pool light path Measurement channel where into detection error, with This simultaneously, most impurity is barred from filter by microparticle and fibrin filter 11 so that booster 12 is blocked The situation of plug greatly reduces.
Wherein, microparticle and fibrin filter are the first flanges by first half-shell 1 as shown in Figure 2, Figure 3 and Figure 4 In second flange 6 of 4 the second half-shells 2 of insertion, the transparent filter body of disk like that pairing is assembled is set in the center of first half-shell 1 Inlet is put, liquid port is set out in the center of the second half-shell 2, cavity, including first be sequentially connected are formed in vivo in filter Cavity 5, the second cavity 8 and the 3rd cavity 10, wherein the second cavity 8 is filled by translucent patty filter core 9.Filter core 9 and The first cavity 5 is formed between one half-shell, the 3rd cavity 10 is formed between the second half-shell, the second half-shell 2, which also has, holds filter core The step surface 7 of end face.
The filter can also be used in the fluid path of the glycolated hemoglobin analysis of other supercharging forms, for stopping miscellaneous keep away Exempt from pipeline blockage.Such as the integral low pressure ion exchange glycosylated hemoglobin point mentioned in Chinese patent literature CN103245791A Analyzer.
Different with thickness according to the diameter of filtration core, inventor did many experiments, drew data below.
Filter core uses hydrophobic ultra-high molecular weight polyethylene UHMW-PE, and being modified sintering through hydrophilizing agent surface forms, can also Saturating material, other polythene material micron pore sizes are filtered using hydrophilic polyethene micron pore size and filter saturating material or with micron pore size Filter antireflective film material, the material is only used for big in glycosylated hemoglobin detection analysis instrument equipment filter agent or blood sample Grain thing.
Shape:Filter core is column, and its cross section can be circle, sector, square, rectangle, rhombus or other irregular shapes Shape.
Filter core diameter:6.0mm~18.5mm
Filter core aperture:2.0μm(Micron)~100.00 μm(Micron)
Filter core thickness:1.00mm~12.00mm
Filter core weight:0.03g~0.75g
Filter core pressure:60kpa~2000kpa
The technical parameter of booster is as follows:
Fixed column exterior cylindrical shape, square column type, rhombus cylindricality, triangle cylindricality
Fixed column size diameter:30mm~60mm, height:75mm~135mm
Pipe parameter material:Horse forint pipe, thermoplastic rubber's pipe, silicone tube, pvc pipe
Bore:0.3mm~2.75mm, length of tube:450cm~2100cm
Pipeline pressure 4kPa~45kPa
0 DEG C~45 DEG C of environment temperature.
In the description of the invention, in addition it is also necessary to explanation, unless otherwise clearly defined and limited, term " setting ", " installation ", " connected ", " connection " should be interpreted broadly, for example, it may be fixedly connected or be detachably connected, or one Connect body;Can be mechanical connection or electrical connection;Can be joined directly together, can also be indirect by intermediary It is connected, can is the connection of two element internals.For the ordinary skill in the art, on being understood with concrete condition State the concrete meaning of term in the present invention.
It should be noted that:Similar label and letter represents similar terms in following accompanying drawing, therefore, once a certain Xiang Yi It is defined in individual accompanying drawing, then it further need not be defined and explained in subsequent accompanying drawing.
In the description of the invention, it is necessary to explanation, term " " center ", " on ", " under ", "left", "right", " vertical ", The orientation or position relationship of the instruction such as " level ", " interior ", " outer " be based on orientation shown in the drawings or position relationship, or should Orientation or position relationship that invention product is usually put when using, are for only for ease of the description present invention and simplify description, without It is that instruction or the signified device of hint or element must have specific orientation, with specific azimuth configuration and operation, therefore not It is understood that as limitation of the present invention.In addition, term " first ", " second ", " the 3rd " etc. are only used for distinguishing description, and it can not manage Solve to indicate or imply relative importance.
The preferred embodiment of the present invention is the foregoing is only, is not intended to limit the invention, for this area For technical staff, the present invention can have various modifications and variations, in the range of the principle and technological thought of the present invention, to this A little embodiments carry out a variety of changes, modifications, equivalent substitutions and improvements etc., should be included in the scope of the protection.

Claims (6)

1. a kind of glycolated hemoglobin analysis pressurizing filter system, including glycolated hemoglobin analysis, the HbAle Protein analyzer has sample introduction mechanism, chromatographic column and the colorimetric pool being sequentially connected in series by pipeline, it is characterised in that:The end of the pipeline End is sequentially connected in series microparticle and fibrin filter and booster, and the booster has the pipeline section of spiral winding;The mistake Filter has the filter body of disk like, and the center at filter body two ends sets inlet and outlet respectively, in filter in vivo filled with patty filter Core, the filter core uses hydrophobic ultra-high molecular weight polyethylene UHMW-PE, and being modified sintering through hydrophilizing agent surface forms.
2. glycolated hemoglobin analysis pressurizing filter system according to claim 1, it is characterised in that:Spiral shell on booster The pipeline section of rotation winding is a flexible pipe being wound on hollow reel, including is close to the inner ring of spool wound clockwise, and inverse Hour hands are wrapped in the outer ring on inner ring, and the starting point of inner ring winding is used as the fluid intake of booster, the terminal conduct of outer ring winding The fluid issuing of booster.
3. glycolated hemoglobin analysis pressurizing filter system according to claim 1, it is characterised in that:The microparticle And fibrin filter is the transparent filter body of disk like being assembled to form by first half-shell and the second half-shell pairing, the filter has in vivo There is cavity.
4. glycolated hemoglobin analysis pressurizing filter system according to claim 3, it is characterised in that:The cavity bag The first cavity being sequentially connected, the second cavity and the 3rd cavity are included, is filled wherein the second cavity is filtered by translucent patty, and The diameter of second cavity is more than the second cavity and the second cavity.
5. glycolated hemoglobin analysis pressurizing filter system according to claim 3, it is characterised in that:Described the first half The side of shell has the first flange, and the inner side of the first flange is used for clamp filter core, and the side of second half-shell is convex with second It is caught on the outside of edge, the first flange in the second flange, the second half-shell also has the step surface for holding filter core end face.
6. the boosting method of glycolated hemoglobin analysis pressurizing filter system according to claim 1, it is characterised in that: In the removal waste fluid line end of glycolated hemoglobin analysis, microparticle and fibrin filter and booster are sequentially connected in series, Booster is the pipeline section of one section of spiral helicine spiral winding, increases the resistance of Drainage pipe, by the pipe-line system of closing to it Sample and eluent in front end colorimetric pool and chromatographic column produce back pressure, prevent dissolved gas releasing in sample and eluent Put, it is to avoid bubbing formation bubble is adsorbed on the tube wall of colorimetric pool light path Measurement channel, at the same time microparticle and fiber Most impurity is barred from filter by albumen filter.
CN201710183521.9A 2017-03-24 2017-03-24 Glycolated hemoglobin analysis pressurizing filter system and method Pending CN107192588A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710183521.9A CN107192588A (en) 2017-03-24 2017-03-24 Glycolated hemoglobin analysis pressurizing filter system and method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710183521.9A CN107192588A (en) 2017-03-24 2017-03-24 Glycolated hemoglobin analysis pressurizing filter system and method

Publications (1)

Publication Number Publication Date
CN107192588A true CN107192588A (en) 2017-09-22

Family

ID=59871693

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710183521.9A Pending CN107192588A (en) 2017-03-24 2017-03-24 Glycolated hemoglobin analysis pressurizing filter system and method

Country Status (1)

Country Link
CN (1) CN107192588A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113640255A (en) * 2021-03-17 2021-11-12 王奔 Accurate instant detection POCT glycated hemoglobin analyzer

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2352190Y (en) * 1998-10-19 1999-12-08 郭聪寿 Infusion liquid filtering apparatus
CN101496921A (en) * 2008-10-29 2009-08-05 李林风 Medicine liquid filter with stage treatment
CN202057584U (en) * 2011-04-06 2011-11-30 江苏奥迪康医学科技有限公司 Structure for restraining resolvable gas by using glycolated hemoglobin analysis meter and photometer
CN102512875A (en) * 2011-12-30 2012-06-27 上海百菲特环保科技有限公司 Preparation method for ultra-high molecular weight polyethylene filtering material
CN205808797U (en) * 2016-07-01 2016-12-14 大连技嘉科技有限公司 Glycolated hemoglobin analysis pot strainer
CN106404982A (en) * 2016-12-21 2017-02-15 王松 Glycosylated hemoglobin analyzer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2352190Y (en) * 1998-10-19 1999-12-08 郭聪寿 Infusion liquid filtering apparatus
CN101496921A (en) * 2008-10-29 2009-08-05 李林风 Medicine liquid filter with stage treatment
CN202057584U (en) * 2011-04-06 2011-11-30 江苏奥迪康医学科技有限公司 Structure for restraining resolvable gas by using glycolated hemoglobin analysis meter and photometer
CN102512875A (en) * 2011-12-30 2012-06-27 上海百菲特环保科技有限公司 Preparation method for ultra-high molecular weight polyethylene filtering material
CN205808797U (en) * 2016-07-01 2016-12-14 大连技嘉科技有限公司 Glycolated hemoglobin analysis pot strainer
CN106404982A (en) * 2016-12-21 2017-02-15 王松 Glycosylated hemoglobin analyzer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113640255A (en) * 2021-03-17 2021-11-12 王奔 Accurate instant detection POCT glycated hemoglobin analyzer
CN113640255B (en) * 2021-03-17 2022-07-22 南京鸿瑞杰生物医疗科技有限公司 Accurate instant detection POCT glycated hemoglobin analyzer

Similar Documents

Publication Publication Date Title
EP2957306B1 (en) Blood purification column
CN101180089B (en) Body fluid treating filter device
CA1227440A (en) In-line filter
CN2780207Y (en) Disposable active carbon blood perfusion device
KR870001735B1 (en) Purification method of water
JPH06505640A (en) Rectifier dialyzer, membrane and method
JPWO2004094047A1 (en) Hollow fiber membrane fluid processor
CN105343954B (en) Compound apparatus for purifying blood and preparation method thereof
CN106000109A (en) Hollow fiber ultramicro-filtration membrane assembly and membrane performance detection device
CN107192588A (en) Glycolated hemoglobin analysis pressurizing filter system and method
CN104755156B (en) The method of operation of scrubbing membrane module
CN206609682U (en) Glycolated hemoglobin analysis pressurizing filter system
JPS58163490A (en) Method and apparatus for purification of water
CN108295326A (en) A kind of ultrapure haemodialyser of two-chamber
CN205367936U (en) Multi -stage filtration reverse osmosis water purification installation
CN219462091U (en) Hemodialysis adsorber
CN205073372U (en) Compound blood purifying device
JPS6388007A (en) Virus free module
CN107890780A (en) A kind of ultrafiltration, counter-infiltration one membrane component and preparation method thereof
CN210544415U (en) Ultrafiltration membrane assembly
US20080035550A1 (en) Device, with a backup filter, for producing sterile liquid
CN102178986A (en) Blood extracorporeal circulation magnetic sterilizing device
JP2005118506A (en) On-line massive fluid replacement type hemodialyzer
JP7224104B2 (en) Dialysis device with improved internal filtration and method of manufacture
CN208864911U (en) A kind of novel aseptic haemodialyser

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination