CN107184828A - A kind of lotion for treating gynaecologic vaginal infection and preparation method thereof - Google Patents
A kind of lotion for treating gynaecologic vaginal infection and preparation method thereof Download PDFInfo
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- CN107184828A CN107184828A CN201710364489.4A CN201710364489A CN107184828A CN 107184828 A CN107184828 A CN 107184828A CN 201710364489 A CN201710364489 A CN 201710364489A CN 107184828 A CN107184828 A CN 107184828A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of lotion for treating gynaecologic vaginal infection and preparation method thereof, it is specific that the invention discloses a kind of pharmaceutical composition for treating gynaecologic vaginal infection, described pharmaceutical composition contains the extract of raw medicinal material or the raw medicinal material, wherein the raw medicinal material includes:The coptis, radish seed, rhizoma Gastrodiae, radix rehmanniae recen, cape jasmine, Polygonum multiflower knotweed, Fructus Aurantii, moutan bark, oyster, dried orange peel and the radix paeoniae rubrathe.The medicine of the present invention has effects that significantly clearing heat and detoxicating, desinsection is antipruritic, eliminating dampness stops band, its antipruritic, stop-band, antiphlogistic effects are excellent, with significant antibacterial insecticidal action, to inflammatory vagina mucosa, vagina cleanness degree is abnormal and urethral stimulant symptom improves significantly, and with safely, have no side effect the characteristics of.
Description
Technical field
The invention belongs to field of medicaments, specifically, the present invention relates to a kind of lotion and its system for treating gynaecologic vaginal infection
Preparation Method.
Background technology
Infective vaginitis are gynaecology's common diseases, and when pathogen invades vagina, vaginal mucosa is made under certain conditions
Produce inflammatory activity and form vaginitis.Wherein it is not that the vaginitis as caused by special pathogen claims nonspecific vaginitis;
The trichomonal vaginitis of vagina infection claims trichomonas vaginitis;The microbial vaginitis of vagina infection Candida albicans claims fungi
Property vaginitis.It is a kind of common sympton under pruritus vulvae band, directly endangers vast body of women health.Under band, pruritus vulvae severe patient can cause
It is infertile, and into harm people's happy life and a physically and mentally healthy social concern.
With Chinese medical discrimination viewpoint, pruritus vulvae band subordinate's damp heat downward flowing type is in the majority, and multifactor body is insufficiency of the spleen, or excessively overstrain ponder over,
Diet impairment of the spleen without rule, it is wet from interior life, it is wet it is turbid accumulate hold back, long and change heat.Or living environment is moist, experiences damp evil;Or through row, postpartum
When vessels of the uterus is hollow, the foul heresy of wet poison is taken advantage of a weak point, directly violates uterus.Or depressed rage impairing the liver, long strongly fragrantization heat, Liver Channel heated, lower gram
Spleen soil is damp and hot to hand over vehement.Vagina infection patient is simultaneously often accompanied by lassitude in the daytime, slow in reacting, fatigue and asthenia, very then vexed annoyance
Etc. symptom, influence women is physically and mentally healthy, studying and living.With the change of modern society's life mode, its clinic hair in recent years
Sick rate has the trend constantly risen.
The content of the invention
It is an object of the invention to provide one kind that a kind of, effect easy to use to vagina infection has no side effect significantly, safely
Treat lotion of gynaecologic vaginal infection and preparation method thereof.
The first aspect of the present invention provides a kind of pharmaceutical composition for treating gynaecologic vaginal infection, described pharmaceutical composition
Extract containing raw medicinal material or the raw medicinal material, wherein the raw medicinal material includes:The coptis, radish seed, rhizoma Gastrodiae, the dried rhizome of rehmannia
Huang, cape jasmine, Polygonum multiflower knotweed, Fructus Aurantii, moutan bark, oyster, dried orange peel and the radix paeoniae rubrathe;Also, the parts by weight of described raw medicinal material are as follows:
Coptis 3-10
Radish seed 2-7
Rhizoma Gastrodiae 3-10
Radix rehmanniae recen 3-10
Cape jasmine 3-6
Polygonum multiflower knotweed 2-5
Fructus Aurantii 2-5
Moutan bark 2-5
Oyster 2-7
Dried orange peel 3-7
Radix paeoniae rubrathe 3-10.
In another preference, the raw medicinal material is by the coptis, radish seed, rhizoma Gastrodiae, radix rehmanniae recen, cape jasmine, Polygonum multiflower knotweed, trifoliate orange
Shell, moutan bark, oyster, dried orange peel and the radix paeoniae rubrathe are constituted.
In another preference, described extract includes:Water extract or aqueous extract (include but is not limited to alcohol molten
Liquid extract, the alcohol is ethanol, methanol or propyl alcohol).
In another preference, described aqueous extract refers to the extract with aqueous solvent extraction.
In another preference, described aqueous solvent refers to by water and solvent (such as alcohol, including ethanol) institute compatible with water
The mixed solvent of composition, wherein water content are 10-99.5wt%, preferably 50-90wt%.
In another preference, the raw medicinal material includes:
30-100 grams of the coptis
20-70 grams of radish seed
30-100 grams of rhizoma Gastrodiae
30-100 grams of radix rehmanniae recen
30-60 grams of cape jasmine
20-50 grams of Polygonum multiflower knotweed
20-50 grams of Fructus Aurantii
20-50 grams of moutan bark
20-70 grams of oyster
30-70 grams of dried orange peel, and
30-100 grams of the radix paeoniae rubrathe.
In another preference, described pharmaceutical composition is external preparation.
In another preference, described pharmaceutical composition is lotion.
In another preference, described pharmaceutical composition is that specification is 5-30ml/ parts.
In another preference, sodium alginate is also included in described pharmaceutical composition, it is therefore preferable to 0.5-5 parts by weight.
The second aspect of the present invention provides the purposes of pharmaceutical composition as described in the first aspect of the invention, for preparing
Treat the medicine of vagina infection.
In another preference, the usage amount of the medicine is 1 dose for each person every day, and daily dosage is equivalent to 10-
200 grams are done total medicinal material, and total medicinal material is preferably done equivalent to 20 grams.
Third aspect present invention provides a kind of method for the pharmaceutical composition for preparing treatment gynaecologic vaginal infection, the side
Method includes step:
(a) raw medicinal material is provided, the raw medicinal material includes:The coptis, radish seed, rhizoma Gastrodiae, radix rehmanniae recen, cape jasmine, Polygonum multiflower knotweed,
Fructus Aurantii, moutan bark, oyster, dried orange peel and the radix paeoniae rubrathe;Also, the parts by weight of described raw medicinal material are as follows:
Coptis 3-10
Radish seed 2-7
Rhizoma Gastrodiae 3-10
Radix rehmanniae recen 3-10
Cape jasmine 3-6
Polygonum multiflower knotweed 2-5
Fructus Aurantii 2-5
Moutan bark 2-5
Oyster 2-7
Dried orange peel 3-7
Radix paeoniae rubrathe 3-10;And
(b) raw medicinal material is extracted, so as to obtain the extract of the medicinal material.
In another preference, pH is adjusted to be that 3-5 is extracted with acetic acid in step (b) extraction process.
In another preference, methods described also includes step (c), and marine alga is added in the extract obtained to step (b)
Sour sodium 0.5-1% (wt).
In another preference, methods described also includes step (d), adjusts extract solution pH to be 4.5 with acetic acid.
It should be understood that within the scope of the present invention, above-mentioned each technical characteristic of the invention and have in below (eg embodiment)
It can be combined with each other between each technical characteristic of body description, so as to constitute new or preferred technical scheme.As space is limited, exist
This no longer tires out one by one states.
Embodiment
The present inventor, by largely screening and testing, is found that one kind is controlled first by long-term in-depth study extensively
Treat the pharmaceutical composition of gynaecologic vaginal infection, the party is with the coptis, radish seed, rhizoma Gastrodiae, radix rehmanniae recen, cape jasmine, Polygonum multiflower knotweed, Fructus Aurantii, male
The root bark of tree peony, oyster, dried orange peel and the radix paeoniae rubrathe are composition, and effective therapeutic effect is reached by scientific matching.Clinical tests prove that safety has
Imitate and have no side effect, can prolonged application.The present invention is completed on this basis.Clinical observation present invention treatment gynaecologic vaginal infection
Pharmaceutical composition, it is evident in efficacy, it is safe and reliable, not yet find obvious side effect, shown unique characteristics in clinical application, can
It is effectively improved vagina infection symptom, it is to avoid the occurrence and development of complication.
Drug component
The coptis:For ranunculaceae plant coptis Coptis chinensis Franch., triangle leaf coptis Coptis
Deltoidea C.Y.Cheng et Hsiao or cloud connect Coptis teeta Wall. dry rhizome, and its active ingredient is small
Bark of a cork tree alkali.Pharmacological action:Antipyretic, antibacterial, antiviral, anti-oxidant etc. are acted on.
Radish seed:For the dry mature seed of crucifer radish;It is pungent, sweet, put down;Return lung, spleen, stomach;It is usually used in gastral cavity
Abdominal distention and pain, constipation, stagnate rush down dysentery.《Japan hanako materia medica》:Water grinds clothes, tells wind phlegm;Vinegar grinds detumescence poison.
Rhizoma Gastrodiae:Mainly containing compositions such as vanillyl alcohol, vanillin, gastrodin, polysaccharide, retinoid material, mucilaginous substances;
Gan Ping, return liver warp;Function Inflammation Zhijing, calming the liver, dispelling wind and removing obstruction in the meridians;Headache, dizziness for treating liver wind agitation, also can use
In lockjaw etc..
Radix rehmanniae recen:Scrophulariaceae, glutinous rehmannia platymiscium, the root tuber of glutinous rehmannia, perennial vertical herbage, its main component:β-paddy steroid
Alcohol (β-Sitosterol), mannitol (Mannitol) and a small amount of stigmasterol (Stigmasterol), micro campesterol
(Campesterol).Pharmacological action:Strengthen myocardial contractive power, adjust blood pressure, not only stopped blooding but also anti-freezing, anti-inflammatory antiallergy.
Cape jasmine:It is the fruit of Rubiaceae Rubiaceae plant cape jasmines, fruit constituents containing iridoid:Gardenoside
(gardenoside), all square rafter glucoside (geniposide), all square rafter (genipin-1-
Gentiobioside) etc., there is protect liver cholagogic, relieving haperacidity etc. is acted on.
Polygonum multiflower knotweed:For the drying rattan of polygonum multiflorum thunb;It is sweet, flat;The thoughts of returning home, Liver Channel;Function nourishing heart, calms the nerves, dredging collateral,
Wind-dispelling;It is mainly used in deficiency of blood bodily pain, ulcer, scrofula, wind sore scabies tinea.《Book on Chinese herbal medicine is new again》:Labor is controlled in bowl spares gas, network of passing through, promoting blood circulation
Wound.
Fructus Aurantii:Medicinal source for rutaceae bitter orange Citrus aurantium L. and its variety drying not
Ripening fruits, containing the material such as volatile oil and glycosides displayed.Muscular movement is promoted to shrink increase.
Moutan bark:For ranunculaceae peony dry root skin, its main component is Paeoniflorin (paeonifolrin), oxidation
Paeoniflorin (oxypaeoniflorin), benzoylpaeoniflorin (benzoylpaeoniflorin), paeonol (paeonol) is male
Red phenol glucoside (paeonoside).Coronary blood flow can be increased, cardiac output is reduced, suppress blood platelet office level, antibacterial strengthens body fluid
And cellular immunity.
Oyster:For the long oyster of Ostreidae animal, ostrea talienwhanensis Crosse, Crassostrea rivularis shell;It is salty, it is slightly cold;Return liver, courage, kidney
Through;Function is calming the liver, transquilization with heavy material, softening and resolving hard mass work(, restrains astringent or styptic treatment for spontaneous sweating.《This warp》:Main typhoid fever fever and chills, a kind of malaria is voluminous, frightened to anger
Anger, except slow mouse fistula is arrested, woman is red white with.
Dried orange peel:For rutaceae orange and its dry mature skin of variety;It is bitter, pungent, temperature;Return lung, the spleen channel;Function
Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.《This warp》:The main heat of lump in the abdomen in the heart, inverse gas, sharp water paddy, long term usage are deodorized, lower gas.
The radix paeoniae rubrathe:For the root block of Ranunculaceae Chinese herbaceous peony platymiscium, its main component:Paeoniflorin (paeoniflorin), aoxidizes Chinese herbaceous peony
Medicine glucoside (oxy-paeoniflorin), benzoylpaeoniflorin (benzoylpaooniflorin), albiflorin (albi-florin).
Can antithrombus formation, platelet aggregation-against.
Preparation and application
Preparation method:By the raw medicinal material according to the present invention, water extraction or alcohol extracting (pH 3-5) filter to take extract and add marine alga
Sour sodium 0.5-1% (wt), the traditional Chinese medicine lotion for the gynaecologic vaginal infection that obtained medical treatment with acetic acid tune pH for 4.5.
Usage:Clean external genital after with wash device flushing, each 20ml.
The present inventor's research is found, obtains extract solution using acid solution extraction, drug effect is stronger, preferably to be washed as vagina
Agent is used, and further study show that, add after appropriate sodium alginate, the speed of patient's recovery from illness can be dramatically increased, effectively
Reduce treatment time, significantly reduce treatment cost.
Main advantages of the present invention include:
The medicine of the present invention has effects that obvious clearing heat and detoxicating, desinsection is antipruritic, eliminating dampness stops band, its antipruritic, stop-band, resists
Scorching excellent effect, with significant antibacterial insecticidal action, to inflammatory vagina mucosa, vagina cleanness degree exception and urethral stimulation
Shape improves significantly, and with safely, have no side effect the characteristics of.
With reference to specific embodiment, the present invention is expanded on further.It should be understood that these embodiments are merely to illustrate the present invention
Rather than limitation the scope of the present invention.The experimental method of unreceipted actual conditions in the following example, generally according to conventional strip
Part, or according to the condition proposed by manufacturer.Unless otherwise indicated, otherwise percentage and number are percentage by weight and weight
Number.
Preparation example 1
Formula is as follows:
100 grams of the coptis
70 grams of radish seed
30 grams of rhizoma Gastrodiae
100 grams of radix rehmanniae recen
30 grams of cape jasmine
50 grams of Polygonum multiflower knotweed
20 grams of Fructus Aurantii
20 grams of moutan bark
70 grams of oyster
70 grams of dried orange peel, and
30 grams of the radix paeoniae rubrathe.
2000 grams of water of addition, vinegar acid for adjusting pH 3.0, immersion 30min is used instead again to 60min, after boiling by intense fire to be cooked by slow fire
Half an hour, filtering removes the dregs of a decoction and obtains extract solution, and extract solution is concentrated into 1 milliliter of extract solution of equivalent to 1 gram medicinal material, adds extract solution
The sodium alginate of weight 0.5%, vinegar acid for adjusting pH to 4.5 produces the lotion for the treatment of gynaecologic vaginal infection.
Preparation example 2
Formula is as follows:
30 grams of the coptis
20 grams of radish seed
100 grams of rhizoma Gastrodiae
30 grams of radix rehmanniae recen
60 grams of cape jasmine
20 grams of Polygonum multiflower knotweed
50 grams of Fructus Aurantii
50 grams of moutan bark
20 grams of oyster
30 grams of dried orange peel, and
100 grams of the radix paeoniae rubrathe.
2000 grams of water of addition, vinegar acid for adjusting pH 4.0, immersion 30min is used instead again to 60min, after boiling by intense fire to be cooked by slow fire
Half an hour, filtering removes the dregs of a decoction and obtains extract solution, and extract solution is concentrated into 1 milliliter of extract solution of equivalent to 1 gram medicinal material, adds extract solution
The sodium alginate of weight 1%, vinegar acid for adjusting pH to 4.5 produces the lotion for the treatment of gynaecologic vaginal infection.
Preparation example 3
50 grams of the coptis
40 grams of radish seed
80 grams of rhizoma Gastrodiae
60 grams of radix rehmanniae recen
40 grams of cape jasmine
30 grams of Polygonum multiflower knotweed
30 grams of Fructus Aurantii
20 grams of moutan bark
60 grams of oyster
40 grams of dried orange peel, and
70 grams of the radix paeoniae rubrathe.
2000 gram of 30% (v/v) ethanol water is added, vinegar acid for adjusting pH 5.0 soaks 30min to 60min, and intense fire is boiled
Used instead again after boiling and be cooked by slow fire half an hour, filtering removes the dregs of a decoction and obtains extract solution, extract solution is concentrated into equivalent to the 1 gram milli of medicinal material 1
Extract solution is risen, the sodium alginate of extract solution weight 0.8% is added, vinegar acid for adjusting pH to 4.5 produces treatment gynaecologic vaginal infection
Lotion.
Embodiment 1
Clinical research
The present inventor is from June, 2015-2016 year August, with the lotion for treatment of the treatment gynaecologic vaginal infection of the present invention
Case 180, is summarized as follows.
1st, clinical data
1.1 general information
All cases derive from this outpatient service, totally 180, are randomly divided into treatment group and control group.Treatment group 90;Control
Group 90;Age was at 18-58 years old.Treated after treatment group patient menstrual from the 4th day using the lotion of the present invention, daily 1
Agent, 1 dose of 20ml divides 2 times and used, once in the morning and once at night, each menstruation cycle therapy 14 days, and continuous 2 menstrual cycles for the treatment of are one
The individual course for the treatment of.Control group uses clotrimazole suppository.
1.2 diagnostic criteria
Leucorrhea increasing, color are yellow or smelly, pudendal pruritus, and vaginal fluid smear for microscopic examination finds trichomonad or mould, foregoing 180
Patient is the vaginitis patient for possessing foregoing several symptoms.
2nd, observation of curative effect
Cure:Leukorrhea amount and color switch to normally, and pudendal pruritus disappear, and vaginal fluid smear for microscopic examination is without trichomonad or mould
Bacterium.
Effectively:Leukorrhea amount and color switch to normally, and pudendal pruritus disappear, and vaginal fluid smear for microscopic examination finds a small amount of drop
Worm or mould.
It is invalid:Clinical symptom and sign is compared with pre-treatment without improvement.
Treatment results show:
(1) treatment group:
Clinical cure 68, accounts for 76%;
Effective 22, account for 24%;
Invalid 0;
Total effective rate 100%;
(2) control group:
Clinical cure 25, accounts for 28%;
Effective 62, account for 69%;
Invalid 0;
Total effective rate 100%.
Model case
Name:Liu's * * ages:45 years old
Head examines the date:2015-7-10
Main suit:Vulva burns excitement, the green dirt of leukorrhea color purulence, band foam.
Prescription:Lotion is formulated using embodiment 1,1 course for the treatment of is cured;Follow-up 6 months, does not recur.
Name:Zhao's * * ages:27 years old
Head examines the date:2016-04-10
Main suit:Pruritus vulvue, vaginal exudates are in yellow green.
Prescription:Lotion is formulated using embodiment 2,1 course for the treatment of is cured;Follow-up 6 months, does not recur.
Name:Guo's * * ages:38 years old
Head examines the date:2015-09-28
Main suit:There are burn feeling and itch, leukorrhea yellow green purulence band foam in vulva part.
Prescription:Lotion is formulated using embodiment 3,1 course for the treatment of is cured;Follow-up 6 months, does not recur.
All documents referred in the present invention are all incorporated as reference in this application, independent just as each document
It is incorporated as with reference to such.In addition, it is to be understood that after the above-mentioned instruction content of the present invention has been read, those skilled in the art can
To be made various changes or modifications to the present invention, these equivalent form of values equally fall within the model that the application appended claims are limited
Enclose.
Claims (10)
1. a kind of pharmaceutical composition for treating gynaecologic vaginal infection, it is characterised in that described pharmaceutical composition contains raw medicinal material
Or the extract of the raw medicinal material, wherein the raw medicinal material includes:The coptis, radish seed, rhizoma Gastrodiae, radix rehmanniae recen, cape jasmine, night hand over
Rattan, Fructus Aurantii, moutan bark, oyster, dried orange peel and the radix paeoniae rubrathe;Also, the parts by weight of described raw medicinal material are as follows:
Coptis 3-10
Radish seed 2-7
Rhizoma Gastrodiae 3-10
Radix rehmanniae recen 3-10
Cape jasmine 3-6
Polygonum multiflower knotweed 2-5
Fructus Aurantii 2-5
Moutan bark 2-5
Oyster 2-7
Dried orange peel 3-7
Radix paeoniae rubrathe 3-10.
2. pharmaceutical composition as claimed in claim 1, it is characterised in that the raw medicinal material by the coptis, radish seed, rhizoma Gastrodiae,
Radix rehmanniae recen, cape jasmine, Polygonum multiflower knotweed, Fructus Aurantii, moutan bark, oyster, dried orange peel and the radix paeoniae rubrathe are constituted.
3. pharmaceutical composition as claimed in claim 1, it is characterised in that described extract includes:Water extract is aqueous
Extract.
4. pharmaceutical composition as claimed in claim 3, it is characterised in that described aqueous extract refers to be carried with aqueous solvent
The extract taken.
5. pharmaceutical composition as claimed in claim 4, it is characterised in that described aqueous solvent refers to by water and compatible with water
The mixed solvent that solvent is constituted, wherein water content are 10-99.5wt%.
6. the purposes of pharmaceutical composition as claimed in claim 1, the medicine for preparing treatment vagina infection.
7. a kind of method for the pharmaceutical composition for preparing treatment gynaecologic vaginal infection, it is characterised in that methods described includes step:
(a) raw medicinal material is provided, the raw medicinal material includes:The coptis, radish seed, rhizoma Gastrodiae, radix rehmanniae recen, cape jasmine, Polygonum multiflower knotweed, trifoliate orange
Shell, moutan bark, oyster, dried orange peel and the radix paeoniae rubrathe;Also, the parts by weight of described raw medicinal material are as follows:
Coptis 3-10
Radish seed 2-7
Rhizoma Gastrodiae 3-10
Radix rehmanniae recen 3-10
Cape jasmine 3-6
Polygonum multiflower knotweed 2-5
Fructus Aurantii 2-5
Moutan bark 2-5
Oyster 2-7
Dried orange peel 3-7
Radix paeoniae rubrathe 3-10;And
(b) raw medicinal material is extracted, so as to obtain the extract of the medicinal material.
8. method as claimed in claim 7, it is characterised in that adjust pH to be that 3-5 enters with acetic acid in step (b) extraction process
Row is extracted.
9. method as claimed in claim 7, it is characterised in that methods described also includes step (c), is obtained to step (b)
Sodium alginate 0.5-1% (wt) is added in extract.
10. method as claimed in claim 9, it is characterised in that methods described also includes step (d), is adjusted with acetic acid and extracted
Liquid pH is 4.5.
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101057892A (en) * | 2006-04-19 | 2007-10-24 | 河南省宛西制药股份有限公司 | Medicinal composition for treating vaginal diseases and its preparation method and application |
-
2017
- 2017-05-22 CN CN201710364489.4A patent/CN107184828A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101057892A (en) * | 2006-04-19 | 2007-10-24 | 河南省宛西制药股份有限公司 | Medicinal composition for treating vaginal diseases and its preparation method and application |
Non-Patent Citations (1)
Title |
---|
杨懿等: "单味黄连煎剂治疗外阴阴道假丝酵母菌阴道病81例疗效观察", 《中华医院感染学杂志》 * |
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