CN107184535A - Cosmetics containing the pitch-dark pigment of siphonopods and preparation method thereof - Google Patents
Cosmetics containing the pitch-dark pigment of siphonopods and preparation method thereof Download PDFInfo
- Publication number
- CN107184535A CN107184535A CN201710413918.2A CN201710413918A CN107184535A CN 107184535 A CN107184535 A CN 107184535A CN 201710413918 A CN201710413918 A CN 201710413918A CN 107184535 A CN107184535 A CN 107184535A
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- Prior art keywords
- siphonopods
- pitch
- dark pigment
- cosmetics
- component
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Abstract
The invention discloses the cosmetics containing the pitch-dark pigment of siphonopods, it is made up of the component of following weight percentage：Antioxidant composition A 5 12%, oil phase component B 7 20%, auxiliary agent D 0.5 2.0%, surplus is water phase components C, and the every percentage sum of the above is 100%, and described antioxidant composition A includes the pitch-dark pigment of siphonopods.Cosmetics produced by the present invention have superpower oxidation resistance, can effectively remove the active oxygen radical for bringing various skin problems, make skin anti-aging, and physical efficiency recovery occurs and accelerated for delayed motion fatigue.
Description
Technical field
The present invention relates to a kind of cosmetics, and in particular to a kind of cosmetics and its preparation side containing with the pitch-dark pigment of siphonopods
Method.
Background technology
The pitch-dark pigment of siphonopods mainly includes squid ink black pigment, the pitch-dark pigment of octopus, the pitch-dark pigment of inkfish.Siphonopods ink
Juice is important weapon when siphonopods hides natural enemy, is present in siphonopods ink sac.Natural ink compositions are complicated, contain ink black
Element, polysaccharide, protein, fat, ash grade many kinds of substance.Pitch-dark pigment is isolated by prepared Chinese ink, as one kind of natural pigment,
Water insoluble and most liquid medium, but dissolve in alkali lye, chlorethanol and diethylamine solution.Pitch-dark pigment, which has, to be removed freely
The function of base, because it can produce a large amount of Semiquinone Radicals, and Semiquinone Radicals very can easily receive or confess one
Electronics, therefore the pitch-dark pigment of siphonopods can be used as antioxidant.
With the progress of science, people gradually extract beneficial element, such as seaweed extract, in skin care item from marine species
Boundary has also started the research and development of products using ocean as element, and existing in the market does not occur the cosmetic containing the pitch-dark pigment of siphonopods also
Product.
The content of the invention
It is an object of the invention to provide a kind of cosmetics containing the pitch-dark pigment of siphonopods and preparation method thereof, stability
It is good, good in oxidation resistance.
To achieve the above object, the present invention uses following technical scheme：
Cosmetics containing the pitch-dark pigment of siphonopods, it is made up of the component of following weight percentage：Antioxidant composition A
5-12%, oil phase component B 7-20%, auxiliary agent D 0.5-2.0%, surplus are water phase components C, the every percentage sum of the above
For 100%, described antioxidant composition A includes the pitch-dark pigment of siphonopods.
Wherein, described antioxidant composition A also includes one or both of high sub- polyphenol and sargassum thunbergii polyphenol in sea.
Preferably, described antioxidant composition A is composed of the following components, and the weight percent that each component accounts for cosmetics total amount contains
Measure and be：The pitch-dark pigment 2-6% of siphonopods, sea high sub- polyphenol 2-4%, sargassum thunbergii polyphenol 1-2%.
Wherein, described oil phase component B is made up of lower any 2~4 kinds of components：PEG-20 stearates, PEG-100 are stearic
Acid esters, saualane, isopropyl myristate.
Preferably, the oil phase component B is composed of the following components, and each component accounts for the weight percentage of cosmetics total amount
For：PEG-20 stearates 0.5-2%, PEG-100 stearate 1.5-3%, saualane 2-5%, isopropyl myristate 3-
10%.
Wherein, the water phase components C is made up of following component, and the weight percentage that each component accounts for cosmetics total amount is：
EDETATE SODIUM 0.02-0.1%, allantoin 0.05-0.3%, pantothenic acid 0.08-0.4%, xanthans 0.1-0.3%, water surplus.
Wherein, the auxiliary agent D is made up of essence, preservative and toner.
The invention also discloses the preparation method of the above-mentioned cosmetics containing the pitch-dark pigment of siphonopods, comprise the following steps：
A, oil phase component B is proportionally added into oil phase pot, is heated to 80-85 DEG C, is incubated 10min~15min, stir molten
Solution is uniform.
B, water phase components C is proportionally added into aqueous phase pot, is heated to 80-85 DEG C, insulation is in 10min~15min, stirring
It is uniformly dissolved.
C, the oil phase component B for being uniformly dissolved step a are pumped into vacuum emulsification pot, then slow suction water phase components C, homogeneous
15~20min, insulated and stirred 10min~15min, then vacuumizes and cools.
D, when being cooled to 30~40 DEG C, antioxidant composition A and auxiliary agent D is proportionally added into, is stirred.
Wherein, the pitch-dark pigment of siphonopods in antioxidant composition A is prepared according to the following steps：
(1) the pitch-dark pigments of are extracted：Freezing smashing, the accessory substance ink sac produced during the siphonopods such as squid, inkfish are processed freezes
Knot, and crushed with pulverizer, it is soaked in water.
(2) centrifugations are shelled, and step (1) is crushed into soaked ink sac is put into centrifuge, and the rotating speed of centrifuge is set to
300r/min~600r/min, centrifugation time is that reject precipitation takes and stays supernatant after 10min, centrifugation.
(3) secondary centrifugings, the supernatant of step (2) centrifuges 15min with 8000r/min~12000r/min rotating speed again,
Reject supernatant, which takes, stays precipitation.
(4) alkali lye is dissolved, and the NaOH solution of 0.5mol/L~1mol/L concentration is added in the precipitation that step (3) is obtained and is made
It is dissolved, and is placed in water-bath and leaches after a period of time, and supernatant is extracted in centrifugation.
(5) acid solutions are precipitated, and HCl solution is added in the supernatant that step (4) is obtained and is adjusted to after pH value is 1.5~2, standing
15min is centrifuged with 8000r/min~12000r/min rotating speed, precipitation is taken, by precipitation washing several times, vacuum freeze drying is
.
Preferably, described antioxidant composition A also includes one or both of high sub- polyphenol and sargassum thunbergii polyphenol in sea, sea
The preparation method of high sub- polyphenol or sargassum thunbergii polyphenol is：The high son in sea or sargassum thunbergii raw material are put into the ethanol that mass concentration is 75%
In solution, the weight of ethanol solution is 2-3 times of the high sub or sargassum thunbergii raw material raw material weight in sea, is flowed back at ambient pressure 30-60 points
Clock, obtains extract solution, and aforesaid operations are repeated 2 times to the solid residue filtered out, merges extract solution, is carried out under conditions of 35 DEG C
It is concentrated under reduced pressure, obtains concentrate, continuous concentration stops concentration, gained concentrate is through cold untill the proportion of concentration liquid measure is 1.1
Jelly is dried to obtain powder material.
Cosmetics produced by the present invention have superpower oxidation resistance, can effectively remove the active oxygen for bringing various skin problems
Free radical, makes skin anti-aging, and physical efficiency recovery occurs and accelerated for delayed motion fatigue.
Embodiment
In order that those skilled in the art more fully understands technical scheme, with reference to specific embodiment pair
The present invention is described in further detail.
Embodiment 1-4
By the corresponding embodiment 1-4 of table 1, each raw material is weighed, you can the cosmetics of the present invention are made.
Cosmetic formulations table of the table 1 containing the pitch-dark pigment of siphonopods
Cosmetics of the invention containing the pitch-dark pigment of siphonopods are prepared in accordance with the following steps：
A, oil phase component B is proportionally added into oil phase pot, is heated to 80-85 DEG C, is incubated 10min~15min, stir molten
Solution is uniform；
B, water phase components C is proportionally added into aqueous phase pot, is heated to 80-85 DEG C, insulation is in 10min~15min, stirring
It is uniformly dissolved；
C, the oil phase component B for being uniformly dissolved step a are pumped into vacuum emulsification pot, then slow suction water phase components C, homogeneous
15~20min, insulated and stirred 10min~15min, then vacuumizes and cools；
D, when being cooled to 30~40 DEG C, antioxidant composition A and auxiliary agent D is proportionally added into, is stirred.Anti-oxidant group
The pitch-dark pigment of siphonopods divided in A is prepared according to the following steps：
(1) pitch-dark pigment is extracted：Freezing smashing, the accessory substance ink sac produced during the siphonopods such as squid, inkfish are processed freezes
Knot, and crushed with pulverizer, it is soaked in water.
(2) centrifugation is shelled, and step (1) is crushed into soaked ink sac is put into centrifuge, and the rotating speed of centrifuge is set to
300r/min~600r/min, centrifugation time is that reject precipitation takes and stays supernatant after 10min, centrifugation；
(3) secondary centrifuging, the supernatant of step (2) centrifuges 15min with 8000r/min~12000r/min rotating speed again,
Reject supernatant, which takes, stays precipitation；
(4) alkali lye is dissolved, and the NaOH solution of 0.5mol/L~1mol/L concentration is added in the precipitation that step (3) is obtained and makes it
Dissolving, is placed in water-bath and leaches after a period of time, and supernatant is extracted in centrifugation；
(5) acid solution is precipitated, add in the supernatant that step (4) is obtained HCl solution be adjusted to pH value be after 1.5~2, standing with
8000r/min~12000r/min rotating speed centrifugation 15min, takes precipitation, by precipitation washing several times, vacuum freeze drying is
.
The preparation method of high sub- polyphenol or the sargassum thunbergii polyphenol in sea is in antioxidant composition A：
The high son in sea or sargassum thunbergii raw material are put into the ethanol solution that mass concentration is 75%, the weight of ethanol solution is sea
2-3 times of high son or sargassum thunbergii raw material raw material weight, flows back 30-60 minutes, extract solution is obtained, to consolidating for filtering out at ambient pressure
Body residue repeats aforesaid operations 2 times, merges extract solution, is concentrated under reduced pressure under conditions of 35 DEG C, obtains concentrate, continues dense
Untill the proportion for being reduced to concentration liquid measure is 1.1, stop concentration, gained concentrate is freeze-dried to obtain powder material.
The obtained cosmetics containing the pitch-dark pigment of siphonopods of the embodiment of the present invention 1 are subjected to following measure, continuous mode
It is as follows：
1st, superoxide anion ability is removed
Compound concentration is 0.1molL-1Phosphate buffer (pH is 8.34) and draw 0.5mL in test tube, add
1.0mL distilled water, test tube is placed on 25 DEG C of water bath with thermostatic control 20min, the 10mmolL added after 0.5mL preheatings-1Pyrogallol is molten
Liquid, mixes rapidly timing, with 10mmolL-1Hydrochloric acid replaces pyrogallol solution as blank control, is surveyed at wavelength 325nm
Determine start recording data (A after the UV absorption of solution, 30s1), every 30s records once until 4min (A2), as the following formula (1)
Calculate mouse thymus cells speed SO0。
A in formula1For the UV absorption of the 0.5th minute solution；A2For the UV absorption of the 4th minute solution；SO0For neighbour
Benzenetriol autoxidation speed；
It is 0.1molL to draw 0.5mL concentration-1Phosphate buffer in test tube, add 1.0mL of the present invention, test tube
25 DEG C of water bath with thermostatic control 20min are placed on, the 10mmolL added after 0.5mL preheatings-1Pyrogallol solution, mixes rapidly timing,
With 10mmolL-1Hydrochloric acid replaces pyrogallol solution as blank control, and solution after sample-adding is then determined according to the method described above
UV absorption, calculates mouse thymus cells speed SO after sample-adding1.Finally (2) calculate solution of the present invention to O as the following formula2 -'s
Clearance rate.
SO in formula1To add mouse thymus cells speed after solution of the present invention；C is solution of the present invention to O2 -Clearance rate
(%).
Test result：Pyrogallol occurs autoxidation chain reaction and discharges substantial amounts of O in the basic conditions2, O2Enter again
One step accelerates the oxidation of pyrogallol, generates a series of intermediate products for having characteristic absorption in visible region.By adding antioxygen
Agent, detects absorbance change of the solution at 325nm to evaluate the effect of antioxidant.Solution of the present invention is to superoxide anion
(O2 -) inhibitory action substantially, the present invention remove O2 -Ability it is stronger, clearance rate C ≈ 92.4%.
2nd, scavenging hydroxyl ability
Compound concentration is 9mmolL respectively-1Ferrous sulfate, 8.8mmolL-1Hydrogen peroxide, 9mmolL-1Salicylic acid-
Ethanol solution, draws 0.5mL in test tube, adds solution 1.0mL of the present invention successively, anti-in 37 DEG C of waters bath with thermostatic control after mixing
30min is answered, the light absorption value of solution is determined at wavelength 510nm, A is designated as；H is replaced with distilled water2O2, determined at wavelength 510nm
The light absorption value of solution, is designated as A0；Replace solution of the present invention as blank using distilled water, the suction of solution is determined at wavelength 510nm
Light value, is designated as AIt is empty.(3) calculate clearance rate of the solution of the present invention to OH as the following formula.
A is the light absorption value for adding solution after solution of the present invention in formula；A0Not add H2O2The light absorption value of background；AIt is emptyFor blank
The light absorption value of pipe；C1For clearance rate (%) of the present invention to OH.
Test result：OH is chemical property extremely active oxygen radical, is endangered also very big.Fenton reaction systems can
To produce OH, what OH can be selective combines with salicylic acid, produces 2,3- dihydroxy-benzoic acids, utilizes ultraviolet spectrophotometry
The amount of above-mentioned intermediate product is detected to describe the removing OH abilities of the present invention.The present invention is very strong to OH Scavenging activity, clearly
Except rate C1≈ 96.9%.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art the invention discloses technical scope in, the change or replacement that can be readily occurred in,
It should all be included within the scope of the present invention.
Claims (10)
1. the cosmetics containing the pitch-dark pigment of siphonopods, it is characterised in that it is made up of the component of following weight percentage：It is anti-
Oxidation component A 5-12%, oil phase component B 7-20%, auxiliary agent D 0.5-2.0%, surplus are water phase components C, the every percentage of the above
It is 100% than sum, described antioxidant composition A includes the pitch-dark pigment of siphonopods.
2. the cosmetics as claimed in claim 1 containing the pitch-dark pigment of siphonopods, it is characterised in that described antioxidant composition
A also includes one or both of high sub- polyphenol and sargassum thunbergii polyphenol in sea.
3. the cosmetics as claimed in claim 2 containing the pitch-dark pigment of siphonopods, it is characterised in that described antioxidant composition
A is composed of the following components, and the weight percentage that each component accounts for cosmetics total amount is：Siphonopods pitch-dark pigment 2-6%, Hai Songzi
Polyphenol 2-4%, sargassum thunbergii polyphenol 1-2%.
4. the cosmetics as claimed in claim 1 containing the pitch-dark pigment of siphonopods, it is characterised in that described oil phase component B
It is made up of following any 2~4 kinds of components：PEG-20 stearates, PEG-100 stearates, saualane, myristic acid isopropyl
Ester.
5. the cosmetics containing the pitch-dark pigment of siphonopods as claimed in claim 4, it is characterised in that the oil phase component B by
Following components is constituted, and the weight percentage that each component accounts for cosmetics total amount is：PEG-20 stearates 0.5-2%, PEG-100
Stearate 1.5-3%, saualane 2-5%, isopropyl myristate 3-10%.
6. the cosmetics containing the pitch-dark pigment of siphonopods as claimed in claim 1, it is characterised in that the water phase components C by
Following component is constituted, and the weight percentage that each component accounts for cosmetics total amount is：EDETATE SODIUM 0.02-0.1%, allantoin 0.05-
0.3%, pantothenic acid 0.08-0.4%, xanthans 0.1-0.3%, water surplus.
7. the cosmetics containing the pitch-dark pigment of siphonopods as claimed in claim 1, it is characterised in that the auxiliary agent D by essence,
Preservative and toner composition.
8. the preparation method of the cosmetics containing the pitch-dark pigment of siphonopods described in any one of claim 1~7, its feature exists
In comprising the following steps：
A, oil phase component B is proportionally added into oil phase pot, is heated to 80-85 DEG C, is incubated 10min~15min, stirring and dissolving is equal
It is even；
B, water phase components C is proportionally added into aqueous phase pot, is heated to 80-85 DEG C, is incubated in 10min~15min, stirring and dissolving
Uniformly；
C, the oil phase component B for being uniformly dissolved step a are pumped into vacuum emulsification pot, then slow suction water phase components C, and homogeneous 15~
20min, insulated and stirred 10min~15min, then vacuumizes and cools；
D, when being cooled to 30~40 DEG C, antioxidant composition A and auxiliary agent D is proportionally added into, is stirred.
9. the preparation method of the cosmetics as claimed in claim 8 containing the pitch-dark pigment of siphonopods, it is characterised in that：It is anti-oxidant
The pitch-dark pigment of siphonopods in component A is prepared according to the following steps：
(1) the pitch-dark pigments of are extracted：Freezing smashing, the accessory substance ink sac produced during the siphonopods such as squid, inkfish are processed freezes,
And crushed with pulverizer, it is soaked in water；
(2) centrifugations are shelled, and step (1) is crushed into soaked ink sac is put into centrifuge, and the rotating speed of centrifuge is set to 300r/
Min~600r/min, centrifugation time is that reject precipitation takes and stays supernatant after 10min, centrifugation；
(3) secondary centrifugings, the supernatant of step (2) centrifuges 15min, reject with 8000r/min~12000r/min rotating speed again
Supernatant, which takes, stays precipitation；
(4) alkali lye is dissolved, and the NaOH solution of 0.5mol/L~1mol/L concentration is added in the precipitation that step (3) is obtained and makes its molten
Solution, is placed in water-bath and leaches after a period of time, and supernatant is extracted in centrifugation；
(5) acid solutions are precipitated, add in the supernatant that step (4) is obtained HCl solution be adjusted to pH value be after 1.5~2, standing with
8000r/min~12000r/min rotating speed centrifugation 15min, takes precipitation, by precipitation washing several times, vacuum freeze drying is
.
10. the preparation method of the cosmetics as claimed in claim 9 containing the pitch-dark pigment of siphonopods, it is characterised in that：It is described
Antioxidant composition A also include one or both of high sub- polyphenol and sargassum thunbergii polyphenol in sea, sea high sub- polyphenol or sargassum thunbergii are more
The preparation method of phenol is：The high son in sea or sargassum thunbergii raw material are put into the ethanol solution that mass concentration is 75%, the weight of ethanol solution
2-3 times for the high son in sea or sargassum thunbergii raw material raw material weight is measured, flows back 30-60 minutes at ambient pressure, obtains extract solution, to filtering
The solid residue gone out repeats aforesaid operations 2 times, merges extract solution, is concentrated under reduced pressure under conditions of 35 DEG C, obtains concentrate,
Continuous concentration stops concentration, gained concentrate is freeze-dried to obtain powdered thing untill the proportion of concentration liquid measure is 1.1
Material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710413918.2A CN107184535A (en) | 2017-06-05 | 2017-06-05 | Cosmetics containing the pitch-dark pigment of siphonopods and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710413918.2A CN107184535A (en) | 2017-06-05 | 2017-06-05 | Cosmetics containing the pitch-dark pigment of siphonopods and preparation method thereof |
Publications (1)
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| CN107184535A true CN107184535A (en) | 2017-09-22 |
Family
ID=59877148
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| CN201710413918.2A Pending CN107184535A (en) | 2017-06-05 | 2017-06-05 | Cosmetics containing the pitch-dark pigment of siphonopods and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108795092A (en) * | 2017-11-02 | 2018-11-13 | 安发（福建）生物科技有限公司 | A kind of preparation method of the pitch-dark pigment of marine animal |
| CN109939061A (en) * | 2019-05-14 | 2019-06-28 | 连云港诗碧曼生物科技有限公司 | A kind of safe and non-stimulating white hair blackening Essence and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104000773A (en) * | 2014-06-17 | 2014-08-27 | 广州市雅蝶化妆品制造有限公司 | Natural antioxidant composite cosmetic and preparation method thereof |
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2017
- 2017-06-05 CN CN201710413918.2A patent/CN107184535A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104000773A (en) * | 2014-06-17 | 2014-08-27 | 广州市雅蝶化妆品制造有限公司 | Natural antioxidant composite cosmetic and preparation method thereof |
| CN105733299A (en) * | 2016-02-02 | 2016-07-06 | 福建省水产研究所 | Preparation method and application of insoluble and soluble squid melanin |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108795092A (en) * | 2017-11-02 | 2018-11-13 | 安发（福建）生物科技有限公司 | A kind of preparation method of the pitch-dark pigment of marine animal |
| CN109939061A (en) * | 2019-05-14 | 2019-06-28 | 连云港诗碧曼生物科技有限公司 | A kind of safe and non-stimulating white hair blackening Essence and preparation method thereof |
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