CN107183699A - It is a kind of to remove the food of free radical - Google Patents

It is a kind of to remove the food of free radical Download PDF

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Publication number
CN107183699A
CN107183699A CN201710346713.7A CN201710346713A CN107183699A CN 107183699 A CN107183699 A CN 107183699A CN 201710346713 A CN201710346713 A CN 201710346713A CN 107183699 A CN107183699 A CN 107183699A
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China
Prior art keywords
parts
food
free radical
remove
fruit
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Chinese (zh)
Inventor
黄允
梁建
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Liuzhou North Science And Technology Service Co Ltd
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Liuzhou North Science And Technology Service Co Ltd
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Priority to CN201710346713.7A priority Critical patent/CN107183699A/en
Publication of CN107183699A publication Critical patent/CN107183699A/en
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/638Ligustrum, e.g. Chinese privet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/82Theaceae (Tea family), e.g. camellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The food of free radical can be removed the invention discloses a kind of, raw material includes the following each component of parts by weight:20 30 parts of purple perilla, 10 30 parts of grape pip, 20 30 parts of Momordica grosvenori, 10 30 parts of lecithin, 15 25 parts of radix glycyrrhizae, 15 20 parts of ginkgo leaf, 10 20 parts of Tea Polyphenols, 10 30 parts of the fruit of glossy privet.Identified by physicochemical property, toxicological assessment, functional experiment show, food composition of the invention is clear and definite, stability is good, have no toxic side effect, antioxidation significantly, be a kind of functional food with antioxidation.

Description

It is a kind of to remove the food of free radical
Technical field
The food of free radical can be removed the present invention relates to a kind of, belongs to field of food.
Background technology
Oxidative stress (Oxidative Stress) refers to body when by various destructive stimuluses, internal high activity molecule Such as active oxygen radical (reactive oxygen species, ROS) and active nitrogen free radical (reactive nitrogen Species, RNS) produce excessively, degree of oxidation exceeds the removing of oxide, and oxidative system and antioxidant system are unbalance, so as to lead Cause the damage of the large biological molecule such as body tissue cell and albumen and nucleic acid.Research confirms that oxidative stress can cause beta Cell of islet work( Energy loss injures peripheral insulin resistance, so as to lead diabetogenic generation;And endothelial dysfunction can be caused, cause painstaking effort Pipe disease;In addition, can also trigger a series of diseases such as autoimmune disease, disease in the blood system and cancer, to health Cause greatly infringement.Therefore control oxidative stress is for maintaining body health to have extremely important effect.Find safe and effective Polyphenoils seem particularly urgent.
The anti-oxidation medicine of current clinical practice mainly has MAOI, dopamine-receptor stimulant, dimension life Element etc..These medicines have different degrees of side effect, unsuitable long-term taking.In recent years numerous studies have demonstrated that Natural Food Thing composition is safely and effectively at anti-oxidant aspect.
The content of the invention
The technical problem to be solved in the present invention is to overcome existing defect to remove the food of free radical there is provided a kind of Product, remove human free radical, and stability is good, and cost is low.
In order to solve the above-mentioned technical problem, the invention provides following technical scheme:
A kind of to remove the food of free radical, raw material includes the following each component of parts by weight:20-30 parts of purple perilla, grape 10-30 parts of seed, 20-30 parts of Momordica grosvenori, 10-30 parts of lecithin, 15-25 parts of radix glycyrrhizae, 15-20 parts of ginkgo leaf, Tea Polyphenols 10-20 Part, 10-30 parts of the fruit of glossy privet.
Preferably, raw material includes the following each component of parts by weight:24 parts of purple perilla, 19 parts of grape pip, 23 parts of Momordica grosvenori, lecithin 18 parts of fat, 22 parts of radix glycyrrhizae, 18 parts of ginkgo leaf, 17 parts of Tea Polyphenols, 22 parts of the fruit of glossy privet.
Preferably, raw material includes the following each component of parts by weight:20 parts of purple perilla, 30 parts of grape pip, 20 parts of Momordica grosvenori, lecithin 30 parts of fat, 15 parts of radix glycyrrhizae, 20 parts of ginkgo leaf, 10 parts of Tea Polyphenols, 30 parts of the fruit of glossy privet.
Preferably, raw material includes the following each component of parts by weight:30 parts of purple perilla, 10 parts of grape pip, 30 parts of Momordica grosvenori, lecithin 10 parts of fat, 25 parts of radix glycyrrhizae, 15 parts of ginkgo leaf, 20 parts of Tea Polyphenols, 10 parts of the fruit of glossy privet.
The preparation method of the described food that can remove free radical, by purple perilla, grape pip, Momordica grosvenori, radix glycyrrhizae, ginkgo leaf With the fruit of glossy privet dry, then crush be 120-150 mesh powders, mix with Tea Polyphenols and lecithin, produce described in can remove The food of free radical.
Beneficial effects of the present invention:Identified by physicochemical property, toxicological assessment, functional experiment show, this hair Bright food composition is clear and definite, stability is good, have no toxic side effect, antioxidation significantly, be a kind of work(with antioxidation Can food.
Embodiment
The preferred embodiments of the present invention are illustrated below, it will be appreciated that preferred embodiment described herein is only used In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1:
A kind of to remove the food of free radical, raw material includes the following each component of parts by weight:24 parts of purple perilla, grape pip 19 Part, 23 parts of Momordica grosvenori, 18 parts of lecithin, 22 parts of radix glycyrrhizae, 18 parts of ginkgo leaf, 17 parts of Tea Polyphenols, 22 parts of the fruit of glossy privet.
The preparation method of the described food that can remove free radical, by purple perilla, grape pip, Momordica grosvenori, radix glycyrrhizae, ginkgo leaf With the fruit of glossy privet dry, then crush be 120-150 mesh powders, mix with Tea Polyphenols and lecithin, produce described in can remove The food of free radical.
Embodiment 2:
A kind of to remove the food of free radical, raw material includes the following each component of parts by weight:20 parts of purple perilla, grape pip 30 Part, 20 parts of Momordica grosvenori, 30 parts of lecithin, 15 parts of radix glycyrrhizae, 20 parts of ginkgo leaf, 10 parts of Tea Polyphenols, 30 parts of the fruit of glossy privet.
The preparation method of the described food that can remove free radical, by purple perilla, grape pip, Momordica grosvenori, radix glycyrrhizae, ginkgo leaf With the fruit of glossy privet dry, then crush be 120-150 mesh powders, mix with Tea Polyphenols and lecithin, produce described in can remove The food of free radical.
Embodiment 3:
A kind of to remove the food of free radical, raw material includes the following each component of parts by weight:30 parts of purple perilla, grape pip 10 Part, 30 parts of Momordica grosvenori, 10 parts of lecithin, 25 parts of radix glycyrrhizae, 15 parts of ginkgo leaf, 20 parts of Tea Polyphenols, 10 parts of the fruit of glossy privet.
The preparation method of the described food that can remove free radical, by purple perilla, grape pip, Momordica grosvenori, radix glycyrrhizae, ginkgo leaf With the fruit of glossy privet dry, then crush be 120-150 mesh powders, mix with Tea Polyphenols and lecithin, produce described in can remove The food of free radical.
Comparative example 1:
A kind of to remove the food of free radical, raw material includes the following each component of parts by weight:43 parts of grape pip, Momordica grosvenori 23 parts, 18 parts of lecithin, 22 parts of radix glycyrrhizae, 18 parts of ginkgo leaf, 17 parts of Tea Polyphenols, 22 parts of the fruit of glossy privet.
The preparation method of the described food that can remove free radical, by purple perilla, grape pip, Momordica grosvenori, radix glycyrrhizae, ginkgo leaf With the fruit of glossy privet dry, then crush be 120-150 mesh powders, mix with Tea Polyphenols and lecithin, produce described in can remove The food of free radical.
Comparative example 2:
A kind of to remove the food of free radical, raw material includes the following each component of parts by weight:43 parts of purple perilla, Momordica grosvenori 23 Part, 18 parts of lecithin, 22 parts of radix glycyrrhizae, 18 parts of ginkgo leaf, 17 parts of Tea Polyphenols, 22 parts of the fruit of glossy privet.
The preparation method of the described food that can remove free radical, by purple perilla, grape pip, Momordica grosvenori, radix glycyrrhizae, ginkgo leaf With the fruit of glossy privet dry, then crush be 120-150 mesh powders, mix with Tea Polyphenols and lecithin, produce described in can remove The food of free radical.
Comparative example 3:The product of embodiment 3 in patent CN201610365279.2.
Experimental example 1:Radicals scavenging is tested
1st, test principle:DPPH spectrophotometry principle is in absolute ethyl alcohol and ethanol-water system according to DHHP Middle presentation darkviolet, has absorption maximum under 517nm and 525nm respectively.Free radical scavenger can make purple gradually retreat, root DHHP content, Scavenging activity of the reaction free radical scavenger to DHHP are determined according to the change of absorbance.
2nd, test specimen:
Sample 1-3:Sample prepared by 1-3 of the embodiment of the present invention.
Reference substance 1-3:The sample of comparative example 1-3 preparation.
3rd, test method:Compound concentration is 1 × 10-4Mol/L DPPH ethanol solutions.Take 2mLDPPH standards molten Liquid, is placed in test tube, adds sample solution 2mL, places after 30min, and absorbance is determined in 517nm.Surveyed according to following equation Determine DPPH clearance rates:
DHHP clearance rate=[1- (Ai-Aj)/Ac] × 100%;
Ai:The absorbance of 2mL testing sample solution+2mLDPPH solution;
Aj:The absorbance of 2mL testing sample solution+2mL95% ethanol;
Ac:The absorbance of the absorbance+2mL95% ethanol of 2mLDPPH solution.
The measure testing sample of 0 month, 6 months, 12 months and 18 months, preservation condition:Vial sealing is kept in dark place, Indoor shady place is routinely placed.
4th, experimental result
4.1 0 months detection DHHP clearance rate:It is shown in Table 1.
Table 1:0 month clearance rate (%) to DHHP
The result of table 1 is shown, compared with reference substance 1-3, and sample 1-3 shows excellent DHHP elimination effects, sample 1 Clearance rate is optimal.
4.2 6 months detection DHHP clearance rate:It is shown in Table 2.
Table 2:6 months clearance rates (%) to DHHP
The result of table 2 is shown, compared with reference substance 1-3, and sample 1-3 shows good DHHP elimination effects, sample 1 Clearance rate is optimal.
4.3 12 months detection DHHP clearance rate:It is shown in Table 3.
Table 3:12 months clearance rates (%) to DHHP
The result of table 3 is shown, compared with reference substance 1-3, and sample 1-3 shows preferable DHHP elimination effects, sample 1 Clearance rate is optimal.
4.4 18 months detection DHHP clearance rate:It is shown in Table 4.
Table 4:18 months clearance rates (%) to DHHP
The result of table 4 is shown, compared with reference substance 1-3, and sample 1-3 shows certain DHHP elimination effects, sample 1 Clearance rate is optimal.
Finally it should be noted that:The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, Although the present invention is described in detail with reference to the foregoing embodiments, for those skilled in the art, it still may be used To be modified to the technical scheme described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic. Within the spirit and principles of the invention, any modification, equivalent substitution and improvements made etc., should be included in the present invention's Within protection domain.

Claims (5)

1. a kind of can remove the food of free radical, it is characterised in that:Raw material includes the following each component of parts by weight:Purple perilla 20- 30 parts, 10-30 parts of grape pip, 20-30 parts of Momordica grosvenori, 10-30 parts of lecithin, 15-25 parts of radix glycyrrhizae, 15-20 parts of ginkgo leaf, tea it is many 10-20 parts of phenol, 10-30 parts of the fruit of glossy privet.
2. according to claim 1 can remove the food of free radical, it is characterised in that:It is following that raw material includes parts by weight Each component:24 parts of purple perilla, 19 parts of grape pip, 23 parts of Momordica grosvenori, 18 parts of lecithin, 22 parts of radix glycyrrhizae, 18 parts of ginkgo leaf, Tea Polyphenols 17 Part, 22 parts of the fruit of glossy privet.
3. according to claim 1 can remove the food of free radical, it is characterised in that:It is following that raw material includes parts by weight Each component:20 parts of purple perilla, 30 parts of grape pip, 20 parts of Momordica grosvenori, 30 parts of lecithin, 15 parts of radix glycyrrhizae, 20 parts of ginkgo leaf, Tea Polyphenols 10 Part, 30 parts of the fruit of glossy privet.
4. according to claim 1 can remove the food of free radical, it is characterised in that:It is following that raw material includes parts by weight Each component:30 parts of purple perilla, 10 parts of grape pip, 30 parts of Momordica grosvenori, 10 parts of lecithin, 25 parts of radix glycyrrhizae, 15 parts of ginkgo leaf, Tea Polyphenols 20 Part, 10 parts of the fruit of glossy privet.
5. the preparation method of the food according to any one of claim 1 to 4 that can remove free radical, its feature exists In:Purple perilla, grape pip, Momordica grosvenori, radix glycyrrhizae, ginkgo leaf and the fruit of glossy privet are dried, it is 120-150 mesh powders then to crush, with Tea Polyphenols and lecithin mixing, producing described can remove the food of free radical.
CN201710346713.7A 2017-05-17 2017-05-17 It is a kind of to remove the food of free radical Withdrawn CN107183699A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101224260A (en) * 2006-12-13 2008-07-23 天津市弗兰德医药科技发展有限公司 Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract
CN105054012A (en) * 2015-07-28 2015-11-18 重庆市优胜科技发展有限公司 Health-care product to scavenge active oxygen free radicals in body and regulate endogenous hormone levels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101224260A (en) * 2006-12-13 2008-07-23 天津市弗兰德医药科技发展有限公司 Health product compounds consisting of lecithin, grape seed extract and ginkgo leaf extract
CN105054012A (en) * 2015-07-28 2015-11-18 重庆市优胜科技发展有限公司 Health-care product to scavenge active oxygen free radicals in body and regulate endogenous hormone levels

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘海英等: "我国86种药食两用植物的抗氧化活性及其与总酚的相关性分析", 《西北农林科技大学学报(自然科学版)》 *

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