CN107180167A - The checking method and device detected for hereditary disease gene diagnosis - Google Patents

The checking method and device detected for hereditary disease gene diagnosis Download PDF

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CN107180167A
CN107180167A CN201710371620.XA CN201710371620A CN107180167A CN 107180167 A CN107180167 A CN 107180167A CN 201710371620 A CN201710371620 A CN 201710371620A CN 107180167 A CN107180167 A CN 107180167A
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matching entries
project
default
pathological examination
examination
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CN107180167B (en
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王家健
陶然
王永松
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Hainan Jinyu Medical Testing Center Co Ltd
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Hainan Jinyu Medical Testing Center Co Ltd
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    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00ICT programming tools or database systems specially adapted for bioinformatics
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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Abstract

It is disclosed by the invention to be instructed for the checking method that hereditary disease gene diagnosis is detected according to the examination & verification to pending project received, start to judge whether the detecting system and patient information of the project meet default examination & verification condition;If meeting, it is determined that the seeking scope of the matching entries;If the seeking scope of the matching entries is only limitted to same bar code, the pathological examination of the matching entries is then searched in the first database, if the seeking scope of matching entries is extended under different bar codes, first search the matching entries under same bar code in the first database, when being searched in the first database less than matching entries under same bar code, begin look for the matching entries under different bar codes in the second database, according to the contradiction condition of default pending project and matching entries, obtain the auditing result of the pathological examination of the pending project, largely reduce manual analysis and the input compared, reduce error rate, improve the efficiency of examination & verification.

Description

The checking method and device detected for hereditary disease gene diagnosis
Technical field
The present invention relates to medical detection field, more particularly to a kind of checking method detected for hereditary disease gene diagnosis and Device.
Background technology
It is also more specialized and various as the inspection service of medical diagnosis on disease means with constantly perfecting for medical system Change.With the increase of the project of inspection, the increase of specimen amount, the sample turnaround time will extend according to original flow, but the above Clinical demand and laws and regulations requirement require that the sample turnaround time is shortened in laboratory as far as possible, how sample to be divided without any confusion Class, reasonable effective Optimal Experimental room testing process, the reasonable convenience of laboratory information system design becomes shortening sample The key link of turnaround time.The classification that current independent laboratory carries out project is mainly divided:Physics and chemistry mass spectrum inspection, genome inspection Test, pathological diagnosis, biochemical luminous inspection, immunological test, other comprehensive tests etc., because detection project is more, the project of adding pushes away old Go out new fast, the requirement to testing result auditor is also constantly lifted.
Exceptional sample, except sample interference, such as piarhemia, haemolysis, in addition to result need the project that artificial judgment is screened, this portion The confirmation of point result is needed to carry out artificial treatment, and such as centrifugation is surveyed again, push jack microscopy or contact are clinical.This part sample expends a large amount of Time can significantly postpone other reports send the time;Simultaneously under the pressure of sample turnaround time, lab assistant can It can neglect or simplify due handling process, cause the risk of result to be significantly increased.Nowadays, almost all of laboratory report List is accused by manually signing and issuing, it is about more than 1000 that one, which is signed and issued report personnel to sign and issue reporting quantities a working day, and And these work are largely limited at night to morning (21:00-04:00) carry out, the period prolonged computation is examined Nuclear Data, is easy to cause vision and the dual fatigue of body and mind, causes the generation of mistake;Meanwhile, if the result of report is related to Comparison and analysis between section, in addition it is also necessary to substantial amounts of manual historical record inquiry, whole data analysis work will continue 6 hours with On.
The content of the invention
The purpose of the embodiment of the present invention is to provide a kind of checking method and device detected for hereditary disease gene diagnosis, energy Logical contradiction between automatic early-warning pathological examination, the reasonability of automatic inspection pathological examination is compared and analyzed without artificial.
To achieve the above object, the embodiments of the invention provide a kind of examination & verification side detected for hereditary disease gene diagnosis Method, including step:
Receive the examination & verification to the pathological examination of the pending project under any bar code to instruct, judge the pending project Whether detecting system matches with default detecting system, and judges whether the patient information of the bar code limits with default data System matches;
If the detecting system of the pending project matches with default detecting system, and the patient information of the bar code Match with the limitation of default data, it is determined that the seeking scope of default matching entries;Wherein, the matching entries for institute State the project of the advance association of pending project;
If the seeking scope of default matching entries includes the matching entries under same bar code, but does not include under different bar codes Matching entries when, then M pathological examination of the matching entries is obtained according to the first database;Wherein, M >=0;Wherein, institute Stating the first database includes the testing result of several projects under the bar code;
If the seeking scope of default matching entries includes the matching under matching entries and different bar codes under same bar code During project, then N number of testing result of the matching entries is obtained according to the first database;Wherein, N >=0;
As N=0, then X testing result of the matching entries is obtained according to the second database;Wherein, X >=0;Its In, the second database includes the testing result of several projects under different bar codes;The occurrence obtained according to the second database Mesh need to meet default condition, the default condition be other bar codes where the matching entries patient information with it is described The patient information of bar code where pending project matches;
When M, which is more than or equal to 1, N, is more than or equal to 1 or X more than or equal to 1, according to the pending project and matching The contradiction condition of project, judges that the pathological examination of the pending project and matching entries whether there is contradiction, obtain described in treat The auditing result of the pathological examination of examination & verification project;Wherein, if there is contradiction, the examination & verification of the pathological examination of the pending project As a result do not pass through for examination & verification;If in the absence of contradiction, the auditing result of the pathological examination of the pending project passes through for examination & verification.
Compared with prior art, the checking method disclosed by the invention detected for hereditary disease gene diagnosis is according to receiving The examination & verification of pending project is instructed, start to judge whether the detecting system and patient information of the project meet default examine Core condition;If meeting, it is determined that the seeking scope of the matching entries;If the seeking scope of the matching entries is only limitted to same Bar code, then search the pathological examination of the matching entries in the first database, if the seeking scope of matching entries is extended to not During with bar code, the matching entries under same bar code in the first database are first searched, are searched when in the first database less than same During matching entries under bar code, the matching entries under different bar codes in the second database are begun look for, according to default pending The contradiction condition of project and matching entries, obtains the auditing result of the pathological examination of the pending project, largely Manual analysis and the input compared are reduced, error rate is reduced, the efficiency of examination & verification is improved.
As the improvement of such scheme, the pathological examination type of the pending project and matching entries include numeric type and Text-type.
As the improvement of such scheme, the contradiction condition of the pending project and matching entries is specially:
The pathological examination of the pending project is that the pathological examination of ascendant trend and the matching entries is downward trend; Wherein, the ascendant trend is the upper limit threshold more than default term of reference, and the downward trend is described less than default The lower threshold of term of reference;The pathological examination type of the pending project and matching entries is numeric type.
As the improvement of such scheme, the contradiction condition of the pending project and matching entries is:
The pathological examination of the pending project is less than default numerical value and the pathological examination of matching entries and default text This is consistent;Wherein, the pathological examination type of the matching entries is numeric type, and the pathological examination type of the matching entries is text This type.
As the improvement of such scheme, the matching entries include first item and second item, the pending project Contradiction condition with matching entries is specially:
The pathological examination of the pending project is less than default numerical value, the pathological examination of first item and default text The pathological examination of consistent and second item is more than default numerical value;Wherein, the pathology of the pending project and second item Result type is numeric type, and the pathological examination type of the first item is text-type.Matching entries need according to have verified that with The internal association of pending project is preset, it is ensured that the science and preciseness of examination & verification.
It is used as the improvement of such scheme, in addition to step:
If X is equal to 0, judge whether the pathological examination of the pending project meets default implied condition;
If the pathological examination of the pending project meets default implied condition, alerting signal is sent;Wherein, it is described to carry Signal of waking up is used to remind the pathological examination for receiving the matching entries.
As the improvement of such scheme, the patient information of the bar code matches with the limitation of default data to be specifically included: The patient age of the bar code is in default scope, the Gender of the bar code and default sex limit consistent and institute State the corresponding information for hospital of bar code and default hospital limitation it is consistent in one or more.
As the improvement of such scheme, in addition to step:
According to the auditing result of each pathological examination in the pending project, early warning is sent;Wherein, if described treat At least there is the early warning result of a pathological examination in examination & verification project obstructed out-of-date to audit, send the prompting that early warning does not pass through; If the auditing result of each pathological examination is that examination & verification passes through in the pending project, the prompting that early warning passes through is sent;
According to the early warning result of each pending project under the bar code, early warning is sent;Wherein, if under the bar code At least there is the early warning result of a pending project obstructed out-of-date for early warning, send the prompting that early warning does not pass through;If institute The early warning result for stating each pending project under bar code be early warning by when, send the prompting that early warning passes through.
As the improvement of such scheme, it is specially according to the pathological examination that the second database obtains the matching entries:
Other bar codes where the pathological examination of the matching entries is obtained according to second database;
Obtain other described bar codes and obtain corresponding patient information, by the patient information of other bar codes and the bar code Patient information be compared, matched when patient condition and the patient condition of the bar code of other bar codes meet hospital, When sex matching, name matches and the difference at age are less than default threshold value, then the matching is obtained according to other described bar codes The pathological examination of project.Above-mentioned steps can be under the different bar codes of the same patient of quick obtaining matching entries, to judge first item Pathological examination it is whether reasonable.
The embodiment of the present invention additionally provides a kind of examination & verification device detected for hereditary disease gene diagnosis, including:
Judge module, for receiving the instruction of the examination & verification to the pathological examination of the pending project under any bar code, judges institute Whether the detecting system for stating pending project matches with default detecting system, and judge the bar code patient information whether Match with the limitation of default data;
Range determination module, if the detecting system for the pending project matches with default detecting system, and The patient information of the bar code matches with the limitation of default data, it is determined that the seeking scope of default matching entries;Wherein, The matching entries are the project with the advance association of the pending project;
First searching modul, if the seeking scope for default matching entries includes the matching entries under same bar code, But when not including the matching entries under different bar codes, then M pathological examination of the matching entries is obtained according to the first database; Wherein, M >=0;
Second searching modul, if for default matching entries seeking scope include same bar code under matching entries and During matching entries under different bar codes, then N number of testing result of the matching entries is obtained according to the first database;Wherein, N >= 0;
3rd searching modul, for as N=0, then obtaining X detection knot of the matching entries according to the second database Really;Wherein, X >=0;Wherein, the second database includes the testing result of several projects under different bar codes;According to the second data The matching entries that storehouse is obtained need to meet default condition, and the default condition is other bar codes where the matching entries Patient information and the patient information of the bar code where the pending project match;
Auditing module, for when M is more than or equal to 1, N and is more than or equal to 1 or X more than or equal to 1, according to described pending The contradiction condition of core project and matching entries, judges that the pathological examination of the pending project and matching entries whether there is lance Shield, obtains the auditing result of the pathological examination of the pending project;Wherein, if there is contradiction, the pending project The auditing result of pathological examination does not pass through for examination & verification;If in the absence of contradiction, the examination & verification of the pathological examination of the pending project As a result pass through for examination & verification.
Compared with prior art, compared with prior art, the examination & verification device of pathological examination disclosed by the invention is according to reception The examination & verification to pending project arrived is instructed, and is begun through judge module and is judged that the detecting system and patient information of the project are It is no to meet default examination & verification condition;If meeting, the seeking scope of the matching entries is determined by range determination module;If institute The seeking scope for stating matching entries is only limitted to same bar code, then searches described in the first database by the first searching modul Pathological examination with project, if the seeking scope of the matching entries also includes the matching entries under different bar codes, by the Two searching moduls search the pathological examination of the matching entries in the first database and the second database, then by the examination & verification mould Root tuber obtains the examination & verification of the pathological examination of the pending project according to the contradiction condition of default pending project and matching entries As a result, manual analysis and the input compared are largely reduced, error rate is reduced, the efficiency of examination & verification is improved.
Brief description of the drawings
Fig. 1 is that a kind of flow of checking method for hereditary disease gene diagnosis detection in a wherein embodiment of the invention is shown It is intended to.
Fig. 2 is that a kind of flow of checking method for hereditary disease gene diagnosis detection in a wherein embodiment of the invention is shown It is intended to.
Fig. 3 is the schematic flow sheet of step S4 in a wherein embodiment of the invention.
Fig. 4 is that a kind of flow of checking method for hereditary disease gene diagnosis detection in a wherein embodiment of the invention is shown It is intended to.
Fig. 5 is the interface schematic diagram of the default auditing rule of the present invention
Fig. 6 is that pending project audits obstructed out-of-date early warning schematic diagram.
Fig. 7 is that a kind of structure of examination & verification device for hereditary disease gene diagnosis detection in a wherein embodiment of the invention is shown It is intended to.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete Site preparation is described, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.It is based on Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under the premise of creative work is not made Embodiment, belongs to the scope of protection of the invention.
It is a kind of stream for checking method detected for hereditary disease gene diagnosis that the embodiment of the present invention 1 is provided referring to Fig. 1 Journey schematic diagram, including step:
The examination & verification of S1, reception to the pathological examination of the pending project under any bar code is instructed, and judges the pending item Whether purpose detecting system matches with default detecting system, and judge the bar code patient information whether with default money Material limitation matches;
Wherein, the detecting system includes device name, device signal and reagent producer etc., it is possible to understand that, audited Journey need to consider the difference of the result caused by the difference of detecting system.Preferably, the patient information of the bar code and default money Material limitation, which matches, to be specifically included:The patient age of the bar code is in default scope, the Gender of the bar code and pre- If sex limit the consistent and described corresponding information for hospital of bar code and default hospital limit it is consistent in one kind or many Kind.
If S2, the detecting system of the pending project match with default detecting system, and the patient of the bar code Information matches with the limitation of default data, it is determined that the seeking scope of default matching entries;Wherein, the matching entries are With the project of the advance association of the pending project;
Wherein, same patient can correspond to different bar codes, according to the scope of matching entries set in advance, can be treated described Matching entries are searched under examination & verification project bar code, matching entries can be also searched under different bar codes, of same patient can be obtained With project;
It should be understood that the pathological examination type of the pending project and matching entries includes numeric type and text-type, Such as high-risk HPV-DNA testing result is numeric type, and the pathological examination of HPV (HPV16/18-DNA) is text This type (negative or positive).
If the seeking scope of S3, default matching entries includes the matching entries under same bar code, but does not include different bars During the lower matching entries of code, then according to M pathological examination of the first database acquisition matching entries;Wherein, M >=0;Its In, first database includes the testing result of several projects under the bar code;
When M is 0, i.e., matching entries can not be obtained under same bar code, therefore the pending project can not be obtained The auditing result of pathological examination.
If the seeking scope of S4, default matching entries includes under matching entries and different bar codes under same bar code During with project, then N number of testing result of the matching entries is obtained according to the first database;Wherein, N >=0;
S5, as N=0, then X testing result of the matching entries is obtained according to the second database;Wherein, X >=0; Wherein, the second database includes the testing result of several projects under different bar codes;The matching obtained according to the second database Project need to meet default condition, patient information and institute of the default condition for other bar codes where the matching entries The patient information for stating the bar code where pending project matches;
, need to be by specimen information typing (including hospital, project and patient), sample point in the auditing system of the project of inspection Match somebody with somebody, result typing, result submit, result examination & verification, result approval and result issue process.In this programme, first number Include having audited project according to storehouse and the second database, i.e., including having audited the project and announced project do not issued.Wherein The project of issue has also needed time limit requirement, and the time limit need to preset according to the difference of project, to cause the occurrence obtained Mesh has reference significance.
S6, when M be more than or equal to 1, N be more than or equal to 1 or X be more than or equal to 1 when, according to the pending project and Contradiction condition with project, judges that the pathological examination of the pending project and matching entries whether there is contradiction, obtains described The auditing result of the pathological examination of pending project;Wherein, if there is contradiction, the pathological examination of the pending project examine Core result does not pass through for examination & verification;If in the absence of contradiction, the auditing result of the pathological examination of the pending project is logical for examination & verification Cross.
Wherein, the contradiction condition of pending project and matching entries, can experimental the principles of science preset;
When it is implemented, being instructed according to the examination & verification to pending project received, start to judge the detection of the project Whether system and patient information meet default examination & verification condition;If meeting, it is determined that the seeking scope of the matching entries;If institute The seeking scope for stating matching entries is only limitted to same bar code, then the pathology knot of the matching entries is searched in the first database Really, if the seeking scope of matching entries is extended under different bar codes, the matching under same bar code in the first database is first searched Project, when being searched in the first database less than matching entries under same bar code, begins look for different bars in the second database Matching entries under code, according to the contradiction condition of default pending project and matching entries, obtain the pending project The auditing result of pathological examination, largely reduces manual analysis and the input compared, reduces error rate, improves examination & verification Efficiency.
Due to multiple pathological examinations of pending project can be received under same bar code, a pathological examination is often received, Whether just once whether the pathological examination passes through for examination & verification, can be audited according to each pathological examination in pending project and send prompting letter Number, therefore on the basis of above-described embodiment, as shown in Fig. 2 another preferred embodiment also includes step:
S7, the auditing result according to each pathological examination in the pending project, send early warning;Wherein, if institute State in pending project at least that to there is the early warning result of a pathological examination obstructed out-of-date to audit, send that early warning do not pass through carries Show;If the auditing result of each pathological examination is that examination & verification passes through in the pending project, the prompting that early warning passes through is sent;
S8, the early warning result according to each pending project under the bar code, send early warning;Wherein, if the bar At least there is the early warning result of a pending project under code obstructed out-of-date for early warning, send the prompting that early warning does not pass through; If under the bar code early warning result of each pending project be early warning by when, send the prompting that early warning passes through.
By such scheme, gradient is reminded in the early warning from big to small of achievable concept and range, when barcode label be early warning not By when, such as labeled as it is red when, then it represents that exist under the bar code and audit unsanctioned project;It can be obtained according to the bar code The unsanctioned project of examination & verification is checked, equally mark is does not pass through to the project, and the project not passed through by the early warning can Find the pathological examination of abnormality.On the other hand, when barcode label passes through for early warning, is such as labeled as green, then it represents that Project under the bar code, which is audited, to be passed through;When barcode label is space-time, such as white, then it represents that all items under the bar code Auditing result is sky.Certainly, also there is a kind of situation is, when the project and auditing result that pass through under same bar code in the presence of examination & verification are Then it is admixture by the barcode label during project of sky.Said process is applied to the auditing system of inspection project, can subtract While few labor workload, the degree of accuracy is improved, with important directive significance.
Wherein, because the physiology of people is to be in be continually changing process, therefore pathological examination is with ageing.In setting During seeking scope, the first database and the second database need to set the period of the published data of lookup, to ensure occurrence Purpose pathological examination has reference significance.
Preferably, the contradiction condition for stating pending project and matching entries is specially:The pathology knot of the pending project Fruit is that the pathological examination of ascendant trend and the matching entries is downward trend;Wherein, the ascendant trend is more than default The upper limit threshold of term of reference, the downward trend is the lower threshold less than the default term of reference;It is described pending The pathological examination type of project and matching entries is numeric type.It should be understood that the term of reference be Scientific summarization just Normal scope.
Preferably, the contradiction condition of the pending project and matching entries is:The pathological examination of the pending project Less than default numerical value and the pathological examination of matching entries is consistent with default text;Wherein, the pathology knot of the matching entries Fruit type is numeric type, and the pathological examination type of the matching entries is text-type.
In another preferred embodiment, the matching entries include first item and second item, the pending project Contradiction condition with matching entries is specially:The pathological examination of the pending project is less than default numerical value, first item Pathological examination pathological examination consistent and second item with default text is more than default numerical value;Wherein, it is described pending The pathological examination type of project and second item is numeric type, and the pathological examination type of the first item is text-type.
Preferably, as shown in figure 3, specific according to the pathological examination of the second database acquisition matching entries in step S4 For:
S41, other bar codes according to where the pathological examination of second database acquisition matching entries;
S42, obtain other described bar codes and obtain corresponding patient information, by the patient information of other bar codes with it is described The patient information of bar code is compared, when the patient condition of other bar codes and the patient condition of the bar code meet hospital Match somebody with somebody, when sex matching, name matches and the difference at age are less than default threshold value, then obtain described according to other described bar codes Pathological examination with project.
In the step, find after other bar codes of same patient, the matching can be searched under other described bar codes The pathological examination of project, whether reasonably to be referred to as the pathological examination for judging the first item.
Above-mentioned steps are looked into by first searching other bar codes of same patient in historical record, then under other described bar codes Look for matching entries, it is possible to understand that, in another preferred embodiment, the matching entries can be also obtained in the second database Each pathological examination, then judge bar code where the pathological examination of the matching entries whether with the bar code where pending project Match.
In medical system, when the pending project meets specific condition, in order to make a definite diagnosis a certain disease, increase is needed The secondary proof that matching entries pass through as the pending project examination & verification, therefore, as shown in figure 4, a preferred embodiment is also wrapped Include step:
If S9, X are equal to 0, judge whether the pathological examination of the pending project meets default implied condition;
If N is equal to 0, in the absence of the pathological examination of the matching entries of same patient.
If S10, the pathological examination of the pending project meet default implied condition, alerting signal is sent;Wherein, institute State alerting signal be used for remind the reception matching entries pathological examination.
Wherein, the implied condition is usually the voucher for diagnosing a certain disease, such as two double of results are that great three positive can be made To diagnose a kind of voucher of hepatitis B, but the pathological examination of the pending project is when meeting default implied condition, can not Determine whether the pathological examination is accurate, when the pathological examination is inaccurate, it is most likely that occur the situation of disease mistaken diagnosis.Therefore it is The accuracy of the above-mentioned pathological examination of checking, need to send alerting signal to remind and receive the pathological examinations of the matching entries, from And the pathological examinations of the matching entries is obtained as the standard for auditing the first item, the assistant that can be also made a definite diagnosis as disease Card.For example, when two double of results are great three positive, within the default period, system does not receive liver function seven, then can send out Go out alerting signal.
It is previously mentioned, need to be by specimen information typing (including hospital, project and disease in the auditing system of the project of inspection People), sample distribution, result typing, result submit, result examination & verification, result approval and result issue process.It is preferable to carry out one In example, when the issue for receiving any project to be released is instructed, check whether the pathological examination of band issue project meets pre- If conditions for diagnostics, if meet default conditions for diagnostics, show corresponding diagnosis content.
It should be noted that above-mentioned be applied to that examination & verification rule can be preset for the checking method that hereditary disease gene diagnosis is detected Auditing system then, as shown in figure 5,1. being limited for default data, it can be seen that data is limited to sex for female, and the age needs big It is 2. default detecting system in 20 years old, including device name, unit type and reagent producer, 3. combined for the examination & verification of setting, 4. the pending project and matching entries included for examination & verification combination, including HbA2, β-thalassemia Genotyping (17 kinds of mutation) and β-thalassemia (HBB) sequencing, the pending project and matching entries are relative concept, and Do not specify;5. it is the seeking scope of the matching entries set, when being set to 0 day, represents that seeking scope only includes same bar Matching entries under code;When being set to non-zero day, represent that the scope searched is included with the occurrence under bar code and under different bar codes Mesh, is 6. the logical contradiction relation of setting, then thinks described when pending project and matching entries meet logical contradiction relation Pending project examination & verification does not pass through.Based on the auditing rule in Fig. 5, the auditing result of pending project can be automatically obtained.Wherein, When choosing " non-" in Figure 5,6. for setting normal condition relation, i.e., be normal condition when meeting logical relation 6., It is abnormality when being unsatisfactory for logical relation 6..
If for example, as shown in fig. 6, pending project is HbA2, matching entries are β-thalassemia genes Parting (17 kinds of mutation) and β-thalassemia (HBB) sequencing, if HbA2 result is poor more than 5, β-Mediterranean Blood Genotyping (17 kinds of mutation) result that result is " being not detected by mutation ", β-thalassemia (HBB) is sequenced is feminine gender, Pathogenic gene mutation is not detected by, then the auditing result of HbA2 does not pass through for examination & verification, then three under the bar code Individual project sends early warning, and the early warning of display is thalassemia testing result contradiction, and determines that the bar code is Examination & verification does not pass through, and shows that early warning does not pass through.In addition, when the state of the project under the bar code is that examination & verification passes through, this Code is shown as early warning and passed through;When the state of the project of the bar code, which includes examination & verification, to be passed through and do not audit, the bar code is shown as treating Confirm;When the state of the project of the bar code is not audit, the bar code is shown as no early warning.Wherein, early warning not by, it is pre- Police passes through, to be confirmed and without early warning state need to be distinguished by different colors.
It is a kind of structural representation of the examination & verification device for pathological examination that a wherein embodiment of the invention is provided referring to Fig. 7, Including:
Judge module 101, for receiving the instruction of the examination & verification to the pathological examination of the pending project under any bar code, judges Whether the detecting system of the pending project matches with default detecting system, and judges that the patient information of the bar code is It is no to match with the limitation of default data;
Range determination module 102, if the detecting system for the pending project matches with default detecting system, And the patient information of the bar code matches with the limitation of default data, it is determined that the seeking scope of default matching entries;Its In, the matching entries are the project with the advance association of the pending project;
First searching modul 103, if the seeking scope for default matching entries includes the occurrence under same bar code Mesh, but when not including the matching entries under different bar codes, then M pathology knot of the matching entries is obtained according to the first database Really;Wherein, M >=0;
Second searching modul 104, if including under same bar code for the seeking scope for default matching entries During with matching entries under project and different bar codes, then N number of testing result of the matching entries is obtained according to the first database; Wherein, N >=0;
3rd searching modul 105, for as N=0, then obtain the matching entries according to the second database X to examine Survey result;Wherein, X >=0;Wherein, the second database includes the testing result of several projects under different bar codes;According to second The matching entries that database is obtained need to meet default condition, and the default condition is other where the matching entries The patient information and the patient information of the bar code where the pending project of code match;
Auditing module 106, for when M is more than or equal to 1, N and is more than or equal to 1 or X more than or equal to 1, according to described The contradiction condition of pending project and matching entries, judges that the pathological examination of the pending project and matching entries whether there is Contradiction, obtains the auditing result of the pathological examination of the pending project;Wherein, if there is contradiction, the pending project Pathological examination auditing result for examination & verification do not pass through;If in the absence of contradiction, the pathological examination of the pending project is examined Core result passes through for examination & verification.
To sum up, the checking method disclosed by the invention detected for hereditary disease gene diagnosis is according to receiving to pending The examination & verification instruction of project, starts to judge whether the detecting system and patient information of the project meet default examination & verification condition;If Meet, it is determined that the seeking scope of the matching entries;If the seeking scope of the matching entries is only limitted to same bar code, The pathological examination of the matching entries is searched in first database, if the seeking scope of matching entries is extended under different bar codes When, the matching entries under same bar code in the first database are first searched, when being searched in the first database less than under same bar code During matching entries, begin look in the second database the matching entries under different bar codes, according to default pending project and Contradiction condition with project, obtains the auditing result of the pathological examination of the pending project, largely reduces artificial Analysis and the input compared, reduce error rate, improve the efficiency of examination & verification.
Described above is the preferred embodiment of the present invention, it is noted that for those skilled in the art For, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications are also considered as Protection scope of the present invention.

Claims (10)

1. a kind of checking method detected for hereditary disease gene diagnosis, it is characterised in that including step:
Receive the examination & verification to the pathological examination of the pending project under any bar code to instruct, judge the detection of the pending project Whether system matches with default detecting system, and judges whether the patient information of the bar code limits phase with default data Matching;
If the detecting system of the pending project matches with default detecting system, and the patient information of the bar code with it is pre- If data limitation match, it is determined that the seeking scope of default matching entries;Wherein, the matching entries are to be treated with described The project of the advance association of examination & verification project;
If the seeking scope of default matching entries includes the matching entries under same bar code, but does not include under different bar codes During with project, then M pathological examination of the matching entries is obtained according to the first database;Wherein, M >=0;Wherein, described One database includes the testing result of several projects under the bar code;
If the seeking scope of default matching entries includes the matching entries under matching entries and different bar codes under same bar code When, then N number of testing result of the matching entries is obtained according to the first database;Wherein, N >=0;
As N=0, then X testing result of the matching entries is obtained according to the second database;Wherein, X >=0;Wherein, Two databases include the testing result of several projects under different bar codes;It need to be expired according to the matching entries that the second database is obtained The default condition of foot, the default condition be other bar codes where the matching entries patient information with it is described pending The patient information of bar code where project matches;
When M, which is more than or equal to 1, N, is more than or equal to 1 or X more than or equal to 1, according to the pending project and matching entries Contradiction condition, judge that the pathological examination of the pending project and matching entries whether there is contradiction, obtain described pending The auditing result of the pathological examination of project;Wherein, if there is contradiction, the auditing result of the pathological examination of the pending project Do not pass through for examination & verification;If in the absence of contradiction, the auditing result of the pathological examination of the pending project passes through for examination & verification.
2. the checking method detected as claimed in claim 1 for hereditary disease gene diagnosis, it is characterised in that described pending The pathological examination type of project and matching entries includes numeric type and text-type.
3. the checking method detected as claimed in claim 2 for hereditary disease gene diagnosis, it is characterised in that described pending The contradiction condition of project and matching entries is specially:
The pathological examination of the pending project is that the pathological examination of ascendant trend and the matching entries is downward trend;Its In, the ascendant trend is the upper limit threshold more than default term of reference, and the downward trend is less than the default ginseng Examine the lower threshold of scope;The pathological examination type of the pending project and matching entries is numeric type.
4. the checking method detected as claimed in claim 2 for hereditary disease gene diagnosis, it is characterised in that described pending The contradiction condition of project and matching entries is:
The pathological examination of the pending project is less than default numerical value and the pathological examination of matching entries and default text one Cause;Wherein, the pathological examination type of the matching entries is numeric type, and the pathological examination type of the matching entries is text Type.
5. the checking method detected as claimed in claim 2 for hereditary disease gene diagnosis, it is characterised in that the occurrence Mesh includes first item and second item, and the contradiction condition of the pending project and matching entries is specially:
It is consistent with default text that the pathological examination of the pending project is less than default numerical value, the pathological examination of first item And the pathological examination of second item is more than default numerical value;Wherein, the pathological examination of the pending project and second item Type is numeric type, and the pathological examination type of the first item is text-type.
6. the checking method detected as claimed in claim 1 for hereditary disease gene diagnosis, it is characterised in that also including step Suddenly:
If X is equal to 0, judge whether the pathological examination of the pending project meets default implied condition;
If the pathological examination of the pending project meets default implied condition, alerting signal is sent;Wherein, it is described to remind letter Number it is used to remind the pathological examination for receiving the matching entries.
7. the checking method detected as claimed in claim 1 for hereditary disease gene diagnosis, it is characterised in that the bar code Patient information matches with the limitation of default data to be specifically included:The patient age of the bar code in default scope, it is described The Gender of bar code and default sex limit the consistent and described corresponding information for hospital of bar code and the limitation of default hospital One or more in consistent.
8. the checking method detected as claimed in claim 1 for hereditary disease gene diagnosis, it is characterised in that also including step Suddenly:
According to the auditing result of each pathological examination in the pending project, early warning is sent;Wherein, if described pending At least there is the early warning result of a pathological examination in project obstructed out-of-date to audit, send the prompting that early warning does not pass through;If institute When the auditing result for stating each pathological examination in pending project is that examination & verification passes through, the prompting that early warning passes through is sent;
According to the early warning result of each pending project under the bar code, early warning is sent;Wherein, if under the bar code at least Early warning result in the presence of a pending project is obstructed out-of-date for early warning, sends the prompting that early warning does not pass through;If the bar Under code the early warning result of each pending project be early warning by when, send the prompting that early warning passes through.
9. the checking method detected as claimed in claim 1 for hereditary disease gene diagnosis, it is characterised in that according to the second number The pathological examination for obtaining the matching entries according to storehouse is specially:
Other bar codes where the pathological examination of the matching entries is obtained according to second database;
Obtain other described bar codes and obtain corresponding patient information, by the patient information of other bar codes and the trouble of the bar code Person's information is compared, and is matched when patient condition and the patient condition of the bar code of other bar codes meet hospital, sex When matching, name matches and the difference at age are less than default threshold value, then the matching entries are obtained according to other described bar codes Pathological examination.
10. a kind of examination & verification device detected for hereditary disease gene diagnosis, it is characterised in that including:
Judge module, instructs for receiving the examination & verification to the pathological examination of the pending project under any bar code, is treated described in judgement Whether the detecting system of examination & verification project matches with default detecting system, and judge the bar code patient information whether with advance If data limitation match;
Range determination module, if the detecting system for the pending project matches with default detecting system, and it is described The patient information of bar code matches with the limitation of default data, it is determined that the seeking scope of default matching entries;Wherein, it is described Matching entries are the project with the advance association of the pending project;
First searching modul, if the seeking scope for default matching entries includes the matching entries under same bar code, but not During including matching entries under different bar codes, then M pathological examination of the matching entries is obtained according to the first database;Its In, M >=0;
Second searching modul, if the seeking scope for default matching entries includes the matching entries and difference under same bar code During matching entries under bar code, then N number of testing result of the matching entries is obtained according to the first database;Wherein, N >=0;
3rd searching modul, for as N=0, then obtaining X testing result of the matching entries according to the second database; Wherein, X >=0;Wherein, the second database includes the testing result of several projects under different bar codes;According to the second database The matching entries of acquisition need to meet default condition, the trouble of other bar codes of the default condition where the matching entries The patient information of person's information and the bar code where the pending project matches;
Auditing module, for when M is more than or equal to 1, N and is more than or equal to 1 or X more than or equal to 1, according to the pending item The contradiction condition of mesh and matching entries, judges that the pathological examination of the pending project and matching entries whether there is contradiction, obtains Obtain the auditing result of the pathological examination of the pending project;Wherein, if there is contradiction, the pathology knot of the pending project The auditing result of fruit does not pass through for examination & verification;If in the absence of contradiction, the auditing result of the pathological examination of the pending project is Examination & verification passes through.
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