CN107174741A - Transcranial magnetic stimulation system based on the orthogonal splayed coil group of magnetic resonance manifold type - Google Patents
Transcranial magnetic stimulation system based on the orthogonal splayed coil group of magnetic resonance manifold type Download PDFInfo
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- CN107174741A CN107174741A CN201710231103.2A CN201710231103A CN107174741A CN 107174741 A CN107174741 A CN 107174741A CN 201710231103 A CN201710231103 A CN 201710231103A CN 107174741 A CN107174741 A CN 107174741A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
Abstract
The present invention provides a kind of transcranial magnetic stimulation system based on the orthogonal splayed coil group of magnetic resonance manifold type, and the system constitutes splayed coil group by splayed coil I and coil II are orthogonal.Circumscribed between the first resonance coil, the second resonance coil in system, the 3rd resonance coil and the 4th resonance coil are circumscribed, and four resonance coils are internal diameter 56mm, external diameter 62mm；Corresponding four groups of source coils and the concyclic heart of resonance coil, the size of four source coils is internal diameter 30mm, external diameter 36mm.When beneficial effect effect is that the system source coil is passed through same intensity electric current, for encephalic with the increase of even depth affected part stimulus intensity；The capacity usage ratio being transmitted to by source coil on skull model is improved more than three times.While raising energy utilization efficiency and reduction exciting current intensity requirement is met, can realize stimulates the reinforcement of depth, while increasing the accuracy of target position stimulation.
Description
Technical field
Gained knowledge the present invention relates to biomedical engineering electromagnetism, so as to propose a kind of based on orthogonal eight word of magnetic resonance manifold type
The transcranial magnetic stimulation system of shape coil group.
Background technology
Electromagnetic field effect can produce certain biological effect when organism, this be biological electrical field developing direction it
One.Transcranial magnetic stimulation (TMS) is a kind of noninvasive biostimulation technology, and it produces induction field using time-varying magnetic field, causes biology
Electric current conducts in the tissue, changes the action potential of Cerebral Cortex Neuronal Cells, the metabolism of influence intracerebral and neural electrical activity.Since
Barker in 1985 et al. successfully using Neural stem cell technology realized first on human body corticocerebral nervous centralis stimulate with
Come, TMS just gets more and more people's extensive concerning.TMS devices mainly include pulse current generating loop and magnetic stimulating coil, often now
Coil has circular coil, splayed coil, quatrefoil coil, H-shaped coil etc..However, the coil topology existed can not be by
The stimulus intensity that induction field focuses on target area and is maintained on brain surface, so as to affect deep brain response to treatment.Thorn
It is to judge the most important factor of TMS systematic functions to swash intensity, depth and focusing.
In recent years, scientific research personnel has been carried out a large amount of trials to improve the stimulation depth of TMS systems and the performance of focus.
Since Ueno et al. proposed first splayed coil in 1988, it is often made in scientific research and clinical test after
With.Splayed coil is placed in same plane by two single circular coils (or multiturn circular coil) and forms splayed structure；When using
Reverse current is passed through in two (group) coils, the focusing magnetic field of generation is located at the lower section of both wings coil the tangent, then two
There is maximum in (group) coil intersection magnetic field intensity, rate of change, the stimulus used using this electric field induced as diagnosis and treatment.
However, the technology there is also some problems at present, wherein it is the most prominent be traditional splayed coil stimulation it is strong
Spend and depth, the focus level stimulated and stimulate Shortcomings between efficiency, it is impossible to accurately and effectively stimulation target.Enough
Stimulate depth that tissue of the magnetic stimulator below human body surface can be made still to have certain stimulus intensity, so could be to encephalic
Nerve fiber is effectively stimulated.High degree of focus can reduce field stimulation, and enhancing stimulates specific aim, reduces to non-target tissue
Influence.Traditional splayed coil is as a kind of common TMS stimulus configuration, it is advantageous that stimulation can be improved preferably
Focusing, but its penetration depth stimulated is reduced, and stimulate less efficient, meanwhile, it needs high power and high current, no
Beneficial to TMS family expenses.
The content of the invention
The deficiency existed for existing TMS technologies, the present invention proposes a kind of the improved new of combination magnetic resonance coupling principle
The transcranial magnetic stimulation system of the orthogonal splayed coil group of type.The feelings in enhancing stimulus intensity and focus level are realized using the system
Under condition, energy supply is reduced, while improving stimulates efficiency, so that realize more accurately and effectively stimulates than traditional splayed coil
Target.
To achieve the above object, the technical solution adopted by the present invention is to provide orthogonal eight word based on magnetic resonance coupling principle
Shape coil group transcranial magnetic stimulation system, wherein：The orthogonal splayed coil group transcranial magnetic stimulation system includes circuit topology I
With circuit topology II, circuit topology I includes the circumscribed composition splayed loop constructions of first coil unit A and the second coil unit B,
Circuit topology II is by tertiary coil unit C and the 4th coil unit D is circumscribed constitutes splayed loop construction；First coil unit A
Include the first source coil, the first resonance coil, the second coil unit B includes the second source coil, the second resonance coil, the 3rd
Coil unit C includes the 3rd source coil, the 3rd resonance coil, and the 4th coil unit D includes the 4th source coil, the 4th resonance
Coil；First resonance coil, the second resonance coil are circumscribed, and the 3rd resonance coil, the 4th resonance coil are circumscribed, each coil unit
In all concyclic heart of source coil and resonance coil, and the internal diameter and external diameter of source coil are 30mm, 36mm respectively, resonance coil
Internal diameter and external diameter are 56mm, 62mm respectively.
The effect of the present invention is the orthogonal splayed coil group transcranial magnetic stimulation system compared with conventional orthogonal splayed coil group
There is the advantage of obvious stimulus intensity in transcranial magnetic stimulation system, locally stimulus intensity can be made to improve 3.6 times or so, implement thorn
When swashing, if being provided to source coil and traditional splayed coil group identical current strength, due to the presence of resonance coil, MRC is just
Hand over the energy conduction efficiency of splayed coil groupImproved more than three times compared to conventional orthogonal splayed coil group.
Brief description of the drawings
Fig. 1 is the circuit of the orthogonal splayed coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention
Topological diagram；
Fig. 2-1, Fig. 2-2 be respectively conventional orthogonal splayed coil group and the present invention based on magnetic resonance coupling principle just
Hand over the coil space configuration picture of splayed coil group transcranial magnetic stimulation system；
Fig. 3-1-1, Fig. 3-1-2 be respectively conventional orthogonal splayed coil group and the present invention based on magnetic resonance coupling principle
Orthogonal splayed coil group transcranial magnetic stimulation system stimulates the simulation comparison figure of focusing at selected depth, and Fig. 3-1-3 are magnetic
The size of induction.
Fig. 4-1 is for conventional orthogonal splayed coil group with the present invention based on the orthogonal splayed coil of magnetic resonance coupling principle
Magnetic induction intensity comparison diagram when group transcranial magnetic stimulation system is stimulated at brain epidermis；
Fig. 4-2 is for conventional orthogonal splayed coil group with the present invention based on the orthogonal splayed coil of magnetic resonance coupling principle
Induced current density comparison diagram when group transcranial magnetic stimulation system is stimulated at brain epidermis；
Fig. 5 is for conventional orthogonal splayed coil group with the present invention based on the orthogonal splayed coil group of magnetic resonance coupling principle
The stimulus intensity of transcranial magnetic stimulation system and stimulation efficiency comparative scheme.
In figure：
1st, the first source coil 2, the first resonance coil 3, the second source coil
4th, the second resonance coil 5, the 3rd source coil 6, the 3rd resonance coil
7th, the 4th source coil 8, the 4th resonance coil A, first coil unit
B, the second coil unit C, tertiary coil cells D, the 4th coil unit
Ⅰ、Ⅱ：Splayed coil topology structure
Embodiment
With reference to orthogonal splayed coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle of the accompanying drawing to the present invention
Structure be described.
The design philosophy of the orthogonal splayed coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention
It is the frequency sensitivity using magnetic resonance coupled system, improves tradition based on orthogonal splayed coil group structure design
The circuit topology and coil space configuration of transcranial magnetic stimulation technology, realize stimulus intensity, stimulate depth and stimulate efficiency equal
Meeting desired target position stimulates.
The orthogonal splayed coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle that Fig. 1 show the present invention is complete
The circuit topological structure of whole splayed coil.Orthogonal splayed coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle
Structure be：Described orthogonal splayed coil system is united, and the splayed coil being made up of circuit topology I and II is orthogonal to constitute line
Circle group.Wherein, circuit topology I includes the circumscribed composition splayed loop constructions of first coil unit A and the second coil unit B, electricity
Road topology II is by tertiary coil unit C and the 4th coil unit D is circumscribed constitutes splayed loop construction.First coil unit A by
First source coil 1, the first resonance coil 2 are constituted, and the second coil unit B is made up of the second source coil 3, the second resonance coil 4, the
Three-winding unit C is made up of the 3rd source coil 5, the 3rd resonance coil 6, and the 4th coil unit D is humorous by the 4th source coil the 7, the 4th
The coil 8 that shakes is constituted.First resonance coil 2, the second resonance coil 4 are circumscribed, and the 3rd resonance coil 6, the 4th resonance coil 8 are circumscribed.
Source coil and the concyclic heart of resonance coil in each coil unit, and source coil internal diameter and external diameter be respectively 30mm,
36mm, the internal diameter and external diameter of resonance coil are 56mm, 62mm respectively.
In the system, first coil unit A circuit structure is described as follows：Circuit unit is by handing over where first source coil
Flow power supply AC1, resistance Rs1, inductance Ls1, electric capacity Cs1It is in series, circuit unit is by resistance R where the first resonance coilr1, inductance
Lr1, electric capacity Cr1It is in series.Inductance Ls1And Lr1Between there is mutual inductance, mutual inductance is M1.Second coil unit B circuit knot
Structure is described as follows：Circuit unit is by AC power AC where second source coil2, resistance Rs2, inductance Ls2, electric capacity Cs2It is in series,
Circuit unit is by resistance R where second resonance coilr2, inductance Lr2, electric capacity Cr2It is in series.Inductance Ls2And Lr2Between exist it is mutual
Sense, mutual inductance is M2.Tertiary coil unit C circuit structure is described as follows：Circuit unit is by exchanging where 3rd source coil
Power supply AC3, resistance Rs3, inductance Ls3, electric capacity Cs3It is in series, circuit unit is by resistance R where the 3rd resonance coilr3, inductance
Lr3, electric capacity Cr3It is in series.Inductance Ls3And Lr3Between there is mutual inductance, mutual inductance is M3.4th coil unit D circuit knot
Structure is described as follows：Circuit unit is by AC power AC where 4th source coil4, resistance Rs4, inductance Ls4, electric capacity Cs4It is in series,
Circuit unit is by resistance R where 4th resonance coilr4, inductance Lr4, electric capacity Cr4It is in series.Inductance Ls4And Lr4Between exist it is mutual
Sense, mutual inductance is M4。
Described first coil unit A, the second coil unit B is combined into splayed coil I, tertiary coil unit C and
Four coil unit D are combined into splayed coil II, coil I and the orthogonal composition splayed coil group of coil II.Constituted splayed
The midpoint discharge current direction that two coil unit centers of coil are tangent is consistent, by coil I in the design use of instrument
Target position stimulation point is corresponded to the middle part of the splayed coil group of the orthogonal composition of coil II.
First in the first coil unit A, the second coil unit B, tertiary coil unit C and the 4th coil unit D
Source coil 1, the first resonance coil 2, the second source coil 3, the second resonance coil 4, the 3rd source coil 5, the 3rd resonance coil 6, the
Circuit unit where four source coils 7, the 4th resonance coil 8, each circuit parameter makes each circuit unit constitute resonance circuit.
During work operation, resonance occurs simultaneously for the circuit part where this four coil units, and resonant frequency is AC power AC
Frequency of supply ω0, at the same time source coil and resonance coil result in reactive power in maximum current value, resonance circuit
Loss is zero.In addition, the first coil unit A and the second coil unit B, tertiary coil unit C and the 4th coil unit D are retouched
The two single resonance coils stated are all placed in same plane respectively, and each point of contact intersection is stimulation target spot.
Orthogonal splayed coil group transcranial magnetic stimulation system proposed by the present invention depends on magnetic resonance coupling principle.Splayed
Coil I and II constitutes the overall electricity of the orthogonal splayed structure coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle
Road, the first source coil 1 and the first resonance coil 2, the second source coil 3 and the second resonance coil 4, the 3rd source coil 5 and the 3rd are humorous
It is all the biography that electric energy is realized by the principle of electromagnetic induction to shake between the source coil 7 of coil 6 and the 4th and the 4th resonance coil 8
Pass.
By designing the circuit parameter of the first source coil 1, the first resonance coil 2 in circuit topology first coil unit A, make
Each circuit unit constitutes resonance circuit, meets resonance characteristic, i.e.,
In second coil unit B, tertiary coil unit C and the 4th coil unit D, the parameter of circuit topology
It is identical with parameter designing in A, it can obtain
For the second coil unit B, have
For tertiary coil unit C, have
For the 4th coil unit D, have
Therefore, resonance occurs simultaneously in the course of the work for each circuit unit, and its resonant frequency is AC power AC confession
Electric frequencies omega0.At the same time source coil, resonance coil can obtain reactive power consumption in maximum current value, resonance circuit
It is zero, being so beneficial to improve stimulates efficiency.
By taking first coil unit A as an example, illustrate new coil topological structure.In first coil unit A, the first source coil 1,
First resonance coil is arranged in co-axial alignment, and the first source coil 1 and the first resonance coil 2 are in the same plane of space, this
Space structure make it that the coefficient of coup of the first source coil 1 and the first resonance coil 2 is big compared with the coefficient of coup of other arrangement architectures, the
The close coupling relation of one resonance coil 2 and the first source coil 1, it is ensured that the first resonance coil 2 is by electromagnetic induction from the first source
Coil 1 obtains higher energy.
Fig. 2-1, Fig. 2-2 are conventional orthogonal splayed coil group and the orthogonal splayed based on magnetic resonance coupling principle respectively
The coil space configuration of coil group transcranial magnetic stimulation system.Coil 1-8 in Fig. 2-2 corresponds respectively to A, B, C, D tetra- in Fig. 1
Source coil, resonance coil in coil unit.Orthogonal eight word based on magnetic resonance coupling principle is can clearly be seen that by Fig. 2-2
The coil spread pattern of shape coil group transcranial magnetic stimulation system.
Fig. 3-1-1, Fig. 3-1-2 are respectively described in conventional orthogonal splayed coil group and based on magnetic resonance coupling principle
Under orthogonal splayed coil group transcranial magnetic stimulation system is stimulated, the magnetic induction inside the depth apart from scalp surface 4mm, head
The focus condition of intensity.Wherein, Fig. 3-1-3 are the sizes of magnetic induction intensity.By Fig. 3-1-1, Fig. 3-1-2 it is recognised that
Orthogonal splayed coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle compares conventional orthogonal splayed coil group, thorn
Swash and more concentrate, degree of focus is higher, and stimulus intensity is bigger.
Fig. 4-1, Fig. 4-2 are respectively described in conventional orthogonal splayed coil group and based on the orthogonal of magnetic resonance coupling principle
Under splayed coil group transcranial magnetic stimulation system is stimulated, the distribution pair of skull model top layer magnetic induction intensity and induced current density
The situation of ratio.In Fig. 4-1, Fig. 4-2, conventional orthogonal splayed coil group and the orthogonal splayed coil based on magnetic resonance coupling principle
Magnetic induction intensity and density peak value under the system stimulation of group transcranial magnetic stimulation are both present in most short with coil point of contact distance
On target site.From Fig. 4-1, Fig. 4-2 it can be seen that, conventional orthogonal splayed coil group and based on magnetic resonance coupling principle just
Hand over splayed coil group transcranial magnetic stimulation system stimulate the peak value of lower resulting magnetic induction intensity be respectively 0.1868mT,
0.7544mT；Induced current density peak value is 1.291mA/m respectively2、5.951mA/m2, i.e., of the invention is coupled based on magnetic resonance
The orthogonal splayed coil group transcranial magnetic stimulation system of principle is compared with conventional orthogonal splayed coil group, local excitation intensity energy
Enough improve nearly 3.6 times.
Fig. 5 show conventional orthogonal splayed coil group and the orthogonal splayed coil group warp based on magnetic resonance coupling principle
Cranium magnetic stimulation system energy utilization efficiency and local excitation intensity contrast figure.Based on magnetic resonance coupling it can be seen from data in figure
The orthogonal splayed coil group transcranial magnetic stimulation system of principle is closed compared with conventional orthogonal splayed coil group, local excitation intensity
Nearly 3.6 times are improved, energy utilization efficiency is improved more than 3 times.
Claims (3)
1. a kind of orthogonal splayed coil group transcranial magnetic stimulation system based on magnetic resonance coupling principle, it is characterized in that：It is described just
Splayed coil group transcranial magnetic stimulation system is handed over to include circuit topology I and circuit topology II, circuit topology I includes first coil
Unit A and the second coil unit B is circumscribed to constitute splayed loop construction, and circuit topology II is by tertiary coil unit C and the 4th line
Coil unit D is circumscribed to constitute splayed loop construction；First coil unit A includes the first source coil (1), the first resonance coil
(2), the second coil unit B includes the second source coil (3), the second resonance coil (4), and tertiary coil unit C includes the 3rd
Source coil (5), the 3rd resonance coil (6), the 4th coil unit D include the 4th source coil (7), the 4th resonance coil (8)；The
One resonance coil (2), the second resonance coil (4) are circumscribed, and the 3rd resonance coil (6), the 4th resonance coil (8) are circumscribed, each line
The all concyclic heart of source coil and resonance coil in coil unit, and the internal diameter and external diameter of source coil are 30mm, 36mm, resonance respectively
The internal diameter and external diameter of coil are 56mm, 62mm respectively；
The first coil unit A of system circuit structure is：Circuit unit is by AC power AC where first source coil1, electricity
Hinder Rs1, inductance Ls1, electric capacity Cs1Circuit unit is by resistance R where series connection, the first resonance coilr1, inductance Lr1, electric capacity Cr2Series connection,
Inductance Ls1And Lr1Between there is mutual inductance, mutual inductance is M1；Second coil unit B circuit structure is：Where second source coil
Circuit unit is by AC power AC2, resistance Rs2, inductance Ls2, electric capacity Cs2It is in series, circuit unit where the second resonance coil
By resistance Rr2, inductance Lr2, electric capacity Cr2Series connection, inductance Ls2And Lr2Between there is mutual inductance, mutual inductance is M2；Tertiary coil unit C
Circuit structure be described as follows：Circuit unit is by AC power AC where 3rd source coil3, resistance Rs3, inductance Ls3, electric capacity Cs3
It is in series, circuit unit is by resistance R where the 3rd resonance coilr3, inductance Lr3, electric capacity Cr3Series connection, inductance Ls3And Lr3Between
There is mutual inductance, mutual inductance is M3；4th coil unit D circuit structure is described as follows：Circuit unit where 4th source coil
By AC power AC4, resistance Rs4, inductance Ls4, electric capacity Cs4It is in series, circuit unit is by resistance R where the 4th resonance coilr4、
Inductance Lr4, electric capacity Cr4Series connection, inductance Ls4And Lr4Between there is mutual inductance, mutual inductance is M4；
Described first coil unit A, the second coil unit B is combined into splayed coil I, tertiary coil unit C and the 4th line
Coil unit D is combined into splayed coil II, coil I and the orthogonal composition splayed coil group of coil II, constitutes splayed coil
The tangent midpoint discharge current direction in two coil unit centers it is consistent, by coil I and eight words of the orthogonal composition of coil II
The middle part of shape coil group corresponds to target position stimulation point.
2. the orthogonal splayed coil group transcranial magnetic stimulation system according to claim 1 based on magnetic resonance coupling principle,
It is characterized in that：Where in the first coil unit A, the second coil unit B, tertiary coil unit C, the 4th coil unit D
Circuit unit, each circuit parameter makes each circuit unit constitute resonance circuit；During work operation, the first source coil (1), first
Circuit unit where resonance coil (2), circuit unit where the second source coil (3), the second resonance coil (4), the 3rd source coil
(5) simultaneously resonance occurs for, the 3rd resonance coil (6), the circuit unit where the 4th source coil (7), the 4th resonance coil (8),
And resonant frequency is AC power AC frequency of supply ω0, at the same time four source coils and four resonance coils can
It is zero to obtain reactive power loss in maximum current value, resonance circuit.
3. the orthogonal splayed coil group transcranial magnetic stimulation system according to claim 1 based on magnetic resonance coupling principle,
It is characterized in that：Two single resonance coils of the first coil unit A and the second coil unit B descriptions are placed in same plane, the
Two single resonance coils of three-winding unit C and the 4th coil unit D descriptions are placed in same plane, and each point of contact intersection is stimulation
Target spot.
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Cited By (1)
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| CN109260595A (en) * | 2018-11-08 | 2019-01-25 | 深圳英智科技有限公司 | Cerebral magnetic stimulation coil and preparation method thereof |
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Application publication date: 20170919 |