CN101357251B - Multichannel nerve electric stimulation transmission device based on micro-coil array - Google Patents
Multichannel nerve electric stimulation transmission device based on micro-coil array Download PDFInfo
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- CN101357251B CN101357251B CN2008100703073A CN200810070307A CN101357251B CN 101357251 B CN101357251 B CN 101357251B CN 2008100703073 A CN2008100703073 A CN 2008100703073A CN 200810070307 A CN200810070307 A CN 200810070307A CN 101357251 B CN101357251 B CN 101357251B
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Abstract
The invention discloses a microcoil array-based multichannel electrical nerve stimulation transmission device. The device comprises a stimulation signal generation and emission unit array and a stimulation signal receiving unit array; the stimulation signal generation and emission unit array consists of a plurality of arranged stimulation signal generation and emission units, and the stimulation signal receiving unit array consists of a plurality of arranged stimulation signal receiving units. The stimulation signal generation and emission unit is composed of a transmitting coil, a power amplifier, an AM modulation circuit, a pulse signal generation circuit and a high-frequency oscillation circuit, and is used for setting amplitude, frequency and pulse width of the stimulation pulse which is coupled to a receiving coil implanted in body by a transmitting coil in a form of a high-frequency resonance electromagnetic field, and supplied to stimulating electrodes. The device executes parallel signal transmission by a plurality of channels established by the microcoil array, signals between channels are independently transmitted by carrier signals with different frequencies, thus the device has high economic benefits and social benefits.
Description
Technical field
The invention belongs to a kind of Medical Instruments technical field, particularly the transdermal multichannel nerve electric stimulation transmission device of implantable medical device.
Background technology
The implantation medical equipment kind is a lot, and range of application is also very wide, as brain stimulation device, spinal cord stimulation device, peripheral nerve stimulation device, muscle stimulator, cochlear implant and artificial vision's prosthese etc.These instruments all belong to the nerve electric stimulation system in essence, principle is a characteristic of utilizing the impaired back neuronal function up and down of nerve conduction bundle to remain, by electrode and the coupling of the neural broken ends of fractured bone, apply the repetition pulse electrical stimulation signal, utilize nerve that the Artificial Control signal that adds is transmitted in its response, thereby produce and excite naturally duplicate neural impulse, realize the regeneration of nerve signal, the function of nervous system of decline is rebuild, reach the purpose of treatment or functional rehabilitation and reconstruction.
The initial application of electricity irritation is by placing electrode stimulating nerve, the muscle on the skin, the therapeutical effect that plays pain relieving, improves blood circulation, exercises one's muscles.Nearly decades, along with the development of neuromedicine, and the dissection location of disease and the understanding of the cause of disease deepened gradually, there is the people to adopt corresponding neural position to implement the therapy of electricity irritation and obtain obvious curative effects to medicine and the unconspicuous patient of operative treatment.At present, along with subject development such as biology, electronics and materialogies, the development of implantable nerve stimulating technology rapidly, worked out different implantable nerve stimulation apparatus, typically have U.S. Medtronic company pain therapeutic equipment, deep brain stimulation device (Deep Brain Stimulator, DBS) and the implantation cochlear implant of Australian Cochlear company etc.In recent years, the domestic research of also carrying out this respect, Li Gangs etc. have reported a kind of implanted deep brain stimulation system that body internal stimulus device battery is carried out wireless charging by external controller in Chinese patent (application number 200410019937.x); Li Luming etc. have reported a kind of implantable nerve electric pulse stimulation system that can external software upgrading in Chinese patent (application number 200510116704.6).
But be point-to-point communication between the peripheral control unit of above-mentioned these implantable stimulation systems and the stimulator for implantation in vivo, only can stimulate, can't be applied to the nerve stimulation that needs multichannel, many target spots to stimulate single nerve or local muscle.A perfect stimulator should be exported by a plurality of stimulations that separate, may be more than eight outputs.Therefore, multichannel implantable neural stimulating system has appearred, as Chinese invention patent " the implantable nerve stimulator of multichannel " (application number 86103049) is to adopt an individual outer conveyer and an individual interior receptor, and the receptor back has a plurality of output channels to receive on the stimulating electrode.Chinese invention patent (application number 200710093244.9) " implantation type wireless limbs sport control nerve stimulation network system and control method " is to adopt an external wireless control terminal and a plurality of body internal stimuluss unit to carry out exchanges data and receive control command by its RF transceiver for another example.
As seen the shortcoming of above-mentioned these multi-channel systems be in vivo with the transmission arranged side by side of external a plurality of channel signals of being unrealized when carrying out transfer of data, so just limited the transmission frequency of data.
Inventive method
At the deficiencies in the prior art, the purpose of this invention is to provide a kind of multichannel nerve electric stimulation transmission device based on micro-coil array, set up the transmission arranged side by side that a plurality of passages are realized signal in vivo and in vitro.
The present invention addresses the above problem the technical scheme that is adopted:
A kind of multichannel nerve electric stimulation transmission device based on micro-coil array, this device comprises that stimulus signal produces and transmitter unit array, stimulus signal receiving element array, described stimulus signal produces and the transmitter unit array is to be arranged by a plurality of stimulus signals generations and transmitter unit to form, described stimulus signal receiving element array is rearranged by a plurality of stimulus signal receiving elements, each stimulus signal produces and the unique corresponding stimulus signal receiving element of transmitter unit forms a nerve electric stimulation transmission channel, it is characterized in that:
Described stimulus signal produces and transmitter unit comprises pulse signal generation circuit, high-frequency oscillating circuits, the AM modulation circuit, power amplifier and transmitting coil, two inputs of AM modulation circuit link to each other with the outfan of pulse signal generation circuit and high-frequency oscillating circuits respectively, outfan links to each other with the input of power amplifier, the outfan of power amplifier connects the two ends of the transmitting coil that is made of the spiral inductance coil, described AM modulation circuit is modulated to the pulse signal that pulse signal generation circuit produces on the high-frequency carrier signal of high-frequency oscillating circuits generation in amplitude-modulated mode, undertaken being launched with the form of frequency electromagnetic waves by transmitting coil after the power amplification by power amplifier through amplitude-modulated pulse signal;
Described stimulus signal receiving element comprises receiving coil, diode peak envelop detection circuit, filter circuit and stimulating electrode, the two ends of described receiving coil are connected to the input of diode peak envelop detection circuit, the outfan of diode peak envelop detection circuit is connected to the input of filter circuit, the outfan of filter circuit links to each other with stimulating electrode, the high frequency electromagnetic wave signal that described receiving coil coupling transmitting coil launches, and induce the high frequency electrical signal consistent with the high-frequency carrier signal frequency, finally demodulate boost pulse by the detection of diode peak envelop detection circuit and the filtering of filter circuit, boost pulse imports the target area through stimulating electrode, and the target area neuron is produced stimulation.
Described stimulus signal generation and transmitter unit are corresponding one by one with described stimulus signal receiving element, and stimulus signal produces and the transmitting coil of transmitter unit and the coaxial correspondence of receiving coil of stimulus signal receiving element.Described receiving coil is less than described transmitting coil.
The transmitting coil of described stimulus signal generation and transmitter unit array, and the receiving coil of stimulus signal receiving element array all is little coils; Described device is set up multichannel by micro-coil array, the transmission of each interchannel signal walks abreast, each nerve electric stimulation transmission channel has own independent radiating circuit and receiving circuit, and stimulation pulse signal and carrier signal are provided with separately, and each nerve electric stimulation transmission channel adopts the high-frequency carrier signal independent transmission of different frequency.
Described stimulus signal receiving circuit unit, AM demodulator circuit adopt the diode peak envelop detection to realize passive design, need not battery powered.Simultaneously, the printed board of receiving coil and diode peak envelop detection circuit, filter circuit is integrated.
Described receiving coil adopts bilayer or multilayer board planar spiral inductor coil or uses the MEMS technology and make little coil.
The pulse signal that described pulse signal generation circuit generation amplitude, pulsewidth, frequency can be regulated.
Compared with prior art, the present invention has following beneficial effect:
A, the present invention adopt AM modulation, demodulation mode, demodulator circuit is selected diode peak envelop detection circuit for use, realize passive design in the body, need not the battery implant into body, operation once more after having avoided battery power to exhaust, the misery and the operation that have reduced the patient are dangerous, have alleviated patient's financial burden.
B, the present invention adopt the mode of micro-coil array to realize multichannel design, can transmit multiple signals simultaneously in body, have realized the multichannel design that the inside and outside data transmit.
C, the present invention provide technical support for the multichannel design of implantation medical equipment.
D, of many uses can be used for all kinds of embedded nerve stimulators, muscle stimulator, cochlear implant etc., and the present invention has high economic benefit and social benefit.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the theory diagram of single channel nerve electric stimulation transmission device.
Reference numeral is as follows:
1 is stimulus signal generation and transmitter unit array, 2 is tissue, and 3 is stimulus signal receiving element array, and 4 is transmitting coil, 5 is receiving coil, 6 is pulse signal generation circuit, and 7 is high-frequency oscillating circuits, and 8 is the AM modulation circuit, 9 is power amplifier, 10 is diode peak envelop detection circuit, and 11 is filter circuit, and 12 is stimulating electrode.
The specific embodiment
Below in conjunction with the specific embodiment multichannel nerve electric stimulation transmission device based on micro-coil array of the present invention is elaborated.
Be illustrated in figure 1 as the structure of the multichannel nerve electric stimulation transmission device based on micro-coil array of the present invention, comprise being positioned at that external stimulus signal produces and transmitter unit array 1 and the stimulus signal receiving element array 3 that implants.Each stimulus signal produces and the unique corresponding stimulus signal receiving element of transmitter unit forms a nerve electric stimulation transmission channel.
Further, the structure of each passage as shown in Figure 2, stimulus signal produces and transmitter unit is made up of pulse signal generation circuit 6, high-frequency oscillating circuits 7, AM modulation circuit 8, power amplifier 9, transmitting coil 4.The stimulus signal receiving element is made of receiving coil 5, diode peak envelop detection circuit 10, filter circuit 11, stimulating electrode 12.AM modulation circuit 8 is modulated to the signal that pulse signal generation circuit 6 produces on the high-frequency carrier signal of high-frequency oscillating circuits 7 generations in amplitude-modulated mode, and amplitude-modulated signal is undertaken being launched with the form of frequency electromagnetic waves by external transmitting coil 4 after the power amplification by power amplifier 9.Based on the electromagnetic coupled principle, the magnetic signal that the receiving coil 5 coupling transmitting coils of arranging by coaxial manner 4 launch, and induce the high frequency electrical signal consistent with carrier frequency, finally demodulate boost pulse by diode peak envelop detection circuit 10, filter circuit 11, boost pulse imports the target area through stimulating electrode 12, and the target area neuron is produced stimulation.
Wherein, pulse signal generation circuit 6 is used for producing the boost pulse that sends on the stimulating electrode 12, and the amplitude of pulse, pulsewidth, frequency can be adjusted according to different needs.Diode peak envelop detection circuit 10 is made up of diode and electric capacity, resistance, and is simple in structure, and do not need the power supply power supply, realized the passive design of body internal circuit, and reduced the volume and weight of implant part as far as possible.
As shown in Figure 1, multichannel realization is the permutation and combination of the identical single channel transmitting device of a plurality of structures.Wherein the stimulus signal of each passage, carrier frequency can be provided with separately as required, do not disturb mutually between the stimulus signal passage that is transmitted in addition.
Receiving coil 5 both can be little coil that bilayer or multilamellar stacking-type printed board planar spiral inductor coil also are processed into the MEMS technology in the body, the shape of coil also has multiple choices, every layer can be designed to circle, octagon, square or ellipse etc., and overall appearance can be cylinder, taper or planar structure.The final realization of receiving coil is integrated with the printed board of diode peak envelop detection circuit 10, filter circuit 11 and stimulating electrode 12, reduces the volume of implant part.
Stimulating electrode 12 can adopt titanium or other metal materials such as gold, silver, ferrum etc. to make, and makes the back and plates the titanium protective layer at the outer surface of stimulating electrode.
As follows based on one of embodiment of the multichannel nerve electric stimulation transmission device of micro-coil array:
Be placed in the outer radiating circuit of human body, pulse signal generation circuit produces the pulse of amplitude 0.5-4 volt (equivalence is applied on the built-in stimulating electrode), frequency 0.5-300 hertz, pulse width 100 to 1000 microseconds, pulse is coupled on the receiving coil of implanting exterior dura under the skull by the transmitting coil that is close to patient's scalp, receiving coil adopts multilamellar stacking-type printed board planar spiral inductor coil design.The diameter of transmitting coil is 5-10mm, coil height is 1-5mm, the outermost ring diameter of receiving coil is 3-5mm, adopt four-way, carrier frequency is respectively 2MHZ, 3.28MHZ, 6MHZ, 13.56MHZ, wherein each passage transmitting coil and receiving coil are aimed at coaxial manner, and spacing is 3-7mm, and four pairs of coils are arranged according to the 2*2 matrix-style.The boost pulse that receiving coil receives is applied on the stimulating electrode that is placed in primary visual cortex, and nervous tissue stimulates to visual cortex, inspires specific neural excitation pattern at visual cortex, to rebuild the part visual performance.
The receiving coil of implanting adopts good polyimides or the epoxy resin of bio-compatibility to seal.Outer body is water-proofing treatment in addition.
Claims (2)
1. based on the multichannel nerve electric stimulation transmission device of micro-coil array, this device comprises that stimulus signal produces and transmitter unit array, stimulus signal receiving element array, described stimulus signal produces and the transmitter unit array is to be arranged by a plurality of stimulus signals generations and transmitter unit to form, described stimulus signal receiving element array is rearranged by a plurality of stimulus signal receiving elements, each stimulus signal produces and the unique corresponding stimulus signal receiving element of transmitter unit forms a nerve electric stimulation transmission channel, it is characterized in that:
Described stimulus signal produces and transmitter unit comprises pulse signal generation circuit, high-frequency oscillating circuits, the AM modulation circuit, power amplifier and transmitting coil, two inputs of AM modulation circuit link to each other with the outfan of pulse signal generation circuit and high-frequency oscillating circuits respectively, outfan links to each other with the input of power amplifier, the outfan of power amplifier connects the two ends of the transmitting coil that is made of the spiral inductance coil, described AM modulation circuit is modulated to the pulse signal that pulse signal generation circuit produces on the high-frequency carrier signal of high-frequency oscillating circuits generation in amplitude-modulated mode, undertaken being launched with the form of frequency electromagnetic waves by transmitting coil after the power amplification by power amplifier through amplitude-modulated pulse signal; Described stimulus signal receiving element comprises receiving coil, diode peak envelop detection circuit, filter circuit and stimulating electrode, the two ends of described receiving coil are connected to the input of diode peak envelop detection circuit, the outfan of diode peak envelop detection circuit is connected to the input of filter circuit, the outfan of filter circuit links to each other with stimulating electrode, the high frequency electromagnetic wave signal that described receiving coil coupling transmitting coil launches, and induce the high frequency electrical signal consistent with the high-frequency carrier signal frequency, finally demodulate boost pulse by the detection of diode peak envelop detection circuit and the filtering of filter circuit, boost pulse imports the target area through stimulating electrode, and the target area neuron is produced stimulation;
The transmitting coil of described stimulus signal generation and transmitter unit array, and the receiving coil of stimulus signal receiving element array all is little coils; Described device is set up multichannel by micro-coil array, the transmission of each interchannel signal walks abreast, each nerve electric stimulation transmission channel has own independent radiating circuit and receiving circuit, and stimulation pulse signal and carrier signal are provided with separately, and each nerve electric stimulation transmission channel adopts the high-frequency carrier signal independent transmission of different frequency.
2. multichannel nerve electric stimulation transmission device according to claim 1 is characterized in that,
Stimulus signal generation and transmitter unit are corresponding one by one with the stimulus signal receiving element, and stimulus signal produces and the transmitting coil of transmitter unit and the coaxial correspondence of receiving coil of stimulus signal receiving element; Described receiving coil is less than described transmitting coil.
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| CN2008100703073A CN101357251B (en) | 2008-09-17 | 2008-09-17 | Multichannel nerve electric stimulation transmission device based on micro-coil array |
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| CN2008100703073A CN101357251B (en) | 2008-09-17 | 2008-09-17 | Multichannel nerve electric stimulation transmission device based on micro-coil array |
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| CN101357251B true CN101357251B (en) | 2011-04-13 |
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Families Citing this family (15)
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| CN101526491B (en) * | 2009-04-16 | 2012-03-21 | 福州大学 | Multi-channel gate of electrochemistry electrode array chip |
| CN102247137B (en) * | 2010-05-19 | 2013-06-19 | 中国科学院电子学研究所 | Microelectrode array-based multichannel neural information detection system |
| CN102025178A (en) * | 2010-12-20 | 2011-04-20 | 中兴通讯股份有限公司 | Terminal and wireless charging method and system of terminal |
| CN103949012A (en) * | 2014-05-21 | 2014-07-30 | 上海谨诺医疗科技有限公司 | Multiple-address controllable miniature neuromuscular blockade electrical stimulation system |
| CN104224406B (en) * | 2014-10-08 | 2016-01-13 | 浙江诺尔康神经电子科技股份有限公司 | Cochlear implant reverse signal radio frequency transmission receiving chip and system |
| CN105311749B (en) * | 2015-05-11 | 2018-03-09 | 南京神桥医疗器械有限公司 | A kind of regulation device of implantation type electric stimulation extremity motor function |
| CN105310680B (en) * | 2015-05-14 | 2018-03-27 | 南京神桥医疗器械有限公司 | A kind of implantable nerve signal blocker |
| CN104873330B (en) * | 2015-06-19 | 2017-06-13 | 浙江诺尔康神经电子科技股份有限公司 | A kind of artificial retina implant |
| CN105488987B (en) * | 2016-01-19 | 2018-12-28 | 东南大学 | A kind of passive and wireless micro-machinery switch array control system |
| CN212817627U (en) * | 2017-12-29 | 2021-03-30 | 深圳硅基仿生科技有限公司 | Radio frequency signal detection device and retina stimulator |
| CN109718468A (en) * | 2019-01-13 | 2019-05-07 | 常州瑞神安医疗器械有限公司 | A kind of external current electrode |
| CN112600316B (en) * | 2020-12-17 | 2021-08-20 | 牡丹江医学院 | Low-electromagnetic-radiation vision prosthesis wireless charging system and control method thereof |
| CN113144428B (en) * | 2021-01-21 | 2023-07-04 | 北京工业大学 | Multichannel wireless optogenetic stimulation system and method |
| CN113589941A (en) * | 2021-08-31 | 2021-11-02 | 北京京东方技术开发有限公司 | Brain-computer interface system |
| CN115814275B (en) * | 2022-12-29 | 2023-11-17 | 常州汇海医疗科技有限公司 | Non-invasive pulse cell stimulation technology guided tissue regeneration device |
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