CN105251124A - Magnetic-resonance-coupling-principle-based transcranial magnetic stimulation system - Google Patents
Magnetic-resonance-coupling-principle-based transcranial magnetic stimulation system Download PDFInfo
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- CN105251124A CN105251124A CN201510548177.XA CN201510548177A CN105251124A CN 105251124 A CN105251124 A CN 105251124A CN 201510548177 A CN201510548177 A CN 201510548177A CN 105251124 A CN105251124 A CN 105251124A
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Abstract
The invention provides a magnetic-resonance-coupling-principle-based transcranial magnetic stimulation system. A circuit topology of the system consists of a source coil circuit unit, a stimulating coil circuit unit, and a regulating coil circuit unit, wherein the units are connected mutually; a coil topology unit includes a source coil, a stimulating coil, and a regulating coil, wherein the coils are coupled mutually. In all circuit units of the circuit topology, inductors L1, L2 and L3 correspond to the source coil, the stimulating coil, and the regulating coil in the coil topology. The system has the following beneficial effects: compared with the traditional single-coil transcranial magnetic stimulation equipment, the provided system uses a surface stimulation are of a certain relative threshold value as a focusing parameter, so that the focusing property is improved by about half; a maximum induced current density of a selected arc path is used as a simulated intensity parameter to improve the simulated intensity by about nine times; and the simulation demonstrates that stimulus intensity is improved by 150%. With the system, accurate target position simulation is realized and the simulation dept is enhanced obviously; and the high simulation efficiency is guaranteed and the requirement of excitation current reduction is met.
Description
Technical field
The present invention relates to transcranial magnetic stimulation technology, particularly a kind of transcranial magnetic stimulation system based on magnetic resonance coupling principle.
Background technology
Transcranial magnetic stimulation (Transcranialmagneticsimulation, TMS) be a kind of test-and-treat method of new non-invasive mental sickness, it utilizes the magnetic coil be placed in above scalp to produce time-varying magnetic field, induction field is generated in the nervous tissue of cerebral cortex and brain inside by electromagnetic induction, produce faradic current, thus change the action potential of cell, affect brain intracellular metabolite and neural activity.Compared with electricity irritation, Neural stem cell only can induce Weak current at brain, can not produce and have an intense pain, substantially not have sense of discomfort, and it is than electrical stimulation technology safe ready more, more easily for patient accepts.These advantages make transcranial magnetic stimulation technology be widely used: in clinical practice, supplement CT and MRI the objective evidence of not obtainable nervus motorius defect, the method for quick, the cheap important cortical areas of functional localization can also be provided for brain patient with operation.In brain basic research, use TMS non-invasively can close specific cortical areas function with the important brain district of identification participation Given task; In treatment use, for some due to the excited change of threshold value of neurocyte or the mental sickness of exception, as depression, schizophrenia, the treatment of epilepsy etc. has remarkable result.
But this technology also exists some problems at present, general TMS coil, its focusing stimulated, stimulus intensity and stimulation efficiency also have problem to be modified.The degree of focus of coil determines the scope of Neural stem cell effect, and the focusing of intensifier coil can reduce the possibility that irrelevant nervous tissue is upset.The intensity stimulated can affect the degree of depth of Neural stem cell, and the high stimulation degree of depth just likely realizes the effective stimulus organized dark cranial nerve.Meanwhile, in order to improve the stimulus intensity of coil, needing to strengthen the charging current of coil, big current high power loss will be produced like this, and then limit it and move towards household application market.
Summary of the invention
For the Problems existing of prior art, the invention provides a kind of transcranial magnetic stimulation system based on magnetic coupling resonance principle.One of its object utilizes this system to realize the stronger electromagnetic stimulation of focusing, and two of its object is the degree of depth electromagnetic stimulations utilizing this system to realize brain, and three of its object realizes high efficiency brain electromagnetic stimulation.
For achieving the above object, the invention provides a kind of transcranial magnetic stimulation system based on magnetic resonance coupling principle, wherein: this system includes circuit topology, coil topology, described circuit topology includes interconnective source coil circuit unit, stimulating coil circuit unit, regulating winding circuit unit, and described coil topology includes the source coil, stimulating coil, the regulating winding that intercouple.
Inductance L in each circuit unit of described circuit topology
1, L
2, L
3corresponding with the source coil in coil topology, stimulating coil, regulating winding respectively.
The invention has the beneficial effects as follows that this transcranial magnetic stimulation system based on magnetic coupling resonance principle is compared with traditional unicoil transcranial magnetic stimulation equipment, with the surface stimulation area of a certain relative threshold for focusing parameter, about its focusing improves half, with the maximum induced current density of selected arc path for stimulus intensity parameter, then its stimulus intensity improves about 9 times, and emulation simultaneously shows to stimulate efficiency to improve 150%.In a word, the transcranial magnetic stimulation system based on magnetic coupling resonance principle that the present invention proposes can realize target position more accurately to stimulate, and stimulate the degree of depth obviously to strengthen, meanwhile ensure the requirement of higher stimulation efficiency, reduce the requirement of exciting current, the domestic process of transcranial magnetic stimulation system can be advanced.
Accompanying drawing explanation
Fig. 1 is the circuit topology figure of the transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention;
Fig. 2 is the coil topology figure of the transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention;
Fig. 3 is the simulation comparison figure of the stimulation focusing of magnetic stimulation system proposed by the invention and traditional unicoil transcranial magnetic stimulation system;
Fig. 4-1,4-2 are the simulation comparison figure of the stimulus intensity of magnetic stimulation system proposed by the invention and traditional unicoil transcranial magnetic stimulation system.
In figure:
1, circuit topology 2, source coil circuit unit 3, stimulating coil circuit unit
4, regulating winding circuit unit 5, coil topology 6, source coil 7, stimulating coil
8, regulating winding 11, alternating current power supply
Detailed description of the invention
By reference to the accompanying drawings the structure of the transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention is described.
The innovative point of the transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention is the frequency sensitivity utilizing magnetic resonance coupled system, the target position improve circuit topology and the coil topology of traditional transcranial magnetic stimulation technology, realize stimulus intensity, stimulating the degree of depth and stimulate efficiency all to meet the demands stimulates.
The circuit topological structure of the transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention as depicted in figs. 1 and 2 and coil topology structure.Transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention comprises the circuit topology 1 be made up of source coil circuit unit 2, stimulating coil circuit unit 3 and regulating winding circuit unit 4 and the coil topology 5 be made up of source coil 6, stimulating coil 7 and regulating winding 8.
Transcranial magnetic stimulation system based on magnetic resonance coupling principle of the present invention depends on magnetic resonance coupling principle.Source coil circuit unit 2, stimulating coil circuit unit 3 and regulating winding circuit unit 4 constitute the integrated circuit of the transcranial magnetic stimulation system based on magnetic resonance coupling principle, are realized the transmission of electric energy between them by the principle of electromagnetic induction.Source coil circuit unit 2 provides the exciting current of alternation for source coil 6, and stimulating coil circuit unit 3 provides exciting current for stimulating coil 7, and regulating winding circuit unit 4 provides exciting current for regulating winding 8.Inductance L in each circuit unit of circuit topology 1
1, L
2, L
3corresponding with the source coil 6 in coil topology 5, stimulating coil 7, regulating winding 8 respectively.
By the circuit parameter of source coil circuit unit 2, stimulating coil circuit unit 3 and regulating winding circuit unit 4 in design circuit topology 1, make each circuit unit form resonance circuit, meet resonance characteristic, namely
Therefore, there is resonance in the course of the work in each circuit unit simultaneously, its resonant frequency is the frequency of supply ω of alternating current power supply 11
0.Meanwhile source coil 6, stimulating coil 7 and regulating winding 8 can obtain maximum current value, and in resonance circuit, reactive power consumption is zero, and being of value to like this improving stimulates efficiency.
Source coil 6, stimulating coil 7 and regulating winding 8 is arranged in co-axial alignment, and source coil 6 and stimulating coil 7 are positioned at space same plane, this space structure makes source coil 6 large compared with the coefficient of coup of other arrangement architecture with the coefficient of coup of stimulating coil 7, source coil 6 and the close coupling relation of stimulating coil 7, ensure that stimulating coil 7 obtains higher energy by electromagnetic induction from source coil 6.The size of stimulating coil 7 is large compared with traditional unicoil, thus improves the stimulation degree of depth.Fig. 3 is the stimulus intensity comparison diagram of emulation experiment gained, selected radian path is the camber line on the head model surface being positioned at coil plane normal surface, there is the advantage of obvious stimulus intensity as seen based on transcranial magnetic stimulation system more traditional unicoil transcranial magnetic stimulation system of MRC.
When implementing to stimulate, regulating winding 8 is placed in the scalp surface stimulating target position, utilizes the advantage that the more traditional unicoil of the size of regulating winding 8 is large, thus improves stimulation focusing.Fig. 4-1,4-2 are the stimulation focusing comparison diagram of emulation experiment gained, dark parts is the part exceeding respective 75% maximum induced current density, and the transcranial magnetic stimulation system more traditional unicoil transcranial magnetic stimulation system as seen based on MRC has obvious focusing advantage.
Claims (3)
1. the transcranial magnetic stimulation system based on magnetic resonance coupling principle, it is characterized in that: this system includes circuit topology (1), coil topology (5), described circuit topology (1) includes interconnective source coil circuit unit (2), stimulating coil circuit unit (3), regulating winding circuit unit (4), and described coil topology (5) includes the source coil (6), stimulating coil (7), the regulating winding (8) that intercouple;
Inductance L in described circuit topology (1) each circuit unit
1, L
2, L
3corresponding with the source coil (6) in coil topology (5), stimulating coil (7), regulating winding (8) respectively.
2. the transcranial magnetic stimulation system based on magnetic resonance coupling principle according to claim 1, it is characterized in that: the source coil circuit unit (2) in described circuit topology (1), stimulating coil circuit unit (3) and regulating winding circuit unit (4), by the circuit parameter of described each circuit unit, each circuit unit is made to form resonance circuit, when work runs, source coil circuit unit (2), there is resonance in stimulating coil circuit unit (3) and regulating winding circuit unit (4) simultaneously, and resonant frequency is the frequency of supply ω of alternating current power supply (11)
0, meanwhile source coil (6), stimulating coil (7), regulating winding (8) all can obtain maximum current value, and in resonance circuit, reactive power loss is zero.
3. the transcranial magnetic stimulation system based on magnetic resonance coupling principle according to claim 1, it is characterized in that: the source coil (6) in described coil topology (5), stimulating coil (7) and regulating winding (8) are arranged in co-axial alignment, source coil (6) and stimulating coil (7) are positioned at space same plane, and source coil (6) is enclosed among stimulating coil (7), when implementing to stimulate, regulating winding (8) is placed in the scalp surface stimulating target position, exciting current is passed to source coil (6), realizes transcranial magnetic stimulation.
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| CN201510548177.XA CN105251124A (en) | 2015-08-31 | 2015-08-31 | Magnetic-resonance-coupling-principle-based transcranial magnetic stimulation system |
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| CN201510548177.XA CN105251124A (en) | 2015-08-31 | 2015-08-31 | Magnetic-resonance-coupling-principle-based transcranial magnetic stimulation system |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107174741A (en) * | 2017-04-11 | 2017-09-19 | 天津大学 | Transcranial magnetic stimulation system based on the orthogonal splayed coil group of magnetic resonance manifold type |
| CN107469233A (en) * | 2017-08-30 | 2017-12-15 | 天津大学 | Quatrefoil coil transcranial magnetic stimulation system based on magnetic resonance coupling principle |
| CN108472494A (en) * | 2016-03-04 | 2018-08-31 | 国立大学法人东京大学 | Coil and use its magnetic stimulating device |
| CN111135465A (en) * | 2020-01-14 | 2020-05-12 | 天津大学 | Deep transcranial magnetic coil stimulation device based on time interference |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101912668A (en) * | 2010-07-26 | 2010-12-15 | 香港脑泰科技有限公司 | Navigation transcranial magnetic stimulation treatment system |
| CN202366330U (en) * | 2011-11-30 | 2012-08-08 | 深圳市康立高科技有限公司 | Integrated transcranial magnetic stimulation device |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101912668A (en) * | 2010-07-26 | 2010-12-15 | 香港脑泰科技有限公司 | Navigation transcranial magnetic stimulation treatment system |
| CN202366330U (en) * | 2011-11-30 | 2012-08-08 | 深圳市康立高科技有限公司 | Integrated transcranial magnetic stimulation device |
Non-Patent Citations (1)
| Title |
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| 罗斌 等: "磁谐振耦合式单中继线圈无线功率接力传输系统的建模与分析", 《中国电机工程学报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108472494A (en) * | 2016-03-04 | 2018-08-31 | 国立大学法人东京大学 | Coil and use its magnetic stimulating device |
| CN108472494B (en) * | 2016-03-04 | 2022-03-29 | 国立大学法人东京大学 | Coil and magnetic stimulation device using same |
| CN107174741A (en) * | 2017-04-11 | 2017-09-19 | 天津大学 | Transcranial magnetic stimulation system based on the orthogonal splayed coil group of magnetic resonance manifold type |
| CN107469233A (en) * | 2017-08-30 | 2017-12-15 | 天津大学 | Quatrefoil coil transcranial magnetic stimulation system based on magnetic resonance coupling principle |
| CN111135465A (en) * | 2020-01-14 | 2020-05-12 | 天津大学 | Deep transcranial magnetic coil stimulation device based on time interference |
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Application publication date: 20160120 |