CN107174373A

CN107174373A - Filter unit

Info

Publication number: CN107174373A
Application number: CN201610134581.7A
Authority: CN
Inventors: 李中华; 张琳琳; 韩建超; 祁勇翔; 丁双喜; 苗铮华
Original assignee: Minimally Invasive Medical Technology (shanghai) Co Ltd
Current assignee: Shanghai lanmai Medical Technology Co.,Ltd.
Priority date: 2016-03-09
Filing date: 2016-03-09
Publication date: 2017-09-19
Anticipated expiration: 2036-03-09
Also published as: CN107174373B

Abstract

The invention provides a kind of filter unit, the filter unit includes filter element, constraint component and support member, the filter element, constraint component and support member are made by Biodegradable material, and the constraint component is used to constrain the filter element, the support member connects the filter element and is coaxially disposed with the filter element, and the time that the constraint component completes to degrade is shorter than the time that the filter element and support member complete degraded.The present invention is implanted by minimally invasive surgery, because its all parts is made by Biodegradable material, so that after the completion of all parts work, all parts can voluntarily degrade in vivo, until disappearing in vivo, permanent filter unit long-term existence had so both been solved the problem of the vena cave occlusion brought in vivo and permanent immunity rejection etc., the problem of second operation, the filter that provisional filter unit brings can not take out etc. is turn avoid.

Description

Filter unit

Technical field

The present invention relates to technical field of medical instruments, more particularly to a kind of filter unit.

Background technology

Pulmonary thromboembolism (PE, Pulmonary Embolism, abbreviation pulmonary embolism) refers to caulked material (being usually thrombus) enters pulmonary artery and its branch, the case and clinic for blocking tissue blood supply caused State, its incidence of disease occupies the 3rd, the whole world, is only second to acute coronary artery syndrome and cerebral apoplexy, its case fatality rate It is only second to tumour and acute myocardial infarction.Specifically, in the dead crowd of China's inpatient, 10% is dead In PE, PE case fatality rate about 8.7%.In western countries, PE patient numbers about 250,000 are newly sent out in the U.S. every year, And the Europe PE incidences of disease are also high compared with the U.S..ICU research find, cause PE DVT (DVT, Deep Venous Thrombosis) incidence 27%, especially in bone surgery, openheart surgery, operations on cranium and brain Afterwards, DVT incidences are up to 60%.

At present, patient typically passes through chemicals, the machines such as oral or injection aspirin, heparin, warfarin The mode such as tool rehabilitation prevention apparatus or the traditional filter of implantation treats PE.Wherein, drug therapy can make medicine Into hematological system, phlebothrombosis is effectively dissolved, the generation of DVT and pulmonary embolism is greatly reduced Rate.In addition, mechanical rehabilitation prevention apparatus mainly carries out cycle extrusion by air bag to both legs, with The occurrence probability of the pre- preventing thrombosis accumulation by way of external force is extruded, reduction deep vein embolism and pulmonary embolism. In addition, to the patient with anticoagulation contraindication or anticoagulant therapy failure, lower limb filter unit can be used Prevented.These treatment methods all achieve positive effect in terms of prophylactic treatment pulmonary embolism, but Some problems are individually present.

For lower limb filter unit, it enters human body by venipuncture, tight after self-expanding release Inferior caval vein is pasted, phlebothrombosis is captured, prevents pulmonary embolism.Clinically widely used filter unit has Many kinds, but can generally be divided into two major classes：Permanent filter unit and provisional filter unit.

Permanent filter unit is intervened by single performs the operation, and permanent implanted human body captures thrombus.It is implanted into Afterwards, there is endothelialization in filter unit agent structure, is fixed at inferior caval vein, long-term filtering blood.But its In the presence of structural break pierces through blood vessel, thrombus and accumulates initiation blood vessel blockage for a long time or trigger long-term serious be immunized Rejection equivalent risk.

The operating process of provisional filter unit includes filter implantation and filter reclaims two parts.First operation In, provisional filter unit is transported to retrocaval by venipuncture and precisely discharged, and captures thrombus；Plant Enter after certain time, reclaimed by venipuncture, the related thrombus of provisional filter unit is removed into body Outside.But there is also its limitation for recuperability filter unit：, it is necessary to be led using thrombolysis during filter unit recovery Pipe may cause the hemorrhagic symptom that patient is serious to carrying out thromboembolism treatment at thrombus accumulation；Additionally, due to blood Endothelial tubeization can cause filter unit to be difficult to take out, or even heavy damage blood vessel during taking-up.If but not entering Row filter unit is reclaimed, and fracture or occluding vascular may occur in itself for its structure, jeopardizes patient vitals' safety； Meanwhile, secondary filter is reclaimed in surgical procedure, often be there are massive dropping situations, is added lethal The risk of pulmonary embolism, also increases psychology and the financial burden of patient.

The content of the invention

It is an object of the invention to provide a kind of filter unit, to solve permanent filter unit in the prior art Be chronically implanted the vena cave occlusion of initiation, the second operation that permanent immunity rejection, recyclable filter are brought And filter the problems such as can not take out in one or more.

In order to solve the above technical problems, the invention provides a kind of filter unit, including：

Filter element；

Constraint component, for constraining the filter element；And

Support member, connects the filter element and is coaxially disposed with the filter element；

Wherein, the filter element, constraint component and support member are made by Biodegradable material, and And the constraint component completes the time of degraded than the filter element and the time of support member completion degraded It is short.

It is preferred that, in described filter unit, the filter element includes many along the filter unit Axially extending filtering muscle；Many it is described filtering muscle it is circumferentially distributed, and many it is described filtering muscle one end by The constraint component constraint is together.

It is preferred that, in described filter unit, the every filtering muscle is in multiple positions and the supporting part Part is connected.

It is preferred that, in described filter unit, the constraint component includes a flexible body, many mistakes The one end for filtering muscle is constrained together by the flexible body.

It is preferred that, in described filter unit, one end of the every filtering muscle has the ring of cans Shape structure, the cyclic structure of many filtering muscle is constrained together by the flexible body.

It is preferred that, in described filter unit, one end of the every filtering muscle has the ring of cans Shape structure；And in many filtering muscle, the cyclic structure of a part of filtering muscle stacks gradually to form the One preformed hole, the cyclic structure of filtering muscle stacks gradually to form the second preformed hole described in another part；It is described about Beam part includes the first fixture and the second fixture, and each fixture includes body and connection is described The fixing end at body two ends；The body of first fixture is inserted in first preformed hole, and passes through it The cyclic structure of a part of filtering muscle of two fixing end fixed constraints；The body of second fixture is inserted Enter in second preformed hole, and by filtering the ring of muscle described in two fixing end fixed constraint another part Shape structure.

It is preferred that, in described filter unit, in many filtering muscle, at least two filtering muscle One end there is helicoidal structure, the helicoidal structures of at least two filterings muscle are constrained in institute respectively State the two ends of filter unit.

It is preferred that, in described filter unit, first preformed hole and second preformed hole difference shape The two ends of filter unit described in Cheng Yu.

It is preferred that, in described filter unit, the filtering muscle of arbitrary neighborhood two is respectively by described first Fixture and the second fixture are constrained in the different ends of the filter unit.

It is preferred that, in described filter unit, the support member includes multiple support rings, each described Support ring includes tubing or wire rod with waveform or dentation；Multiple support rings are filled with the filter Put coaxially arranged, and arranged along the axially spaced-apart and noninterlace of the filter unit.

It is preferred that, in described filter unit, the wire rod includes crest portion and trough portion, and each institute The trough portion or crest portion stated in support ring is connected with the filtering muscle.

It is preferred that, in described filter unit, the tubing includes tooth crest and bottom of the tooth portion, each described Tooth crest and bottom of the tooth portion in support ring are connected with the filtering muscle.

It is preferred that, in described filter unit, in the same support ring, all connection teeth One end of the filtering muscle at top is constrained to one end of the filter unit, and two tooth crest of arbitrary neighborhood Between be provided with the filtering muscle in a connection bottom of the tooth portion, the one of the filtering muscle in all connection bottom of the tooth portions End is constrained to the other end of the filter unit.

It is preferred that, in described filter unit, the filter unit also include connecting the support member or The positioning element of filter element, position of the positioning element to position the filter unit.

It is preferred that, in described filter unit, the material of the positioning element is development metal material.

It is preferred that, in described filter unit, the positioning element is arranged at the supporting part including one end Anchoring members on part and/or filter element, the quantity of the anchoring members is multiple.

It is preferred that, in described filter unit, the filter element and support member hot-melt adhesive paste.

It is preferred that, in described filter unit, the material of the constraint component is PDLGA or degradable Magnesium alloy.

It is preferred that, in described filter unit, the material of the filter element and support member is PLGA Or PLLA.

It is preferred that, in described filter unit, the filter element completes the time of degraded than the support The time that part completes degraded is short.

It is preferred that, in described filter unit, the filter element completes degraded with the support member Time is identical.

Compared to prior art, filter unit of the invention is implanted by minimally invasive surgery, because its is each Individual part is made by Biodegradable material so that after the completion of all parts work, all parts can be in body It is interior voluntarily to degrade, until disappearing in vivo, permanent filter unit long-term existence had so both been solved in body The problem of vena cave occlusion, initiation permanent immunity rejection for inside bringing etc., it turn avoid provisional filter The problems such as next second operation of device band, filter can not take out.

Brief description of the drawings

Fig. 1 is the front view of the filter unit of the embodiment of the present invention one；

Fig. 2 is the top view of the filter unit shown in Fig. 1；

Fig. 3 is the front view of the filter unit of the embodiment of the present invention one；

Fig. 4 is the top view of the filter unit shown in Fig. 3；

Fig. 5 is the stereogram of the filter unit of the embodiment of the present invention two；

Fig. 6 is the front view of the filter unit shown in Fig. 5；

Fig. 7 is the top view of the filter unit shown in Fig. 6；

Fig. 8 is the partial enlarged drawing of the filter unit of the embodiment of the present invention two；

Fig. 9 is the partial enlarged drawing of the filter unit of the embodiment of the present invention two.

Description of reference numerals in figure is as follows：

1000th, 2000- filter units；1100th, 2100- constraint components；1200th, 2200- filter elements；1300、 2300- support members；1301- crests portion；1302- troughs portion；2301- tooth crest；2302- bottom of the tooth portion；2400- Positioning element；2210- helicoidal structures.

Embodiment

To make the purpose of the present invention, advantages and features clearer, below in conjunction with accompanying drawing, 1~9 couple of present invention is carried The filter unit gone out is described in further detail.It should be noted that, accompanying drawing using very simplified form and Non- accurately ratio is used, only for the purpose of facilitating and clarifying the purpose of the embodiments of the invention.

Embodiment one

Fig. 1 is illustrated that the front view of the filter unit of the embodiment of the present invention one, and Fig. 2 is illustrated that Fig. 1 institutes The top view of the filter unit shown.

Refering to Fig. 1~2, the filter unit 1000 includes constraint component 1100, filter element 1200 and branch Support part part 1300, the constraint component 1200, filter element 1200 and support member 1300 can by biology Degradable material is made；Wherein：The support member 1300 is coaxially disposed with filter element 1200, and is connected Filter element 1200, with structural support filter element 1200；The constraint component 1100 was constrained in Filter one end of part 1200 so that one end closing of filter element 1200 is so as to capture thrombus, and it is described about Beam part 1100 completes the time of degraded than filter element 1200 and the time of the completion degraded of support member 1300 It is short.Here, degradation time depends on multinomial factor, including it is the molecular weight of material therefor, crystallinity, hydrophilic Property, the volume of each part, surface area and environmental factor etc., the specific time for completing degraded can be by this area Technical staff selects as needed.But, those skilled in the art will be appreciated that, the constraint component 1100 is complete Time into degraded is the constraint component 1100 since in implantation human body up to losing physical characteristic completely When (main), now, the constraint component 1100 does not possess constraint filter element 1200 completely Act on, likewise, the time that the filter element 1200 and support member 1300 complete degraded refers to it Since implantation human body at the time of losing physical characteristic completely.

The filter unit 1000 of the present embodiment is implanted by minimally invasive surgery, and its all part is by life Biodegradable material is made, due to Biodegradable material in vivo, can progressively be degraded into and human body is not endangered Harmful product is simultaneously excreted with metabolism, and the permanent immunity that can so eliminate the initiation of Permanent implantation thing repels The risk of reaction.In addition, the preferential degradation of constraint component 1100, therefore without progress second operation Filter element 1200 is opened, so as to eliminate the risk of vena cave occlusion, the safety of operation technique is improved Property, reduce the pain of corrective surgery.

Optional, the Biodegradable material is, for example, PLA (Poly Lactic-co-Glycolic Acid, letter Claim PLA) etc. medical biodegradable high polymer material, the present invention this is had no particular limits.

More optional, (i.e. DL- lactides and glycolide is random common by PDLGA for the constraint component 1100 Polymers) material is made, wherein, the mol ratio of DL- lactides and glycolide is 50:50, i.e. DL- lactides Molar content be 50%, the molar content of glycolide is also 50%.

As a kind of embodiment, the time that the constraint component 1100 completes degraded is the filter unit 1~2 month after 1000 implantation human bodies.However, the constraint component 1100 of the present invention completes the time bag of degraded Include but be not limited to 1~2 month, can specifically set according to actual needs.

Optional, the filter element 1200 is by PLGA (i.e. the random copolymer of L- lactides and glycolide) Material is made, and the mol ratio of L- lactides and glycolide is 82 in PLGA used in the present invention:18, I.e. the molar content of L- lactides is 82%, and the molar content of glycolide is 18%.

Same to be used as optionally, the time that the filter element 1200 completes degraded is the filter unit 1000 It is implanted into 12~16 months after human body.Here, the present invention does not make specific restriction, can be according to actual conditions Adjustment.

Optional, the support member 1300 is by PLGA (i.e. the random copolymer of L- lactides and glycolide) Material is made, and the mol ratio of L- lactides and glycolide is 82 in PLGA used in the present invention:18, I.e. the molar content of L- lactides is 82%, and the molar content of glycolide is 18%.The support The time that part 1300 completes degraded is 12~16 months that the filter unit 1000 is implanted into after human body.

More optional, the filter element 1200 completes to degrade simultaneously with support member 1300, i.e., both complete The time of degraded is identical.Or, the filter element 1200 completes the time of degraded than support member 1300 The time for completing degraded is short.

Hold above-mentioned, PLGA (random copolymer of L- lactides and glycolide) and PDLGA (DL- lactides with The random copolymer of glycolide) there is good biodegradability and biocompatibility, glass transition temperature is more than 40 DEG C, therefore using effect is good.

Further, one end of the filter element 1200 is fettered by constraint component 1100, and forms closing knot Structure, while the other end of the filter element 1200 can be fixed together with support member 1300, and is formed Uncovered structure.The other end of further described filter element 1200 and the hot-melt adhesive paste of support member 1300, Good fixing effect,

For example shown in Fig. 1~2, the filter element 1200 prolongs including many axial directions along filter unit 1000 The filtering muscle stretched, many filtering muscle are circumferentially distributed, and many described one end for filtering muscle are by constriction Part 1100 is constrained together.The filtering muscle can be silk, pipe etc., and the specific present invention is not particularly limited.

In addition, the every filtering muscle is connected in multiple positions with support member 1300, such as described supporting part Part 1300 includes multiple support rings, and each support ring is made up of the wire rod (or tubing) of waveform, the line Material (or tubing) includes crest portion 1301 and trough portion 1302, and multiple support rings and filter unit 1000 is coaxially arranged, and is arranged along the axially spaced-apart of filter unit 1000, and preferably noninterlace is arranged.The line The quantity of the waveform of material (or tubing) is 6~8, optional 2~4 of the quantity of the support ring.

The quantity of support ring shown in Fig. 1 and Fig. 2 is three, one of support ring and many filterings The end hot-melt adhesive paste of muscle, the body hot-melt adhesive paste of another two support ring successively with many filtering muscle.More Specifically, the trough portion 1302 (or crest portion 1301) in each support ring connects with the filtering muscle hot melt Connect.It is preferred that the hot-melt adhesive paste point of each support ring is located at the inner side of the filtering muscle.

Further, the constraint component 1100 includes a flexible body, such as silk, band, the specific present invention Do not limit, as long as being easy to constrain filter element 1200.

In the present embodiment, the constraint component 1100 by a flexible body by it is all filtering muscle one end Bundle, in this way, just one end of filter element 1200 can be constrained to form enclosed construction, so that incited somebody to action Filter the constraint of part 1200 and form a network structure.The network structure is substantially tapered, to catch vena cave Endovascular thrombus.

Preferably, as a kind of embodiment, every filtering muscle include be sequentially connected confinement section, first Fillter section and the second fillter section, wherein one end bending extension shape of first fillter section by the confinement section Into second fillter section is formed by one end bending extension of first fillter section；Using when, all mistakes The confinement section for filtering muscle is constrained together by a flexible body, the second fillter section rings of preferably all filtering muscle Shape is distributed to form straight-tube shape, and the first fillter section annular spread formation cone.

Then, as shown in figs. 34, in another embodiment, the confinement section of every filtering muscle is away from described first The end of fillter section has the cyclic structure of cans so that the flexible body of the constraint component 1100 can be worn In the cyclic structure for entering the every filtering muscle, so that by all filtering muscle constraints together, it is such to set, Be conducive to being lifted the fix tightly soundness of constraint component 1100.

Embodiment two

Fig. 5 is illustrated that the schematic perspective view of the filter unit of the embodiment of the present invention two, and Fig. 6 is illustrated that Fig. 5 The front view of shown filter unit, Fig. 7 is illustrated that the top view of the filter unit shown in Fig. 6.

Refering to Fig. 5~7, the filter unit 2000 includes constraint component 2100, filter element 2200, support Part 2300 and positioning element 2400, the filter element 2200, constraint component 2100 and support member 2300 are made by Biodegradable material；The support member 2300 is coaxially disposed with filter element 220, And filter element 2200 is connected, with structural support filter element 2200；The constraint component 2100 is about Beam filter part 2200, so that at least one end closing of filter element 2200 is so as to capture thrombus；The positioning Part 2400 connects support member 2300 or filter element 2200, for positioning filter unit 2000 in blood Position in pipe；And the constraint component 2100 completes the time of degraded than the He of filter element 2200 The time that support member 2300 completes degraded is short.

Compared to embodiment one, the filter unit 2000 of the present embodiment by setting up a positioning element 2400, During so that it implanting, the positioning element 2400 can be fixed on vascular wall, so that fixed filter unit 2000 position, prevents it to be shifted over, and so improves the accuracy of operation technique, good operation effect.

More excellent, the positioning element 2400 is made up of development metal material, such as platinumiridio, tantalum alloy, gold The development metal such as product is made, on the one hand for positioning the position of fixed filter unit 2000 in the blood vessels, separately On the one hand it can be developed in real time by X-ray in surgical procedure, with filter unit in real-time confirmation surgical procedure 2000 position in the blood vessels.

Optional, the positioning element 2400 includes an anchoring members, to be pierced into vascular wall, so that fixed filter Device device 2000.The quantity of the anchoring members is multiple, and each anchoring members are fixed by way of grappling In support member 2300, preferably each anchoring members are anchored to filter element 2200 and support member 2300 Tie point on.

In the present embodiment, the constraint component 2100 is optional to be made up of degradable magnesium alloy material, and degraded is completed Time for the filter unit 2000 implant after 3~4 months.

Poly- left breast in the filter element 2200 and optional (PLA) by PLA of support member 2300 Sour (PLLA) material is made, and because PLLA belongs to polylactic acid-based absorbable material, its metabolite is human body Eubolism product, with good histocompatbility, therefore, using effect is good.However, the present invention is right The Biodegradable material of constraint component 2100, filter element 2200 and support member 2300 is not special Limit.

Optional, the filter element 2200 and support member 2300 are tubing, and are preferably carved by laser Machine-shaping is carved, machining accuracy is high, crudy is good, and be applicable the tubing with complex appearance is made. The degraded deadline of the filter element 2200 and support member 2300 is chosen as 24~36 months.It is preferred that The time of the completion degraded of the filter element 2200 is shorter than the time of the completion degraded of support member 2300, Or the time that the time of the completion of filter element 2200 degraded and support member 2300 complete to degrade is identical.

Further, the two ends of the filter element 2200 are fettered by constraint component 2100, so that filter is filled The two ends for putting 2000 are constrained.Say in more detail, the filter element 2200 includes many along filter The axially extending filtering muscle of device 2000, many filtering muscle are circumferentially distributed, are perfectly even distributed, So as to form substantially elliposoidal structure.

Further, many it is described filtering muscle in, a part filtering muscle one end by constraint component 2100 about Bundled together, to form one end of filter unit 2000, and the part filters the other end and the support of muscle The hot-melt adhesive paste of part 2300；At the same time, one end of another part filtering muscle accordingly passes through constraint component 2100 Together, to form the other end of filter unit 2000, and described another part filters the another of muscle for constraint End similarly with the hot-melt adhesive paste of support member 2300；In this way, just simply and easily foring elliposoidal screen pack Structure.

It is preferred that, one end of any two adjacent head muscle is constrained in filter unit 2000 by constraint component 2100 Different ends.One end of such as every filtering muscle has the cyclic structure of cans, and above-mentioned a part of mistake The cyclic structure of filter muscle stacks gradually to form the first preformed hole, while above-mentioned another part filters the ring-type knot of muscle Structure stacks gradually to form the second preformed hole.First preformed hole and the second preformed hole are respectively formed in the filter The two ends of device device.Here, the optional constraint component 2100 includes the first fixture and the second fixture, The fixture is, for example, pin, and each fixture includes body and connects the body two ends Fixing end；During constraint, the body of first fixture is inserted in first preformed hole, and by its two Individual these cyclic structures of fixing end fixed constraint；Correspondingly, the body insertion described the of second fixture In two preformed holes, and pass through two corresponding cyclic structure of fixing end fixed constraint.

With continued reference to Fig. 6, the support member 2300 includes multiple support rings, and each support ring is by dentation Tubing is constituted, such as rectangle pipe material or circular pipe；Wherein described tubing includes tooth crest 2301 and bottom of the tooth Portion 2302, the quantity of the dentation of the optional tubing is 6~8；And multiple support rings and filter unit 2000 is coaxially arranged, and is arranged along the axially spaced-apart of filter unit 2000；It is preferred that multiple support rings are along axle Arranged to noninterlace, the quantity of the support ring is 2~4.In addition, the grappling of above-mentioned positioning element 2400 Part can be interspersed tooth crest 2301 and bottom of the tooth portion 2302 in the support ring.

The quantity of support ring shown in wherein Fig. 5 and Fig. 6 is three, the He of tooth crest 2301 of each support ring Muscle hot-melt adhesive paste filters with described in bottom of the tooth portion 2302, so as to form filter screen structure.Specifically, for Same support ring, each of which tooth crest 2301 and a filtering muscle hot-melt adhesive paste, and all tooth connections The filtering muscle at top 2301 passes through at least two constrictions respectively with the filtering muscle of all tooth connection bottoms 2302 Part 2100 is constrained to the two ends of filter unit 2000.

The filter unit 2000 of the present embodiment by the top of tooth connection 2301 all filtering muscle by being constrained to filter One end of device device 2000, and all filtering muscle of tooth connection bottom 2302 are constrained to filter unit 2000 The other end, can so form two layers of filter structure, so as to increase the probability of thrombus capture.

Filter unit 2000 is for example placed in inferior caval vein the initial segment, one end filter of the filter unit 2000 Thrombus is collected in close to the side of vascular wall by net, and the thrombus being missed continues to be captured by the filter screen of the other end And it is collected in the opposite side of filter screen.Further, since the two ends of the filter unit 2000 are close to symmetrical structure, So that the two ends of filter unit 2000 are used equally for capturing thrombus, the applicability of filter unit 2000 is improved.

Preferably, as a kind of embodiment, every filtering muscle include be sequentially connected confinement section, first Fillter section and the second fillter section, wherein one end bending extension shape of first fillter section by the confinement section Into, and second fillter section by first fillter section one end bending extension is formed, and every filter muscle Confinement section there is the cyclic structures of cans.Second fillter section of optional every filtering muscle and support ring heat Molten connection.

In such as Fig. 8~9, another embodiment, in many filtering muscle, at least there are the constraints of two filtering muscle Section has helicoidal structure 2210, wherein the helicoidal structure 2210 of a filtering muscle is constrained in filter unit 2000 one end, the helicoidal structure 2210 of another filtering muscle is constrained in the other end of filter unit 2000. Using when, the helicoidal structure 2210 that the fixture of the constraint component 2100 filters muscle by compressing will be same The filtering muscle of one end is assembled together.Because filtering muscle is compressed, cause it to provide constraint component 2100 and hold Continuous tension force, and the constraint component 2100 is by tension force due to being acted on, its degradation speed can be than very fast. This, Fig. 9 is illustrated that the helicoidal structure 2210 shown in Fig. 8 by the schematic diagram after fixture compression.

Based on above-described embodiment, the course of work of filter unit of the invention is：First, the filter is filled Put and implant, and make the support member against (being generally close to) blood vessel；Secondly, the is being passed through After one predetermined design time, the constraint component completes degraded, causes the filter unit along blood flow side To opening, so as to not continue to stop that blood passes through；Then, after second predetermined design time is passed through, The filter element and support member degraded are completed, and are excreted with metabolism.Here, described One predetermined design time is the time that the constraint component completes degraded, during second predetermined design Between be time that the filter element and support member complete degraded.

Specifically, within the first predetermined design time that the filter unit implants, the filter Massive in device device catcher vein blood vessel, the thrombus of capture can be by blood (or coordinating thrombolytic drug) Dissolving, and with the passage of Implantation Time, the support member is by the inner membrance bag of vena cave vascular wall hyperplasia Cover, at the same time the filter element is also progressively coated by the inner membrance of vena cave vascular wall hyperplasia, then, when The filter unit is implanted when reaching first predetermined design time, and the constraint component degraded is completed, Afterwards, when the filter unit, which implants, reaches second predetermined design time, the filter element and Support member degraded is completed.

Here, based on embodiment two, the course of work of filter unit of the invention also includes：In the filter During device implantable intravascular, the positioning element is fixed on blood vessel, so that the fixed filter unit Position, so as to prevent filter unit to be shifted over.It is more optional also to include：By being made up of development metal material Positioning element position the position of the filter unit in the blood vessels, to lift the efficiency and standard of operation technique Exactness.

Compared to prior art, the present invention is implanted by minimally invasive surgery, due to its all parts by Biodegradable material is made so that after the completion of all parts work, all parts can voluntarily drop in vivo On the one hand solution, until disappearing in vivo, so solve permanent filter unit long-term existence and brought in vivo Vena cave occlusion, the problem of trigger permanent immunity rejection, on the other hand solve provisional filter dress Put the problems such as second operation brought, filter can not take out.

Foregoing description is only the description to present pre-ferred embodiments, not to any limit of the scope of the invention Calmly, the those of ordinary skill in field of the present invention does according to the disclosure above content any change, modification, belong to In the protection domain of claims.

Claims

1. a kind of filter unit, it is characterised in that including：

Filter element；

Constraint component, for constraining the filter element；And

2. filter unit according to claim 1, it is characterised in that the filter element includes many Along the axially extending filtering muscle of the filter unit；The many filtering muscle are circumferentially distributed, and many institutes The one end for stating filtering muscle is constrained together by the constraint component.

3. filter unit according to claim 2, it is characterised in that the every filtering muscle is multiple Position is connected with the support member.

4. filter unit according to claim 2, it is characterised in that it is soft that the constraint component includes one Property body, many it is described filtering muscle one end by the flexible body constrain together.

5. filter unit according to claim 4, it is characterised in that one end of the every filtering muscle Cyclic structure with cans, the cyclic structure of many filtering muscle is constrained in by the flexible body Together.

6. filter unit according to claim 2, it is characterised in that one end of the every filtering muscle Cyclic structure with cans；And in many filtering muscle, the ring-type knot of a part of filtering muscle Structure stacks gradually to form the first preformed hole, and the cyclic structure that muscle is filtered described in another part stacks gradually to form the Two preformed holes；The constraint component includes the first fixture and the second fixture, and each fixture includes Body and the fixing end at the connection body two ends；The body insertion described first of first fixture is pre- In boxing out, and pass through the cyclic structure of a part of filtering muscle of two fixing end fixed constraint；Described The body of two fixtures is inserted in second preformed hole, and passes through two another portion of fixing end fixed constraint Divide the cyclic structure of the filtering muscle.

7. filter unit according to claim 6, it is characterised in that in many filtering muscle, extremely One end of few two filtering muscle has helicoidal structure, the helical form of at least two filterings muscle Structure is constrained in the two ends of the filter unit respectively.

8. the filter unit according to claim 6 or 7, it is characterised in that first preformed hole and Second preformed hole is respectively formed in the two ends of the filter unit.

9. filter unit according to claim 8, it is characterised in that the filtering of arbitrary neighborhood two Muscle is constrained in the different ends of the filter unit by first fixture and the second fixture respectively.

10. filter unit according to claim 2, it is characterised in that the support member includes many Individual support ring, each support ring includes tubing or wire rod with waveform or dentation；It is multiple described Support ring and the filter unit are coaxially arranged, and are arranged along the axially spaced-apart and noninterlace of the filter unit.

11. filter unit according to claim 10, it is characterised in that the wire rod includes crest portion With trough portion, the trough portion or crest portion in each support ring are connected with the filter element.

12. filter unit according to claim 10, it is characterised in that the tubing includes tooth crest With bottom of the tooth portion, each the tooth crest in the support ring and bottom of the tooth portion are connected with the filtering muscle.

13. filter unit according to claim 12, it is characterised in that in the same support ring In, one end of the filtering muscle of all connection tooth crest is constrained to one end of the filter unit, and arbitrarily The filtering muscle in a connection bottom of the tooth portion is provided between the two neighboring tooth crest, described in all connections One end of the filtering muscle in bottom of the tooth portion is constrained to the other end of the filter unit.

14. filter unit according to claim 1, it is characterised in that the filter unit also includes The positioning element of the support member or filter element is connected, the positioning element is to position the filter dress The position put.

15. filter unit according to claim 14, it is characterised in that the material of the positioning element For development metal material.

16. the filter unit according to claims 14 or 15, it is characterised in that the positioning element The anchoring members in the support member and/or filter element, the number of the anchoring members are arranged at including one end Measure to be multiple.

17. filter unit according to claim 1, it is characterised in that the filter element and support Part hot-melt adhesive paste.

18. filter unit according to claim 1, it is characterised in that the material of the constraint component For PDLGA or degradable magnesium alloy.

19. filter unit according to claim 1, it is characterised in that the filter element and support The material of part is PLGA or PLLA.

20. filter unit according to claim 1, it is characterised in that the filter element completes drop The time of solution is shorter than the time that the support member completes degraded.

21. filter unit according to claim 1, it is characterised in that the filter element with it is described The time that support member completes degraded is identical.