CN116919650A

CN116919650A - Absorbable filter

Info

Publication number: CN116919650A
Application number: CN202311196813.8A
Authority: CN
Inventors: 郑殿会; 张玉龙; 李会钗
Original assignee: Beijing Xinyou Medical Technology Co ltd
Current assignee: Beijing Xinyou Medical Technology Co ltd
Priority date: 2023-09-18
Filing date: 2023-09-18
Publication date: 2023-10-24
Anticipated expiration: 2043-09-18
Also published as: CN116919650B

Abstract

The invention provides an absorbable filter, which relates to the field of medical appliances, and comprises an anchoring bracket, a filter plug bracket and a binding wire made of an in-vivo degradable medical material; the anchoring bracket is opened to be cylindrical, and the outer peripheral wall of the anchoring bracket is provided with rear anchoring thorns; the filter plug bracket is opened to be in a shape that the front end is bound by the binding wire and the rear end is opened, and the front end of the filter plug bracket is provided with a front anchoring thorn; the rear end of the filter plug bracket is connected with the front end of the anchoring bracket; under the conditions that the implanted binding wire is not degraded and broken, the anchoring bracket and the filtering plug bracket are both opened, the rear anchoring thorns are anchored on the inner wall of the blood vessel, and the front anchoring thorns are far away from the inner wall of the blood vessel; after the binding wire is degraded and broken, the front end of the filter plug bracket rebounds outwards along the radial direction, so that the front end of the filter plug bracket is opened, and the front anchoring thorns are anchored on the inner wall of the blood vessel. The invention relieves the technical problems that the tensile strength of the collecting net of the vena cava filter in the prior art is reduced, so that the collecting net cannot be completely adhered to the wall, thereby causing recurrent DVT and even falling off to form PE.

Description

Absorbable filter

Technical Field

The invention relates to the field of medical instruments, in particular to an absorbable filter.

Background

The vena cava filter can capture fatal free thrombus, is an effective means for treating deep vein thrombosis (Deep venous thrombosis, DVT) and preventing pulmonary embolism (pulmonary embolism, PE), and is mainly divided into a non-degradable vena cava filter and a degradable filter; non-degradable vena cava filters are further classified into temporary vena cava filters, switchable vena cava filters and permanent vena cava filters, and there are some unavoidable complications of the non-degradable vena cava filters, such as: "vascular bleeding, breakage, even perforation, etc.", whereas degradable filters have a series of problems like low support strength, large particle fragments blocking pulmonary artery after degradation.

Disclosure of Invention

The present invention aims to provide an absorbable filter to alleviate the above technical problems of the prior art.

In order to achieve the above purpose, the embodiment of the present invention adopts the following technical scheme:

the embodiment of the invention provides an absorbable filter, which comprises an anchoring bracket, a filter plug bracket and a binding wire made of medical materials capable of degrading in vivo;

the anchoring support is opened to be cylindrical, and a rear anchoring thorn is arranged on the peripheral wall of the anchoring support section;

the filter plug support is opened to be in a shape that the front end is bound by the binding wire and the rear end is opened, and the front end of the filter plug support is preformed to have a movement trend of rebounding outwards along the radial direction all the time; a front anchoring thorn is arranged on the peripheral surface of the front end of the filter plug bracket;

the rear end of the filter plug bracket is connected with the front end of the anchoring bracket;

under the conditions that the binding wire is implanted and not degraded and broken, the anchoring bracket and the filter plug bracket are both opened, the rear anchoring thorns are anchored on the inner wall of the blood vessel, and the front anchoring thorns are far away from the inner wall of the blood vessel; after the binding wires are degraded and broken, the front end of the filter plug support rebounds outwards along the radial direction, so that the front end of the filter plug support is opened, and the front anchoring thorns are anchored on the inner wall of the blood vessel.

In the embodiment, (1) in the degradation process of the binding wire, the front anchoring thorns ensure that the anchoring bracket is not shifted, so that the filter plug bracket is not shifted, and the tension of the absorbable filter is prevented from falling off to form thrombus, (2) after the degradation of the binding wire is broken, the front anchoring thorns at the front end of the filter plug bracket are used for anchoring the absorbable filter to the inner wall of a blood vessel, so that the absorbable filter is prevented from falling off to form thrombus, and the undegradable part of the absorbable filter and the inner wall of the blood vessel are endothelialized; thus, the problem of recurrent DVT and even filter shedding to form PE is avoided throughout the plug and degradation process.

In an alternative implementation manner of the present embodiment, preferably, the binding wire winds around the front end of the filter plug bracket for at least one circle, and two ends of the binding wire are respectively fixed to the front end of the filter plug bracket so as to bind the front end of the filter plug bracket; and the diameter of the binding wire gradually decreases from two ends to the middle part.

In an alternative implementation of this embodiment, it is preferable that the plug support includes a plurality of filter arms; the plurality of filter arms are distributed at intervals along the circumferential direction of the anchoring support.

Wherein: preferably, each filter arm is respectively provided with a respective side branch part, and the side branch parts on two adjacent filter arms are mutually overlapped to intercept thrombus under the condition that the binding wire is not degraded and broken.

Preferably, the front end of the anchoring bracket is provided with an extension connecting part;

one of the extending connecting parts and the rear ends of the filter arms is provided with a clip, the other is provided with a double-side clamping groove, and the clip is clamped and fixed in the double-side clamping groove.

Preferably, the outer peripheral surface of each filter arm is respectively provided with a wire feeding groove for feeding binding wires.

Further preferably, two ends of the binding wire are respectively provided with a retaining ring, and the retaining rings are respectively sleeved in a wire feeding groove of the filter arm.

Furthermore, in an alternative implementation of the present embodiment, it is more preferable that the anchoring stent is made of an in vivo degradable medical material.

Further preferably, the width of the portion of the anchoring frame provided with the rear anchoring thorn is larger than the width of other portions of the anchoring frame.

In an alternative implementation manner of this embodiment, it is preferable that the rear end of the anchor bracket is provided with a first developing portion, and the front end of the plug bracket is provided with a second developing portion.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic view of the overall structure of an absorbable filter according to an embodiment of the present invention;

FIG. 2 is an enlarged view of the part of the structure of the portion A in FIG. 1;

FIG. 3 is an enlarged view of a part of the structure of the portion B in FIG. 1;

FIG. 4 is an enlarged view of a part of the structure of the portion C in FIG. 1;

FIG. 5 is a side view of an embodiment of the present invention providing an absorbable filter from the perspective of FIG. 1;

FIG. 6 is a schematic view of the overall structure of a single filter arm of a plug holder in an absorbable filter according to an embodiment of the present invention;

FIG. 7 is a schematic view of the overall structure of an anchor stent in an absorbable filter according to an embodiment of the present invention;

FIG. 8 is an enlarged view of a portion of the structure of the portion D of FIG. 7;

FIG. 9 is an enlarged view of the portion of the structure at E in FIG. 7;

FIG. 10 is a schematic view showing the overall structure of a binder wire in an absorbable filter according to an embodiment of the present invention;

FIG. 11 is a schematic view showing the overall structure of a binder wire in an absorptive filter according to an embodiment of the present invention;

FIG. 12 is a diagram of an embodiment of an absorbable filter, implanted and without degradation of the binding wire;

FIG. 13 is a diagram showing the state of the front end of the plug portion in rebound adherence after implantation and degradation and fracture of the binding threads of the absorbable filter according to the embodiment of the present invention;

FIG. 14 is a state diagram showing the complete endothelialization of the plug stent and the vessel wall after implantation and degradation of both the tie wire and the anchor stent in an alternative embodiment of the present invention wherein both the tie wire and the anchor stent are degradable structures in an absorbable filter;

FIG. 15 is an alternative block diagram of the filter arms of the plug support in an embodiment of the present invention;

fig. 16 is a plan expanded view of the structure shown in fig. 15.

Icon: 100-inner wall of blood vessel; 1-anchoring a stent; 101-post anchoring thorns; 11-an extension connection; 111-double sided card slots; 112-a developing mounting bar; 2-a filter plug bracket; 201-front anchor thorn; 21-a filter arm; 211-side branches; 212-clip; 213-wire feeding grooves; 3-binding wires; 31-snap ring; 41-a first developing portion; 42-a second developing section.

Detailed Description

For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It should be noted that: like reference numerals and letters designate like items in the drawings, and thus once an item is defined in one drawing, no further definition or explanation thereof is necessary in the subsequent drawings.

In the description of the present invention, it should be noted that, directions or positional relationships indicated by terms such as "front end", "rear end", "inner", "outer", etc., are directions or positional relationships based on those shown in the drawings, or those that are conventionally put in place when the inventive product is used, are merely for convenience of describing the present invention and simplifying the description, and are not indicative or implying that the apparatus or element to be referred to must have a specific direction, be configured and operated in a specific direction, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and the like, are used merely to distinguish between descriptions and should not be construed as indicating or implying relative importance.

In particular, in the present invention, after the filter is implanted, the downstream in the blood flow direction is the front end of the filter, and the upstream is the rear end of the filter.

In the description of the present invention, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.

Some embodiments of the present invention are described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be combined with each other without conflict.

This embodiment provides an absorbable filter, referring to fig. 1 to 5, comprising an anchor stent 1, a plug stent 2, and a binding wire 3 made of an in vivo degradable medical material.

Specifically, the anchoring bracket 1 is opened to be cylindrical, and a rear anchoring thorn 101 is arranged on the peripheral wall of the section of the anchoring bracket 1; the filter plug support 2 is opened to be in a shape that the front end is bound by the binding wire 3 and the rear end is opened, and the filter plug support 2 is prefabricated to have a movement trend that the front end always rebounds outwards along the radial direction; a front anchoring thorn 201 is arranged on the outer peripheral surface of the front end of the filter plug bracket 2; the rear end of the plug holder 2 is connected to the front end of the anchor holder 1.

In the case of the implanted and binding wire 3 not degraded and broken, as shown in fig. 12, the anchoring stent 1 and the plug stent 2 are both opened, and the rear anchoring thorn 101 is anchored to the inner wall 100 of the blood vessel, the front anchoring thorn 201 is far away from the inner wall 100 of the blood vessel, and the opening modes of the anchoring stent 1 include but are not limited to: (1) The anchoring stent 1 itself is an elastic stent which is self-expanded into a cylindrical shape after being released by a delivery tube of a delivery device, and has a front anchoring spike 201 on its outer peripheral surface to pierce the inner wall 100 of a blood vessel; (2) When the anchoring stent 1 is conveyed into a patient, the balloon is simultaneously stretched into the anchoring stent 1, after the anchoring stent 1 is released, the balloon is expanded, the front anchoring thorns 201 on the peripheral wall of the anchoring stent 1 are penetrated into the inner wall 100 of the blood vessel, and then the balloon is withdrawn; or alternatively, the anchoring stent 1 is opened, and the front anchoring spike 201 is made to pierce the inner wall 100 of the blood vessel, the anchoring stent 1 being kept in the opened cylindrical shape;

waiting for a period of time, the binding wires 3 will be degraded and broken, so that the front end of the filter plug bracket 2 is released;

after the binding wire 3 is degraded and broken, as shown in fig. 13, the front end of the filter plug stent 2 rebounds radially outwards, so that the front end of the filter plug stent 2 is opened, and the front anchoring thorns 201 are anchored to the inner wall 100 of the blood vessel, so that the blood flow is smooth.

In this embodiment, (1) during the degradation of the binding wire 3, the front anchoring thorn 201 ensures that the anchoring stent 1 is not shifted, and further ensures that the filter plug stent 2 is not shifted, so as to avoid the tension drop of the absorbable filter from falling off to form thrombus, (2) after the degradation of the binding wire 3 is broken, the front anchoring thorn 201 at the front end of the filter plug stent 2 is used for anchoring the absorbable filter to the inner wall 100 of the blood vessel, so as to avoid the absorbable filter from falling off to form thrombus until the undegraded part of the absorbable filter is endothelialized with the inner wall 100 of the blood vessel; thus, the problem of recurrent DVT and even filter shedding to form PE is avoided throughout the plug and degradation process.

In addition, in order to avoid the problem that the binding wire 3 is released into thrombus to form PE, in an alternative implementation of this embodiment, it is preferable that, as shown in fig. 10 and 11, the binding wire 3 is wound around the front end of the plug holder 2 for at least one week, and both ends of the binding wire 3 are respectively fixed to the front end of the plug holder 2 to bind the front end of the plug holder 2; the diameter of the binding wire 3 gradually decreases from both ends to the middle. Thus, after the absorbable filter is implanted, the binding wire 3 starts to degrade and breaks from the thinnest part of the absorbable filter along with the time, and the degradation is complete from the thin part to the thick part, namely, the binding wire 3 is degraded from the middle to the two ends, and the two ends of the binding wire 3 are respectively fixed at the front ends of the filter plug bracket 2, so that the binding wire 3 cannot fall off into blood to form thrombus. The binding wire 3 may be, but is not limited to, woven from a plurality of strands to control the diameter of each portion during the weaving process.

In an alternative implementation of the present embodiment, and with reference to fig. 6 to 9, and in combination with fig. 1 to 5, the plug holder 2 comprises a plurality of filter arms 21; these filter arms 21 are spaced apart along the circumference of the anchor stent 1. After the constraint wire 3 is degraded by the arrangement, the filter arms 21 dispersedly support the inner wall 100 of the blood vessel, the contact part of the filter plug support 2 and the blood vessel wall hardly generates radial supporting force on the blood vessel wall, the filter arms 21 are not interfered with each other, the flexibility is good, and the damage such as perforation and the like to the blood vessel can not be caused along with the contraction and the expansion of the blood vessel.

Each filter arm 21 is preferably, but not limited to, formed from a nickel titanium alloy tube or other alloy or other metallic material by laser engraving, wherein: the structure of each filter arm 21 may be as shown in fig. 5 and 6, and includes a rod-shaped main arm, and a plurality of side branch parts 211 connected to the rod-shaped main arm and extending to two sides of the rod-shaped main arm, where the binding wire 3 is not degraded and broken, the side branch parts 211 on two adjacent filter arms 21 overlap each other to intercept thrombus; alternatively, as shown in fig. 15 and 16, each filter arm 21 includes a front rod, a middle structure and a rear rod that are sequentially connected in the axial direction, the middle structure is formed by butt joint of a symmetrical left wave-shaped structure and a right wave-shaped structure, the peaks of the left wave-shaped structure and the peaks of the right wave-shaped structure together form side branch portions 211 of each filter arm 21, and the side branch portions 211 on two adjacent filter arms 21 overlap each other to intercept thrombus under the condition that the binding wire 3 is not degraded and broken.

Preferably, as shown in fig. 1, 3, 7 and 8, the front end of the anchoring bracket 1 is provided with an extension connection portion 11; one of the extending connection portion 11 and the rear end of each filter arm 21 is provided with a clip 212, and the other is provided with a double-sided clamping groove 111, and the clip 212 is clamped and fixed in the double-sided clamping groove 111, so as to realize the fixed connection between the front end of the anchoring bracket 1 and the rear end of the filter plug bracket 2, and have the effects of convenient manufacture and reliable connection.

Preferably, as shown in fig. 2 and 6, the outer peripheral surface of each filter arm 21 is provided with at least one wire feeding groove 213 for feeding the binding wire 3, and the position of the binding wire 3 binding the front end of the filter arm 21 can be limited by the wire feeding groove 213, so that the binding wire 3 is prevented from loosening.

It is further preferred that, as shown in fig. 2, 10 and 11, the two ends of the binding wire 3 are respectively provided with a retaining ring 31, and the retaining rings 31 are respectively sleeved in the wire feeding grooves 213 of one filter arm 21, and the wire feeding grooves 213 are preferably but not limited to at least two on each filter arm 21 so as to provide separate fixing positions for the end of the binding wire 3 on each filter arm 21 for selective use during assembly.

Furthermore, in each alternative embodiment of the present example, it is preferable that the anchor stent 1 is made of an in vivo degradable medical material, and in the structure of this alternative embodiment, after the implantation and degradation of both the binding wire 3 and the anchor stent 1, the state diagram of the complete endothelialization of the plug stent 2 and the vessel wall is as shown in fig. 14, when the gradual endothelialization and degradation of the anchor stent 1 are completed, the radial supporting force of the absorbable filter on the vessel will gradually decrease or even disappear, and particularly when the plug stent 2 is made of a plurality of mutually independent filter arms 21, only a plurality of filter arms 21 remain in the human body, and the filter arms 21 are separated from each other, so that any radial supporting force will not be applied to the vessel inner wall to avoid the symptoms such as vessel perforation under the permanent support.

It is further preferred that the degradation time of the anchoring stent 1 is made greater than the degradation break time of the binding wire 3, and specific implementations include, but are not limited to, making the width or thickness of each portion of the anchoring stent 1 greater than the diameter of the thinnest portion of the binding wire 3, the anchoring stent 1 preferably being cut from a biodegradable tube.

It is further preferred that the width of the portion of the anchoring frame 1 provided with the rear anchoring thorn 101 is larger than the width of the other portions of the anchoring frame 1, so that when the portion of the anchoring thorn 101 is degraded, the anchoring and fixing is performed by the anchoring thorn 101 before the other portions are degraded, and it is worth mentioning that before the anchoring frame 1 is degraded, endothelialization occurs between the anchoring frame 1 and the inner wall 100 of the blood vessel, and thus, no fragmented thrombus is generated in the blood vessel.

Further, in an alternative implementation of the present embodiment, it is preferable that, as shown in fig. 1, the anchor bracket 1 is provided at a rear end thereof with a first developing portion 41, and the plug bracket 2 is provided at a front end thereof with a second developing portion 42, so as to assist in implantation and observation of an end state after implantation.

Preferably, as shown in fig. 1, 4 and 7, the anchoring bracket 1 includes a mesh body, the mesh body is opened to be cylindrical, a plurality of developing mounting rods 112 are arranged at the rear end of the mesh body along the circumferential direction of the mesh body at intervals, the developing mounting rods 112 extend along the axial direction, and the first developing part 41 is a developing ring sleeved and fixed on the developing mounting rods 112. Similarly, the second developing portion 42 may be a developing ring fitted and fixed to the outside of the tip of each filter arm 21, and the first developing portion 41 and the second developing portion 42 may be formed by, but not limited to, shaping a developing material such as platinum iridium alloy.

Finally, it should be noted that: in the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described by differences from other embodiments, and identical and similar parts between the embodiments are only required to be seen with each other; the above embodiments in the present specification are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.

Claims

1. An absorbable filter, characterized by: comprises an anchoring bracket (1), a filter plug bracket (2) and a binding wire (3) made of medical material which can be degraded in vivo;

the anchoring support (1) is opened to be cylindrical, and a rear anchoring thorn (101) is arranged on the peripheral wall of the section of the anchoring support (1);

the filter plug support (2) is opened to be in a shape that the front end is bound by the binding wire (3) and the rear end is opened, and the filter plug support (2) is prefabricated to have a movement trend that the front end always rebounds outwards along the radial direction; a front anchoring thorn (201) is arranged on the peripheral surface of the front end of the filter plug bracket (2);

the rear end of the filter plug bracket (2) is connected with the front end of the anchoring bracket (1);

in the case of implantation and without degradation and fracture of the binding wire (3), both the anchoring stent (1) and the plug stent (2) are open, and the rear anchoring spike (101) is anchored to the vessel inner wall, the front anchoring spike (201) being remote from the vessel inner wall; after the binding wire (3) is degraded and broken, the front end of the filter plug support (2) rebounds outwards along the radial direction, so that the front end of the filter plug support (2) is opened, and the front anchoring thorns (201) are anchored on the inner wall of the blood vessel.

2. The absorbable filter of claim 1, wherein: the binding wire (3) winds at least one circle around the front end of the filter plug support (2), and two ends of the binding wire (3) are respectively fixed at the front end of the filter plug support (2) so as to bind the front end of the filter plug support (2); and the diameter of the binding wire (3) gradually decreases from two ends to the middle part.

3. The absorbable filter of claim 1 or 2, wherein: the filter plug support (2) comprises a plurality of filter arms (21); the plurality of filter arms (21) are distributed at intervals along the circumferential direction of the anchoring bracket (1).

4. An absorbable filter as set forth in claim 3 wherein: and each filter arm (21) is respectively provided with a respective side branch part (211), and the side branch parts (211) on two adjacent filter arms (21) are mutually overlapped to intercept thrombus under the condition that the binding wire (3) is not degraded and broken.

5. An absorbable filter as set forth in claim 3 wherein: the front end of the anchoring bracket (1) is provided with an extension connecting part (11);

one of the extending connecting parts (11) and the rear ends of the filter arms (21) is provided with a clip (212), the other is provided with a double-side clamping groove (111), and the clip (212) is clamped and fixed in the double-side clamping groove (111).

6. An absorbable filter as set forth in claim 3 wherein: the outer peripheral surface of each filter arm (21) is respectively provided with a wire feeding groove (213) for feeding the binding wires (3).

7. The absorbable filter of claim 6, wherein: two ends of the binding wire (3) are respectively provided with a retaining ring (31), and the retaining rings (31) are respectively sleeved in a wire feeding groove (213) of the filter arm (21).

8. The absorbable filter of claim 1, wherein: the anchoring bracket (1) is made of medical material which can be degraded in vivo.

9. The absorbable filter of claim 8, wherein: the width of the part of the anchoring support (1) provided with the rear anchoring thorn (101) is larger than the width of other parts of the anchoring support (1).

10. The absorbable filter of claim 1, wherein: the rear end of the anchoring bracket (1) is provided with a first developing part (41), and the front end of the filter plug bracket (2) is provided with a second developing part (42).