CN107158471A - A kind of preparation method of golden cypress compound bio glass tissue repair materials - Google Patents

A kind of preparation method of golden cypress compound bio glass tissue repair materials Download PDF

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Publication number
CN107158471A
CN107158471A CN201710405127.5A CN201710405127A CN107158471A CN 107158471 A CN107158471 A CN 107158471A CN 201710405127 A CN201710405127 A CN 201710405127A CN 107158471 A CN107158471 A CN 107158471A
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solution
golden cypress
preparation
repair materials
tissue repair
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王吉鹏
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Hefei Create Technology Co Ltd
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Hefei Create Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3637—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Materials For Medical Uses (AREA)

Abstract

A kind of preparation method of golden cypress compound bio glass tissue repair materials, belongs to biological medicine Material Field, including：Repair materials are made in the preparation of cortex phellodendri extract, the preparation of PLA solution, the preparation of bio-vitric solution, electrostatic spinning.Wherein golden cypress has antibacterial action, and PLA can improve the mechanical performance of material, and bio-vitric can improve the medicinal properties of material.Tissue renovation material produced by the present invention has good mechanical performance, tissue repair performance and drug attachment.

Description

A kind of preparation method of golden cypress compound bio glass tissue repair materials
Technical field
The invention belongs to biological medicine Material Field, more particularly to a kind of golden cypress compound bio glass tissue repair materials Preparation method.
Background technology
So far, people's more attention is influence of the bio-vitric component to bioactivity to self-discovery bio-vitric.Nanometer The rise of technology, makes people start to recognize that structure also has a major impact bioactivity, more pays attention to dimensional effect, microcosmic Influence of the fine structure to material structure and performance.Nanometer biological glass, mesoporous biological from nano-scale R ＆ D design Glass is even more the concern for enjoying domestic and foreign scholars.Bio-vitric energy active cell gene, is conducive to strengthening the propagation of cell with dividing Change, the effect with self-bone grafting and osteoacusis.But in view of the presence of its amorphous silicon skeleton, bio-vitric is still rendered as amorphous State, bad mechanical property, and drug attachment is poor, its application on biological medicine material need further exploitation.
The content of the invention
In order to solve problems of the prior art, the invention provides a kind of good mechanical property, and with excellent The preparation method of the golden cypress compound bio glass tissue repair materials of drug attachment.
The present invention uses following technical scheme：
A kind of preparation method of golden cypress compound bio glass tissue repair materials, comprises the following steps：
Step one：Golden cypress is cleaned, and is placed at aeration-drying and is air-dried, the golden cypress after air-drying is placed in 90 8min is dried under the conditions of DEG C, by dried golden cypress, is put into pulverizer and crushes, the golden cypress after crushing is crossed into 60 mesh sieves, obtains yellow Bai Fen；
Step 2：2g golden cypress powder is weighed, is placed in the wide-mouth bottle for filling 100ml absolute ethyl alcohols, under 40 DEG C of temperature conditionss Constant temperature extracts 10h, and filter residue is taken out after solution is filtered, and 50ml absolute ethyl alcohol and the constant temperature under the conditions of 40 DEG C are added into filter residue 20min is extracted, filtrate will be merged twice after filtering again, and rotary evaporation is carried out under the conditions of 58 DEG C, cumulative volume is concentrated into For 5ml, cortex phellodendri extract is obtained；
Step 3：Particles of polylactic acid is dissolved in chloroform, 6.5wt% solution is configured to, ultrasonically treated 30 minutes, 24 hours are stirred at room temperature until PLA all dissolves, and are added the absolute ethyl alcohol of volume fraction 35%, are stirred at room temperature 24 Hour is uniform to solution clarification, obtains PLA solution；
Step 4：By 5g PEOs-PPOX-, that PEO triblock copolymer is dissolved in 62g volumes is dense Spend in the ethanol solution for 70%, after being sufficiently stirred for, sequentially add 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO3)2·4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 5：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, biology is made Glass solution；
Step 6：By PLA solution, cortex phellodendri extract, bio-vitric solution in mass ratio 50:2:8 are well mixed, and make It is disperseed with ultrasonic oscillation, magnetic agitation 1h under the conditions of 50 DEG C, then continue to stir 8h at room temperature, obtain sticky molten Liquid is placed in the medical needle tubing being connected with high-pressure installation, and repair materials are made by electrostatic spinning, and high-pressure installation voltage is 20kV, Obtained material is dried in vacuo at 40 DEG C.
It is preferred that, the capacity of the medical needle tubing described in step 6 is 20ml.
It is preferred that, the syringe needle of the medical needle tubing described in step 6 is fixed at electrostatic spinning receiver board 20cm.
The beneficial effects of the present invention are：
1) PLA has good biodegradability, while also having good Bioabsorbable and bio-compatible Property, any environmental issue will not be left after degradation, and in medical field, oneself is considered as most promising degradable macromolecule material Material.
2) bio-vitric has good biocompatibility, and the function with tissue repair, and energy active cell gene has Propagation and differentiation beneficial to enhancing cell, the effect with self-bone grafting and osteoacusis.
3) golden cypress has heat-clearing and damp-drying drug, purging intense heat, except steaming, effect of detoxification sore treatment.Golden cypress also has antibacterial action：Golden cypress Antibiotic effective ingredient is jamaicin, therefore its pharmacological action is substantially similar to the coptis, but content is low compared with the coptis.In vitro test is to golden yellow Color staphylococcus, pneumococcus, corynebacterium diphtheriae, Streptococcus viridans, shigella dysenteriae, hemolytic streptococcus, meningococcus, suddenly Random vibrios, bacillus anthracis are effective or have stronger inhibitory action；Also have to hay bacillus, Bordetella pertussis, clostridium tetani Inhibitory action；To H37Rv, mycobacterium tuberculosis without direct repression, but bacterium number can be reduced, but concentration up to 1% when present Bacteriostasis.When making experimental therapy with cavy inoculation Mycobacterium hominis (H37Rv), oral or injection curative effect is very poor.It is right The cavy of Mycobacterium bovis is inoculated with, during the hydrochloric acid crystal intramuscular injection of phellodendron extract, there is certain curative effect.Golden cypress is to tuberculosis The clinical symptoms of people and x-ray inspection take a favorable turn, and better than the coptis.In test tube, golden cypress decoction or preserved material are to common pathogenic Fungi has different degrees of bacteriostasis.
4) PLA can improve the mechanical performance of material, and bio-vitric can improve the medicinal properties of material.
5) material prepared using electrostatic spinning technique, with good porosity, is conducive to the attachment of medicine.
Embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
A kind of preparation method of golden cypress compound bio glass tissue repair materials, comprises the following steps：
Step one：Golden cypress is cleaned, and is placed at aeration-drying and is air-dried, the golden cypress after air-drying is placed in 90 8min is dried under the conditions of DEG C, by dried golden cypress, is put into pulverizer and crushes, the golden cypress after crushing is crossed into 60 mesh sieves, obtains yellow Bai Fen；
Step 2：2g golden cypress powder is weighed, is placed in the wide-mouth bottle for filling 100ml absolute ethyl alcohols, under 40 DEG C of temperature conditionss Constant temperature extracts 10h, and filter residue is taken out after solution is filtered, and 50ml absolute ethyl alcohol and the constant temperature under the conditions of 40 DEG C are added into filter residue 20min is extracted, filtrate will be merged twice after filtering again, and rotary evaporation is carried out under the conditions of 58 DEG C, cumulative volume is concentrated into For 5ml, cortex phellodendri extract is obtained；
Step 3：Particles of polylactic acid is dissolved in chloroform, 6.5wt% solution is configured to, ultrasonically treated 30 minutes, 24 hours are stirred at room temperature until PLA all dissolves, and are added the absolute ethyl alcohol of volume fraction 35%, are stirred at room temperature 24 Hour is uniform to solution clarification, obtains PLA solution；
Step 4：By 5g PEOs-PPOX-, that PEO triblock copolymer is dissolved in 62g volumes is dense Spend in the ethanol solution for 70%, after being sufficiently stirred for, sequentially add 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO3)2·4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 5：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, biology is made Glass solution；
Step 6：By PLA solution, cortex phellodendri extract, bio-vitric solution in mass ratio 50:2:8 are well mixed, and make It is disperseed with ultrasonic oscillation, magnetic agitation 1h under the conditions of 50 DEG C, then continue to stir 8h at room temperature, obtain sticky molten Liquid is placed in the medical needle tubing being connected with high-pressure installation, and repair materials are made by electrostatic spinning, and high-pressure installation voltage is 20kV, Obtained material is dried in vacuo at 40 DEG C.
The capacity of medical needle tubing described in step 6 is 20ml, and the syringe needle of the medical needle tubing described in step 6 is fixed on At electrostatic spinning receiver board 20cm.

Claims (3)

1. a kind of preparation method of golden cypress compound bio glass tissue repair materials, it is characterised in that comprise the following steps：
Step one：Golden cypress is cleaned, and is placed at aeration-drying and is air-dried, the golden cypress after air-drying is placed in 90 DEG C of bars 8min is dried under part, by dried golden cypress, is put into pulverizer and crushes, the golden cypress after crushing is crossed into 60 mesh sieves, golden cypress powder is obtained；
Step 2：2g golden cypress powder is weighed, is placed in the wide-mouth bottle for filling 100ml absolute ethyl alcohols, the constant temperature under 40 DEG C of temperature conditionss 10h is extracted, filter residue is taken out after solution is filtered, 50ml absolute ethyl alcohol is added into filter residue and constant temperature is extracted under the conditions of 40 DEG C 20min, filtrate will merge twice after filtering again, and carry out rotary evaporation under the conditions of 58 DEG C, and being concentrated into cumulative volume is 5ml, obtains cortex phellodendri extract；
Step 3：Particles of polylactic acid is dissolved in chloroform, 6.5wt% solution is configured to, ultrasonically treated 30 minutes, in room temperature Lower stirring adds the absolute ethyl alcohol of volume fraction 35%, is stirred at room temperature 24 hours for 24 hours until PLA all dissolvings It is uniform to solution clarification, obtain PLA solution；
Step 4：5g PEO-PPOX-PEO triblock copolymers are dissolved in into 62g volumetric concentrations is In 70% ethanol solution, after being sufficiently stirred for, 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO are sequentially added3)2· 4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 5：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, bio-vitric is made Solution；
Step 6：By PLA solution, cortex phellodendri extract, bio-vitric solution in mass ratio 50:2:8 are well mixed, using super Sound wave shock disperses to it, magnetic agitation 1h under the conditions of 50 DEG C, then continues to stir 8h at room temperature, obtains viscous solution and puts In the medical needle tubing being connected with high-pressure installation, repair materials are made by electrostatic spinning, high-pressure installation voltage is 20kV, will be made The material obtained is dried in vacuo at 40 DEG C.
2. a kind of preparation method of golden cypress compound bio glass tissue repair materials according to claim 1, its feature exists In：The capacity of medical needle tubing described in step 6 is 20ml.
3. a kind of preparation method of golden cypress compound bio glass tissue repair materials according to claim 1, its feature exists In：The syringe needle of medical needle tubing described in step 6 is fixed at electrostatic spinning receiver board 20cm.
CN201710405127.5A 2017-05-31 2017-05-31 A kind of preparation method of golden cypress compound bio glass tissue repair materials Pending CN107158471A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109594195A (en) * 2019-01-25 2019-04-09 蓝怡科技集团股份有限公司 A kind of cotton shape fibrous framework and its preparation method and application

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104096261A (en) * 2013-04-09 2014-10-15 上海交通大学医学院附属第九人民医院 Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104096261A (en) * 2013-04-09 2014-10-15 上海交通大学医学院附属第九人民医院 Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109594195A (en) * 2019-01-25 2019-04-09 蓝怡科技集团股份有限公司 A kind of cotton shape fibrous framework and its preparation method and application
CN109594195B (en) * 2019-01-25 2021-11-05 蓝怡科技集团股份有限公司 Cotton-shaped fiber scaffold and preparation method and application thereof

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