CN107185049A - A kind of preparation method of chitosan compound biological activity glass tissue renovation material - Google Patents

A kind of preparation method of chitosan compound biological activity glass tissue renovation material Download PDF

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Publication number
CN107185049A
CN107185049A CN201710399528.4A CN201710399528A CN107185049A CN 107185049 A CN107185049 A CN 107185049A CN 201710399528 A CN201710399528 A CN 201710399528A CN 107185049 A CN107185049 A CN 107185049A
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China
Prior art keywords
solution
chitosan
preparation
biological activity
compound biological
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CN201710399528.4A
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Chinese (zh)
Inventor
王吉鹏
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Hefei Create Technology Co Ltd
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Hefei Create Technology Co Ltd
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Priority to CN201710399528.4A priority Critical patent/CN107185049A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
    • D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
    • D04H1/4382—Stretched reticular film fibres; Composite fibres; Mixed fibres; Ultrafine fibres; Fibres for artificial leather
    • D—TEXTILES; PAPER
    • D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
    • D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
    • D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
    • D04H1/70—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres
    • D04H1/72—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged
    • D04H1/728—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A kind of preparation method of chitosan compound biological activity glass tissue renovation material, belongs to biological medicine Material Field, including：Repair materials are made in the preparation of chitosan-acetic acid solution, the preparation of bioactivity glass solution, electrostatic spinning.Wherein chitosan can improve the mechanical performance of material, and bioactivity glass can improve the medicinal properties of material.Tissue renovation material produced by the present invention has good mechanical performance, tissue repair performance and drug attachment.

Description

A kind of preparation method of chitosan compound biological activity glass tissue renovation material
Technical field
The invention belongs to biological medicine Material Field, more particularly to a kind of chitosan compound biological activity glass tissue repair The preparation method of material.
Background technology
So far, people's more attention is shadow of the bioactivity glass component to bioactivity to self-discovery bioactivity glass Ring.The rise of nanometer technology, makes people start to recognize that structure also has a major impact bioactivity, more pays attention to size effect Should, influence of the microcosmic fine structure to material structure and performance.Nanometer biological glass, Jie from nano-scale R ＆ D design Hole bio-vitric is even more the concern for enjoying domestic and foreign scholars.Bio-vitric energy active cell gene, is conducive to strengthening the increasing of cell Grow and break up, the effect with self-bone grafting and osteoacusis.But in view of the presence of its amorphous silicon skeleton, bio-vitric is still rendered as Amorphous state, bad mechanical property, and drug attachment is poor, its application on biological medicine material need further exploitation.
The content of the invention
In order to solve problems of the prior art, the invention provides a kind of good mechanical property, and with excellent The preparation method of the chitosan compound biological activity glass tissue renovation material of drug attachment.
The present invention uses following technical scheme：
A kind of preparation method of chitosan compound biological activity glass tissue renovation material, comprises the following steps：
Step one：By chitosan and the acetic acid of mass concentration 1% by weight 1:8 are well mixed, and chitosan acetic acid is made Solution；
Step 2：By 5g PEOs-PPOX-, that PEO triblock copolymer is dissolved in 62g volumes is dense Spend in the ethanol solution for 70%, after being sufficiently stirred for, sequentially add 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO3)2·4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 3：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, biology is made Activity glass solution；
Step 4：By chitosan-acetic acid solution and bioactivity glass solution in mass ratio 50:11 are well mixed, using super Sound wave shock disperses to it, magnetic agitation 1h under the conditions of 50 DEG C, then continues to stir 8h at room temperature, obtains viscous solution and puts In the medical needle tubing being connected with high-pressure installation, repair materials are made by electrostatic spinning, high-pressure installation voltage is 20kV, will be made The material obtained is dried in vacuo at 40 DEG C.
It is preferred that, the capacity of the medical needle tubing described in step 4 is 20ml.
It is preferred that, the syringe needle of the medical needle tubing described in step 4 is fixed at electrostatic spinning receiver board 20cm.
The beneficial effects of the present invention are：
1) chitosan has good biocompatibility, and with good fungistatic effect.
2) bioactivity glass has good biocompatibility, and the function with tissue repair, can active cell base Cause, is conducive to strengthening propagation and the differentiation of cell, the effect with self-bone grafting and osteoacusis.
3) chitosan can improve the mechanical performance of material, and bioactivity glass can improve the medicinal properties of material.
4) material prepared using electrostatic spinning technique, with good porosity, is conducive to the attachment of medicine.
Embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
A kind of preparation method of chitosan compound biological activity glass tissue renovation material, comprises the following steps：
Step one：By chitosan and the acetic acid of mass concentration 1% by weight 1:8 are well mixed, and chitosan acetic acid is made Solution；
Step 2：By 5g PEOs-PPOX-, that PEO triblock copolymer is dissolved in 62g volumes is dense Spend in the ethanol solution for 70%, after being sufficiently stirred for, sequentially add 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO3)2·4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 3：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, biology is made Activity glass solution；
Step 4：By chitosan-acetic acid solution and bioactivity glass solution in mass ratio 50:11 are well mixed, using super Sound wave shock disperses to it, magnetic agitation 1h under the conditions of 50 DEG C, then continues to stir 8h at room temperature, obtains viscous solution and puts In the medical needle tubing being connected with high-pressure installation, repair materials are made by electrostatic spinning, high-pressure installation voltage is 20kV, will be made The material obtained is dried in vacuo at 40 DEG C.
The capacity of medical needle tubing described in step 4 is 20ml；The syringe needle of described medical needle tubing is fixed on apart from electrostatic At spinning receiver board 20cm.

Claims (3)

1. a kind of preparation method of chitosan compound biological activity glass tissue renovation material, it is characterised in that including following step Suddenly：
Step one：By chitosan and the acetic acid of mass concentration 1% by weight 1:8 are well mixed, and chitosan-acetic acid solution is made；
Step 2：5g PEO-PPOX-PEO triblock copolymers are dissolved in into 62g volumetric concentrations is In 70% ethanol solution, after being sufficiently stirred for, 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO are sequentially added3)2· 4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 3：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, bioactivity is made Glass solution；
Step 4：By chitosan-acetic acid solution and bioactivity glass solution in mass ratio 50:11 are well mixed, and use ultrasonic wave Concussion it is disperseed, magnetic agitation 1h under the conditions of 50 DEG C, then at room temperature continue stir 8h, obtain viscous solution be placed in In the medical needle tubing of high-pressure installation connection, repair materials are made by electrostatic spinning, high-pressure installation voltage is 20kV, will be obtained Material is dried in vacuo at 40 DEG C.
2. a kind of preparation method of chitosan compound biological activity glass tissue renovation material according to claim 1, its It is characterised by：The capacity of medical needle tubing described in step 4 is 20ml.
3. a kind of preparation method of chitosan compound biological activity glass tissue renovation material according to claim 1, its It is characterised by：The syringe needle of medical needle tubing described in step 4 is fixed at electrostatic spinning receiver board 20cm.
CN201710399528.4A 2017-05-31 2017-05-31 A kind of preparation method of chitosan compound biological activity glass tissue renovation material Pending CN107185049A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110420350A (en) * 2019-08-28 2019-11-08 深圳先进技术研究院 Adherency temperature-sensitive hydrogel of compound bio glass and its preparation method and application
CN112709002A (en) * 2020-12-04 2021-04-27 广州贝奥吉因生物科技股份有限公司 Alginate antibacterial composite membrane and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104096262A (en) * 2013-04-09 2014-10-15 上海交通大学医学院附属第九人民医院 Collagen/chitosan/mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104096262A (en) * 2013-04-09 2014-10-15 上海交通大学医学院附属第九人民医院 Collagen/chitosan/mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110420350A (en) * 2019-08-28 2019-11-08 深圳先进技术研究院 Adherency temperature-sensitive hydrogel of compound bio glass and its preparation method and application
CN110420350B (en) * 2019-08-28 2021-10-22 深圳先进技术研究院 Adhesive temperature-sensitive hydrogel of composite bioglass and preparation method and application thereof
CN112709002A (en) * 2020-12-04 2021-04-27 广州贝奥吉因生物科技股份有限公司 Alginate antibacterial composite membrane and preparation method thereof

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