CN107158469A - A kind of preparation method of chitin compound bio glass tissue repair materials - Google Patents

A kind of preparation method of chitin compound bio glass tissue repair materials Download PDF

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Publication number
CN107158469A
CN107158469A CN201710400497.XA CN201710400497A CN107158469A CN 107158469 A CN107158469 A CN 107158469A CN 201710400497 A CN201710400497 A CN 201710400497A CN 107158469 A CN107158469 A CN 107158469A
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Prior art keywords
solution
chitin
preparation
repair materials
tissue repair
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CN201710400497.XA
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Chinese (zh)
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王吉鹏
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Hefei Create Technology Co Ltd
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Hefei Create Technology Co Ltd
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Priority to CN201710400497.XA priority Critical patent/CN107158469A/en
Publication of CN107158469A publication Critical patent/CN107158469A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A kind of preparation method of chitin compound bio glass tissue repair materials, belongs to biological medicine Material Field, including：Repair materials are made in the preparation of chitin solution, the preparation of bio-vitric solution, electrostatic spinning.Wherein chitin can improve the mechanical performance of material and with anti-microbial property, and bio-vitric can improve the medicinal properties of material.Tissue renovation material produced by the present invention has good mechanical performance, tissue repair performance and drug attachment.

Description

A kind of preparation method of chitin compound bio glass tissue repair materials
Technical field
The invention belongs to biological medicine Material Field, more particularly to a kind of chitin compound bio glass tissue repair materials Preparation method.
Background technology
So far, people's more attention is influence of the bio-vitric component to bioactivity to self-discovery bio-vitric.Nanometer The rise of technology, makes people start to recognize that structure also has a major impact bioactivity, more pays attention to dimensional effect, microcosmic Influence of the fine structure to material structure and performance.Nanometer biological glass, mesoporous biological from nano-scale R ＆ D design Glass is even more the concern for enjoying domestic and foreign scholars.Bio-vitric energy active cell gene, is conducive to strengthening the propagation of cell with dividing Change, the effect with self-bone grafting and osteoacusis.But in view of the presence of its amorphous silicon skeleton, bio-vitric is still rendered as amorphous State, bad mechanical property, and drug attachment is poor, its application on biological medicine material need further exploitation.
The content of the invention
In order to solve problems of the prior art, the invention provides a kind of good mechanical property, and with excellent The preparation method of the chitin compound bio glass tissue repair materials of drug attachment.
The present invention uses following technical scheme：
A kind of preparation method of chitin compound bio glass tissue repair materials, comprises the following steps：
Step one：Weigh 10g chitins to be placed in three-necked flask, and add 3mol/L hydrochloric acid solution, wherein chitin Rate of charge with hydrochloric acid solution is 1/30gmL-1, by mixed solution boiling reflux, during be stirred continuously, to continue 6 small for reaction Shi Hou, mixed solution is centrifuged and supernatant liquid is removed, takes lower sediment thing to be replaced in three-necked flask and by 1/30g mL-1Rate of charge is added in 3mol/L hydrochloric acid solution, continues to be heated to reflux after 6 hours, and mixed solution is centrifuged and removed Layer liquid, takes lower sediment thing to be rinsed repeatedly with deionized water between pH value reaches 3-4,100mL is added in sediment Deionized water carries out ultrasonic disperse, then finely dispersed dispersion liquid is transferred into the bag filter that molecular cut off is 8000-14000 In, it is dipped in deionized water and is dialysed, per 2h with changing a deionized water, until solution ph is inside and outside bag filter 7, the dispersion liquid dialysed is filtered by sand core funnel, is added to after filtering in 50mL deionized waters and is carried out ultrasonic disperse, is disperseed 30mL acetone is added after uniform and carries out centrifugal treating, lower sediment thing is taken again by its ultrasonic disperse in trifluoroethanol solution, makes Into the chitin solution of mass concentration 12%；
Step 2：By 5g PEOs-PPOX-, that PEO triblock copolymer is dissolved in 62g volumes is dense Spend in the ethanol solution for 70%, after being sufficiently stirred for, sequentially add 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO3)2·4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 3：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, biology is made Glass solution；
Step 4：By chitin solution and bio-vitric solution in mass ratio 50:9 are well mixed, and use ultrasonic oscillation It is disperseed, magnetic agitation 1h under the conditions of 50 DEG C, then continue to stir 8h at room temperature, obtained viscous solution and be placed in and high pressure In the medical needle tubing of device connection, repair materials are made by electrostatic spinning, high-pressure installation voltage is 20kV, by obtained material It is dried in vacuo at 40 DEG C.
It is preferred that, the capacity of the medical needle tubing described in step 4 is 20ml.
It is preferred that, the syringe needle of the medical needle tubing described in step 4 is fixed at electrostatic spinning receiver board 20cm.
The beneficial effects of the present invention are：
1) chitin has good biocompatibility, antibiotic property and excellent mechanical performance.
2) bio-vitric has good biocompatibility, and the function with tissue repair, and energy active cell gene has Propagation and differentiation beneficial to enhancing cell, the effect with self-bone grafting and osteoacusis.
3) chitin can improve the mechanical performance of material, and bio-vitric can improve the medicinal properties of material.
4) material prepared using electrostatic spinning technique, with good porosity, is conducive to the attachment of medicine.
Embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
A kind of preparation method of chitin compound bio glass tissue repair materials, comprises the following steps：
Step one：Weigh 10g chitins to be placed in three-necked flask, and add 3mol/L hydrochloric acid solution, wherein chitin Rate of charge with hydrochloric acid solution is 1/30gmL-1, by mixed solution boiling reflux, during be stirred continuously, to continue 6 small for reaction Shi Hou, mixed solution is centrifuged and supernatant liquid is removed, takes lower sediment thing to be replaced in three-necked flask and by 1/30g mL-1Rate of charge is added in 3mol/L hydrochloric acid solution, continues to be heated to reflux after 6 hours, and mixed solution is centrifuged and removed Layer liquid, takes lower sediment thing to be rinsed repeatedly with deionized water between pH value reaches 3-4,100mL is added in sediment Deionized water carries out ultrasonic disperse, then finely dispersed dispersion liquid is transferred into the bag filter that molecular cut off is 8000-14000 In, it is dipped in deionized water and is dialysed, per 2h with changing a deionized water, until solution ph is inside and outside bag filter 7, the dispersion liquid dialysed is filtered by sand core funnel, is added to after filtering in 50mL deionized waters and is carried out ultrasonic disperse, is disperseed 30mL acetone is added after uniform and carries out centrifugal treating, lower sediment thing is taken again by its ultrasonic disperse in trifluoroethanol solution, makes Into the chitin solution of mass concentration 12%；
Step 2：By 5g PEOs-PPOX-, that PEO triblock copolymer is dissolved in 62g volumes is dense Spend in the ethanol solution for 70%, after being sufficiently stirred for, sequentially add 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO3)2·4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 3：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, biology is made Glass solution；
Step 4：By chitin solution and bio-vitric solution in mass ratio 50:9 are well mixed, and use ultrasonic oscillation It is disperseed, magnetic agitation 1h under the conditions of 50 DEG C, then continue to stir 8h at room temperature, obtained viscous solution and be placed in and high pressure In the medical needle tubing of device connection, repair materials are made by electrostatic spinning, high-pressure installation voltage is 20kV, by obtained material It is dried in vacuo at 40 DEG C.
The capacity of medical needle tubing described in step 4 is 20ml；The syringe needle of described medical needle tubing is fixed on apart from electrostatic At spinning receiver board 20cm.

Claims (3)

1. a kind of preparation method of chitin compound bio glass tissue repair materials, it is characterised in that comprise the following steps：
Step one：Weigh 10g chitins to be placed in three-necked flask, and add 3mol/L hydrochloric acid solution, wherein chitin and salt The rate of charge of acid solution is 1/30gmL-1, by mixed solution boiling reflux, during be stirred continuously, reaction continue after 6 hours, Mixed solution is centrifuged and supernatant liquid is removed, takes lower sediment thing to be replaced in three-necked flask and by 1/30gmL-1Feed intake Than being added in 3mol/L hydrochloric acid solution, continue to be heated to reflux after 6 hours, mixed solution centrifuged and supernatant liquid is removed, Take lower sediment thing to be rinsed repeatedly with deionized water between pH value reaches 3-4,100mL deionized waters are added in sediment Ultrasonic disperse is carried out, then finely dispersed dispersion liquid is transferred in the bag filter that molecular cut off is 8000-14000, by it Dialysed in immersion deionized water, per 2h with changing a deionized water, until solution ph is 7 inside and outside bag filter, dialysis Good dispersion liquid is filtered by sand core funnel, is added to after filtering in 50mL deionized waters and is carried out ultrasonic disperse, after being uniformly dispersed Add 30mL acetone and carry out centrifugal treating, take lower sediment thing again by its ultrasonic disperse in trifluoroethanol solution, quality is made The chitin solution of concentration 12%；
Step 2：5g PEO-PPOX-PEO triblock copolymers are dissolved in into 62g volumetric concentrations is In 70% ethanol solution, after being sufficiently stirred for, 6g silester, 0.7g triethyl phosphates, 1.5gCa (NO are sequentially added3)2· 4H2O, 1g0.5M hydrochloric acid solution, obtain mixed liquor；
Step 3：Mixed liquor is stirred at room temperature after 24h and stood, when solution is in thick solution, that is, bio-vitric is made Solution；
Step 4：By chitin solution and bio-vitric solution in mass ratio 50:9 are well mixed, using ultrasonic oscillation to it Disperseed, magnetic agitation 1h under the conditions of 50 DEG C, then continue to stir 8h at room temperature, obtained viscous solution and be placed in and high-pressure installation In the medical needle tubing of connection, repair materials are made by electrostatic spinning, high-pressure installation voltage is 20kV, by obtained material 40 It is dried in vacuo at DEG C.
2. a kind of preparation method of chitin compound bio glass tissue repair materials according to claim 1, its feature It is：The capacity of medical needle tubing described in step 4 is 20ml.
3. a kind of preparation method of chitin compound bio glass tissue repair materials according to claim 1, its feature It is：The syringe needle of medical needle tubing described in step 4 is fixed at electrostatic spinning receiver board 20cm.
CN201710400497.XA 2017-05-31 2017-05-31 A kind of preparation method of chitin compound bio glass tissue repair materials Pending CN107158469A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1403166A (en) * 2002-09-26 2003-03-19 东南大学 Absorbable active tissue matter for repairing hard tissue and its prepn
CN104096261A (en) * 2013-04-09 2014-10-15 上海交通大学医学院附属第九人民医院 Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof
CN104120500A (en) * 2013-04-23 2014-10-29 上海交通大学医学院附属第九人民医院 Fish collagen/mesoporous bioglass composite nanofiber membrane and making method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1403166A (en) * 2002-09-26 2003-03-19 东南大学 Absorbable active tissue matter for repairing hard tissue and its prepn
CN104096261A (en) * 2013-04-09 2014-10-15 上海交通大学医学院附属第九人民医院 Gelatin / mesoporous bioactive glass composite nanofiber membrane material and preparation method thereof
CN104120500A (en) * 2013-04-23 2014-10-29 上海交通大学医学院附属第九人民医院 Fish collagen/mesoporous bioglass composite nanofiber membrane and making method thereof

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