CN107126498A - A kind of pharmaceutical composition for treating vaginitis - Google Patents
A kind of pharmaceutical composition for treating vaginitis Download PDFInfo
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- CN107126498A CN107126498A CN201710331463.XA CN201710331463A CN107126498A CN 107126498 A CN107126498 A CN 107126498A CN 201710331463 A CN201710331463 A CN 201710331463A CN 107126498 A CN107126498 A CN 107126498A
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- oil
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- vaginitis
- vagina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Plant Substances (AREA)
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Abstract
The invention provides a kind of pharmaceutical composition for treating vaginitis, the composition of following percentage by weight, garlic oil 26 33%, old camellia oil 47 55%, apricot kernel oil 15 22%, dimethyl sulfoxide 1 5% are included.The pharmaceutical composition composition of the present invention is simple, and convenient sources are without any side effects, have significant curative effect to colpitis.
Description
Technical field
The application is related to a kind of pharmaceutical composition, more particularly to a kind of pharmaceutical composition for treating vaginitis.
Background technology
Gynecology colpitis is the inflammation of connective tissue under vaginal mucosa and mucous membrane, is the common disease of Out-patient Clinic of Department of Gynecology, according to
The difference of pathogen infection, vaginitis is mainly segmented into trichomonas vaginitis, bacterial vaginitis and colpomycosis etc.
Three kinds.Due to anatomy and Biological characteristics, the intrusion of the vagina of normal healthy women to pathogen has natural defense function, when
The natural defense function of vagina is destroyed, then pathogen is easy to intrusion, causes colpitis, youngest daughter and postmenopausal women due to
Estrogen deficiency, vagina epithelium is belittled, and intracellular glycogen content is reduced, and vaginal pH is high, therefore vagina is lower for the resistance, compares the youth
Phase and women of child-bearing age's susceptible.
It is mainly antibiotic currently used for the medicine for the treatment of vaginitis, the administration of oral or pessary, such as Ornidazole, first
Nitre azoles, Tinidazole, Ofloxacin and ketoconazole etc., gradually develop immunity to drugs in crowd, curative effect reduce it is obvious that and
And generally side effect or adverse reaction, such as nausea and vomiting, anorexia, fash, diarrhoea occurs in medication, influence medication continues
Property.
Traditional Chinese medical herbal treatment gynaecological disease is started with from Overall View, and dispersing stagnated hepatoqi is strengthened the body resistance to consolidate the constitution, promoting blood circulation and removing blood stasis, softening and resolving hard mass,
It is clearing heat and detoxicating, increasingly it is taken seriously using treatment by Chinese herbs gynecological disease, still, the Chinese medicine package of existing treatment vaginitis is containing life
Pharmacopoeia class is more, complicated component, and quality of production control is difficult, limits practical application.
The content of the invention
The drug regimen of vaginitis can be effectively treated it is an object of the invention to overcome the deficiencies of the prior art and provide a kind of
Thing.With promoting the circulation of qi broken stasis of blood, clearing heat and detoxicating, desinsection is antipruritic the effect of, it is red and swollen and cloudy for pruritus of vagina, vagina and vulva mucous membrane
Road secretion, which such as increases at the colpitis, has significant curative effect.
The pharmaceutical composition of the present invention, using natural plant composition, component is simple, and convenient sources are with low cost, without any
Toxic side effect, and short treating period, instant effect, the treatment to vaginitis can reach the purpose treated both principal and secondary aspect of disease.
A kind of pharmaceutical composition for treating vaginitis, includes the composition of following percentage by weight,
Garlic oil 26-33%, old camellia oil 47-55%, apricot kernel oil 15-22%, dimethyl sulfoxide 1-5%.
Preferably, the composition of following percentage by weight is included according to the Chinese medicine composition of the treatment vaginitis of the present invention,
Garlic oil 30%, old camellia oil 50%, apricot kernel oil 18%, dimethyl sulfoxide 2%.
Garlic oil has bactericidal action, especially there is extremely strong sterilization effect to the main germ candida albicans for causing vaginitis
Really.Old camellia oil has the antipruritic effect of swelling and pain relieving.Apricot kernel oil has the effect for repairing epidermal cell, makes impaired epidermis
Cell restore normal growth rapidly.Dimethyl sulfoxide can strengthen the permeability of mentioned component, improve suction of the human body to mentioned component
Receive and utilize.
The present invention uses old camellia oil, the preferably old camellia oil of more than 5 years.
The composition of the present invention can be prepared by the following method：
(1) by the raw material by weight well mixed；
(2) suitable auxiliary material is added, vagina administration preparation is made.
It can add suitable auxiliary material various formulations are made to the pharmaceutical composition of the treatment vaginitis according to the present invention,
Such as soft capsule, suppository, vagina effervescence or ointment, preferred soft capsule.
Suitable auxiliary material can be selected from glycerin gelatine, stearic acid, polyethylene glycol, chitosan, Tween-80, hypromellose
One or more in element, cyclodextrin.
In the pharmaceutical preparation being made, pharmaceutical composition of the invention and the weight ratio of auxiliary material can be 1:1-50, it is preferable that 1:
1-10, more preferably 1:1-5.
Vaginitis includes colpomycosis, trichomonas vaginitis, bacterial vaginitis or mixed vaginitis.
The pharmaceutical composition of present invention treatment vaginitis, composition is simple, has no toxic side effect.
The pharmaceutical composition for the treatment of vaginitis of the present invention has significant curative effect to vaginitis, with short treating period, instant effect,
The high advantage of cure rate.
Embodiment
The invention provides a kind of pharmaceutical composition for treating vaginitis, the composition of following percentage by weight is included：Garlic
Oily 26-33%, old camellia oil 47-55%, apricot kernel oil 15-22%, dimethyl sulfoxide 1-5%.
The composition of the composition of the present invention comes from natural plants, and convenient sources are without any side effects.
Garlic oil is material obtained from being extracted from garlic, and containing critically important active sulfide, it is a kind of wide spectrum
Antibacterial material, with activating cell, promotes energy production, increase antibacterial and anti-virus ability, quickening metabolism, fatigue-relieving
Etc. a variety of pharmacological functions.
Garlic oil has bactericidal action, especially there is extremely strong sterilization effect to the main germ candida albicans for causing vaginitis
Really.
Camellia oil is the fat oil obtained with the mature seed of plant of theaceae oil tea or Camellia yuansienensis by milling process.Mountain
Tea oil is sweet, cool in nature；Return large intestine channel.With clearing away heat and eliminating dampeness, the effect such as desinsection removing toxic substances.It is camellia oil energy antibacterial, antiviral and kill micro-
Bacterium.
The old shallower fragrance of camellia oil color is light, and the resting period more long lighter fragrance of tea oil color more light does not have even yet
Savory, older camellia oil is more sticky having or even can be with wire drawing as honey.Camellia oil contains abundant vitamin, oil
Acid and unrighted acid, are easily absorbed by the skin.Fresh camellia oil is alkaline, and old camellia oil by depositing for a long time
Put acid value to increase in faintly acid, more gentle non-stimulated using old camellia oil, more long camellia oil is more easily absorbed by the skin.
Apricot kernel oil is containing abundant vitamin and aliphatic acid, with good skin-friendly, is to moisten oil well, is adapted to dry
Property, acne and sensitive skin use, with releiving and antianaphylactic good effects, also can very itch as treatment, red and swollen, drying
Used with the formula of inflammation, the situation that the redness of eczema is itched can be mitigated.Also there is analgesia and abirritant effect, can isolate
Ultraviolet, the effect for improving cutaneous autoimmune.
Apricot kernel oil has the effect for repairing epidermal cell, impaired epidermal cell is restore normal growth rapidly.
In terms of medicine, dimethyl sulfoxide (DMSO) has anti-inflammatory analgetic effect, there is strong penetration to skin, thus can dissolve some medicines
Thing, makes this kind of medicine permeate to reach therapeutic purposes to human body.Using this carrier characteristics of dimethyl sulfoxide (DMSO), it can strengthen
The permeability of mentioned component, improves human body and mentioned component is absorbed.
The pharmaceutical composition of the treatment vaginitis of the present invention can be prepared via a method which, for example, the raw material is pressed
Ratio is well mixed；Then suitable auxiliary material is added, vagina administration preparation is made.
It can add suitable auxiliary material various formulations are made to the pharmaceutical composition of the treatment vaginitis according to the present invention,
Vagina administration preparation is preferably made, such as soft capsule, suppository, vagina effervescence or ointment.
Suitable auxiliary material can be selected from glycerin gelatine, stearic acid, polyethylene glycol, chitosan, Tween-80, hypromellose
One or more in element, cyclodextrin.
In the pharmaceutical preparation being made, pharmaceutical composition of the invention and the weight ratio of auxiliary material can be 1:1-50, it is preferable that 1:
1-10, more preferably 1:2-5.
Embodiment
First, embodiment is prepared
Embodiment 1
(1) raw material is prepared：50 grams of the old camellia oil that 30 grams, 5 years of garlic oil, 18 grams of apricot kernel oil, 2 grams of dimethyl sulfoxide.
(2) above-mentioned raw materials are well mixed, add 300 grams of Tween-80s and 100 grams of cyclodextrin, 50 soft capsules are made.
Embodiment 2
(1) raw material is prepared：48 grams of the old camellia oil that 29 grams, 5 years of garlic oil, 20 grams of apricot kernel oil, 3 grams of dimethyl sulfoxide.
(2) above-mentioned raw materials are well mixed, add 250 grams of PEG-4000s and 100 grams of cyclodextrin, 50 flexible glues are made
Capsule.
Embodiment 3
(1) raw material is prepared：53 grams of the old camellia oil that 28 grams, 5 years of garlic oil, 16 grams of apricot kernel oil, 3 grams of dimethyl sulfoxide.
(2) above-mentioned raw materials are well mixed, add 300 grams of PEG-6000s and 150 grams of hydroxypropyl methylcelluloses, be made
50 soft capsules.
2nd, test examples
For the effect for the pharmaceutical composition for further illustrating the present invention, the soft capsule prepared using embodiment 1-3 is to vagina
Inflammation is treated.
1st, medicine irritation is tested
With reference to medicine irritation investigative technique guideline, rabbit vagina irritation test is done, daily vagina administration 1 time,
Successive administration 7 days, keeps the soft capsule prepared by embodiment 1 to be contacted with rabbit vagina more than 6 hours, is disabling 1 respectively daily
It and put to death rabbit after 7 days, take its vagina tissue.
Rabbit has no obvious discomfort during medication, is observed visually between rabbit vagina and surrounding tissue and is showed no substantially
The abnormal change of congested, oedema and secretion, show to be administered 1 time a day, continuous 7 days repeat administrations to rabbit vagina mucous membrane without
Obvious excitant.Through pathology cut sections for microscopic examination, vagina tissue is normal, and mucous epithelium, muscle layer are showed no Histopathology change,
Thus illustrate the medicine without obvious irritation.
2nd, clinical effectiveness is tested
(1) diagnostic criteria：Leucorrhea increasing, yellow or smelly, pudendal pruritus, vaginal fluid smear for microscopic examination finds trichomonad or mould
Bacterium.
Case selection meets vagina inflammation diagnostic criteria, and 87 vaginitis out-patients, age 23-61 Sui are collected altogether.At random
It is divided into three groups, is treated respectively using the embodiment 1-3 soft capsules prepared.
(2) application method
Using soft capsule made from 1-3 according to embodiments of the present invention, one one, every night vagina administration, with 7 days for one
The course for the treatment of.
(3) efficacy assessment standard
Cure：Leukorrhea amount and color switch to normally, and private parts not itch, vaginal fluid smear for microscopic examination does not find trichomonad or mould
Bacterium.
Effectively：Leukorrhea amount and color switch to normally, and private parts not itch, vaginal fluid smear for microscopic examination finds 1-2 trichomonad
Or mould.
It is invalid：Clinical symptom and sign is unchanged compared with pre-treatment without improvement.
(4) therapeutic effect
First group of soft capsule for not prepared to third component using embodiment 1-3, vagina administration, continuous use 7 days, treatment
Effect is shown in Table 1.
Table 1
| Project | Case load | Cure | Effectively | It is invalid | Cure rate |
| First group | 29 | 26 | 3 | 0 | 89.6% |
| Second group | 29 | 25 | 4 | 0 | 86.2% |
| 3rd group | 29 | 22 | 7 | 0 | 75.8% |
| It is total | 87 | 73 | 14 | 0 | 83.9% |
As it can be seen from table 1 vaginitis patient is treated with 1-3 of the embodiment of the present invention soft capsules prepared respectively,
Total effective rate reaches 100%, and total cure rate reaches 83.9%.As a result show, the pharmaceutical composition for the treatment of vaginitis of the invention
There is significant curative effect to vaginitis.
Claims (7)
1. a kind of pharmaceutical composition for treating vaginitis, includes the composition of following percentage by weight：Garlic oil 26-33%, it is old
Camellia oil 47-55%, apricot kernel oil 15-22%, dimethyl sulfoxide 1-5%.
2. pharmaceutical composition according to claim 1, includes the composition of following percentage by weight：Garlic oil 30%, it is old
Camellia oil 50%, apricot kernel oil 18%, dimethyl sulfoxide 2%.
3. pharmaceutical composition according to claim 1 or 2, the old camellia oil is the camellia oil of more than 5 years.
4. the preparation method of pharmaceutical composition according to claim 1, comprises the following steps：
(1) by the raw material by weight well mixed；
(2) suitable auxiliary material is added, vagina administration preparation is made.
5. preparation method according to claim 4, the auxiliary material can be selected from glycerin gelatine, stearic acid, polyethylene glycol, shell
One or more in glycan, Tween-80, hydroxypropyl methylcellulose, cyclodextrin.
6. preparation method according to claim 4, the vagina administration preparation includes soft capsule, suppository, vagina effervescence
And ointment.
7. the preparation method according to any one of claim 4-6, in pharmaceutical preparation, described pharmaceutical composition and auxiliary material
Weight ratio be 1:1-50.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710331463.XA CN107126498A (en) | 2017-05-11 | 2017-05-11 | A kind of pharmaceutical composition for treating vaginitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710331463.XA CN107126498A (en) | 2017-05-11 | 2017-05-11 | A kind of pharmaceutical composition for treating vaginitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107126498A true CN107126498A (en) | 2017-09-05 |
Family
ID=59731709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710331463.XA Pending CN107126498A (en) | 2017-05-11 | 2017-05-11 | A kind of pharmaceutical composition for treating vaginitis |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224258A (en) * | 2008-02-02 | 2008-07-23 | 夏建明 | Application of camellia oil in preparing external nursing liquid |
-
2017
- 2017-05-11 CN CN201710331463.XA patent/CN107126498A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101224258A (en) * | 2008-02-02 | 2008-07-23 | 夏建明 | Application of camellia oil in preparing external nursing liquid |
Non-Patent Citations (1)
| Title |
|---|
| 张志奇等: "精油对女性生殖活动和妇科疾病的影响", 《现代药物与临床》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Changrun Inventor after: Li Qiaoling Inventor before: Li Changrun |
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| CB03 | Change of inventor or designer information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170905 |
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| RJ01 | Rejection of invention patent application after publication |