CN107106062B - 可植入的电极组件 - Google Patents

可植入的电极组件 Download PDF

Info

Publication number
CN107106062B
CN107106062B CN201580054335.4A CN201580054335A CN107106062B CN 107106062 B CN107106062 B CN 107106062B CN 201580054335 A CN201580054335 A CN 201580054335A CN 107106062 B CN107106062 B CN 107106062B
Authority
CN
China
Prior art keywords
electrode
electrode assembly
carrier matrix
assembly according
strips
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201580054335.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN107106062A (zh
Inventor
D·普拉赫塔
M·吉雷特米伦
T·施蒂格利茨
J·曾特纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neuroloop GmbH
Original Assignee
Neuroloop GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuroloop GmbH filed Critical Neuroloop GmbH
Publication of CN107106062A publication Critical patent/CN107106062A/zh
Application granted granted Critical
Publication of CN107106062B publication Critical patent/CN107106062B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0556—Cuff electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/388—Nerve conduction study, e.g. detecting action potential of peripheral nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/06—Arrangements of multiple sensors of different types
    • A61B2562/066—Arrangements of multiple sensors of different types in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/164—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Electrotherapy Devices (AREA)
CN201580054335.4A 2014-10-07 2015-10-07 可植入的电极组件 Active CN107106062B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102014014927.7A DE102014014927A1 (de) 2014-10-07 2014-10-07 Implantierbare Elektrodenanordnung
DE102014014927.7 2014-10-07
PCT/EP2015/073129 WO2016055512A1 (de) 2014-10-07 2015-10-07 Implantierbare elektrodenanordnung

Publications (2)

Publication Number Publication Date
CN107106062A CN107106062A (zh) 2017-08-29
CN107106062B true CN107106062B (zh) 2020-08-11

Family

ID=54251527

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580054335.4A Active CN107106062B (zh) 2014-10-07 2015-10-07 可植入的电极组件

Country Status (14)

Country Link
US (2) US11850419B2 (https=)
EP (1) EP3204105B1 (https=)
JP (1) JP6644062B2 (https=)
KR (2) KR101831116B1 (https=)
CN (1) CN107106062B (https=)
AU (1) AU2015330072B2 (https=)
CA (1) CA2962338C (https=)
DE (1) DE102014014927A1 (https=)
DK (1) DK3204105T3 (https=)
ES (1) ES2702881T3 (https=)
HR (1) HRP20181487T1 (https=)
HU (1) HUE040315T2 (https=)
PL (1) PL3204105T3 (https=)
WO (1) WO2016055512A1 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102014014927A1 (de) 2014-10-07 2016-04-07 Neuroloop GmbH Implantierbare Elektrodenanordnung
DE102016222712A1 (de) * 2016-11-18 2018-05-24 Neuroloop GmbH Implantierbare elektrische, multipolige Verbindungsstruktur
DE102017209773A1 (de) * 2017-06-09 2018-12-13 Neuroloop GmbH Implantierbare elektrische Verbindungsstruktur
GB2563651A (en) * 2017-06-22 2018-12-26 Galvani Bioelectronics Ltd Nerve stimulation and monitoring device
WO2019070625A1 (en) * 2017-10-02 2019-04-11 Case Western Reserve University NERVE ELECTRODE DESIGN FOR MODIFIED NERVE FOR STABLE RECORDING AND / OR STIMULATION
DE102017222362B4 (de) 2017-12-11 2021-03-04 Neuroloop GmbH Vorrichtung zur extravasalen oder extraneuronalen Befestigung eines Implantats
EP3727563A1 (en) 2017-12-21 2020-10-28 Galvani Bioelectronics Limited Nerve stimulation device for unidirectional stimulation and current steering
WO2019122817A1 (en) 2017-12-21 2019-06-27 Galvani Bioelectronics Limited Nerve stimulation device for current steering
DE102018204036B4 (de) 2018-03-16 2025-05-08 Neuroloop GmbH Implantat in Art einer Wickelmanschetten-Elektrodenanordnung
DE102018207709A1 (de) * 2018-05-17 2019-11-21 Neuroloop GmbH Vorrichtung zur extravasalen oder extraneuronalen Befestigung eines medizinischen Implantats in Art einer Wickelmanschette
DE102018213120A1 (de) * 2018-08-06 2020-02-06 Neuroloop GmbH Medizinisches Implantat in Art einer Wickelmanschetten-Elektrodenanordnung
DE102018213119A1 (de) * 2018-08-06 2020-02-06 Neuroloop GmbH Medizinisches Implantat mit einer als Wickelmanschette ausgebildeten Elektrodenanordnung
CN112739410B (zh) 2018-09-18 2024-10-11 威里利生命科学有限责任公司 具有连接到颅骨安装包的整体式引线部件的刺激系统
WO2020060881A1 (en) 2018-09-18 2020-03-26 Verily Life Sciences Llc Monolithic lead assembly and methods of microfabricating a monolithic lead assembly
US11395923B2 (en) 2018-11-16 2022-07-26 Verily Life Sciences Llc Branched proximal connectors for high density neural interfaces
DE102019206388A1 (de) * 2019-05-03 2020-11-05 Neuroloop GmbH Implantierbare elektrische Kontaktanordnung
CN114641904A (zh) * 2019-10-10 2022-06-17 瑞普尔有限责任公司 用于耦接电极和电子部件的系统和方法
DE102020117142A1 (de) 2020-06-30 2021-12-30 Neuroloop GmbH Medizinisches Handhabungsset
CA3193733A1 (en) 2020-09-02 2022-03-10 The Alfred E. Mann Foundation For Scientific Research Electrode leads having multi-application nerve cuffs and associated systems and methods
US12350489B2 (en) 2021-03-30 2025-07-08 The Alfred E. Mann Foundation For Scientific Research Electrode leads having nerve cuffs and associated systems and methods
WO2023149911A1 (en) 2022-02-01 2023-08-10 The Alfred E. Mann Foundation For Scientific Research Electrode leads having nerve contact elements with coil contacts and associated systems and methods
WO2024010990A1 (en) 2022-07-05 2024-01-11 The Alfred E. Mann Foundation For Scientific Research Tissue stimulation apparatus and methods of making the same
DE102022122699B3 (de) 2022-09-07 2024-01-11 Neuroloop GmbH Medizinisches Implantat in Form einer Wickelmanschette
AU2023350980A1 (en) * 2022-09-29 2025-04-03 The Alfred E. Mann Foundation For Scientific Research Electrode leads having nerve cuffs and associated systems and methods
DE102022133134A1 (de) 2022-12-13 2024-06-13 Neuroloop GmbH Medizinisches elektronisches Implantat
DE102023104126A1 (de) 2023-02-20 2024-08-22 Neuroloop GmbH Elektrische Schaltungsanordnung zur Erzeugung von stromgesteuerten elektrischen Signalen
DE102023104119A1 (de) 2023-02-20 2024-08-22 Neuroloop GmbH Elektrische Schaltungsanordnung für eine biomedizinische Schnittstelle
WO2024226804A1 (en) * 2023-04-26 2024-10-31 The Regents Of The University Of California Fully implantable speech neuroprosthesis device, system and methods for using same
DE102023110861A1 (de) 2023-04-27 2024-10-31 Neuroloop GmbH Mobiles, an eine Person anlegbares, elektrisches Ladesystem für ein Implantat mit einem elektrischen Energiespeicher
DE102023126302A1 (de) 2023-09-27 2025-03-27 Neuroloop GmbH Medizinische implantierbare Anordnung
DE102023126618A1 (de) 2023-09-29 2025-04-03 Neuroloop GmbH Manschettenförmiges medizinisches Implantat
DE102023126630A1 (de) 2023-09-29 2025-04-03 Neuroloop GmbH Medizinisches Implantat
DE102023126781A1 (de) * 2023-10-02 2025-04-03 Neuroloop GmbH Manschettenförmiges medizinisches Implantat
DE102024107942A1 (de) * 2024-03-20 2025-09-25 Neuroloop GmbH Anordnung zur Signal- und Energieversorgung eines medizinischen aktiven Implantats
DE102024131646A1 (de) 2024-10-30 2026-04-30 Neuroloop GmbH Medizinisches Implantat mit einer über eine Längserstreckung verfügenden, elektrischen Leitungsanordnung

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5324322A (en) * 1992-04-20 1994-06-28 Case Western Reserve University Thin film implantable electrode and method of manufacture
US5501703A (en) * 1994-01-24 1996-03-26 Medtronic, Inc. Multichannel apparatus for epidural spinal cord stimulator
DE4433111A1 (de) 1994-09-16 1996-03-21 Fraunhofer Ges Forschung Cuff-Elektrode
US6052608A (en) * 1998-03-30 2000-04-18 Johnson & Johnson Professional, Inc. Implantable medical electrode contacts
DE10020846A1 (de) * 2000-04-28 2001-12-06 Intelligent Implants Gmbh Mikrokontaktstruktur für Neuroprothesen zur Implantation an Nervengewebe und Verfahren hierzu
US20040024439A1 (en) * 2000-10-11 2004-02-05 Riso Ronald R. Nerve cuff electrode
FR2821275B1 (fr) * 2001-02-28 2004-01-30 Univ Joseph Fourier Structure d'electrodes implantable
EP1372780A4 (en) * 2001-03-30 2006-06-14 Univ Case Western Reserve SYSTEMS AND METHODS FOR SELECTIVELY STIMULATING PARTS LOCATED IN THE INTERNAL HATEYER NERVE ON OR NEAR THE NERF, OR FOR SELECTIVE STIMULATION OF NERVE RAMIFICATIONS IN QUESTION TO INDUCE SPECIFIC PHYSIOLOGICAL RESPONSES
US6600956B2 (en) * 2001-08-21 2003-07-29 Cyberonics, Inc. Circumneural electrode assembly
US7734355B2 (en) * 2001-08-31 2010-06-08 Bio Control Medical (B.C.M.) Ltd. Treatment of disorders by unidirectional nerve stimulation
US20140046407A1 (en) * 2001-08-31 2014-02-13 Bio Control Medical (B.C.M.) Ltd. Nerve stimulation techniques
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US20060111626A1 (en) * 2003-03-27 2006-05-25 Cvrx, Inc. Electrode structures having anti-inflammatory properties and methods of use
US8718791B2 (en) 2003-05-23 2014-05-06 Bio Control Medical (B.C.M.) Ltd. Electrode cuffs
US6999820B2 (en) * 2003-05-29 2006-02-14 Advanced Neuromodulation Systems, Inc. Winged electrode body for spinal cord stimulation
US7480532B2 (en) * 2003-10-22 2009-01-20 Cvrx, Inc. Baroreflex activation for pain control, sedation and sleep
DE10355652A1 (de) * 2003-11-28 2005-06-30 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zur Desynchronisation neuronaler Hirnaktivität
US20060004417A1 (en) * 2004-06-30 2006-01-05 Cvrx, Inc. Baroreflex activation for arrhythmia treatment
US7640057B2 (en) * 2005-04-25 2009-12-29 Cardiac Pacemakers, Inc. Methods of providing neural markers for sensed autonomic nervous system activity
US20080214920A1 (en) * 2005-07-21 2008-09-04 Koninklijke Philips Electronics, N.V. Apparatus and Method For Coupling Implanted Electrodes to Nervous Tissue
AU2007261384B2 (en) * 2006-06-19 2011-08-04 Second Sight Medical Products, Inc. Electrode with increased stability and method of manufacturing the same
DE202007019439U1 (de) * 2006-10-13 2012-09-12 Apnex Medical, Inc. Geräte, Systeme und Methoden zur Behandlung von obstruktiver Schalfapnoe
US9248274B2 (en) 2007-10-10 2016-02-02 Sorin Crm Sas Neurostimulator and method for regulating same
US8918188B2 (en) * 2008-09-26 2014-12-23 Pixium Vision Sa Electrode array and method of manufacturing same
WO2011057137A1 (en) * 2009-11-05 2011-05-12 Neuronexus Technologies Waveguide neural interface device
EP2477467B1 (en) * 2011-01-14 2017-07-26 Second Sight Medical Products, Inc. Method of manufacturing a flexible circuit electrode array
WO2013046040A2 (en) * 2011-09-30 2013-04-04 Adi Mashiach Apparatus and method for controlling energy delivery as a function of degree of coupling
US20130172973A1 (en) * 2012-01-04 2013-07-04 Bruce A. Tockman Neural stimulation device with insulating sheath
CN104582787A (zh) * 2012-04-02 2015-04-29 生物控制医疗(Bcm)有限公司 电极环带
WO2013188871A1 (en) * 2012-06-15 2013-12-19 Case Western Reserve University Implantable cuff and method for functional electrical stimulation and monitoring
TWI498101B (zh) * 2012-08-30 2015-09-01 國立交通大學 神經纖維分佈之分析方法及標準化誘發復合動作電位之量測方法
KR101450859B1 (ko) * 2012-10-10 2014-10-15 한국과학기술연구원 염증 억제용 약물을 구비한 신경 전극 및 그 제조 방법
DE102014014927A1 (de) 2014-10-07 2016-04-07 Neuroloop GmbH Implantierbare Elektrodenanordnung

Also Published As

Publication number Publication date
US12343523B2 (en) 2025-07-01
CN107106062A (zh) 2017-08-29
JP6644062B2 (ja) 2020-02-12
HRP20181487T1 (hr) 2018-11-16
US11850419B2 (en) 2023-12-26
CA2962338C (en) 2022-10-25
EP3204105A1 (de) 2017-08-16
DE102014014927A1 (de) 2016-04-07
ES2702881T3 (es) 2019-03-06
US20240075281A1 (en) 2024-03-07
CA2962338A1 (en) 2016-04-14
KR101831116B1 (ko) 2018-04-04
DK3204105T3 (en) 2018-11-19
AU2015330072B2 (en) 2020-02-13
US20170319846A1 (en) 2017-11-09
EP3204105B1 (de) 2018-08-01
AU2015330072A1 (en) 2017-04-20
WO2016055512A1 (de) 2016-04-14
JP2017530806A (ja) 2017-10-19
HUE040315T2 (hu) 2019-02-28
KR20180019757A (ko) 2018-02-26
KR20170042808A (ko) 2017-04-19
KR102302857B1 (ko) 2021-09-15
PL3204105T3 (pl) 2019-01-31

Similar Documents

Publication Publication Date Title
CN107106062B (zh) 可植入的电极组件
US11224749B2 (en) Implantable assembly
CN108136174B (zh) 可植入式神经刺激装置
AU2014244437B2 (en) Apparatus, systems and methods for delivery of medication to the brain to treat neurological conditions
US20070255320A1 (en) Method and apparatus for forming insulated implantable electrodes
US20200316372A1 (en) Nerve stimulation device for unidirectional stimulation and current steering
JP2016515866A5 (https=)
CN104941065A (zh) 植入式神经电刺激系统以及应用于该植入式神经电刺激系统的保护套
Lee et al. Flexible sling electrode for bidirectional neural signal recording and selective stimulation
Gurel et al. Abstract# 36: toward wearable sensing enabled closed-loop non-invasive vagus nerve stimulation: a study of real-time physiological biomarkers
Nikolayev et al. Abstract# 34: Uniform Current Density Electrodes for a High-Resolution Deep-Brain-Stimulation Lead
Wakerley Electrical Stimulation Methods

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant