CN107095941A - A kind of reunion of fractured tendons and bones gel constituted with Tujia's medicine and preparation method thereof - Google Patents
A kind of reunion of fractured tendons and bones gel constituted with Tujia's medicine and preparation method thereof Download PDFInfo
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- CN107095941A CN107095941A CN201710449320.9A CN201710449320A CN107095941A CN 107095941 A CN107095941 A CN 107095941A CN 201710449320 A CN201710449320 A CN 201710449320A CN 107095941 A CN107095941 A CN 107095941A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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Abstract
The invention belongs to synthetism gel technical field, disclose a kind of with reunion of fractured tendons and bones gel of Tujia's medicine composition and preparation method thereof, with the reunion of fractured tendons and bones gel of Tujia's medicine composition by weight percentage by wilsonii 10%~25%, only positive bar 10%~25%, the old bud 4%~15% of thorn, Acritamer 940 2%~5%, 1,2 propane diols 6%~8%, triethanolamine 0.5%~1.5% and water 30%~68% are constituted；Preparation method includes：Obtain swelling solution；Obtain medicinal powder dispersion；Get it filled powder dispersion and swelling solution is sufficiently mixed uniformly, add triethanolamine, distilled water, stirring produces reunion of fractured tendons and bones gel.The synthetism gel that the present invention is provided has preferable reunion of fractured tendons and bones, promotes the effect of union；Preparation method is simple to operation, efficiently solves the problem of not enough traditional bone-setting ointment matrix source, use inconvenience and holding time length are easily hardened.
Description
Technical field
Coagulated the invention belongs to synthetism gel technical field, more particularly to a kind of reunion of fractured tendons and bones with Tujia's medicine composition
Jelly and preparation method thereof.
Background technology
Injured bones and muscles are clinically most common damages, often occur in daily life, are often accompanied by redness, extravasated blood, pain
Bitterly, the symptom such as dysfunction, and the healing fractured generally comprises organization of hematoma phase, stage of formation of primary callus and poroma transformation phase,
Therefore the time of three months or so is generally required to synostosis since fracture, therefore often has saying for " 100 days injured in the sinews or bones "
Method.
The features such as liniment has rapid-action, easy to use in treatment fracture, bone injury.Number of patent application：
200910063110.1, denomination of invention：A kind of formula of bone-setting ointment；Disclose a kind of formula of bone-setting ointment, its by weight percentage by
Only positive bar 10%~25%, Cortex Acanthopanacis Radicis 10%~25%, the old bud 4%~20% of thorn, vaseline 4%~20%, honey 30%
~70% composition, its preparation method is that only positive bar, Cortex Acanthopanacis Radicis and the old bud of thorn crushed 100 mesh sieves, takes honey to boil filtering and puts
It is cooled to less than 80 DEG C plus vaseline is fully stirred evenly, then will fully be stirred evenly in the honey vaseline liquid of fine drug powder addition heat, is cooled to
Room temperature, packing is produced.It is evenly coated in when using on sterile gauze, is affixed on affected part, is wrapped up and fixed with gauze.
However, prescription taste of traditional Chinese medicine is more using vaseline and honey as matrix, it is poor to there is medicine Release Performance, and skin connects
The time of touching length is so as to cause pruitus, holding time slightly to grow the problems such as then paste hardens not easy to apply.By comparison, it is of the invention
Gel using water-soluble high-molecular material Acritamer 940 as matrix, the compatibility with skin is good, enhances the hydration of skin
Effect, drugloading rate is bigger and is conducive to the percutaneous absorbtion of medicine, to no skin irritation, sensitization, clean simple noresidue etc.
Advantage.
The content of the invention
The problem of existing for prior art, the invention provides a kind of reunion of fractured tendons and bones gel with Tujia's medicine composition
Agent and preparation method thereof.
The present invention is achieved in that a kind of reunion of fractured tendons and bones gel with Tujia's medicine composition, described with Tujia
The reunion of fractured tendons and bones gel of medicine composition is by weight percentage by wilsonii 10%~25%, and only positive bar 10%~25%, thorn is old
Bud 4%~15%, Carbomer-940 2%~5%, 1,2-PD 6%~8%, triethanolamine 0.5%~1.5% and water
30%~68% composition.
Another object of the present invention is to provide a kind of system of the reunion of fractured tendons and bones gel with Tujia's medicine composition
Preparation Method, the preparation method of the reunion of fractured tendons and bones gel with Tujia's medicine composition comprises the following steps：
Step one, Carbomer-940 is taken, is spread on distilled water, is stood overnight, after it is fully swelled, is stirred, i.e.,
Obtain swelling solution；
Step 2, takes wilsonii, and only positive bar, the old bud of thorn is crushed, sieving adds 1,2 propane diols, stirred after mixing,
Produce medicinal powder dispersion；
Step 3, gets it filled powder dispersion and swelling solution is sufficiently mixed uniformly, adds triethanolamine, and distilled water, stirring is produced
Reunion of fractured tendons and bones gel.
Further, the step one is specifically included：
Carbomer-940 2%~5% is taken, is spread on distilled water 15%~30%, stands overnight, after it is fully swelled,
Stir, produce swelling solution.
Further, the step 2 is specifically included：
Wilsonii 10%~25% is taken, only positive bar 10%~25%, the old bud 4%~15% of thorn is crushed, crosses 120 mesh sieves, mixes
1,2 propane diols 6%~8% are added after even, stirs, produces medicinal powder dispersion.
Further, the step 3 is specifically included：
Get it filled powder dispersion and swelling solution is sufficiently mixed uniformly, add triethanolamine 0.5%~1.5%, distilled water 5%~
38%, 0.5~1h is stirred, reunion of fractured tendons and bones gel is produced.
Another object of the present invention is to provide drug paste prepared by a kind of reunion of fractured tendons and bones gel with Tujia's medicine composition.
The gel of the present invention is using water-soluble high-molecular material Acritamer 940 as matrix, and the compatibility with skin is good, increases
The strong aquation of skin, drugloading rate is big and is conducive to the percutaneous absorbtion of medicine, to no skin irritation, sensitization, cleaning
The advantages of simple noresidue, there is preferable facilitation to the healing of fracture.
Brief description of the drawings
Fig. 1 is the preparation method flow of the reunion of fractured tendons and bones gel provided in an embodiment of the present invention with Tujia's medicine composition
Figure.
Fig. 2 is the reunion of fractured tendons and bones gel pictorial diagram provided in an embodiment of the present invention with Tujia's medicine composition.
Fig. 3 is composition HPLC collection of illustrative plates to be measured provided in an embodiment of the present invention.
In figure：A:Syringin standard solution；B:Isofraxidin standard solution；C:Hybrid standard product solution；D:It is cloudy
Property contrast solution.
Fig. 4 is each group new zealand rabbit union situation x-ray figure provided in an embodiment of the present invention.
In figure：a:Normal group；b:Model group；c:Traditional bone-setting ointment group；d:1 group of embodiment；e:2 groups of embodiment；f:Implement
3 groups of example.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
The application principle of the present invention is explained in detail below in conjunction with the accompanying drawings.
Reunion of fractured tendons and bones gel provided in an embodiment of the present invention with Tujia's medicine composition is by weight percentage by thorn five
Plus 10%~25%, only positive bar 10%~25%, the old bud 4%~15% of thorn, Carbomer-940 2%~5%, 1,2-PD
6%~8%, triethanolamine 0.5%~1.5% and water 30%~68% are constituted.
Another object of the present invention is to provide a kind of system of the reunion of fractured tendons and bones gel with Tujia's medicine composition
Preparation Method, the preparation method of the reunion of fractured tendons and bones gel with Tujia's medicine composition comprises the following steps：
S101:Carbomer-940 2%~5% is taken, is spread on distilled water 15%~30%, stands overnight, treats that it is fully molten
After swollen, stir, produce swelling solution.
S102:Wilsonii 10%~25% is taken, only positive bar 10%~25%, the old bud 4%~15% of thorn is crushed, crosses 120 mesh
Sieve, adds 1,2 propane diols 6%~8%, stirs, produce medicinal powder dispersion after mixing.
S103:Get it filled powder dispersion and swelling solution is sufficiently mixed uniformly, add triethanolamine 0.5%~1.5%, distilled water
5%~38%, 0.5~1h is stirred, reunion of fractured tendons and bones gel is produced.
Fig. 2 is the reunion of fractured tendons and bones gel pictorial diagram provided in an embodiment of the present invention with Tujia's medicine composition.
The application principle of the present invention is further described with reference to specific embodiment.
Embodiment 1：
Weigh following bulk drugs：Wilsonii 15g, only positive bar 15g, the old bud 9g, NMF 1,2-PD 6g, card ripple of thorn
Nurse -9402g, triethanolamine 1.0g, distilled water 52g.
Specific preparation method comprises the following steps：The old bud of wilsonii, only positive bar, thorn is weighed by weight, is crushed, mistake
120 mesh sieves, are well mixed, obtain medicine mixing fine powders；Medicinal powder dispersion is made in medicinal powder and 1,2- mixed with propylene glycol again；Separately weigh
Carbomer-940, is uniformly spread on 20g distilled water, stands overnight, and after it is fully swelled, stirs, obtains swelling solution；By medicine
Powder dispersion and swelling solution, triethanolamine mixing are stirred evenly, and add distilled water to 100g, 1h is to being uniformly dispersed for stirring, produces continuous muscle
Synthetism gel.
Embodiment 2：
Weigh following bulk drugs：Wilsonii 15g, only positive bar 15g, the old bud 9g, NMF 1,2-PD 7g, card ripple of thorn
Nurse -9403g, triethanolamine 1.0g, distilled water 50g.
Specific preparation method be the same as Example 1.
Embodiment 3：
Weigh following bulk drugs：Wilsonii 15g, only positive bar 15g, the old bud 9g, NMF 1,2-PD 8g, card ripple of thorn
Nurse -9405g, triethanolamine 1.5g, distilled water 46.5g.
Specific preparation method be the same as Example 1.
Embodiment 4：Performance test.
First, quality evaluation
According to the preparation method of embodiment 1,2,3,6 batches of reunion of fractured tendons and bones gels are prepared respectively.Using comprehensive evaluation index, comment
Mouldability, coating, glossiness and the stability of reunion of fractured tendons and bones gel prepared by valency, determine its pH value：
Cold-resistant stable experiment：Gel 5g is taken to be placed in tool plug test tube, whether -18 DEG C of placement 72h, observation gel has layering existing
As and color change.
Heat-resistant stable is tested：Gel 5g is taken to be placed in tool plug test tube, 2h is placed in 55 DEG C of water-baths, whether observation gel has layering
Phenomenon and color change.
The stable experiment of centrifugation：Take gel 5g to be placed in 10mlEP centrifuge tubes, taken out after 3000r/min centrifugations 30min, observation
Gel whether there is lamination.
PH value is determined：Gel about 0.5g is taken, is placed in 10ml small beakers, 5ml ultra-pure waters are added, it is abundant with clean glass bar
Stirring determines its pH value to being completely dissolved with pH meter.
Standards of grading are shown in Table 1, and evaluation result is shown in Table 2.
The comprehensive grading standard of the reunion of fractured tendons and bones gel of table 1
The reunion of fractured tendons and bones gel of table 2 quality evaluation result (n=6,)
As can be seen from Table 2, embodiments of the invention 1, embodiment 2, the reunion of fractured tendons and bones gel tool prepared by embodiment 3
There are good mouldability, coating, glossiness and stability, its pH value is in the range of 6.5~7.3, close to neutrality, to human body skin
The excitant of skin is small.
2nd, release in vitro evaluation
According to the preparation method of embodiment 1,2,3,6 batches of reunion of fractured tendons and bones gels are prepared respectively.Made with SD skin of rat
For human body skin substitute products, Transdermal Absorption experiment is carried out using Franz diffusion cells method, with patent of invention (number of patent application：
200910063110.1, denomination of invention：A kind of formula of bone-setting ointment) prepared by traditional bone-setting ointment as control, calculate prepared
The Steady penetration rate of Syringin and isofraxidin in reunion of fractured tendons and bones gel.
The detection method of Syringin and isofraxidin is：Syncronis C18 (250 × 4.6mm, 5 μm) chromatographic column；Stream
Dynamic is mutually the phosphoric acid of acetonitrile -0.1% (20:80), flow velocity 1.0ml/min；30 DEG C of column temperature, Detection wavelength 265nm, the μ L of sample size 10.
Under the chromatographic condition, the retention time of Syringin is 10.02min, and the retention time of isofraxidin is 25.38min, separation
Degree is good, and flowing relative sample is without significantly interfering with, and theoretical cam curve is no less than 3000 in terms of isofraxidin.As a result Fig. 3 is seen.
The regression equation of Syringin is A=10686.4546C+1565.7788, linear coefficient r=1.0000；Different piperazine skin
The regression equation of pyridine is A=12297.3054C-5913.7299, linear coefficient r=0.9999；Precision, stability and sample-adding
Recovery experiment meets chromatography requirement.
The Steady penetration rate of Syringin and isofraxidin is surveyed in reunion of fractured tendons and bones gel prepared by embodiment 1,2,3
Surely 3 be the results are shown in Table.
The reunion of fractured tendons and bones gel release in vitro test result of table 3 (n=6,)
As a result show, its active ingredient Syringin of the reunion of fractured tendons and bones gel prepared by the embodiment of the present invention and different piperazine skin
The Steady penetration rate of pyridine is larger, points out its more traditional bone-setting ointment of percutaneous absorbtion effect more preferably.
3rd, drug effect is verified
According to the preparation method reunion of fractured tendons and bones gel of embodiment 1,2,3.By 30 new zealand rabbits (2.5kg ± 0.25kg, hero
Property) with dosage auricular vein injecting anesthetic of 3% yellow Jackets by 25mg/kg, perform the operation and cause both sides fracture of radius and have 3mm
Cranial defect standard fracture model, layering suture not wraps up and fixed, intramuscular injection gentamicin (2mg/kg, qd, 3d) prevention
Infection；6 normal new zealand rabbits carry out sham-operation operation and same treatment.Will fracture new zealand rabbit be randomly divided into 1 group of embodiment,
2 groups of embodiment, 3 groups of embodiment and traditional bone-setting ointment group (n=6), respectively by the reunion of fractured tendons and bones gel of preparation and traditional synthetism
Cream is coated on gauze, wraps up fracture site and fixation, daily dressing 1 time, successive administration 30 days；Sham-operation group and fracture model
Group (n=6) is wrapped up and fixed with gauze, and other processing are not done.
After administration terminates, each group new zealand rabbit injects fiber crops with 3% yellow Jackets by 25mg/kg dosage auricular vein
Liquor-saturated, normotopia shoots X-ray film under the same conditions, and using mono blind method read tablet, external callus and fracture line are scored, standards of grading
It is shown in Table 4.Above-mentioned 2 parameter scores are added as to the x-ray scoring of union, 4 and Fig. 4 are the results are shown in Table.As a result sham-operation group, bone
The x-ray scoring for rolling over 3 groups of model group, traditional bone-setting ointment group, 1 group of embodiment, 2 groups of embodiment and embodiment is respectively 17.66 ±
0.21,2.63 ± 0.37,11.22 ± 1.63,16.41 ± 1.96,15.39 ± 1.77,16.98 ± 0.99, the result shows reality
Applying 1 group of example, the 3 groups of healings to fracture of 2 groups of embodiment and embodiment has preferable facilitation, and more traditional bone-setting ointment effect is more
It is good.
The external callus of table 4 and fracture line X scorings
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.
Claims (6)
1. a kind of reunion of fractured tendons and bones gel with Tujia medicine composition, it is characterised in that described with Tujia's medicine composition
Reunion of fractured tendons and bones gel by weight percentage by wilsonii 10%~25%, only positive bar 10%~25%, the old bud 4% of thorn~
15%th, Carbomer-940 2%~5%, 1,2 propane diols 6%~8%, triethanolamine 0.5%~1.5% and water 30%~68%
Composition.
2. a kind of as claimed in claim 1 with the preparation method of the reunion of fractured tendons and bones gel of Tujia's medicine composition, its feature exists
In the preparation method of the reunion of fractured tendons and bones gel with Tujia's medicine composition comprises the following steps：
Step one, Carbomer-940 is taken, is spread on distilled water, is stood overnight, after it is fully swelled, is stirred, is produced molten
Swollen liquid；
Step 2, takes wilsonii, and only positive bar, the old bud of thorn is crushed, sieving adds 1,2 propane diols, stirs, produce after mixing
Medicinal powder dispersion；
Step 3, gets it filled powder dispersion and swelling solution is sufficiently mixed uniformly, adds triethanolamine, and distilled water, stirring produces continuous muscle
Synthetism gel.
3. as claimed in claim 2 with the preparation method of the reunion of fractured tendons and bones gel of Tujia's medicine composition, it is characterised in that institute
Step one is stated to specifically include：
Carbomer-940 2%~5% is taken, is spread on distilled water 15%~30%, stands overnight, after it is fully swelled, stirring
Uniformly, swelling solution is produced.
4. as claimed in claim 2 with the preparation method of the reunion of fractured tendons and bones gel of Tujia's medicine composition, it is characterised in that institute
Step 2 is stated to specifically include：
Wilsonii 10%~25% is taken, only positive bar 10%~25%, the old bud 4%~15% of thorn is crushed, 120 mesh sieves crossed, after mixing
1,2 propane diols 6%~8% are added, stirs, produces medicinal powder dispersion.
5. as claimed in claim 2 with the preparation method of the reunion of fractured tendons and bones gel of Tujia's medicine composition, it is characterised in that institute
Step 3 is stated to specifically include：
Get it filled powder dispersion and swelling solution is sufficiently mixed uniformly, add triethanolamine 0.5%~1.5%, distilled water 5%~
38%, 0.5~1h is stirred, reunion of fractured tendons and bones gel is produced.
6. the drug paste prepared described in a kind of claim 1 with the reunion of fractured tendons and bones gel of Tujia's medicine composition.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710449320.9A CN107095941A (en) | 2017-06-14 | 2017-06-14 | A kind of reunion of fractured tendons and bones gel constituted with Tujia's medicine and preparation method thereof |
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2017
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| CN101264195A (en) * | 2008-04-30 | 2008-09-17 | 湖北中医学院 | Compound dragon's blood gel preparations and extraction and preparation technique |
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| CN105935401A (en) * | 2015-03-02 | 2016-09-14 | 重庆市中药研究院 | Gel paste for treating injured muscles and bones and preparation method thereof |
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Application publication date: 20170829 |