CN103028103B - Traditional Chinese medicine preparation for treating degenerative knee-joint disease and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating degenerative knee-joint disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating a degenerative knee-joint disease. The traditional Chinese medicine preparation is prepared by the following raw materials in parts by weight: 300-550 parts of cooked monkshood, 200-360 parts of radix aconiti preparata, 200-360 parts of prepared kusnezoff monkshood root, 100-180 parts of garden balsam stem, 100-180 parts of radix clematidis, 30-55 parts of asarum, 100-180 parts of cassia twig, 100-180 parts of teasel, 300-550 parts of kadsura coccinea, 300-550 parts of loranthus parasiticus, 100-180 parts of radix zanthoxyli and 200-400 parts of ginger. The traditional Chinese medicine preparation for transdermal drug delivery has a remarkable treatment effect, is nontoxic, is simple and convenient to use, is accepted by patients easily, and is suitable for popularization.
Description
Technical field
The present invention relates to tcm field, particularly a kind of Chinese medicine preparation for the treatment of degeneration gonarthrosis and preparation method thereof.
Background technology
Osteoarthritis (Osteoarthritis, OA), claim again degenerative osteoarthritis, hyperosteogeny, common clinical, frequently-occurring disease, be one take articular cartilage degenerative change as core, involve sclerotin and comprise comprehensive, the chronic inflammatory disease at many levels, in various degree of synovial membrane, joint capsule and other structures of joint; Be a kind of aseptic, chronic, carry out assault sexually joint, mostly occur in heavy burden joint as positions such as knee joint, spinal column (cervical vertebra and lumbar vertebra), hip, ankle, handss.The number that OA suffers from China accounts for 3% of total population, and wherein major part is degeneration gonarthrosis, and more than 55 years old crowd has primary disease shower approximately 60% through x-ray.
The cause of disease of degeneration gonarthrosis is still not clear, and its sickness rate increases with the increase at age, and women falls ill more than male, can be divided into constitutional and Secondary cases two classes.Constitutional person is multiple is born in person in middle and old age, without clear and definite whole body or local inducement, has certain relation with heredity and physical factors.Secondary cases person can betide person between twenty and fifty, can be secondary to wound, inflammation, joint instability, chronic accumulation strain repeatedly or congenital diseases etc.; Heavy physical labour, especially needs to take the physical work of crouching or kneeling position gesture can increase its sickness rate.
Degeneration gonarthrosis Therapeutic Method has: (1) non-drug therapy; (2) Drug therapy (comprises 1. topical medications; 2. whole body analgesic; 3. joint cavity injection; 4. improve state of an illness class medicine and Chondroprotective agents etc.); (3) (common method has operative treatment: 1. episome enucleation; 2. joint debridement art; 3. osteotomy; 4. arthrodesis; 5. arthroplasty etc.).In modern medicine study, for the Therapeutic Method of primary disease, exist deficiency and limitation separately at present: wherein as in the most widely used current Drug therapy: the conventional medicament that is mainly the treatment knee joint osseous arthritiies such as non-steroidal anti-inflammatory drugs, the symptom such as alleviating pain effectively, temporarily improve function of joint, but can not block the progress of OA, can not improve the pathological state of the tissues such as articular cartilage, in addition these medicines may cause some untoward reaction, and with indometacin and aspirin side effect maximum, if the long-term digestive tract ulcer of causing that has for oral administration, the possibility of renal function injury, after pain relieving, over-activity increases the weight of cartilage infringement.Operative treatment itself is exactly a kind of traumatic treatment, to patient, brings certain misery, and is prone to infection, blood vessel, nerve injury, skin, osteonecrosis, patella low level, the bad complication such as joint motion is limited.
Summary of the invention
Based on this, the invention provides Chinese medicine preparation of a kind for the treatment of degeneration gonarthrosis of percutaneous dosing and preparation method thereof.
Treat a Chinese medicine preparation for degeneration gonarthrosis, the effective ingredient of described Chinese medicine preparation is to be prepared from by the crude drug of following weight parts proportioning: Radix Aconiti Lateralis Preparata 300-550 part, Radix Aconiti Preparata 200-360 part, Radix Aconiti Kusnezoffii Preparata 200-360 part, Herba speranskiae tuberculatae 100-180 part, Radix Clematidis 100-180 part, Herba Asari 30-55 part, Ramulus Cinnamomi 100-180 part, Radix Dipsaci 100-180 part, Caulis Kadsurae Coccineae 300-550 part, Herba Taxilli 300-550 part, Radix Zanthoxyli 100-180 part, Rhizoma Zingiberis Recens 200-400 part.
In an embodiment, the effective ingredient of described Chinese medicine preparation is to be prepared from by the crude drug of following weight parts proportioning therein: Radix Aconiti Lateralis Preparata 400-440 part, Radix Aconiti Preparata 260-300 part, Radix Aconiti Kusnezoffii Preparata 260-300 part, Herba speranskiae tuberculatae 120-160 part, Radix Clematidis 120-160 part, Herba Asari 40-45 part, Ramulus Cinnamomi 120-160 part, Radix Dipsaci 120-160 part, Caulis Kadsurae Coccineae 400-440 part, Herba Taxilli 400-440 part, Radix Zanthoxyli 120-160 part, Rhizoma Zingiberis Recens 250-350 part.
In an embodiment, the effective ingredient of described Chinese medicine preparation is to be prepared from by the crude drug of following weight parts proportioning therein: 420 parts of Radix Aconiti Lateralis Preparata, 280 parts of Radix Aconiti Preparatas, 280 parts of Radix Aconiti Kusnezoffii Preparatas, 140 parts of Herba speranskiae tuberculataes, 140 parts of Radix Clematidis, 42 parts of Herba Asaris, 140 parts of Ramulus Cinnamomi, 140 parts of Radix Dipsacis, 420 parts of Caulis Kadsurae Coccineae, 420 parts of Herba Taxillis, 140 parts of Radix Zanthoxylis, 300 parts, Rhizoma Zingiberis Recens.
More than composition is by weight as allocation proportion, when producing, can increase or reduce according to corresponding ratio, and as large-scale production can be take kilogram as unit, or take ton as unit, but the constant rate of medical material weight proportion between each composition.
In an embodiment, the dosage form of described Chinese medicine preparation is patch, ointment, plaster, liniment, lotion, liniment, tincture, spray, aerosol or gel therein.
In an embodiment, described patch is emplastrum, rubber-emplastrum or cataplasma therein.
Therein in an embodiment, more preferably cataplasma of described patch.
A preparation method for the treatment of the Chinese medicine preparation of degeneration gonarthrosis, comprises the steps:
(1) by the crude drug described in claim 1-3 any one, get Rhizoma Zingiberis Recens and squeeze the juice, obtain Sucus Zingberis, standby;
(2) by all the other crude drug, pulverize medicated powder or through extracting, the concentrated concentrated solution that to obtain;
(3) medicated powder or concentrated solution that Sucus Zingberis step (1) being made and step (2) make, be mixed together and evenly make conventional dosage form with pharmaceutically acceptable excipient, obtains.
In an embodiment, comprise the steps: therein
(1) by the crude drug described in claim 1-3 any one, get Rhizoma Zingiberis Recens and squeeze the juice, obtain Sucus Zingberis, standby;
(2) in all the other crude drug, adding volume fraction is that the alcoholic solution of 60-90% extracts, and the weight portion proportioning of described all the other crude drug and alcoholic solution is 1:6-12; Filter, get filtrate and concentrate to obtain thick paste; Described thick paste is at 60 ℃, and relative density is 1.15-1.25; The weight portion proportioning of described all the other crude drug and alcoholic solution is 1:6-12;
(3) thick paste that Sucus Zingberis step (1) being made and step (2) make, is mixed together and evenly makes conventional dosage form with pharmaceutically acceptable excipient, obtains.
Above-mentioned a kind of Chinese medicine preparation for the treatment of degeneration gonarthrosis, have evident in efficacy, avirulence, easy to use, patient be easy to accept, be applicable to promote advantage and beneficial effect.
The specific embodiment
It is following that in connection with embodiment, the present invention is further elaborated.
The preparation of embodiment 1 arthralgia pain gel
1, prepare crude drug and the weight portion proportioning of arthralgia pain gel as follows:
Radix Aconiti Lateralis Preparata 50g Radix Aconiti Preparata 34g Radix Aconiti Kusnezoffii Preparata 35g Herba speranskiae tuberculatae 17g
Radix Clematidis 17g Herba Asari 5g Ramulus Cinnamomi 16g Radix Dipsaci 16g
Caulis Kadsurae Coccineae 50g Herba Taxilli 50g Radix Zanthoxyli 16g Rhizoma Zingiberis Recens 35g
2, the preparation method of arthralgia pain gel, comprises the steps:
(1) get fresh ginger and squeeze the juice, get juice standby;
(2) by all the other Radix Aconiti Lateralis Preparata etc. ten simply, add 8 times of amount volume fraction 70% alcohol reflux secondaries, each 90min, filters, and filtrate merges, and reclaims ethanol to thick paste (relative density is 1.15-1.25(60 ℃));
(3) in the thick paste of step (2) gained, add 2% Borneolum Syntheticum, 1.5% propylene glycol, mix, with triethanolamine adjusting pH value 6.8～7.2, add Acritamer 940, the Sucus Zingberis of 3% azone and step (1) gained, standing make fully swelling, with triethanolamine regulate pH value 6.8～7.2, adding distil water is to 1000g, grind well, obtain.
The preparation of embodiment 2 arthralgia pain ointment
1, prepare crude drug and the weight portion proportioning of arthralgia pain ointment as follows:
Radix Aconiti Lateralis Preparata 30g Radix Aconiti Preparata 21g Radix Aconiti Kusnezoffii Preparata 22g Herba speranskiae tuberculatae 10g
Radix Clematidis 10g Herba Asari 3.2g Ramulus Cinnamomi 11g Radix Dipsaci 11g
Caulis Kadsurae Coccineae 31g Herba Taxilli 32g Radix Zanthoxyli 11g Rhizoma Zingiberis Recens 25g
2, the preparation method of arthralgia pain ointment, comprises the steps:
(1) get fresh ginger and squeeze the juice, point get juice standby;
(2) simply, add 8 times of amount volume fractions is 70% alcohol reflux secondary to all the other Radix Aconiti Lateralis Preparata etc. ten, and each 90min, filters, and filtrate merges, and reclaims ethanol to thick paste (relative density 1.15-1.25(60 ℃)), standby;
(3) separately get white vaseline 500g, lanoline 30g, put heating in water bath to 90 ℃ melting in container, slowly add the extract drugs concentrated solution thick paste of 60 ℃ and the described Sucus Zingberis of step (1) of step (2) gained, limit edged stirs, and keep 20min at this temperature, fully stir and make mix homogeneously, cool to room temperature, get product.
The preparation of embodiment 3 arthralgia pain cream
1, prepare crude drug and the weight portion proportioning of arthralgia pain cream as follows:
Radix Aconiti Lateralis Preparata 60g Radix Aconiti Preparata 72g Radix Aconiti Kusnezoffii Preparata 70g Herba speranskiae tuberculatae 26g
Radix Clematidis 20g Herba Asari 6.4g Ramulus Cinnamomi 32g Radix Dipsaci 28g
Caulis Kadsurae Coccineae 90g Herba Taxilli 64g Radix Zanthoxyli 34g Rhizoma Zingiberis Recens 50g
2, the preparation method of arthralgia pain cream, comprises the steps:
(1) get fresh ginger and squeeze the juice, point get juice standby;
(2) all the other Radix Aconiti Lateralis Preparata etc. ten are ground into coarse powder simply, using 90% ethanol as solvent, and dipping, percolation, collects percolate, reclaims ethanol to without alcohol taste, is concentrated into thick paste (relative density 1.15-1.25(60 ℃));
(3) in the thick paste of step (2) gained, add the Sucus Zingberis of step (1) gained and 5% Borneolum Syntheticum, mix, add the substrate that has rubber, Colophonium, zinc oxide, vaseline and lanoline to make of 4 times of amounts, make coating, be coated with cream, cutting, lid lining, is cut into small pieces, and obtains.The preparation of embodiment 4 arthralgia pain liniments
1, prepare crude drug and the weight portion proportioning of arthralgia pain liniment as follows:
Radix Aconiti Lateralis Preparata 41g Radix Aconiti Preparata 27g Radix Aconiti Kusnezoffii Preparata 27g Herba speranskiae tuberculatae 13g
Radix Clematidis 13g Herba Asari 4.1g Ramulus Cinnamomi 15g Radix Dipsaci 15g
Caulis Kadsurae Coccineae 43g Herba Taxilli 43g Radix Zanthoxyli 15g Rhizoma Zingiberis Recens 33g
2, the preparation method of arthralgia pain liniment, comprises the steps:
(1) get fresh ginger and squeeze the juice, point get juice standby;
(2) all the other Radix Aconiti Lateralis Preparata etc. ten are ground into coarse powder simply, with 60% ethanol 1000ml, divide dipping three times, flood 7 days, merge impregnation liquid, filtrate for later use;
(3) separately get Borneolum Syntheticum and 3% Mentholum and the Sucus Zingberis of step (1) gained of prescription 5% weight, add appropriate 50% ethanol and make to dissolve, add in the impregnation liquid of step (2) gained, add 50% ethanol to 1000ml, mix, standing, filter, obtain.
The preparation of embodiment 5 arthralgia pain liniment
1, prepare crude drug and the weight portion proportioning of arthralgia pain liniment as follows:
Radix Aconiti Lateralis Preparata 41g Radix Aconiti Preparata 27g Radix Aconiti Kusnezoffii Preparata 27g Herba speranskiae tuberculatae 13g
Radix Clematidis 13g Herba Asari 4.1g Ramulus Cinnamomi 13g Radix Dipsaci 13g
Caulis Kadsurae Coccineae 41g Herba Taxilli 41g Radix Zanthoxyli 13g Rhizoma Zingiberis Recens 26g
2, the preparation method of arthralgia pain liniment, comprises the steps:
(1) get fresh ginger and squeeze the juice, point get juice standby;
(2) all the other Radix Aconiti Lateralis Preparata etc. ten are ground into coarse powder simply, using 80% ethanol as solvent, and dipping, percolation, collects percolate, reclaims ethanol to without alcohol taste, is concentrated into thick paste (relative density 1.15-1.25(60 ℃));
(3) in the thick paste of step (2) gained, add the Sucus Zingberis of step (1) gained and 5% Borneolum Syntheticum, dibutyl phthalate and acetone, after to be dissolved mixing, then add polyvinyl formal-acetal, limit edged stirs, and to all dissolving, then adds 70% ethanol to 1000g, subpackage, sealing, obtains.
The preparation of embodiment 6 arthralgia pain cataplasmas
1, prepare crude drug and the weight portion proportioning of arthralgia pain cataplasma as follows:
Radix Aconiti Lateralis Preparata 420g Radix Aconiti Preparata 280g Radix Aconiti Kusnezoffii Preparata 280g Herba speranskiae tuberculatae 140g
Radix Clematidis 140g Herba Asari 42g Ramulus Cinnamomi 140g Radix Dipsaci 140g
Caulis Kadsurae Coccineae 420g Herba Taxilli 420g Radix Zanthoxyli 140g Rhizoma Zingiberis Recens 300g
2, the preparation method of arthralgia pain cataplasma, comprises the steps:
(1) fresh ginger is squeezed the juice, get juice standby, all the other Radix Aconiti Lateralis Preparata etc. ten simply, are ground into fine powder (being following medicated powder), standby;
Preparation A: after sodium polyacrylate (PANa), carbomer are used respectively glycerol stirring and evenly mixing as A;
Preparation B: after polyvinylpyrrolidone (PVP-k30) is dissolved in water, adds under 90 ℃ of water bath condition and be fully stirred to dissolve in (about 15min) polyvinyl alcohol (PVA) aqueous solution, mix homogeneously obtains B;
Preparation C: the B of gained, under 70 ℃ of water bath condition, is added to gelatin, stir and make gelatin fully swelling, after mix homogeneously, then add sorbester p17, fully stir, after mixing, A is slowly added, limit edged keeps rapid stirring, mixes to obtain C;
Preparation D: after dihydroxyaluminum aminoacetate and glycerol are mixed, add 30% tartaric acid solution 5ml, Sucus Zingberis 3g, mix homogeneously, gradation adds 30g medicated powder (crossing 100 mesh sieves) on a small quantity, must D after being fully uniformly mixed;
(2) cataplasma mastic: with 40g water dissolution CMC-Na, 90-100 ℃ of Water Under bathed, and fully stirs, all 90 ℃ of water bath heat preservations after mix homogeneously, add in C, after mix homogeneously, add again kieselguhr 15g, mix, under 70 ℃ of water bath condition, D gradation is added on a small quantity, and limit edged fully stirs, until mix homogeneously, obtain cataplasma mastic, coating, cutting, is drying to obtain.
More than composition, if in grams, can be made into the dosage particles using for 1000 times, as patch, makes 1000 subsides, each serving consumption, can be 1 subsides.
The clinical research of embodiment 7 arthralgia pain external preparation treatment knee osteoarthritis
Test the medicine of medicine used for preparing according to the embodiment of the present invention 1 ~ 2 and embodiment 6, be called arthralgia pain gel, arthralgia pain ointment, arthralgia pain cataplasma, positive control drug is used that function cures mainly, dosage form, route of administration essentially identical " TIANHE GUTONG TIE ", and experimental result is as follows:
One, research purpose and meaning
By randomized controlled trial, the clinical efficacy of objective evaluation said preparation treatment wind cold wetness type knee osteoarthritis, and observe its safety.
Two, clinical implementation scheme
1, test method
Determining of clinical trial case load should meet regulations and statistical requirement, according to the technical requirement > > of < < provisions for new drugs approval > >, < < study of tcm new drug, the treatment group in this test and the ratio of matched group case load should be not more than 3:1.Wherein the case load of the each group for the treatment of group is no less than 30 examples.When qualified experimenter enters test, grouping adopts the grouping of simple randomization method to treat.
2, the selection of matched group
Select that function cures mainly, dosage form, route of administration essentially identical " TIANHE GUTONG TIE " medicine in contrast.
3, administrated method, dosage
Treatment group: arthralgia pain gel group; Arthralgia pain ointment group; The external of arthralgia pain cataplasma group once a day
Matched group: TIANHE GUTONG TIE external once a day
4, the course for the treatment of
Within 2 weeks, be a course for the treatment of, after the course for the treatment of, sum up curative effect.
5, observation project and index
(1) safety observation
1. answer clinically the possible untoward reaction symptom of close observation, comprise systemic adverse reactions, also should record and whether need drug withdrawal, whether take measures.
2. body of the tongue, tongue fur, pulse condition.
3. just conventional, hepatic and renal function of routine blood test, urine.
(2) curative effect observation
1. the gonalgia: range estimation simulation scale method (VAS), please patient mark according to the degree relevant position on scale that feels the gonalgia.
2. tenderness in knee: range estimation simulation scale method (VAS), please patient mark according to own tenderness degree relevant position on scale.
3. symptom and sign scoring.
4. treat just conventional, hepatic and renal function of routine blood test of inspection, urine after 2 weeks.
Three, efficacy assessment standard
1, the curative effect determinate standard of gonarthrosis
Clinical symptoms and sign to Patients with Knee Osteoarthritis are marked, and 100 points of total scores, according to the scoring before and after treatment, are formulated following efficacy assessment standard:
Excellent: after treatment, total score reaches more than 85 points, or improve 25 points of above persons.
Good: after treatment, total score reaches more than 70 points, or improve 15 points of above persons.
Can: after treatment, total score reaches more than 55 points, or improves 15 points of persons of less than.
Poor: to treat rear total score lower than 55 points, or have no enhancer.
2, traditional Chinese medical science main symptom disease, sign curative effect determinate standard
Integration before and after the traditional Chinese medical science disease treatment of main symptom is carried out to statistical analysis, according to symptom integral change judge effective, invalid; To being only the described property analysis of tongue pulse condition.
3, efficacy analysis
1, two groups of acceptance rate comparisons;
2, two groups of VAS scorings relatively.
Four, the selection of statistical method
After clinical trial finishes, after all clinical datas gather, input computer, building database, carries out data management, carries out statistical analysis with SPSS software.According to " clinical trial collection, cleanup standard working specification ", " clinical trial statistical analysis standard operation standard ", carry out the checking of data, typing, statistical analysis.According to the character of clinical testing data (measurement data and ranked data), select suitable statistical analysis technique.Statistical method, measurement data is added and subtracted standard deviation with average
represent, the relatively employing one factor analysis of variance of average between many groups, if average relatively adopts SNK method between two between neat group of variance, if average relatively adopts Dunnett T3 method between two between heterogeneity of variance group; By SPSS15.0 statistical software, completed; Ranked data are with frequency (f), rate value (P) and average Radit value
represent, adopt Radit to analyze, between group, relatively adopt u-test, by PEMS3.1, added up.α=0.05。
Five, clinical test results
1, respectively organize acceptance rate comparison
Patient carries out efficacy evaluation in treatment after 2 weeks, the results are shown in Table 1.Result demonstration, the total acceptance rate of matched group is 33.3%; The total acceptance rate of arthralgia pain gel group is 66.7%; The total acceptance rate of arthralgia pain ointment group is 63.3%; The total acceptance rate of arthralgia pain cataplasma group is 82.5%; The each treatment group of acceptance rate all increases to some extent compared with matched group, significant difference (P<0.01); Show that arthralgia pain gel, arthralgia pain ointment and arthralgia pain cataplasma are evident in efficacy for treatment degeneration gonarthrosis, wherein, arthralgia pain cataplasma curative effect is outstanding.
The respectively acceptance rate comparison of group treatment degeneration gonarthrosis of table 1 (f, P,
Note: with matched group comparison, * * P<0.01
2, respectively organize VAS scoring relatively
The results are shown in Table 2, after each treatment group and treatment of control group, scoring all obviously reduces (P<0.01) before treatment; Each treatment group is compared with matched group, before treatment, between group, VAS diversity of values is not remarkable, after treatment, treatment group scoring obviously reduces compared with matched group, there is significant difference (P<0.01), show that arthralgia pain gel, arthralgia pain ointment and arthralgia pain cataplasma are evident in efficacy for treatment degeneration gonarthrosis.
The each group of table 2 gonalgia VAS scoring relatively
Note: with matched group comparison, * P<0.05, * * P<0.01; Relatively front with treatment, ▲ P<0.05, ▲ ▲ P<0.01
Six, result and discussion
By observing, we do not find obvious untoward reaction symptom clinically, as systemic adverse reactions and gastrointestinal side effect.For this reason, we think that said preparation is safe.
From the Clinical efficacy comparison of each treatment group and matched group, treatment group external arthralgia pain gel, arthralgia pain ointment, after arthralgia pain cataplasma, curative effect is obviously better than matched group, arthralgia pain gel has been described, arthralgia pain ointment, arthralgia pain cataplasma has good therapeutical effect to knee osteoarthritis, and this medicine avirulence, easy to use, patient is easy to accept.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (8)
1. a Chinese medicine preparation for the treatment of degeneration gonarthrosis, is characterized in that, the effective ingredient of described Chinese medicine preparation is to be prepared from by the crude drug of following weight parts proportioning: Radix Aconiti Lateralis Preparata 300-550 part, Radix Aconiti Preparata 200-360 part, Radix Aconiti Kusnezoffii Preparata 200-360 part, Herba speranskiae tuberculatae 100-180 part, Radix Clematidis 100-180 part, Herba Asari 30-55 part, Ramulus Cinnamomi 100-180 part, Radix Dipsaci 100-180 part, Caulis Kadsurae Coccineae 300-550 part, Herba Taxilli 300-550 part, Radix Zanthoxyli 100-180 part, Rhizoma Zingiberis Recens 200-400 part.
2. Chinese medicine preparation according to claim 1, is characterized in that, the effective ingredient of described Chinese medicine preparation is to be prepared from by the crude drug of following weight parts proportioning: Radix Aconiti Lateralis Preparata 400-440 part, Radix Aconiti Preparata 260-300 part, Radix Aconiti Kusnezoffii Preparata 260-300 part, Herba speranskiae tuberculatae 120-160 part, Radix Clematidis 120-160 part, Herba Asari 40-45 part, Ramulus Cinnamomi 120-160 part, Radix Dipsaci 120-160 part, Caulis Kadsurae Coccineae 400-440 part, Herba Taxilli 400-440 part, Radix Zanthoxyli 120-160 part, Rhizoma Zingiberis Recens 250-350 part.
3. Chinese medicine preparation according to claim 2, is characterized in that, the effective ingredient of described Chinese medicine preparation is to be prepared from by the crude drug of following weight parts proportioning: 420 parts of Radix Aconiti Lateralis Preparata, 280 parts of Radix Aconiti Preparatas, 280 parts of Radix Aconiti Kusnezoffii Preparatas, 140 parts of Herba speranskiae tuberculataes, 140 parts of Radix Clematidis, 42 parts of Herba Asaris, 140 parts of Ramulus Cinnamomi, 140 parts of Radix Dipsacis, 420 parts of Caulis Kadsurae Coccineae, 420 parts of Herba Taxillis, 140 parts of Radix Zanthoxylis, 300 parts, Rhizoma Zingiberis Recens.
4. Chinese medicine preparation according to claim 1, is characterized in that, the dosage form of described Chinese medicine preparation is emplastrum, ointment, plaster, liniment, lotion, liniment, tincture, spray, aerosol or gel.
5. Chinese medicine preparation according to claim 4, is characterized in that, described emplastrum is cataplasma, patch or rubber-emplastrum.
6. a preparation method for the treatment of the Chinese medicine preparation of degeneration gonarthrosis, is characterized in that, comprises the steps:
(1) by the crude drug described in claim 1-3 any one, get Rhizoma Zingiberis Recens and squeeze the juice, obtain Sucus Zingberis, standby;
(2) by all the other crude drug, pulverize medicated powder or through extracting, the concentrated concentrated solution that to obtain;
(3) medicated powder or concentrated solution that Sucus Zingberis step (1) being made and step (2) make, be mixed together and evenly make conventional dosage form with pharmaceutically acceptable excipient, obtains.
7. preparation method according to claim 6, is characterized in that, comprises the steps:
(1) by the crude drug described in claim 1-3 any one, get Rhizoma Zingiberis Recens and squeeze the juice, obtain Sucus Zingberis, standby;
(2) in all the other crude drug, adding volume fraction is that the alcoholic solution of 60-90% extracts, and the weight portion proportioning of described all the other crude drug and alcoholic solution is 1:6-12; Filter, get filtrate and concentrate to obtain thick paste; Described thick paste is at 60 ℃, and relative density is 1.15-1.25;
(3) thick paste that Sucus Zingberis step (1) being made and step (2) make, is mixed together and evenly makes conventional dosage form with pharmaceutically acceptable excipient, obtains.
8. according to the preparation method described in claim 6 or 7, it is characterized in that, the described dosage form of step (3) is emplastrum, ointment, plaster, liniment, lotion, liniment, tincture, spray, aerosol or gel.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101485747A (en) * | 2009-03-04 | 2009-07-22 | 陈新华 | Chinese medicinal composition for treating degenerative pathologic changes of knee joint |
| CN102697899A (en) * | 2012-05-24 | 2012-10-03 | 侯俊 | Traditional Chinese medicine composition for treating osteoarthritis and preparation method thereof |
| CN102772753A (en) * | 2012-06-14 | 2012-11-14 | 薛勇 | Traditional Chinese medicine composition for treating hyperosteogeny and preparation method thereof |
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