CN107095907A - A kind of Chinese medicine composition and preparation method thereof and purposes - Google Patents
A kind of Chinese medicine composition and preparation method thereof and purposes Download PDFInfo
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- 241001104043 Syringa Species 0.000 claims abstract description 16
- 235000004338 Syringa vulgaris Nutrition 0.000 claims abstract description 16
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 15
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229940116229 borneol Drugs 0.000 claims abstract description 15
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- 239000004615 ingredient Substances 0.000 claims abstract description 10
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- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Insects & Arthropods (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese medicine composition, including frutus cnidii, lilac, borneol；Preparation method is also disclosed, is comprised the following steps, (1) adds water to cook frutus cnidii, lilac traditional Chinese medicine ingredients；(2) borneol is dissolved standby；(3) solution of step (1), (2) is mixed, stirred through filtering.The Chinese medicine composition of the present invention is used as reduction glans penis sensitivity, the application for the treatment of premature ejaculation medicine.It is an advantage of the current invention that the drug matching of science, can effectively reduce the susceptibility of glans penis, preparation method is easy, and obtained Chinese medicine external easily forms the production of scale, and use is also more convenient, it is easy to which the marketization is promoted.
Description
Technical field
The invention belongs to male's medication technical field of traditional Chinese medicines, specially a kind of Chinese medicine composition and preparation method thereof with
On the way.
Background technology
Glans penis is also known as glans penis, refers to the sphere of penis front end, and per urethram cavernous body front end, which is expanded, forms, and the front end end has
Urethral orifice, is the conjoint outlet of urine and seminal fluid, is male sex organ more important part, also has to reproduction important
Influence, common glans penis illness is that glans penis is sensitive, leads to not normal sexual life, or even plays obstacle to reproductive function,
Prior art typically reduces the sensitivity of glans penis by physics training, but the training of this physics is grown, and is difficult to adhere to, effect
Also it is not notable.
The content of the invention
The present invention in order to solve the above-mentioned technical problem, the invention provides a kind of Chinese medicine composition and preparation method thereof with
On the way, the purpose of realization is：The hypersensitivity of glans penis is reduced using Chinese medicine, male is recovered normal reproductive function.
To obtain above-mentioned technique effect, the technical solution adopted by the present invention is, a kind of Chinese medicine composition that the present invention is provided,
Its composition includes frutus cnidii, lilac, borneol.
Frutus cnidii Cnidium monnieri (L.) Cuss., alias cicely, is the drying of samphire cnidium monnieri
Ripening fruits.Harvested when summer, two season of autumn fruit maturation, remove impurity, dry.Nature and flavor：It is warm-natured, bitter.Major function：Warm kidney is strengthened
Sun, eliminating dampness, wind-dispelling, desinsection.For Gong Leng, morbid leucorrhoea duye, arthritis with fixed pain caused by dampness pain in the back；Control eczema of vulva, married woman's pruritus vulvae, trichomonas vagina outside
It is scorching.
Lilac, also known as lilac, the platymiscium are machaka or dungarunga, frutus cnidii, cloves flower extract institute
Containing phenol compounds material, borneol can promote the drug ingedient of compatibility to be therewith preferably absorbed by the skin, Chinese medicine of the invention
Composition has plant surface anesthetic effect, and plant surface anesthesia is different from Western medicine chemistry anesthesia, and plant surface anesthesia is more heated
With, it is incremental, be more not in dependence, the heat conduction of glans penis portion can be suppressed, mitigate nerve ending susceptibility,
Heat threshold value is improved, the row's of postponement smart time, the purpose of delay is reached.
Further, frutus cnidii mass percent shared in Chinese medicine composition is 15%, and lilac is in Chinese traditional medicine composition
Shared mass percent is 10% in thing, and borneol mass percent shared in Chinese medicine composition is 5%.
Further, said composition also includes barrenwort, Chinese gall, kuh-seng, the matter that each composition is accounted in Chinese medicine composition
Measuring percentage is, barrenwort 20%, Chinese gall 15%, kuh-seng 15%.Frutus cnidii, barrenwort, cloves, Chinese gall, kuh-seng are extracted
Thing contains class Andrin-like action, using there is slight warmth sensation after product, has to premature ejaculation in good therapeutic effect, Chinese gall
Containing tannic acid material, in use for some time, the active ingredient in this product can form protective film in glans penis and frenulum surface,
Physically-isolated effect is played, further reduction glans penis susceptibility.
Further, said composition also includes ethanol, poly hexamethylene biguanide, the matter that each composition is accounted in Chinese medicine composition
Amount percentage is ethanol 0.5%, poly hexamethylene biguanide 0.018%.The traditional Chinese medicine ingredients of compatibility therewith are enable preferably to preserve medicine
Property composition, is easy to form Chinese medicine external agent.
The invention also discloses the method for preparing above-mentioned Chinese medicine composition, comprise the following steps, (1) is by frutus cnidii, cloves
Flower traditional Chinese medicine ingredients are added water to cook；
(2) borneol is dissolved standby；
(3) solution of step (1), (2) is mixed, stirred through filtering.Preparation method is simple, it is easy to form rule
Modelling is promoted.
Further, the step (1) also includes adding water to cook the sheep leaves of pulse plants, Chinese gall, kuh-seng and frutus cnidii, lilac,
The method of decoction is that 8 times of amount decoctings for adding traditional Chinese medicine ingredients for the first time are boiled 2 hours, adds 6 times of amount decoctings of traditional Chinese medicine ingredients to boil for the second time
1.5 hours, merge decoction liquor after decocting twice, continue to decoct under the conditions of 60 DEG C and decoction liquor is concentrated into relative density is
Stop decocting when 1.1.-1.2.Chinese medicine property of traditional Chinese composition is conducive to preferably to extract.
Further, the step (1) includes adding ethanol into the decoction after decoction, reaches ethanol quality in decoction
To 65%, stir, after standing 24 hours, discard precipitation and take supernatant, then ethanol is added into supernatant, make second in decoction
Amount is reached 75% by alcohol matter, then agitated, standing takes supernatant cycling extraction to stop to without ethanol taste after 24 hours, will most
The decoction obtained eventually is dissolved in water, standby.Through ethanol dissolution extraction, make traditional Chinese medicine liquid more stable, at utmost retain the property of medicine into
Point.
Further, poly hexamethylene biguanide water is also included in the step (2) and dissolves standby.
Passed through after also including filtering in the further step (3)60Co irradiation sterilizations, irradiation dose is 5KGy.Can be thorough
Microorganism in decoction is eliminated, and does not destroy property of medicine composition.
It is the invention also discloses the purposes of above-mentioned Chinese medicine composition, the Chinese medicine composition is quick as reduction glans penis
Sense, the application for the treatment of premature ejaculation medicine.
To sum up, beneficial effects of the present invention include, the drug matching of science, can effectively reduce the sensitivity of glans penis
Degree, preparation method is easy, obtained Chinese medicine external, easily forms the production of scale, and use is also more convenient, it is easy to market
Change and promote.
Embodiment
The present invention is described in further detail below by specific embodiment.
Embodiment one：A kind of Chinese medicine composition that the present invention is provided, its composition includes frutus cnidii, lilac, borneol, cnidium monnieri
Son mass percent shared in Chinese medicine composition is 15%, and lilac mass percent shared in Chinese medicine composition is
10%, borneol mass percent shared in Chinese medicine composition is 5%.
Due to frutus cnidii, the contained phenol compounds material of cloves flower extract, with plant anesthetic effect, can suppress
The heat conduction of glans penis portion, mitigates nerve ending susceptibility, improves heat threshold value, the row's of postponement smart time, reaches delay
Purpose, borneol can promote skin to absorb the drug composition, medicine is played maximum effect.
Embodiment two：The Chinese medicine composition that the present invention is provided, including frutus cnidii, lilac, borneol, barrenwort, Chinese gall,
Kuh-seng；Ethanol, poly hexamethylene biguanide, frutus cnidii mass percent shared in Chinese medicine composition is 15%, and lilac exists
Shared mass percent is 10% in Chinese medicine composition, and borneol mass percent shared in Chinese medicine composition is 5%；It is excessive
The sheep leaves of pulse plants 20%, Chinese gall 15%, kuh-seng 15%；Ethanol 0.5%, poly hexamethylene biguanide 0.018%, surplus are water, medicine neck
The conventional excipient in domain.
Above-mentioned composition can be made to external medicinal liquid, preparation method comprises the following steps, (1) is by barrenwort, Chinese gall, hardship
Participate in frutus cnidii, lilac to add water to cook, the method for decoction boils 2 hours, second to add 8 times of traditional Chinese medicine ingredients to measure decoctings for the first time
6 times of amount decoctings of secondary plus traditional Chinese medicine ingredients are boiled 1.5 hours, merge decoction liquor after decocting twice, continuing decoction under the conditions of 60 DEG C will
Stop decocting when decoction liquor is concentrated into relative density for 1.1.-1.2；
Ethanol is added into the decoction after decoction, ethanol quality in decoction is reached 65%, stirs, 24 hours are stood
Afterwards, discard precipitation and take supernatant, then ethanol is added into supernatant, make in decoction ethanol matter that amount reached into 75%, then agitated,
After standing 24 hours, take supernatant cycling extraction to stop to without ethanol taste, the decoction finally given is dissolved in water, it is standby.
(2) borneol is dissolved into standby, poly hexamethylene biguanide water with ethanol and dissolves standby；
(3) solution of step (1), (2) is mixed, stirs through filtering, passed through after filtering60Co irradiation sterilizations, irradiate agent
Measure as 5KGy.It is divided into 5ml/ bottles of packaging.
Glans penis is smeared with a bottle liquid medicine every time, because barrenwort, cloves, Chinese gall, shrubby sophora extract contain class hero
Gonadotropic Effect, using there is slight warmth sensation after product, there is good therapeutic effect to premature ejaculation, simultaneously because in Chinese gall also
There is tannic acid material, in use for some time, the active ingredient in this product can form protective film in glans penis and frenulum surface, rise
To physically-isolated effect, glans penis susceptibility is further reduced.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that including frutus cnidii, lilac, borneol.
2. Chinese medicine composition according to claim 1, it is characterised in that frutus cnidii quality shared in Chinese medicine composition
Percentage is 15%, and lilac mass percent shared in Chinese medicine composition is 10%, borneol institute in Chinese medicine composition
The mass percent accounted for is 5%.
3. Chinese medicine composition according to claim 1, it is characterised in that said composition also includes barrenwort, Chinese gall, hardship
Ginseng, the mass percent that each composition is accounted in Chinese medicine composition is, barrenwort 20%, Chinese gall 15%, kuh-seng 15%.
4. Chinese medicine composition according to claim 1, it is characterised in that said composition also includes ethanol, polyhexamethylene
Biguanides, the mass percent that each composition is accounted in Chinese medicine composition is ethanol 0.5%, poly hexamethylene biguanide 0.018%.
5. a kind of method for preparing any one of the claim 1-4 Chinese medicine compositions, it is characterised in that this method includes as follows
Step, (1) adds water to cook frutus cnidii, lilac traditional Chinese medicine ingredients；
(2) borneol is dissolved standby；
(3) solution of step (1), (2) is mixed, stirred through filtering.
6. the method for Chinese medicine composition is prepared according to claim 5, it is characterised in that the step (1) also includes will be excessive
The sheep leaves of pulse plants, Chinese gall, kuh-seng and frutus cnidii, lilac are added water to cook, and the method for decoction is first time plus 8 times of amount water of traditional Chinese medicine ingredients
Decoct 2 hours, add 6 times of amount decoctings of traditional Chinese medicine ingredients to boil for the second time 1.5 hours, merge decoction liquor after decocting twice, in 60 DEG C of bars
Continue to decoct under part and stop decocting when decoction liquor is concentrated into relative density for 1.1.-1.2.
7. the method for Chinese medicine composition is prepared according to claim 5, it is characterised in that the step (1) is included to pan-fried
Ethanol is added in decoction after boiling, ethanol quality in decoction is reached 65%, stirs, after standing 24 hours, precipitation is discarded
Take supernatant, then ethanol added into supernatant, make in decoction ethanol matter that amount reached into 75%, then it is agitated, stand 24 hours
Afterwards, take supernatant cycling extraction to stop to without ethanol taste, the decoction finally given is dissolved in water, it is standby.
8. the method for Chinese medicine composition is prepared according to claim 5, it is characterised in that also included in the step (2) poly-
Hexamethylene biguan-ide water dissolves standby.
9. the method for Chinese medicine composition is prepared according to claim 5, it is characterised in that also included in the step (3)
Passed through after filter60Co irradiation sterilizations, irradiation dose is 5KGy.
10. the purposes of the Chinese medicine composition described in a kind of any one of claim 1-5, it is characterised in that by the Chinese medicine composition
It is used as reduction glans penis sensitivity, the application for the treatment of premature ejaculation medicine.
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| CN201710466126.1A CN107095907A (en) | 2017-06-19 | 2017-06-19 | A kind of Chinese medicine composition and preparation method thereof and purposes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109893560A (en) * | 2017-12-07 | 2019-06-18 | 北京利普松生物科技有限公司 | A kind of Chinese medicine composition for warming kidney and enhancing body, Traditional Chinese medicine gel powder and its preparation method and application |
| CN113559193A (en) * | 2021-08-13 | 2021-10-29 | 广州一草佰味科技有限公司 | Preparation process of male delay spray |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109893560A (en) * | 2017-12-07 | 2019-06-18 | 北京利普松生物科技有限公司 | A kind of Chinese medicine composition for warming kidney and enhancing body, Traditional Chinese medicine gel powder and its preparation method and application |
| CN113559193A (en) * | 2021-08-13 | 2021-10-29 | 广州一草佰味科技有限公司 | Preparation process of male delay spray |
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Application publication date: 20170829 |