CN107049971A - Acetazolamide tablet and preparation method thereof - Google Patents
Acetazolamide tablet and preparation method thereof Download PDFInfo
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- CN107049971A CN107049971A CN201710118525.9A CN201710118525A CN107049971A CN 107049971 A CN107049971 A CN 107049971A CN 201710118525 A CN201710118525 A CN 201710118525A CN 107049971 A CN107049971 A CN 107049971A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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Abstract
The invention discloses a kind of acetazolamide tablet and preparation method thereof, the acetazolamide tablet includes the disintegration material of the acetazolamide of 200~300 parts by weight, the lactose of 100~200 parts by weight, the cornstarch of 30~45 parts by weight, the pregelatinized starch of 10~20 parts by weight, the PVP of 5~15 parts by weight, the carboxyrnethyl starch sodium of 10~30 parts by weight, the magnesium stearate of 1~4 parts by weight and 4~10 parts by weight.Acetazolamide tablet not only has a good therapeutic effect to glaucoma in the present invention, and the acetazolamide tablet that provides of the present invention can Fast Stripping, dissolution rate is high, rapid-action, improves bioavilability, reduces side effect.In addition, acetazolamide tablet cost made from the above-mentioned formula of present invention use is low, good drug efficacy, so as to reduce treatment cost.
Description
Technical field
The present invention relates to acetazolamide field, more particularly to a kind of acetazolamide tablet and preparation method thereof.
Background technology
Acetazolamide is a kind of carbonic anhydrase inhibitor, is mainly used in reducing intraocular pressure, suppresses ciliary body skin carbonic anhydrase
Activity, so as to reduce aqueous humor generation, declines intraocular pressure, it is adaptable to treat various types of glaucomas, such as open-angle (chronic herpes
Property) glaucoma, angle-closure glaucoma etc..But, acetazolamide is insoluble in water so that the tablet has disintegration time length, action
Slowly, the low shortcoming of bioavilability, so as to influence the performance of drug effect.
The content of the invention
In view of this, it is an object of the invention to provide a kind of acetazolamide tablet and preparation method thereof, when can shorten disintegration
Between, it is rapid-action, bioavilability is high.
A kind of acetazolamide tablet, includes the raw material of following parts by weight：
Preferably, the raw material of following parts by weight is included：
Preferably, the disintegration material is calcium sulfate and sodium carboxymethyl starch.
Preferably, the mass ratio of the calcium sulfate and the sodium carboxymethyl starch is (1~3):(0.8~2).
Present invention also offers a kind of above-mentioned preparation method of acetazolamide tablet, comprise the following steps：
A) by acetazolamide, lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, stearic acid
Magnesium, disintegration material through screens are standby；And cornstarch is divided into the first cornstarch and the second cornstarch；
B) acetazolamide, lactose, the first cornstarch, pregelatinized starch are weighed, intelligent full automatic high efficiency is incorporated into wet
Dry-mixed, 5~15min in method granulator；PVP, sucrose, purified water are added, is pelletized；
C) particle for making step b) carries out whole grain, drying, obtains acetazolamide dry particl；
D) the acetazolamide dry particl that obtains step c), carboxyrnethyl starch sodium, the second cornstarch are added to Multidirectional motion
In mixer, after 10~15min of mixing, magnesium stearate and disintegration material, tabletting are added, acetazolamide tablet is obtained.
Preferably, drying time is 4~8min in step c), and drying temperature is 50~60 DEG C.
Preferably, the mass ratio of first cornstarch and second cornstarch is (35~40)：(4~6).
Preferably, in step c) whole grain process use vibratory sieve the mesh of screen size 14.
Preferably, the disintegration material is calcium sulfate and sodium carboxymethyl starch.
A kind of acetazolamide tablet that the present invention is provided and preparation method thereof, the acetazolamide tablet includes 200~300 weight
The acetazolamide, the lactose of 100~200 parts by weight, the cornstarch of 30~45 parts by weight, the pregelatinated of 10~20 parts by weight of part
Starch, the PVP of 5~15 parts by weight, the carboxyrnethyl starch sodium of 10~30 parts by weight, the magnesium stearate of 1~4 parts by weight and 4~10
The disintegration material of parts by weight.Acetazolamide tablet not only has good therapeutic effect to glaucoma in the present invention, and the present invention is carried
The acetazolamide tablet of confession can Fast Stripping, dissolution rate is high, rapid-action, improves bioavilability, reduces side effect.Separately
Outside, the present invention is using acetazolamide tablet cost made from above-mentioned formula is low, good drug efficacy, so as to reduce treatment cost.
Embodiment
The invention discloses a kind of acetazolamide tablet and preparation method thereof, those skilled in the art can be used for reference in herein
Hold, be suitably modified technological parameter realization.In particular, the similar replacement and change are to those skilled in the art
For be it will be apparent that they are considered as being included in the present invention.The method of the present invention and reference are by preferably implementing
Example is described, related personnel substantially can not departing from present invention, in spirit and scope to method described herein and
Using being modified or suitably changing with combining, to realize and apply the technology of the present invention.
A kind of acetazolamide tablet that the present invention is provided, includes the raw material of following parts by weight：
In above-mentioned technical proposal, acetazolamide tablet not only has good therapeutic effect to glaucoma, and the present invention is provided
Acetazolamide tablet can Fast Stripping, dissolution rate is high, rapid-action, improves bioavilability, reduces side effect.In addition,
Acetazolamide tablet cost made from the above-mentioned formula of present invention use is low, good drug efficacy, so as to reduce treatment cost.
In the present invention, the parts by weight of acetazolamide are 200~300 parts；In an embodiment of the present invention, acetazolamide
Parts by weight be 230~270 parts；In other embodiments, the parts by weight of acetazolamide are 240~260 parts.
In the present invention, the parts by weight of lactose are 100~200 parts；In an embodiment of the present invention, the parts by weight of lactose
Number is 135~175 parts；In other embodiments, the parts by weight of lactose are 140~160 parts.
In the present invention, the parts by weight of cornstarch are 35~50 parts；In an embodiment of the present invention, cornstarch
Parts by weight are 39~46 parts；In other embodiments, the parts by weight of cornstarch are 41~44 parts.
In the present invention, the parts by weight of pregelatinized starch are 10~20 parts；In an embodiment of the present invention, pregelatinated forms sediment
The parts by weight of powder are 13~17 parts；In other embodiments, the parts by weight of pregelatinized starch are 14~16 parts.
In the present invention, the parts by weight of PVP are 5~15 parts；In an embodiment of the present invention, the weight of PVP
Fraction is 7~12 parts；In other embodiments, the parts by weight of PVP are 9~11 parts.
In the present invention, the parts by weight of sucrose are 5~15 parts；In an embodiment of the present invention, the parts by weight of sucrose
For 7~12 parts；In other embodiments, the weight fraction of PVP is 9~11 parts.
In the present invention, the parts by weight of carboxyrnethyl starch sodium are 10~30 parts；In an embodiment of the present invention, carboxymethylstarch
The parts by weight of sodium are 15~25 parts；In other embodiments, the parts by weight of carboxyrnethyl starch sodium are 18~22 parts.
In the present invention, the parts by weight of magnesium stearate are 1~4 part；In an embodiment of the present invention, the weight of magnesium stearate
It is 1.5~3.5 parts to measure number；In other embodiments, the parts by weight of magnesium stearate are 2~3 parts.
In the present invention, the parts by weight of disintegration material are 4~10 parts；In an embodiment of the present invention, it is disintegrated material
Parts by weight are 6~8 parts；In other embodiments, the parts by weight of disintegration material are 6.5~7.5 parts.
In an embodiment of the present invention, disintegration material is calcium sulfate and sodium carboxymethyl starch.The disintegration material can increase
The disintegration ability of acetazolamide, and then make it that the rapid-action of acetazolamide, bioavilability are high.
In an embodiment of the present invention, the mass ratio of calcium sulfate and sodium carboxymethyl starch is (1~3):(0.8~2).
Present invention also offers a kind of preparation method of acetazolamide tablet, comprise the following steps：
A) by acetazolamide, lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, stearic acid
Magnesium, disintegration material through screens are standby；And cornstarch is divided into the first cornstarch and the second cornstarch；
B) acetazolamide, lactose, the first cornstarch, pregelatinized starch are weighed, intelligent full automatic high efficiency is incorporated into wet
Dry-mixed, 5~15min in method granulator；PVP, sucrose, purified water are added, is pelletized；
C) particle for making step b) carries out whole grain, drying, obtains acetazolamide dry particl；
D) the acetazolamide dry particl that obtains step c), carboxyrnethyl starch sodium, the second cornstarch are added to Multidirectional motion
In mixer, after 10~15min of mixing, magnesium stearate and disintegration material, tabletting are added, acetazolamide tablet is obtained.
Wherein, acetazolamide, lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, stearic acid
Magnesium, disintegration material are same as above, will not be repeated here.
In above-mentioned technical proposal, preparation method is simple, with short production cycle, and production efficiency is high, the acetazolamide prepared
Piece not only has a good therapeutic effect to glaucoma, and the acetazolamide tablet that provides of the present invention being capable of Fast Stripping, dissolution
Degree is high, rapid-action, improves bioavilability, reduces side effect.In addition, present invention process is simply operable, process controllability
Height, is adapted to the big production of industrialization.
In order to ensure the release of product stable homogeneous, product property stable homogeneous is good simultaneously, and differences between batches are small, reappearance
It is excellent.In an embodiment of the present invention, acetazolamide Metformin hydrochloride crosses 20 mesh sieves, lactose, cornstarch, pregelatinated form sediment
Powder, PVP, sucrose, carboxyrnethyl starch sodium, magnesium stearate, disintegration material cross 30 mesh sieves.
In an embodiment of the present invention, drying time is 4~8min in step c), and drying temperature is 60~80 DEG C, so that
So that moisture is in 1wt%-2wt% in dried particle.
In an embodiment of the present invention, the mass ratio of the first cornstarch and the second cornstarch is (35~40)：(4~
6)；Cornstarch is divided into two parts, and added step by step, so as to shorten the disintegration time of acetazolamide tablet.
In an embodiment of the present invention, in step b) purified water 60~70 parts of parts by weight.
In an embodiment of the present invention, in step c) whole grain process use vibratory sieve the mesh of screen size 14 so that
It is 250mg to obtain every acetazolamide tablet.
The acetazolamide tablet provided to further illustrate the present invention with reference to embodiment the present invention and its preparation side
Method is described in detail.
Embodiment 1
Acetazolamide is crossed into 20 mesh sieves, it is lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, hard
Fatty acid magnesium, disintegration material cross 30 mesh sieves, standby；And cornstarch is divided into the cornstarch of 29.88g first and the jade of 5.12g second
Rice starch；200g acetazolamide, 135g lactose, the first cornstarch, 14g pregelatinized starch are weighed, intellectuality is incorporated into complete certainly
Dry-mixed, 5min in dynamic efficient wet granulator；15g PVPs, 12g sucrose, 60g purified waters are added, is pelletized；Will be obtained
Grain is put into the vibratory sieve that screen size is 14 mesh and carries out drying 4min at 70 DEG C again after whole grain, whole grain, obtains acetazolamide
Dry particl；Obtained acetazolamide dry particl, 22g carboxyrnethyl starch sodiums, the second cornstarch are added to Mixers with Multi-direction Movement
In, after mixing 12min, 2g magnesium stearates, 2g calcium sulfate and 4g sodium carboxymethyl starches, tabletting are added, 250mg acetyl is obtained
Azoles amine piece.
Embodiment 2
Acetazolamide is crossed into 20 mesh sieves, it is lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, hard
Fatty acid magnesium, disintegration material cross 30 mesh sieves, standby；And cornstarch is divided into the cornstarch of 43.37g first and the jade of 6.63g second
Rice starch；300g acetazolamide, 175g lactose, the first cornstarch, 16g pregelatinized starch are weighed, intellectuality is incorporated into complete certainly
Dry-mixed, 8min in dynamic efficient wet granulator；5g PVPs, 7g sucrose, 65g purified waters are added, is pelletized；By obtained particle
It is put into the vibratory sieve that screen size is 14 mesh to carry out drying 5min at 70 DEG C again after whole grain, whole grain, obtains acetazolamide and do
Particle；Obtained acetazolamide dry particl, 18g carboxyrnethyl starch sodiums, the second cornstarch are added in Mixers with Multi-direction Movement,
Mix after 107min, add 3g magnesium stearates, 3.64g calcium sulfate and 4.36g sodium carboxymethyl starches, tabletting, obtain 250mg's
Acetazolamide tablet.
Embodiment 3
Acetazolamide is crossed into 20 mesh sieves, it is lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, hard
Fatty acid magnesium, disintegration material cross 30 mesh sieves, standby；And cornstarch is divided into the cornstarch of 34.36g first and the jade of 4.64g second
Rice starch；230g acetazolamide, 140g lactose, the first cornstarch, 13g pregelatinized starch are weighed, intellectuality is incorporated into complete certainly
Dry-mixed, 10min in dynamic efficient wet granulator；12g PVPs, 15g sucrose, 70g purified waters are added, is pelletized；Will be obtained
Particle is put into the vibratory sieve that screen size is 14 mesh and carries out drying 6min at 80 DEG C again after whole grain, whole grain, obtains acetyl azoles
Amine dry particl；Obtained acetazolamide dry particl, 25g carboxyrnethyl starch sodiums, the second cornstarch are added into Multidirectional motion to mix
In machine, after mixing 15min, 1.5g magnesium stearates, 3.61g calcium sulfate and 2.89g sodium carboxymethyl starches, tabletting are added, is obtained
250mg acetazolamide tablet.
Embodiment 4
Acetazolamide is crossed into 20 mesh sieves, it is lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, hard
Fatty acid magnesium, disintegration material cross 30 mesh sieves, standby；And cornstarch is divided into the cornstarch of 41.62g first and the jade of 4.38g second
Rice starch；270g acetazolamide, 160g lactose, the first cornstarch, 17g pregelatinized starch are weighed, intellectuality is incorporated into complete certainly
Dry-mixed, 12min in dynamic efficient wet granulator；7g PVPs, 5g sucrose, 64g purified waters are added, is pelletized；Will be obtained
Grain is put into the vibratory sieve that screen size is 14 mesh and carries out drying 7min at 75 DEG C again after whole grain, whole grain, obtains acetazolamide
Dry particl；Obtained acetazolamide dry particl, 15g carboxyrnethyl starch sodiums, the second cornstarch are added to Mixers with Multi-direction Movement
In, after mixing 13min, 3.5g magnesium stearates, 4.81g calcium sulfate and 2.69g sodium carboxymethyl starches, tabletting are added, is obtained
250mg acetazolamide tablet.
Embodiment 5
Acetazolamide is crossed into 20 mesh sieves, it is lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, hard
Fatty acid magnesium, disintegration material cross 30 mesh sieves, standby；And cornstarch is divided into the cornstarch of 36.76g first and the jade of 4.24g second
Rice starch；240g acetazolamide, 100g lactose, the first cornstarch, 10g pregelatinized starch are weighed, intellectuality is incorporated into complete certainly
Dry-mixed, 15min in dynamic efficient wet granulator；11g PVPs, 11g sucrose, 67g purified waters are added, is pelletized；Will be obtained
Particle is put into the vibratory sieve that screen size is 14 mesh and carries out drying 8min at 65 DEG C again after whole grain, whole grain, obtains acetyl azoles
Amine dry particl；Obtained acetazolamide dry particl, 30g carboxyrnethyl starch sodiums, the second cornstarch are added into Multidirectional motion to mix
In machine, after mixing 15min, 4g magnesium stearates, 2.86g calcium sulfate and 1.14g sodium carboxymethyl starches, tabletting are added, is obtained
250mg acetazolamide tablet.
Embodiment 6
Acetazolamide is crossed into 20 mesh sieves, it is lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, hard
Fatty acid magnesium, disintegration material cross 30 mesh sieves, standby；And cornstarch is divided into the cornstarch of 39.11g first and the jade of 4.89g second
Rice starch；260g acetazolamide, 200g lactose, the first cornstarch, 20g pregelatinized starch are weighed, intellectuality is incorporated into complete certainly
Dry-mixed, 10min in dynamic efficient wet granulator；9g PVPs, 9g sucrose, 66g purified waters are added, is pelletized；Will be obtained
Grain is put into the vibratory sieve that screen size is 14 mesh and carries out drying 6min at 60 DEG C again after whole grain, whole grain, obtains acetazolamide
Dry particl；Obtained acetazolamide dry particl, 10g carboxyrnethyl starch sodiums, the second cornstarch are added to Mixers with Multi-direction Movement
In, after mixing 10min, 1g magnesium stearates, 7.06g calcium sulfate and 2.94g sodium carboxymethyl starches, tabletting are added, 250mg is obtained
Acetazolamide tablet.
Embodiment 7
Acetazolamide is crossed into 20 mesh sieves, it is lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, hard
Fatty acid magnesium, disintegration material cross 30 mesh sieves, standby；And cornstarch is divided into the cornstarch of 37.5g first and the corns of 5g second shallow lake
Powder；250g acetazolamide, 150g lactose, the first cornstarch, 15g pregelatinized starch are weighed, is incorporated into intelligent full-automatic high
Imitate dry-mixed, 10min in wet granulator；10g PVPs, 10g sucrose, 65g purified waters are added, is pelletized；By obtained particle
It is put into the vibratory sieve that screen size is 14 mesh to carry out drying 6min at 70 DEG C again after whole grain, whole grain, obtains acetazolamide and do
Particle；Obtained acetazolamide dry particl, 20g carboxyrnethyl starch sodiums, the second cornstarch are added in Mixers with Multi-direction Movement,
Mix after 12min, add 2.5g magnesium stearates, 4.85g calcium sulfate and 2.15g sodium carboxymethyl starches, tabletting, obtain 250mg
Acetazolamide tablet.
The dissolution rate of acetazolamide tablet made from embodiment 1~7 is measured, 1 is the results are shown in Table.
The dissolution results of the embodiment 1~7 of table 1
The foregoing description of the disclosed embodiments, enables professional and technical personnel in the field to realize or public to institute using this
The described above for the embodiment opened, enables professional and technical personnel in the field to realize or using the present invention.To these embodiments
A variety of modifications will be apparent for those skilled in the art, and generic principles defined herein can be
In the case of not departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention is not intended to be limited to
The embodiments shown herein, and it is to fit to the most wide model consistent with novel features with principles disclosed herein
Enclose.
Claims (9)
1. a kind of acetazolamide tablet, it is characterised in that include the raw material of following parts by weight：
2. acetazolamide tablet as claimed in claim 1, it is characterised in that include the raw material of following parts by weight：
3. acetazolamide tablet as claimed in claim 1 or 2, it is characterised in that the disintegration material is calcium sulfate and carboxymethyl
Sodium starch.
4. acetazolamide tablet as claimed in claim 3, it is characterised in that the matter of the calcium sulfate and the sodium carboxymethyl starch
Amount is than being (1~3):(0.8~2).
5. a kind of preparation method of acetazolamide tablet as claimed in claim 1 or 2, it is characterised in that comprise the following steps：
A) by acetazolamide, lactose, cornstarch, pregelatinized starch, PVP, sucrose, carboxyrnethyl starch sodium, magnesium stearate, collapse
Solve material through screens standby；And cornstarch is divided into the first cornstarch and the second cornstarch；
B) acetazolamide, lactose, the first cornstarch, pregelatinized starch are weighed, intelligent full automatic high efficiency wet method system is incorporated into
Dry-mixed, 5~15min in grain machine；PVP, sucrose, purified water are added, is pelletized；
C) particle for making step b) carries out whole grain, drying, obtains acetazolamide dry particl；
D) the acetazolamide dry particl that obtains step c), carboxyrnethyl starch sodium, the second cornstarch are added to Multidirectional motion mixing
In machine, after 10~15min of mixing, magnesium stearate and disintegration material are added, tabletting obtains acetazolamide tablet.
6. preparation method as claimed in claim 5, it is characterised in that drying time is 4~8min, drying temperature in step c)
For 60~80 DEG C.
7. preparation method as claimed in claim 5, it is characterised in that first cornstarch and second cornstarch
Mass ratio be (35~40)：(4~6).
8. preparation method as claimed in claim 5, it is characterised in that the sieve aperture for the vibratory sieve that whole grain process is used in step c)
The mesh of size 14.
9. preparation method as claimed in claim 5, it is characterised in that the disintegration material is calcium sulfate and CMS
Sodium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710118525.9A CN107049971A (en) | 2017-03-01 | 2017-03-01 | Acetazolamide tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710118525.9A CN107049971A (en) | 2017-03-01 | 2017-03-01 | Acetazolamide tablet and preparation method thereof |
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| CN107049971A true CN107049971A (en) | 2017-08-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710118525.9A Pending CN107049971A (en) | 2017-03-01 | 2017-03-01 | Acetazolamide tablet and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3671633A (en) * | 1971-05-10 | 1972-06-20 | American Cyanamid Co | Process for tabletting acetazolamide |
| CN1704054A (en) * | 2004-05-31 | 2005-12-07 | 马晶 | Dispersible tablet of acetazolamide and its preparation method |
| CN104434837A (en) * | 2014-12-05 | 2015-03-25 | 海南卫康制药(潜山)有限公司 | Acetazolamide composition lyophilized tablet and preparation method thereof |
-
2017
- 2017-03-01 CN CN201710118525.9A patent/CN107049971A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3671633A (en) * | 1971-05-10 | 1972-06-20 | American Cyanamid Co | Process for tabletting acetazolamide |
| CN1704054A (en) * | 2004-05-31 | 2005-12-07 | 马晶 | Dispersible tablet of acetazolamide and its preparation method |
| CN104434837A (en) * | 2014-12-05 | 2015-03-25 | 海南卫康制药(潜山)有限公司 | Acetazolamide composition lyophilized tablet and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 鲁强: "乙酰唑胺固体分散片的制备及体外溶出特性研究", 《齐鲁药事》 * |
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