CN107049911A - A kind of composition for treating red blood silk and its application - Google Patents
A kind of composition for treating red blood silk and its application Download PDFInfo
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- CN107049911A CN107049911A CN201611269819.3A CN201611269819A CN107049911A CN 107049911 A CN107049911 A CN 107049911A CN 201611269819 A CN201611269819 A CN 201611269819A CN 107049911 A CN107049911 A CN 107049911A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21004—Trypsin (3.4.21.4)
Abstract
The present invention relates to composition and its application for treating red blood silk.The composition includes mussel soft tissue extract, trypsase and hyaluronic acid and/or its sodium salt, can optionally include other carriers.The pharmaceutical composition for the treatment of red blood silk prepared by the present invention while effectively treatment skin red blood silk can activating skin cell viability, tighten skin, increase skin resistance, supplemented the nutrients to skin, to skin-whitening and dispel pigment etc. and have good curative effect.Composition of the invention is gentle, non-stimulated, have no toxic side effect, without using dependence, persistent.
Description
Technical field
The present invention relates to medical applications or commodity technical field, more particularly, to a kind of combination for treating red blood silk
Thing and its application.
Background technology
Red blood silk, which is that facial telangiectasias poor performance, cuticula are impaired or a part of capillary position table is shallow, to be caused
Facial phenomenon, a silk is crisscross, such as cobweb, and dispersiveness distribution, severe patient can be linked to be sheet, become to blush.Face
Portion red blood silk patient facial region looks redder than the normally colour of skin, and what is had is only that both sides cheekbone portion is rubescent, and border is rounded.It is this
Skin is thin and sensitive, supercooling, overheat, it is excited when face it is redder.Severe patient can also form deposition color spot, it is difficult to cure,
The beauty of appearance is not only influenceed, also shade can be caused to psychology, great inconvenience is brought to normal life.Cause the original of red blood silk
Because being substantially divided to two big types：Genotype and induction type.Genotype is familial heredity mostly, and induction type is the most common, the original of generation
Because mainly having following several：(1) it is local that corticoid medicine is used for a long time, cause telangiectasis, cause thinning of skin,
Atrophy etc.；(2) blood circulation is obstructed, and vascular wall, which is retarded by silt, makes face that a rule red blood silk is presented；(3) misuse containing hormone or medicine into
Part skin care item, photon delicate skin, tartaric acid, which change the exfoliatings such as skin treatment, makes keratoderma thinning transparent, easily forms red blood silk；(4)
Itself it is sensitive skin, stimulates sensitive to external world, pine when tight when causing peripheral vessel is presented extravasated blood state repeatedly, causes blood vessel
Roundabout expansion, forms red blood silk.
Mussel (Mytilusedulis Linnaeus) is a kind of sea mollusk, belongs to bivalve shellfish, is commonly called as " blue or green
Mouthful " and " mussel ", each coastal state of throughout world.Mussel species are various, and only coastal area of china just has kind more than 30, and economic value is higher
Have kind more than 10, wherein Mytilus galloprovincialis, Perna viridis and Trachyostracous mussel is main breed variety.Enriched Mussel containing protein, fat,
The nutrients such as carbohydrate, calcium, phosphorus, iron, riboflavin, niacin, and with very high medical value.
Trypsase (Trypsin, Parenzyme), EC 3.4.21.4 are one kind from the pancreas extraction of ox, sheep, pig
Serine protein hydrolase.The precursor trypsinogen of pancreas manufacture is secreted into after small intestine, and erepsin activates it, as pancreas egg
White enzyme.Trypsase is endopeptidase, the carboxyl that it can optionally in the lysine and arginine residues of hydrolyzed peptide chain.
Trypsase not only plays digestive ferment, and it is other to limit decomposition chymotrypsinogen, procarboxypeptidase, phosphatide proenzyme etc.
The precursor of enzyme, plays activation.
Hyaluronic acid (Hyaluronic Acid, HA) is one of main component of human body matrix, for O- β-D- grapes
Alditol acidic group (1 → 3)-N- acetyl group-β-D- aminoglucoses glycosyls (1 → 4) are viscous more for one kind of the disaccharide repetitive structure of unit
Sugar, molecular weight is 40,000,000~80,000,000 dalton.Hyaluronic acid has the property that gel is combined to form with a large amount of water.
The method for the treatment of red blood silk is relatively more in the market, typically there is following several.1st, liquid nitrogen cryotherapy：It is applied to
The shallower patient of affected part color, but this method effect is not thorough, and may leave uneven spot after freezing.2nd, photon is controlled
Treat：General photon delicate skin equipment has certain " blindness " to the therapeutic modality of red blood silk, and it is in not any subsidiary conditions
Under just carry out the treatment of large area rashly, due to can not clearly see the place of red blood silk clearly, treat lack of targeted, not only create
Face is big, and treatment number of times is also more (generally requiring 5~8 times), can also make not triggering the skin of red blood silk to be damaged, face's large area hair
Red, pain and recover it is slower.3rd, laser therapy：Laser therapy is typically applicable the deeper nevus flammeus of color, but it requires to treat
Person technically if laser therapy exposure dose is too big, will will form scar, Er Qiechuan because of overexposure very in place
Face is larger, and what is had there is also pigment deposition phenomenon.4th, medicine smears treatment：Stimulate larger, resultant effect is not obvious.In addition,
Patient often carries out skin care in order that the skin controlled oneself is beautiful, delicacy using various cosmetics.Red blood silk is suffered from used in face
On sensitive, produced after allergic, this will bring to patient has big pain；Therefore for a long time, people are thirsty always
Hope find one kind can facial beautification and skin rejuvenation function, make skin fine and smooth, can alleviate or remove the face of people's red blood trace on face or thorax of blushing again
The red products of portion Eradicates, but this problem all fails to be well solved for a long time.
The content of the invention
For solve the effect present in the method for existing treatment red blood silk not thoroughly, easily repeatedly, side effect is strong, easily form anti-
The defects such as the property of medicine, the present invention proposes a kind of composition for treating red blood silk, including mussel soft tissue extract, trypsase and thoroughly
Bright matter acid and/or its sodium salt.
According to one or more embodiments of the present invention, the composition can be by weight：Mussel soft tissue is carried
Take thing 1-20 parts by weight, trypsase 1-40 parts by weight and hyaluronic acid and/or its sodium salt 1-10 parts by weight.
Specifically, according to one or more embodiments of the present invention, based on the weight of composition, mussel soft tissue is extracted
Thing can be such as 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts,
7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14
Part, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts etc.,
Trypsase can be such as 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5
Part, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts etc., hyalomitome
Acid and/or its sodium salt can be such as 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts,
Any specific parts by weight in 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts.
According to one or more embodiments of the present invention, in the composition of the treatment red blood silk：Mussel soft tissue is carried
Thing, trypsase and hyaluronic acid is taken to be individually insulated presence or can be mixed.Here, " isolation is present " refers to three kinds
Composition is to keep the non-interfering independent packaging of respective property to exist." being mixed " refers to that three kinds of compositions are mixed in one
In individual packaging, then or, the combination of two components is present, and separates with third component and exist.
According to one or more embodiments of the present invention, in the composition of the treatment red blood silk：Mussel soft tissue is carried
It can be dry powder to take thing, trypsase and Sodium Hyaluronate.
According to one or more embodiments of the present invention, in the composition of the treatment red blood silk：Mussel soft tissue is carried
It can be liquid to take thing trypsase and hyaluronic acid.
In addition, the present invention also proposes a kind of composition for treating red blood silk, contain mussel soft tissue extract, trypsase
With hyaluronic acid and/or its sodium salt, optionally, it can also contain above-mentioned other active components.
According to the one or more aspects of the present invention, the composition of the treatment red blood silk may further include collagen egg
White and/or elastin laminin isoreactivity composition.
According to the one or more aspects of the present invention, the composition of the treatment red blood silk may further include vitamin
C, honey/honey powder, prinsepia utilis royle oil isoreactivity composition.
According to the one or more aspects of the present invention, the composition of the treatment red blood silk may further include plant and carry
Thing is taken, including but not limited to green-tea extract, purslane extract, Gotu Kola P.E, camomile extract, aloe is extracted
Thing, Extract from Orange Peel etc..
According to the one or more aspects of the present invention, the Extract from Orange Peel can be hesperetin and/or aurantiamarin.
According to the one or more aspects of the present invention, the composition of the treatment red blood silk may further include plant essence
Oil, including but not limited to Rosa Damascana, chamomile essential oil, parsley essential oil, cypress essential oil, Lavender, laurin oil, lemon
Essential oil, grapefruit essential oil and Geranium Essential etc..
According to one or more embodiments of the present invention, the composition is formulated as the final ph after liquid for 2.5-
9.0, for example, it is preferable to pH value is 4.5-8.0, or, such as preferable ph is 5.5-7.0.
According to the present invention one or more embodiments, the mussel soft tissue extract refer to mussel except shell with
Outer component namely mussel soft tissue are raw material, the wherein supernatant for extracting and obtaining by acidic aqueous solution, protein content
For 0.2-15mg/ml, pH value 1.0-6.0.Especially, can be using byssus as raw material.
According to the one or more aspects of the present invention, the mussel includes one in Mytilus galloprovincialis, Perna viridis, Trachyostracous mussel
Kind, two or three.
According to one or more embodiments of the present invention, the acidic aqueous solution can include：Acetic acid-acetate buffer
Liquid, acetic acid, citric acid, perchloric acid etc., but not limited to this.
According to one or more embodiments of the present invention, the protein content of the mussel soft tissue extract can be
Such as 0.2mg/ml, 0.3mg/ml, 0.4mg/ml, 0.5mg/ml, 0.6mg/ml, 0.7mg/ml, 0.8mg/ml, 0.9mg/ml,
1.0mg/ml、1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、
5.0mg/ml、5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、
9.0mg/ml、9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/
Ml, 13.0mg/ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml etc., but not limited to this.
According to one or more embodiments of the present invention, the trypsase can be conventional purchase from the market.
Alternatively, the trypsase can be by saltouing, it is prepared by the method such as column chromatography.
According to one or more embodiments of the present invention, the hyaluronic acid can be conventional purchase from the market.
Alternatively, the hyaluronic acid can be artificial synthesized by using native enzyme polymerisation.Alternatively, the hyaluronic acid
It can be its sodium salt.
According to the one or more aspects of the present invention, the composition can be used for red blood trace on face etc..
According to the one or more aspects of the present invention, the composition can also be containing other conventional or acceptable auxiliary
Material.According to the one or more aspects of the present invention, the auxiliary material can be NMF, antioxidant, bacteriostatic agent, essence or matrix
Material etc..
According to the present invention one or more aspects, described composition can be prepared into facial mask, emulsion, creme, paste,
The formulations such as spray, gel, gel.
In addition, the invention also provides it is being made up of sea-mussel mucin, trypsase and hyaluronic acid or containing it is described into
Application of the composition divided in treatment red blood silk.
A further object of the present invention is related to a kind of method for treating red blood silk, including gives the combination of the present invention
Thing.
According to the one or more aspects of the present invention, the composition according to the present invention, institute are given to subject in need
Composition is stated to be made up of mussel soft tissue extract, trypsase and hyaluronic acid.
According to one or more embodiments of the present invention, the mussel soft tissue extract, trypsase and hyalomitome
Acid can be mixed in composition.
According to one or more embodiments of the present invention, the mussel soft tissue extract, trypsase and hyalomitome
Acid can be individually insulated to be present in composition.Here, when by mussel soft tissue extract, trypsase and hyaluronic acid group
When closing administration, administration can be order of administration or be administered simultaneously, and preferably can be order of administration.For order of administration,
Mussel soft tissue extract, trypsase and hyaluronic acid can be in any order administered.For example, it is soft first to give mussel
Tissue extract gives trypsase and gives hyaluronic acid again again, and whole treatment is continued with the administration of this sequence alternate, or can be with
First give trypsase and give mussel soft tissue extract again and give hyaluronic acid again, continue entirely to control with the administration of this sequence alternate
Treat, or can be administered in every day for the treatment of with different order.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight, and
Hyaluronic acid 1-10 parts by weight.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight,
Hyaluronic acid 1-10 parts by weight, and
Vitamin C 1-50 parts by weight.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight,
Hyaluronic acid 1-10 parts by weight,
Green-tea extract 1-50 parts by weight, and
Purslane extract 1-20 parts by weight.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight,
Hyaluronic acid 1-10 parts by weight,
Prinsepia utilis royle oil 1-20 parts by weight,
Honey 1-50 parts by weight, and
Essential oil 1-20 parts by weight.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight,
Hyaluronic acid 1-10 parts by weight,
Elastin laminin 1-15 parts by weight, and
Growth factor 1-10 parts by weight.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight,
Hyaluronic acid 1-10 parts by weight, and
Gotu Kola P.E 1-2 parts by weight.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight,
Hyaluronic acid 1-10 parts by weight,
Camomile extract 1-15 parts by weight, and
Aloe extract 1-10 parts by weight.
In one aspect of the invention, a kind of composition for treating red blood silk, including：
Mussel soft tissue extract 1-20 parts by weight,
Trypsase 1-40 parts by weight,
Hyaluronic acid 1-10 parts by weight, and
Extract from Orange Peel 1-7 parts by weight.
In addition, the present invention also proposes a kind of pharmaceutical composition for treating red blood silk, contain mussel soft tissue extract, pancreas egg
White enzyme and hyaluronic acid, optionally, can also pharmaceutically be commonly used or acceptable carrier containing other.
According to the one or more aspects of the present invention, the carrier can include any and all solvent, salt, disperse
Medium, coating material, surfactant, antioxidant, preservative (such as antiseptic, antifungal agent), isotonic agent, absorption delay
Agent, drug stabilizing agent, adhesive, excipient, disintegrant, lubricant, sweetener, flavouring, dyestuff etc. and they in it is a kind of, many
Plant or whole combinations, this is well-known to those skilled in the art (for example, see Remington's Pharmaceutical
Sciences,18th Ed.Mack Printing Company,1990,pp.1289-1329).Except with active component not phase
Outside the carrier of appearance, it is contemplated that treatment with or composition in any conventional carrier for using.
The drug regimen for the treatment of red blood silk is prepared using trypsase, hyaluronic acid and mussel soft tissue extractive composition
Thing, not only can effectively treat skin red blood silk, promote skin microcirculation, simultaneously because containing portion in mussel soft tissue extract
Point protein ingredient, molecular weight is big, will not transdermal or percutaneous absorbtion, can lasting stability played a role in skin surface, extension effect
Time, make skin-whitening, have a good complexion.Compared to only with medicine of the hyaluronic acid as active component, combination of the invention
The effect of thing is significantly superior.
The pharmaceutical composition for the treatment of red blood silk prepared by the present invention can be activated while effectively treatment skin red blood silk
Skin cell vitality, tighten skin, increase skin resistance, supplemented the nutrients to skin, to skin-whitening and dispelling pigment etc. and have
Good curative effect.Composition of the invention is gentle, non-stimulated, have no toxic side effect, without using dependence, persistent.
Embodiment
Following examples are illustrated by taking the composition for treating red blood silk as an example, but not limited to this, and the invention described above is proposed
The various red blood silk treatment products comprising mussel soft tissue extract, trypsase and hyaluronic acid and/or its sodium salt fit
For the present invention.
Embodiment 1：The preparation method of mussel soft tissue extract.
Take mussel to shell, collect soft tissue 300g, be divided into three parts, every part adds in the table 1 below of 100ml contents 0.3%
It is mussel soft tissue extract that centrifugation, which obtains supernatant, after acid solution, homogenate 10min.
Protein content and pH value in supernatant are determined, protein content is determined using Coomassie Brilliant Blue.
Table 1
| Example | Acid solution | Protein content | PH value |
| 1 | Citric acid | 2.6mg/ml | 4.5 |
| 2 | Acetic acid | 3.5mg/ml | 3.2 |
| 3 | Perchloric acid | 3.0mg/ml | 1.0 |
Embodiment 2：The facial mask that a kind of mussel soft tissue extract is made
Mussel soft tissue extract dry powder 20mg is taken, adds after deionized water fully dissolves and forms facial mask liquid.By face paper
Face is spread on after absorbent solution in immersion facial mask liquid, facial mask is removed after 30 minutes.
Embodiment 3：The facial mask that a kind of trypsase is made
From Shaanxi, trypsase is bought by Yuan Tai biotechnologies company.Trypsase dry powder 10mg is taken, deionized water is added and fills
Facial mask liquid is formed after dividing dissolving.Face paper is immersed in facial mask liquid and spreads on face after absorbent solution, facial mask is removed after 30 minutes.
Embodiment 4：The facial mask that a kind of mussel soft tissue extract is made with trypsin composition
From Shaanxi, trypsase is bought by Yuan Tai biotechnologies company.Take mussel soft tissue extract dry powder 20mg, tryptose
Enzyme dry powder 10mg, adds after deionized water fully dissolves and forms facial mask liquid.Face paper is immersed in facial mask liquid and applied after absorbent solution
In removing facial mask after face, 30 minutes.
Embodiment 5：A kind of composition facial mask of trypsase, Sodium Hyaluronate and mussel soft tissue extract.
From Shaanxi, trypsase is bought by Yuan Tai biotechnologies company.Trypsase, Sodium Hyaluronate and mussel soft tissue are carried
Take thing to combine the facial mask to be formed to be made up of following components：Mussel soft tissue extract dry powder 20mg, trypsase dry powder 10mg, thoroughly
The sour sodium 15mg of bright matter, adds after deionized water fully dissolves and forms facial mask liquid.Face paper is immersed in facial mask liquid after absorbent solution
Face is spread on, facial mask is removed after 30 minutes.
Embodiment 6：
Collect 48 volunteers and participate in test, be divided into 4 groups, group 1 is made of the mussel soft tissue extract of embodiment 2
Facial mask, the facial mask that group 2 is made of the trypsase of embodiment 3, group 3 uses the mussel soft tissue extract and pancreas of embodiment 4
The facial mask that protease composition is made, group 4 uses trypsase, Sodium Hyaluronate and the mussel soft tissue extract of embodiment 5
Composition facial mask, apply once daily, 10 days are course for the treatment of, are paid a return visit in 1 month and record recurrence.
Curative effect determinate standard：
It is effective：Treat after 3 courses for the treatment of, red blood silk is not almost seen, in a short time without recurrence；
Effectively：Treat after 3 courses for the treatment of, red blood silk is significantly reduced, in a short time without recurrence；
It is invalid：Red blood trace on face is without significant change.
Total effective rate=obvious effective rate+effective percentage.
Curative effect is shown in Table 2.
Table 2:Test curative effect
| It is effective | Effectively | It is invalid | It is total | Efficient (%) | |
| Group 1 | 2 | 3 | 7 | 12 | 41.67 |
| Group 2 | 0 | 0 | 12 | 12 | 0 |
| Group 3 | 5 | 4 | 3 | 12 | 75 |
| Group 4 | 8 | 3 | 1 | 12 | 91.67 |
It can be seen that, after trypsase, Sodium Hyaluronate and mussel soft tissue extractive composition, red blood silk situation has bright
It is aobvious to improve, it was demonstrated that trypsase, Sodium Hyaluronate and mussel soft tissue extractive composition have the function for the treatment of red blood silk.
Embodiment 7：A kind of trypsase, Sodium Hyaluronate and mussel soft tissue extractive composition.
Prepare the composition being made up of following components：Mussel soft tissue extract dry powder 50mg, trypsase dry powder 20mg,
Sodium Hyaluronate 15mg, camomile extract 15mg, add water to 100g and fully dissolve, mix.
Collect 50 volunteers to participate in testing, smear face sooner or later using composition daily 2 times, massage 15-20 minutes, often
7 are a course for the treatment of, stop starting next course for the treatment of after 5 days, amount to 3 courses for the treatment of.
Curative effect determinate standard：
It is effective：Treat after 3 courses for the treatment of, red blood silk is not almost seen, in a short time without recurrence；
Effectively：Treat after 3 courses for the treatment of, red blood silk is significantly reduced, in a short time without recurrence；
It is invalid：Red blood trace on face is without significant change.
Total effective rate=obvious effective rate+effective percentage.
It is effective up to 5 after one course for the treatment of, effective 18, total effective rate 46%；Total effective (containing the previous course for the treatment of) reaches after two courses for the treatment of
27, total effective rate is up to 76%, it is shown that the present invention works very fast.It is effective up to 40 after four courses for the treatment of, effective 6 (red blood silk portions
Divide and disappear), total effective rate 92%.Statistical result after per the course for the treatment of is shown in Table 3.
Statistical result after the every course for the treatment of of table 3
| After one course for the treatment of | After two courses for the treatment of | After three courses for the treatment of | After four courses for the treatment of | |
| Effective (example) | 5 | 27 | 34 | 40 |
| Effectively (example) | 18 | 11 | 9 | 6 |
| Invalid (example) | 27 | 12 | 7 | 4 |
| Total effective rate (%) | 46 | 76 | 86 | 92 |
It can be seen that, after the composition using the present invention, red blood silk situation has clear improvement, it was demonstrated that composition of the invention has
Treat the function of red blood silk.Moreover, it has been found that adding the better of camomile extract, this is adding green-tea extract, horse
Identical knot is also obtained after the other plant extract such as sativa extract, Gotu Kola P.E, aloe extract, Extract from Orange Peel
By data are not shown.
Embodiment 8：A kind of trypsase, Sodium Hyaluronate and mussel soft tissue extractive composition.
Prepare the composition being made up of following components：Mussel soft tissue extract dry powder 100mg, trypsase dry powder
20mg, Sodium Hyaluronate 15mg, vitamin C 0.5g, solid bee honey 0.5g, add water to 100g mixings.
Collect 31 volunteers to participate in using 2 times after test, daily face cleaning, be massaged into absorption, evaluated after 30 days.
Curative effect determinate standard：
It is effective：Treat after 3 courses for the treatment of, red blood silk is not almost seen, in a short time without recurrence；
Effectively：Treat after 3 courses for the treatment of, red blood silk is significantly reduced, in a short time without recurrence；
It is invalid：Red blood trace on face is without significant change.
Total effective rate=obvious effective rate+effective percentage.
It the results are shown in Table 4.
Table 4
| It is effective | Effectively | It is invalid | It is total | Efficient (%) |
| 19 | 9 | 3 | 31 | 90.32 |
After composition using the present invention, red blood silk situation has clear improvement, it was demonstrated that trypsase, Sodium Hyaluronate are with making a gift of
Shellfish soft tissue extractive composition has the function for the treatment of red blood silk.
Embodiment 9：A kind of trypsase, Sodium Hyaluronate and mussel soft tissue extractive composition.
Prepare the composition being made up of following components：Mussel soft tissue extract dry powder 100mg, trypsase dry powder
20mg, Sodium Hyaluronate 15mg, EGF 0.5g, solid bee honey 0.5g, add water to 100g mixings.
Collect 30 volunteers and participate in test, sooner or later each daily to smear once, smearing position is face, and different subjects are left
Right face is grouped at random, fixed respectively per one side of something face to smear placebo, and control evaluation is carried out after 28 days.
Curative effect determinate standard：
It is effective：Treat after 3 courses for the treatment of, red blood silk is not almost seen, in a short time without recurrence；
Effectively：Treat after 3 courses for the treatment of, red blood silk is significantly reduced, in a short time without recurrence；
It is invalid：Red blood trace on face is without significant change.
Total effective rate=obvious effective rate+effective percentage.
After pharmaceutical composition using the present invention, the effective percentage of 28 days is 96%.It is equal to Secondary cases red blood silk therapeutic effect
Significantly.There are the phenomenons such as allergy, skin discomfort without a reaction.
Certainly, the present invention can also have other various embodiments, ripe in the case of without departing substantially from spirit of the invention and its essence
Various corresponding changes and deformation, but these corresponding changes and deformation can be made according to the present invention by knowing those skilled in the art
The protection domain of the claims in the present invention should all be belonged to.
Claims (10)
1. a kind of composition for treating red blood silk, it is characterised in that the composition includes mussel soft tissue extract, tryptose
Enzyme and hyaluronic acid and/or its sodium salt.
2. the composition for the treatment of red blood silk according to claim 1, it is characterised in that the gross weight meter based on composition,
The component of the composition is：Mussel soft tissue extract 1-20 parts by weight, trypsase 1-40 parts by weight, hyaluronic acid and/
Or its sodium salt 1-10 parts by weight, specifically, based on the weight of composition, mussel soft tissue extract can be such as 1 part, 1.5
Part, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts,
9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5
Part, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts, trypsase can be such as 1
Part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5
Part, 9 parts, 9.5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, hyaluronic acid and/or its sodium salt can be for example
1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5
Part, 9 parts, 9.5 parts, any specific parts by weight in 10 parts.
3. the composition of the treatment red blood silk according to foregoing any claim, it is characterised in that the composition enters one
Step includes plant extracts or plants essential oil.
4. according to the composition of the treatment red blood silk of foregoing any claim, it is characterised in that the composition is further wrapped
Other active components are included, including selected from vitamin C, prinsepia utilis royle oil, honey；Collagen, elastin laminin；Growth factor；And
Wherein described plant extracts includes but is not limited to green-tea extract, purslane extract, Gotu Kola P.E, chamomile and extracted
Thing, aloe extract and Extract from Orange Peel；The plants essential oil includes but is not limited to Rosa Damascana, chamomile essential oil, parsley essence
Oil, cypress essential oil, Lavender, laurin oil, lemon, grapefruit essential oil and Geranium Essential be grouped in one kind
Or it is a variety of.
5. according to the composition of the treatment red blood silk of foregoing any claim, wherein in the composition：Mussel soft tissue is carried
Thing, trypsase and hyaluronic acid is taken to be individually insulated presence or be mixed；And/or the composition of wherein described treatment red blood silk
In：Mussel soft tissue extract, trypsase and hyaluronic acid are dry powder or liquid.
6. according to the composition of the treatment red blood silk of foregoing any claim, wherein the composition of the treatment red blood silk is prepared
It is 2.5-9.0 for the final ph after liquid, for example, it is preferable to which pH value is 4.5-8.0, for example, it is preferable to which pH value is 5.5-7.0；With/
Or wherein described mussel soft tissue extract is the supernatant for extracting and obtaining by acidic aqueous solution using mussel soft tissue as raw material
Liquid, wherein protein content are 0.2-15mg/ml, pH value 1.0-6.0.
7. according to the composition of the treatment red blood silk of foregoing any claim, made a gift of wherein the mussel includes Mytilus galloprovincialis, emerald
One kind in shellfish, Trachyostracous mussel, two or three, and/or wherein described acidic aqueous solution includes：Acetic acid-sodium acetate buffer solution,
Acetic acid, citric acid, perchloric acid, or wherein described mussel soft tissue extract protein content be, for example, 0.2mg/ml,
0.3mg/ml、0.4mg/ml、0.5mg/ml、0.6mg/ml、0.7mg/ml、0.8mg/ml、0.9mg/ml、1.0mg/ml、
1.5mg/ml、2.0mg/ml、2.5mg/ml、3.0mg/ml、3.5mg/ml、4.0mg/ml、4.5mg/ml、5.0mg/ml、
5.5mg/ml、6.0mg/ml、6.5mg/ml、7.0mg/ml、7.5mg/ml、8.0mg/ml、8.5mg/ml、9.0mg/ml、
9.5mg/ml、10.0mg/ml、10.5mg/ml、11.0mg/ml、11.5mg/ml、12.0mg/ml、12.5mg/ml、13.0mg/
Ml, 13.5mg/ml, 14.0mg/ml, 14.5mg/ml and 15.0mg/ml.
8. a kind of pharmaceutical composition, it is characterised in that described pharmaceutical composition is the red blood for the treatment of according to foregoing any claim
The composition of silk, or include the composition of the treatment red blood silk according to foregoing any claim, described pharmaceutical composition bag
Include mussel soft tissue extract, trypsase and hyaluronic acid.
9. pharmaceutical composition according to claim 8, the composite medicine further comprises pharmaceutically acceptable carrier, example
As solvent, salt, decentralized medium, coating material, surfactant, antioxidant, preservative (such as antiseptic, antifungal agent),
Isotonic agent, absorption delaying agent, drug stabilizing agent, adhesive, excipient, disintegrant, lubricant, sweetener, flavouring, dyestuff etc.
With a kind of in them, a variety of or whole combinations.
10. pharmaceutical composition according to claim 8 or claim 9, it is characterised in that described pharmaceutical composition is facial mask, emulsion, frost
Agent, paste, spray, gel or gel form.
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| CN201611269819.3A CN107049911A (en) | 2016-12-30 | 2016-12-30 | A kind of composition for treating red blood silk and its application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109745269A (en) * | 2017-11-07 | 2019-05-14 | 陕西博鸿生物科技集团有限公司 | A kind of red capillary maintenance essence and preparation method thereof |
| CN111632013A (en) * | 2020-06-09 | 2020-09-08 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN113244156A (en) * | 2021-05-28 | 2021-08-13 | 广东省科学院化工研究所 | Anti-aging composition and application thereof |
-
2016
- 2016-12-30 CN CN201611269819.3A patent/CN107049911A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109745269A (en) * | 2017-11-07 | 2019-05-14 | 陕西博鸿生物科技集团有限公司 | A kind of red capillary maintenance essence and preparation method thereof |
| CN111632013A (en) * | 2020-06-09 | 2020-09-08 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN111632013B (en) * | 2020-06-09 | 2022-06-28 | 广州市科能化妆品科研有限公司 | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof |
| CN113244156A (en) * | 2021-05-28 | 2021-08-13 | 广东省科学院化工研究所 | Anti-aging composition and application thereof |
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